ES2066882T3 - Quelatos de manganeso(ii). - Google Patents
Quelatos de manganeso(ii).Info
- Publication number
- ES2066882T3 ES2066882T3 ES89910615T ES89910615T ES2066882T3 ES 2066882 T3 ES2066882 T3 ES 2066882T3 ES 89910615 T ES89910615 T ES 89910615T ES 89910615 T ES89910615 T ES 89910615T ES 2066882 T3 ES2066882 T3 ES 2066882T3
- Authority
- ES
- Spain
- Prior art keywords
- chelate
- solution
- base
- protonated
- low osmolarity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 title 1
- 229910052748 manganese Inorganic materials 0.000 title 1
- 239000011572 manganese Substances 0.000 title 1
- WAEMQWOKJMHJLA-UHFFFAOYSA-N Manganese(2+) Chemical compound [Mn+2] WAEMQWOKJMHJLA-UHFFFAOYSA-N 0.000 abstract 5
- 239000013522 chelant Substances 0.000 abstract 5
- 239000000243 solution Substances 0.000 abstract 4
- 239000002738 chelating agent Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 239000002244 precipitate Substances 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 238000002595 magnetic resonance imaging Methods 0.000 abstract 1
- PPNAOCWZXJOHFK-UHFFFAOYSA-N manganese(2+);oxygen(2-) Chemical compound [O-2].[Mn+2] PPNAOCWZXJOHFK-UHFFFAOYSA-N 0.000 abstract 1
- VASIZKWUTCETSD-UHFFFAOYSA-N manganese(II) oxide Inorganic materials [Mn]=O VASIZKWUTCETSD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
- C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Seasonings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Un procedimiento para preparar un quelato de Mn(II), que comprende hacer reaccionar MnO en un medio acuoso, a un pH no mayor que 5 y a una temperatura de 20 a 50º C, con un compuesto quelante distinto de EDTA, siendo el compuesto quelante sustancialmente insoluble en agua y estando sustancialmente protonizado, por cuanto que al menos el 75 % de los protones lábiles existentes en dicho compuesto quelante se presentan en su forma totalmente protonizada, y opcionalmente disolviendo a continuación el quelato de Mn(II) precipitado en una base acuosa.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/249,744 US4889931A (en) | 1988-09-27 | 1988-09-27 | Manganese (II) chelate manufacture |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2066882T3 true ES2066882T3 (es) | 1995-03-16 |
Family
ID=22944806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES89910615T Expired - Lifetime ES2066882T3 (es) | 1988-09-27 | 1989-09-26 | Quelatos de manganeso(ii). |
Country Status (11)
Country | Link |
---|---|
US (1) | US4889931A (es) |
EP (2) | EP0394394B1 (es) |
JP (1) | JP3003940B2 (es) |
AT (1) | ATE117309T1 (es) |
AU (1) | AU4304389A (es) |
DE (1) | DE68920733T2 (es) |
DK (1) | DK131090D0 (es) |
ES (1) | ES2066882T3 (es) |
FI (1) | FI902623A0 (es) |
HU (1) | HU895536D0 (es) |
WO (1) | WO1990003975A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5316757A (en) * | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
US5362476A (en) * | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
US5155224A (en) * | 1988-09-27 | 1992-10-13 | Salutar, Inc. | Manganese (II) chelates |
US5011925A (en) * | 1989-03-09 | 1991-04-30 | Mallinckrodt, Inc. | Morpholinoamido EDTA derivatives |
US5384108A (en) * | 1989-04-24 | 1995-01-24 | Mallinckrodt Medical, Inc. | Magnetic resonance imaging agents |
WO1992003168A1 (de) * | 1990-08-15 | 1992-03-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue verwendung von komplexsalzen |
DE4035760A1 (de) * | 1990-11-08 | 1992-05-14 | Schering Ag | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
DE4107570A1 (de) * | 1991-03-07 | 1992-11-19 | Diagnostikforschung Inst | Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie |
US5330742A (en) * | 1991-08-05 | 1994-07-19 | Mallinckrodt Medical, Inc. | Methods and compositions for magnetic resonance imaging |
US5562894A (en) * | 1991-08-09 | 1996-10-08 | Regents Of The University Of California | Amino-acyl-type and catecholamine-type contrast agents for MRI |
DE4237943C2 (de) * | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
US5480990A (en) * | 1991-12-10 | 1996-01-02 | The Dow Chemical Company | Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents |
US5428139A (en) * | 1991-12-10 | 1995-06-27 | The Dow Chemical Company | Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals |
US5739294A (en) * | 1991-12-10 | 1998-04-14 | The Dow Chemical Company | Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents |
JP2911674B2 (ja) * | 1992-02-20 | 1999-06-23 | 明治乳業株式会社 | 消化管造影用組成物 |
US5401492A (en) * | 1992-12-17 | 1995-03-28 | Sterling Winthrop, Inc. | Water insoluble non-magnetic manganese particles as magnetic resonance contract enhancement agents |
