AR220575A1 - Procedimiento para preparar un derivado de una enzima fibrinolitica in vivo y un producto intermedio sin actividad farmacologica util en dicho procedimiento - Google Patents

Procedimiento para preparar un derivado de una enzima fibrinolitica in vivo y un producto intermedio sin actividad farmacologica util en dicho procedimiento

Info

Publication number
AR220575A1
AR220575A1 AR277800A AR27780079A AR220575A1 AR 220575 A1 AR220575 A1 AR 220575A1 AR 277800 A AR277800 A AR 277800A AR 27780079 A AR27780079 A AR 27780079A AR 220575 A1 AR220575 A1 AR 220575A1
Authority
AR
Argentina
Prior art keywords
procedure
derivative
preparing
intermediate product
pharmacological activity
Prior art date
Application number
AR277800A
Other languages
English (en)
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Application granted granted Critical
Publication of AR220575A1 publication Critical patent/AR220575A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
AR277800A 1978-09-07 1979-08-22 Procedimiento para preparar un derivado de una enzima fibrinolitica in vivo y un producto intermedio sin actividad farmacologica util en dicho procedimiento AR220575A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7835960 1978-09-07

Publications (1)

Publication Number Publication Date
AR220575A1 true AR220575A1 (es) 1980-11-14

Family

ID=10499512

Family Applications (1)

Application Number Title Priority Date Filing Date
AR277800A AR220575A1 (es) 1978-09-07 1979-08-22 Procedimiento para preparar un derivado de una enzima fibrinolitica in vivo y un producto intermedio sin actividad farmacologica util en dicho procedimiento

Country Status (17)

Country Link
US (2) US4285932A (es)
EP (1) EP0009879B1 (es)
JP (3) JPS5537198A (es)
AR (1) AR220575A1 (es)
AU (1) AU524295B2 (es)
CA (1) CA1134295A (es)
DE (1) DE2966301D1 (es)
DK (1) DK160996C (es)
ES (1) ES8101385A1 (es)
HK (1) HK65986A (es)
HU (1) HU182458B (es)
IE (1) IE48478B1 (es)
IL (1) IL58079A0 (es)
LU (1) LU88326I2 (es)
MY (1) MY8500995A (es)
NZ (1) NZ191320A (es)
ZA (1) ZA794294B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
JPS55167275A (en) * 1979-06-15 1980-12-26 Kowa Co Preparation of amidinophenyl ester derivative
EP0028489B1 (en) * 1979-11-05 1983-10-05 Beecham Group Plc Enzyme derivatives, and their preparation
FR2500825B1 (fr) * 1981-02-27 1985-08-23 Torii & Co Ltd Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant
IT1170913B (it) * 1981-04-23 1987-06-03 Manetti & Roberts Italo Brit Procedimento per la produzione di un principio attivo fibrinolitico vasale prodotto enzimatico specifico angiochinasi cosi' ottenuto e sue applicazioni farmaceutiche
EP0091240B1 (en) * 1982-04-07 1985-12-27 Beecham Group Plc Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
US4536391A (en) * 1982-11-17 1985-08-20 Otsuka Pharmaceutical Co. Process for preparing urokinase complex
GB8319538D0 (en) * 1983-07-20 1983-08-24 Beecham Group Plc Compounds
JPS60136520A (ja) * 1983-12-23 1985-07-20 Otsuka Pharmaceut Co Ltd フイブリン吸着性ウロキナ−ゼ複合体
GB8609948D0 (en) * 1986-04-23 1986-05-29 Beecham Group Plc Compounds
US4880776A (en) * 1983-12-24 1989-11-14 Beecham Group P.L.C. Plasmin A-chain urokinase B-chain hybrid protein
GB8334499D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Derivatives
GB8334498D0 (en) * 1983-12-24 1984-02-01 Beecham Group Plc Compounds
GB8400653D0 (en) * 1984-01-11 1984-02-15 Beecham Group Plc Conjugates
US5174994A (en) * 1985-11-11 1992-12-29 Leuven Research & Development Vzw Pharmaceutical composition having thrombolytic activity
EP0266032A1 (en) * 1986-08-29 1988-05-04 Beecham Group Plc Modified fibrinolytic enzyme
GB8707369D0 (en) * 1987-03-27 1987-04-29 Beecham Group Plc Enzyme derivatives
US5009888A (en) * 1987-04-13 1991-04-23 Genzyme Corporation Therapeutic enzyme-antibody complexes
GB8715302D0 (en) * 1987-06-30 1987-08-05 Ordidge R J Nmr spectroscopy
US5302390A (en) * 1987-07-01 1994-04-12 Beecham Group Plc Hybrid proteins of human plasminogen and human t-PA, pharmaceutical compositions and methods of treatment
DK359888A (da) * 1987-07-01 1989-01-02 Beecham Group Plc Fibrinolytisk enzym
US5256642A (en) * 1988-04-01 1993-10-26 The Johns Hopkins University Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
US6458360B1 (en) 1990-04-25 2002-10-01 The Johns Hopkins University Soluble complement regulatory molecules
GB9011861D0 (en) * 1990-05-26 1990-07-18 Beecham Group Plc Novel compounds
GB9013345D0 (en) * 1990-06-14 1990-08-08 Beecham Group Plc Novel compounds
US20040072757A1 (en) * 1990-09-04 2004-04-15 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
US5583107A (en) * 1990-09-04 1996-12-10 Cor Therapeutics, Inc. Agents affecting thrombosis and hemostasis
US5597799A (en) * 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
AU1873092A (en) * 1991-04-09 1992-11-17 Brigham And Women's Hospital Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques
GB9301289D0 (en) * 1993-01-22 1993-03-17 Smithkline Beecham Plc Novel composition
US5589571A (en) * 1994-10-28 1996-12-31 Cor Therapeutics, Inc. Process for production of inhibited forms of activated blood factors
US7544500B2 (en) 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
EP2297317A4 (en) 2008-06-04 2011-12-07 Talecris Biotherapeutics Inc COMPOSITION, METHOD AND NECESSARY FOR THE PREPARATION OF PLASMINE
JP5789521B2 (ja) 2009-03-03 2015-10-07 グリフオルス・セラピユーテイクス・インコーポレーテツドＧｒｉｆｏｌｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． プラスミノーゲンを製造するための組成物、方法およびキット；ならびにそれから製造されるプラスミン
MX2012000475A (es) 2009-07-10 2012-03-26 Thrombogenics Nv Variantes de plasminogeno y plasmina.
ES2534911T3 (es) 2009-08-28 2015-04-30 Thrombogenics N.V. Uso de plasmina para el tratamiento de fallo de filtración después de trabeculectomía
US9121014B2 (en) 2011-01-05 2015-09-01 ThromboGenies NV Plasminogen and plasmin variants
AU2012296884B2 (en) 2011-08-12 2015-02-05 Thrombogenics N.V. Plasminogen and plasmin variants

