AR248405A1 - Procedimiento para obtener dibenzofurano sustituido. - Google Patents
Procedimiento para obtener dibenzofurano sustituido.Info
- Publication number
- AR248405A1 AR248405A1 AR90316737A AR31673790A AR248405A1 AR 248405 A1 AR248405 A1 AR 248405A1 AR 90316737 A AR90316737 A AR 90316737A AR 31673790 A AR31673790 A AR 31673790A AR 248405 A1 AR248405 A1 AR 248405A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- compounds
- group
- aryl
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE BENZOFURANO DE FORMULA (I), DONDE: A) N ES UN ENTERO DE 1 A 5; B) R1 ES ALQUILO, FENILO SUSTITUIDO O NO POR CL, I, BR, -CF3, -OCH3, ALQUILO, - CN, -NH2, -NO2 O -CONH2; PH(CH2)N DONDE N VALE DE 1 A 5, PH(CH2)N DONDE PH ESTA SUSTITUIDO POR CL, BR, I, - CF3, ALQUILO, -CN, -NO2, -NH2 O -COH2 Y C) R2 ES CO2R3, DONDE R3 ES ALQUILO, ARILO, O ARALQUILO, SALES ALCANOATOS, -C(O)NR4R5 DONDE R4 ES HIDROGENO, ALQUILO O ARILO Y R4 = R5 O R4 Y R5 FORMA UN ANILLO HETEROCICLICO CON EL N COMO UNICO HETEROATOMO, TETRAZOL, ACIDO SULFINICO, ACIDO SULFONICO, HEMIESTERES, DE ACIDOS SULFURICOS O DERIVADOS DE SULFONAMIDAS DE LOS MISMOS, QUE COMPRENDE HACER REACCIONAR (IA), DONDE T ES UN GRUPO PROTECTOR SILILETER, A ES =O O -OH CON UN REACTIVO DESBLOQUEANTE, PARA FORMAR LOS COMPUESTO DE DIBENZOFURANO DE FORMULA (IB) Y FORMAN POR REDUCCION DEL GRUPO =O DE A PRESENTE EN LOS COMPUESTOS (IB) PARA FORMAR LOS COMPUESTOS (I) DONDE A ES OH Y SI ES NECESARIO, HIDROLIZAR PREV IAMENTE LOS COMPUESTOS (IB) DONDE ES UN GRUPO COR3, PARA FORMAR LOS COMPUESTOS (I) DONDE R2 ES UN GRUPO ALCANOATO Y LUEGO REDUCIR EL GRUPO =O QUE COMPRENDE A A TAL COMO YA SE HA INDICADO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/409,630 US5019573A (en) | 1989-09-19 | 1989-09-19 | Substituted dibenzofurans and methods of using same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR248405A1 true AR248405A1 (es) | 1995-08-18 |
Family
ID=23621327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR90316737A AR248405A1 (es) | 1989-09-19 | 1990-04-27 | Procedimiento para obtener dibenzofurano sustituido. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5019573A (es) |
| EP (1) | EP0422329B1 (es) |
| JP (1) | JPH03145484A (es) |
| KR (1) | KR0155556B1 (es) |
| CN (1) | CN1042030C (es) |
| AR (1) | AR248405A1 (es) |
| AT (1) | ATE125534T1 (es) |
| AU (1) | AU632851B2 (es) |
| CA (1) | CA2013960C (es) |
| DE (1) | DE69021162T2 (es) |
| DK (1) | DK0422329T3 (es) |
| EG (1) | EG19729A (es) |
| ES (1) | ES2076248T3 (es) |
| FI (1) | FI904448A0 (es) |
| GR (1) | GR3017784T3 (es) |
| IE (1) | IE69050B1 (es) |
| IL (1) | IL93856A (es) |
| NO (1) | NO175780C (es) |
| NZ (1) | NZ233058A (es) |
| PH (1) | PH26748A (es) |
| PT (1) | PT95362B (es) |
| ZA (1) | ZA902345B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980369A (en) * | 1989-09-19 | 1990-12-25 | Allergan, Inc. | Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl or thiochromanyl group having retinoid-like activity |
| EP2520654B8 (en) | 2003-08-26 | 2017-04-19 | The Regents of the University of Colorado, a body corporate | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| CN1318411C (zh) * | 2005-03-21 | 2007-05-30 | 中国海洋大学 | 氢化轮枝霉酮类化合物及其制备方法和用途 |