US5428156A (en) * | 1993-04-02 | 1995-06-27 | Associated Universities, Inc. | Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging |
DE19507820A1 (de) * | 1995-02-21 | 1996-08-22 | Schering Ag | Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel |
DK81095A (da) * | 1995-07-11 | 1997-01-12 | Henrik S Thomsen | Peroralt MR-kontraststof til lever og øvre tarmkanal |
DE69838873T2 (de) * | 1997-07-01 | 2008-12-04 | Ge Healthcare As | Diagnostisches verfahren zum nachweis von myokard-ischämie |
DE19816370B4 (de) * | 1998-04-03 | 2004-09-09 | Schering Ag | Substituierte Mangan-D02A-Komplexe, diese enthaltende diagnostische Mittel und ihre Verwendung |
US6623721B2 (en) * | 2000-12-18 | 2003-09-23 | Draximage, Inc. | Bifunctional chelating compounds containing hydroxamic acid residues |
JP4710749B2 (ja) * | 2006-07-28 | 2011-06-29 | 富士電機システムズ株式会社 | Dc−dcコンバータの制御回路及び方法 |
US9528434B1 (en) | 2011-07-28 | 2016-12-27 | Pratt & Whitney Canada Corp. | Rotary internal combustion engine with pilot subchamber |
US9038594B2 (en) | 2011-07-28 | 2015-05-26 | Pratt & Whitney Canada Corp. | Rotary internal combustion engine with pilot subchamber |
EP2941434B1 (en) * | 2013-01-07 | 2021-03-24 | The General Hospital Corporation | Manganese-based magnetic resonance contrast agents |
JP2018523671A (ja) * | 2015-08-13 | 2018-08-23 | ザ ジェネラル ホスピタル コーポレイション | 分子mrイメージング用マンガン系キレートコンジュゲート |
US10041402B2 (en) | 2016-05-12 | 2018-08-07 | Pratt & Whitney Canada Corp. | Internal combustion engine with split pilot injection |
RU2019139432A (ru) | 2017-05-05 | 2021-06-07 | Сентр фор Проуб Девелопмент энд Коммерсиализэйшн | Фармакокинетическая оптимизация бифункциональных хелатов и их применение |
WO2018204872A2 (en) | 2017-05-05 | 2018-11-08 | Fusion Pharmaceuticals Inc. | Igf-1r monoclonal antibodies and uses thereof |
US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
US10145291B1 (en) | 2017-10-10 | 2018-12-04 | Pratt & Whitney Canada Corp. | Rotary engine and method of combusting fuel |
CN110357828B (zh) * | 2019-08-13 | 2021-03-19 | 牡丹江医学院 | 一种核磁共振造影剂及其制备方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4181672A (en) * | 1977-09-27 | 1980-01-01 | W. R. Grace & Co. | Process for preparing metal chelates |
US4322361A (en) * | 1980-03-03 | 1982-03-30 | The Dow Chemical Company | Method of preparing a manganese chelate having improved properties |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
NL194579C (nl) * | 1983-01-21 | 2002-08-05 | Schering Ag | Diagnostisch middel. |
DE3427980A1 (de) * | 1984-07-28 | 1986-01-30 | Basf Ag, 6700 Ludwigshafen | Mehrspurennaehrstoffduenger |
DE3772785D1 (de) * | 1986-01-23 | 1991-10-17 | Squibb & Sons Inc | 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga. |
EP0250358A3 (en) * | 1986-06-20 | 1988-10-05 | Schering Aktiengesellschaft | Novel complex compounds |
DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
US4935518A (en) * | 1987-05-08 | 1990-06-19 | Salutar, Inc. | Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof |
-
1988
- 1988-09-27 US US07/249,744 patent/US4889931A/en not_active Expired - Lifetime
-
1989
- 1989-09-26 AT AT89910615T patent/ATE117309T1/de not_active IP Right Cessation
- 1989-09-26 JP JP1509974A patent/JP3003940B2/ja not_active Expired - Fee Related
- 1989-09-26 DE DE68920733T patent/DE68920733T2/de not_active Expired - Fee Related
- 1989-09-26 ES ES89910615T patent/ES2066882T3/es not_active Expired - Lifetime
- 1989-09-26 WO PCT/EP1989/001122 patent/WO1990003975A1/en active IP Right Grant
- 1989-09-26 AU AU43043/89A patent/AU4304389A/en not_active Abandoned
- 1989-09-26 EP EP89910615A patent/EP0394394B1/en not_active Expired - Lifetime
- 1989-09-26 HU HU895536A patent/HU895536D0/hu unknown
- 1989-09-26 EP EP89202414A patent/EP0369497A1/en active Pending
-
1990
- 1990-05-25 FI FI902623A patent/FI902623A0/fi not_active IP Right Cessation
- 1990-05-28 DK DK131090A patent/DK131090D0/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP3003940B2 (ja) | 2000-01-31 |
JPH03501491A (ja) | 1991-04-04 |
EP0394394A1 (en) | 1990-10-31 |
DK131090A (da) | 1990-05-28 |
ATE117309T1 (de) | 1995-02-15 |
HU895536D0 (en) | 1990-12-28 |
DE68920733T2 (de) | 1995-06-01 |
WO1990003975A1 (en) | 1990-04-19 |
DE68920733D1 (en) | 1995-03-02 |
US4889931A (en) | 1989-12-26 |
AU4304389A (en) | 1990-05-01 |
DK131090D0 (da) | 1990-05-28 |
EP0394394B1 (en) | 1995-01-18 |
FI902623A0 (fi) | 1990-05-25 |
EP0369497A1 (en) | 1990-05-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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