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions

Also Published As

Publication number Publication date
HK65986A (en) 1986-09-12
IE48478B1 (en) 1985-02-06
US4337244A (en) 1982-06-29
DK160996C (da) 1991-10-28
JPS5537198A (en) 1980-03-15
EP0009879A1 (en) 1980-04-16
US4285932A (en) 1981-08-25
CA1134295A (en) 1982-10-26
IE791696L (en) 1980-03-07
MY8500995A (en) 1985-12-31
JPH0231952B2 (es) 1990-07-17
JPH02154687A (ja) 1990-06-14
JPH05304957A (ja) 1993-11-19
ES483888A0 (es) 1980-12-16
AU524295B2 (en) 1982-09-09
DE2966301D1 (en) 1983-11-17
ZA794294B (en) 1980-08-27
ES8101385A1 (es) 1980-12-16
NZ191320A (en) 1982-09-14
HU182458B (en) 1984-01-30
EP0009879B1 (en) 1983-10-12
AU5004679A (en) 1980-03-13
IL58079A0 (en) 1979-12-30
LU88326I2 (fr) 1994-05-04
DK160996B (da) 1991-05-13
DK373479A (da) 1980-04-11

Similar Documents

Publication Publication Date Title
AR220575A1 (es) Procedimiento para preparar un derivado de una enzima fibrinolitica in vivo y un producto intermedio sin actividad farmacologica util en dicho procedimiento
DE3065190D1 (en) Enzyme derivatives, and their preparation
JPS5592699A (en) Continuous saccharification of cellulosic substance
ZA803545B (en) Hypocholesteremie fermentation products and process of preparation
IT1128187B (it) Procedimento per la preparazione di collageno biogicamente attivo macromolecolare e prodotto ottenuto
JPS5534087A (en) Enzyme composite * method and use
AU4773679A (en) N-alkylated aminoalcohols and their salts
FI801857A (fi) Hyperkolesterolemiska fermentprodukter och foerfarande foer framstaellning av dessa
JPS54163888A (en) Production and use of fixed enzyme product
CS188269B2 (en) Insecticide preparation and method of making the the active substances
PH17548A (en) Pharmacologically active substituted-3-amino-sydnone-imines and process for their preparation
GB2023604B (en) Physiologically active derivatives of esterastin and production thereof
CS193554B2 (en) Insecticide means and method of making the active substance
CS194194B2 (en) Insecticide means and method of making the active substance
JPS5626187A (en) Alcohol oxidase and production
EP0013474A3 (en) Preparation of 2-chloro-5-trifluoromethylpyridine and 2-chloro-5-perchlorofluoromethylpyridines
JPS5435281A (en) Biologically active fixed limit endonuclease derivative and production thereof
GB2034326B (en) Valylieu-cyllysine derivatives process for their preparation and their use for measuring enzyme activity
GB2022096B (en) Immpbilized enzyme and method for production
DE2965361D1 (en) Process for the preparation of optically active alpha-amino acids and their derivatives
GB2034325B (en) Phenyl-alanylvalylargini derivatives process for their preparation and their use for measuring enzyme activity
GB2034718B (en) Prolyl-phenylalanylarginine derivatives process for their preparation and their use for measuring enzyme activity
IL60419A (en) Surface culture of eukariotic cells and production of physiologically active substances from the cells thus obtained
JPS5526900A (en) Fixed enzyme preparation and method
ZA805383B (en) -carbolin-3-carboxylic acid derivatives and methods of preparing the same