AR127235A1 - Pirazoloquinolinas inhibidoras de kras - Google Patents

Pirazoloquinolinas inhibidoras de kras

Info

Publication number
AR127235A1
AR127235A1 ARP220102669A ARP220102669A AR127235A1 AR 127235 A1 AR127235 A1 AR 127235A1 AR P220102669 A ARP220102669 A AR P220102669A AR P220102669 A ARP220102669 A AR P220102669A AR 127235 A1 AR127235 A1 AR 127235A1
Authority
AR
Argentina
Prior art keywords
compounds
pyrazoloquinolines
formulas
formula
group
Prior art date
Application number
ARP220102669A
Other languages
English (en)
Inventor
Wenyu Zhu
xiaozhao Wang
Wenqing Yao
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of AR127235A1 publication Critical patent/AR127235A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compuestos de fórmula (1), métodos de uso de los compuestos para inhibir la actividad de KRAS y composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos son útiles en el tratamiento, prevención o mejoramiento de enfermedades o trastornos asociados con la actividad de KRAS tales como el cáncer. Reivindicación 1: Un compuesto caracterizado porque es de fórmula (1) o una sal farmacéuticamente aceptable del mismo, en donde: R¹ se selecciona entre Cl, CH₃, CH₂F, CHF₂, y CF₃; Cy¹ se selecciona entre los compuestos del grupo de fórmulas (2); R² se selecciona entre F y Cl; R³ se selecciona entre los compuestos del grupo de fórmulas (3); y, Cy² se selecciona entre los compuestos del grupo de fórmulas (4); con la salvedad de que el compuesto de fórmula (1) sea distinto de, @@@@@@@@@
ARP220102669A 2021-10-01 2022-10-03 Pirazoloquinolinas inhibidoras de kras AR127235A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202163261982P 2021-10-01 2021-10-01

Publications (1)

Publication Number Publication Date
AR127235A1 true AR127235A1 (es) 2024-01-03

Family

ID=83902891

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220102669A AR127235A1 (es) 2021-10-01 2022-10-03 Pirazoloquinolinas inhibidoras de kras

Country Status (7)

Country Link
US (1) US12030884B2 (es)
EP (1) EP4408536A1 (es)
JP (1) JP2024537824A (es)
AR (1) AR127235A1 (es)
CA (1) CA3234375A1 (es)
TW (1) TW202330521A (es)
WO (1) WO2023056421A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024206858A1 (en) 2023-03-30 2024-10-03 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof

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Also Published As

Publication number Publication date
TW202330521A (zh) 2023-08-01
US12030884B2 (en) 2024-07-09
JP2024537824A (ja) 2024-10-16
EP4408536A1 (en) 2024-08-07
US20230143938A1 (en) 2023-05-11
WO2023056421A1 (en) 2023-04-06
CA3234375A1 (en) 2023-04-06

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