AR245715A1 - Procedimiento para obtener derivados del cromano. - Google Patents
Procedimiento para obtener derivados del cromano.Info
- Publication number
- AR245715A1 AR245715A1 AR90317000A AR31700090A AR245715A1 AR 245715 A1 AR245715 A1 AR 245715A1 AR 90317000 A AR90317000 A AR 90317000A AR 31700090 A AR31700090 A AR 31700090A AR 245715 A1 AR245715 A1 AR 245715A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- aco
- compound
- nha
- cho
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
OBTENCION DE DERIVADOS DEL CROMANO DE FORMULA (I), DONDE R1 ES A; R2 Y R8 INDEPENDIENTEMENTE SON H O A, Y TAMBIEN, R1 Y R2,JUNTOS, SON ALQUILENO;R3 ES OH, OA U OAC; R4 ES H, Y TAMBIEN R3 Y R4,JUNTOS, SON UNA LIGADURA; R5 ES AR O CNH2N-R9,DONDE R9 ES ALQUENILO, ALQUINILO, OH, OA, CHO, CO-A, CS-A, COOH, COOA, COO-ALQUIL-AR, CS-OA, NO2, NH2, NHA, NA2, CN, F, CL, BR, I, CF3, SA, SO-A, SO2-AO AR;Y N VALE 1, 2 O 3; Y AR ES FENILO SUSTITUIDO O NO CON R10;R6, R7 Y R10, INDEPENDIENTEMENTE SON H, A, HO, AO, CHO, ACO, CF3CO, ACS, HOOC, AOOC, AO-CS, ACO-O, AC-S-O, HIDROXIALQUILO, MERCAPTOALQUILO, NO2,NH2, NHA, NA2, CN, F, CL, BR, I, CF3, AS, ASO, ASO2, AO-SO, AO-SO2, ACNH, AO-CO-NH, H2NSO, HANSO, A2NSO, H2NSO2, HANSO2, A2NSO2, H2NCO,HANCO, A2NCO, H2NCS, HANCS,A2NCS, ASONH, ASO2NH,AOSONH, AOSO2, AOSO2NH, ACO- ALQUILO (C1-6), NITROALQUILO, CIANOLAQUILO, A-C(=NOH), A-C(=NNH2); H2PO3 O A2PO3; A ES ALQUILO; AC ES ALCANOILO O AROILO, Y DONDE SE HACE REACCIONAR UN CROMANO DE FORMULA (II), -X-Y- ES FO RMULA (VI) O -CHE-CR3R8, DONDE E ES CL, BR, I O UN GRUPO DE OH ESTERIFICADO, CAPAZ DE REACCIONAR CON UN COMPUESTO DE FORMULA (III), O BIEN, UN COMPUESTO DE FORMULA IV CON UNCOMPUESTO DE FORMULA: E-R5.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3918041A DE3918041A1 (de) | 1989-06-02 | 1989-06-02 | Chromanderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR245715A1 true AR245715A1 (es) | 1994-02-28 |
Family
ID=6381944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR90317000A AR245715A1 (es) | 1989-06-02 | 1990-06-01 | Procedimiento para obtener derivados del cromano. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5112972A (es) |
| EP (1) | EP0400430B1 (es) |
| JP (1) | JPH0320275A (es) |
| KR (1) | KR910000713A (es) |
| AR (1) | AR245715A1 (es) |
| AT (1) | ATE110072T1 (es) |
| AU (1) | AU623780B2 (es) |
| CA (1) | CA2017961A1 (es) |
| DE (2) | DE3918041A1 (es) |
| DK (1) | DK0400430T3 (es) |
| ES (1) | ES2057262T3 (es) |
| FI (1) | FI95701C (es) |
| HU (1) | HUT58323A (es) |
| IE (1) | IE65098B1 (es) |
| IL (1) | IL94256A (es) |
| NO (1) | NO175976C (es) |
| NZ (1) | NZ233912A (es) |
| PT (1) | PT94225B (es) |
| TW (1) | TW210338B (es) |
| ZA (1) | ZA904227B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3835011A1 (de) * | 1988-10-14 | 1990-04-19 | Merck Patent Gmbh | Chromanderivate |
| US5387587A (en) * | 1986-12-23 | 1995-02-07 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
| DE3837809A1 (de) * | 1988-11-08 | 1990-05-10 | Merck Patent Gmbh | Tetralinderivate |
| DE3924417A1 (de) * | 1989-07-24 | 1991-01-31 | Merck Patent Gmbh | Chromanderivate |
| JP3442815B2 (ja) * | 1992-05-13 | 2003-09-02 | 第一製薬株式会社 | ジアザビシクロアルケン誘導体 |
| GB9316111D0 (en) * | 1993-08-04 | 1993-09-22 | Pfizer Ltd | Benzopyrans |
| EP0677519A4 (en) * | 1993-11-10 | 1996-04-03 | Japan Tobacco Inc | CHROMAN DERIVATIVE AND THERAPEUTIC USE THEREOF. |
| US5470861A (en) * | 1994-08-04 | 1995-11-28 | Hoffmann-La Roche Inc. | Method of promoting hair growth |
| AU7319800A (en) * | 1999-09-24 | 2001-04-24 | Nissan Chemical Industries Ltd. | 4-oxybenzopyran derivative |
| US6677371B1 (en) * | 1999-10-05 | 2004-01-13 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| CA2505500C (en) | 2002-11-12 | 2009-08-18 | Warner-Lambert Company Llc | Method of stimulating hair growth using benzopyrans |
| CA2589363A1 (en) * | 2004-12-13 | 2006-06-22 | Eli Lilly And Company | Spiro derivatives as lipoxygenase inhibitors |