| US20080124303A1 (en) * | 2005-12-12 | 2008-05-29 | Cavit Sciences, Inc | Methods and compositions for treatment of viral infections |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3867409A (en) * | 1969-06-16 | 1975-02-18 | Richardson Merrell Inc | Bis-basic esters of dibenzofuran |
| US3649651A (en) * | 1969-07-02 | 1972-03-14 | American Home Prod | Dibenzofuran derivatives and preparation thereof |
| US4022805A (en) * | 1974-03-07 | 1977-05-10 | Hoffmann-La Roche Inc. | 8-Halo-dibenzofuran-3-acetic acids and certain esters thereof |
| US4769387A (en) * | 1987-11-13 | 1988-09-06 | Abbott Laboratories | Dibenzofuran lipoxygenase inhibiting compounds, compositions and use |
-
1989
- 1989-09-19 US US07/409,630 patent/US5019573A/en not_active Expired - Lifetime
-
1990
- 1990-03-23 IL IL9385690A patent/IL93856A/en active IP Right Grant
- 1990-03-23 NZ NZ233058A patent/NZ233058A/en unknown
- 1990-03-27 ZA ZA902345A patent/ZA902345B/xx unknown
- 1990-04-03 PH PH40317A patent/PH26748A/en unknown
- 1990-04-05 CA CA002013960A patent/CA2013960C/en not_active Expired - Fee Related
- 1990-04-27 DK DK90108031.7T patent/DK0422329T3/da active
- 1990-04-27 AT AT90108031T patent/ATE125534T1/de not_active IP Right Cessation
- 1990-04-27 ES ES90108031T patent/ES2076248T3/es not_active Expired - Lifetime
- 1990-04-27 AR AR90316737A patent/AR248405A1/es active
- 1990-04-27 EP EP90108031A patent/EP0422329B1/en not_active Expired - Lifetime
- 1990-04-27 DE DE69021162T patent/DE69021162T2/de not_active Expired - Fee Related
- 1990-05-06 EG EG26890A patent/EG19729A/xx active
- 1990-05-22 CN CN90103815A patent/CN1042030C/zh not_active Expired - Fee Related
- 1990-08-07 IE IE283690A patent/IE69050B1/en not_active IP Right Cessation
- 1990-09-10 FI FI904448A patent/FI904448A0/fi not_active IP Right Cessation
- 1990-09-18 AU AU62651/90A patent/AU632851B2/en not_active Ceased
- 1990-09-18 NO NO904060A patent/NO175780C/no unknown
- 1990-09-19 PT PT95362A patent/PT95362B/pt not_active IP Right Cessation
- 1990-09-19 JP JP2251662A patent/JPH03145484A/ja active Pending
- 1990-09-19 KR KR1019900014836A patent/KR0155556B1/ko not_active IP Right Cessation
-
1995
- 1995-10-18 GR GR950402886T patent/GR3017784T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5019573A (en) | 1991-05-28 |
| IL93856A (en) | 1996-08-04 |
| NZ233058A (en) | 1991-05-28 |
| CA2013960C (en) | 2000-06-27 |
| NO904060D0 (no) | 1990-09-18 |
| FI904448A0 (fi) | 1990-09-10 |
| PH26748A (en) | 1992-09-28 |
| DE69021162D1 (de) | 1995-08-31 |
| KR910006262A (ko) | 1991-04-29 |
| KR0155556B1 (ko) | 1998-11-16 |
| AU632851B2 (en) | 1993-01-14 |
| CN1042030C (zh) | 1999-02-10 |
| NO175780C (no) | 1994-12-07 |
| DE69021162T2 (de) | 1996-02-15 |
| CA2013960A1 (en) | 1991-03-19 |
| JPH03145484A (ja) | 1991-06-20 |
| ZA902345B (en) | 1990-12-28 |
| EG19729A (en) | 1996-01-31 |
| NO175780B (no) | 1994-08-29 |
| PT95362A (pt) | 1991-06-25 |
| NO904060L (no) | 1991-03-20 |
| EP0422329A1 (en) | 1991-04-17 |
| IE69050B1 (en) | 1996-08-07 |
| AU6265190A (en) | 1991-03-28 |
| IL93856A0 (en) | 1990-12-23 |
| DK0422329T3 (da) | 1995-09-11 |
| GR3017784T3 (en) | 1996-01-31 |
| EP0422329B1 (en) | 1995-07-26 |
| ES2076248T3 (es) | 1995-11-01 |
| ATE125534T1 (de) | 1995-08-15 |
| IE902836A1 (en) | 1991-03-27 |
| CN1050384A (zh) | 1991-04-03 |
| PT95362B (pt) | 1997-06-30 |
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