| WO2007027780A2 (en) * | 2005-09-01 | 2007-03-08 | Janssen Pharmaceutica N.V. | Benzopyran and pyranopyridine derivatives as potassium channel openers |
| WO2024040267A2 (en) * | 2022-08-19 | 2024-02-22 | Mitokinin, Inc. | Direct synthesis of n-(3-substituted-chroman-4-yl)-7h- pyrrolo[2,3-d]pyrimidin-4-amines and derivatives thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2107706A (en) * | 1981-09-25 | 1983-05-05 | Beecham Group Plc | Benzopyrans |
| DE3364145D1 (de) * | 1982-04-08 | 1986-07-24 | Beecham Group Plc | Antihypertensive benzopyranols |
| EP0093534A1 (en) * | 1982-04-28 | 1983-11-09 | Beecham Group Plc | Novel chromanols |
| GB8419516D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
| GB8419515D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
| PT84806B (pt) * | 1986-05-03 | 1989-12-29 | Beecham Group Plc | Processo para a preparacao de benzopiranos |
| DE3726261A1 (de) * | 1986-12-23 | 1988-07-07 | Merck Patent Gmbh | Chromanderivate |
| FR2615191B1 (fr) * | 1987-05-16 | 1991-01-11 | Sandoz Sa | Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments |
| US4971982A (en) * | 1987-07-06 | 1990-11-20 | Hoffmann-La Roche Inc. | Benzopyran derivatives |
| AU628331B2 (en) * | 1988-05-06 | 1992-09-17 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Chroman derivatives |
| EP0346724A1 (de) * | 1988-06-16 | 1989-12-20 | MERCK PATENT GmbH | Chromanderivate |
-
1989
- 1989-06-02 DE DE3918041A patent/DE3918041A1/de not_active Withdrawn
-
1990
- 1990-05-02 IL IL9425690A patent/IL94256A/en not_active IP Right Cessation
- 1990-05-19 ES ES90109529T patent/ES2057262T3/es not_active Expired - Lifetime
- 1990-05-19 DK DK90109529.9T patent/DK0400430T3/da active
- 1990-05-19 EP EP90109529A patent/EP0400430B1/de not_active Expired - Lifetime
- 1990-05-19 DE DE59006817T patent/DE59006817D1/de not_active Expired - Fee Related
- 1990-05-19 AT AT90109529T patent/ATE110072T1/de not_active IP Right Cessation
- 1990-05-28 AU AU56007/90A patent/AU623780B2/en not_active Ceased
- 1990-05-30 KR KR1019900007818A patent/KR910000713A/ko not_active Application Discontinuation
- 1990-05-30 TW TW079104390A patent/TW210338B/zh active
- 1990-05-31 CA CA002017961A patent/CA2017961A1/en not_active Abandoned
- 1990-05-31 US US07/531,490 patent/US5112972A/en not_active Expired - Fee Related
- 1990-05-31 PT PT94225A patent/PT94225B/pt not_active IP Right Cessation
- 1990-06-01 IE IE198890A patent/IE65098B1/en not_active IP Right Cessation
- 1990-06-01 AR AR90317000A patent/AR245715A1/es active
- 1990-06-01 NO NO902459A patent/NO175976C/no unknown
- 1990-06-01 NZ NZ233912A patent/NZ233912A/xx unknown
- 1990-06-01 ZA ZA904227A patent/ZA904227B/xx unknown
- 1990-06-01 FI FI902727A patent/FI95701C/fi not_active IP Right Cessation
- 1990-06-01 HU HU903293A patent/HUT58323A/hu unknown
- 1990-06-01 JP JP2141748A patent/JPH0320275A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ATE110072T1 (de) | 1994-09-15 |
| ZA904227B (en) | 1991-03-27 |
| TW210338B (es) | 1993-08-01 |
| IE901988A1 (en) | 1991-01-02 |
| NO902459L (no) | 1990-12-03 |
| EP0400430A3 (de) | 1991-01-02 |
| AU623780B2 (en) | 1992-05-21 |
| ES2057262T3 (es) | 1994-10-16 |
| DE59006817D1 (de) | 1994-09-22 |
| JPH0320275A (ja) | 1991-01-29 |
| NO175976B (no) | 1994-10-03 |
| NO175976C (no) | 1995-01-11 |
| IL94256A0 (en) | 1991-03-10 |
| PT94225A (pt) | 1991-02-08 |
| DE3918041A1 (de) | 1990-12-06 |
| FI95701C (fi) | 1996-03-11 |
| IE901988L (en) | 1990-12-02 |
| NO902459D0 (no) | 1990-06-01 |
| FI902727A0 (fi) | 1990-06-01 |
| HUT58323A (en) | 1992-02-28 |
| HU903293D0 (en) | 1990-10-28 |
| KR910000713A (ko) | 1991-01-30 |
| CA2017961A1 (en) | 1990-12-02 |
| IL94256A (en) | 1994-04-12 |
| AU5600790A (en) | 1990-12-06 |
| EP0400430A2 (de) | 1990-12-05 |
| FI95701B (fi) | 1995-11-30 |
| EP0400430B1 (de) | 1994-08-17 |
| NZ233912A (en) | 1992-10-28 |
| US5112972A (en) | 1992-05-12 |
| IE65098B1 (en) | 1995-10-04 |
| DK0400430T3 (da) | 1994-09-12 |
| PT94225B (pt) | 1996-12-31 |
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