AR123121A1 - Compuestos de dihidropirimidinona o dihidrotriazinona fusionados con anillo saturado y su uso farmacéutico - Google Patents
Compuestos de dihidropirimidinona o dihidrotriazinona fusionados con anillo saturado y su uso farmacéuticoInfo
- Publication number
- AR123121A1 AR123121A1 ARP190100481A ARP190100481A AR123121A1 AR 123121 A1 AR123121 A1 AR 123121A1 AR P190100481 A ARP190100481 A AR P190100481A AR P190100481 A ARP190100481 A AR P190100481A AR 123121 A1 AR123121 A1 AR 123121A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- coo
- independently
- group
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula [1] en donde R¹ es (1) alquilo C₁₋₈, (2) halo-alquilo C₁₋₈, (3) cicloalquilo C₃₋₈ opcionalmente sustituido con 1 a 3 sustituyentes iguales o diferentes seleccionados del grupo A¹ o (4) cicloalquil C₃₋₈-alquilo C₁₋₄ en donde el resto de cicloalquilo C₃₋₈ puede estar opcionalmente sustituido con 1 a 3 sustituyentes iguales o diferentes seleccionados del grupo A¹, el grupo A¹ es (1) halógeno, (2) alquilo C₁₋₄ y (3) halo-alquilo C₁₋₄, X¹ es (1) un enlace o (2) -O-, R² es (1) hidrógeno o (2) halógeno, R³ es (1) hidrógeno o (2) -Y³-COO-R³⁰, Y³ es (1) alquileno C₁₋₈, (2) cicloalquileno C₃₋₈, (3) cicloalquileno C₅₋₈ en puente o (4) arileno C₆₋₁₄, R³⁰ es (1) hidrógeno o (2) alquilo C₁₋₄, X² es (1) =C(R⁴)- o (2) =N-, R⁴ es (1) hidrógeno o (2) alquilo C₁₋₄, X³ es (1) -C(R⁵)(R⁶)-, X⁴ es (1) un enlace o (2) -C(R⁷)(R⁸)-, X⁵ es (1) -C(R⁹)(R¹⁰)-, (2) -N(R¹¹)- o (3) -O-, R⁵ y R⁶ son cada uno, de modo independiente, (1) hidrógeno, (2) alquilo C₁₋₄, (3) halo-alquilo C₁₋₄, (4) ciano-alquilo C₁₋₄ o (5) alquilo C₁₋₄ sustituido con un sustituyente seleccionado del grupo que consiste en -O-R⁵¹, -CO-R⁶¹, -COO-R⁵², -N(R⁷¹)(R⁷²), -CO-N(R⁷³)(R⁷⁴), -N(R⁷⁵)-CO-R⁶², -N(R⁷⁶)-COO-R⁵³ y - O-S(O)₂-R⁶³, R⁷, R⁸, R⁹ y R¹⁰ son cada uno, de modo independiente, (1) hidrógeno, (2) halógeno, (3) ciano, (4) hidroxi, (5) alquilo C₁₋₄, (6) halo-alquilo C₁₋₄, (7) ciano-alquilo C₁₋₄, (8) alcoxi C₁₋₄ o (9) alquilo C₁₋₄ sustituido con un sustituyente seleccionado del grupo que consiste en -O-R⁵¹, -CO-R⁶¹, -COO-R⁵², -N(R⁷¹)(R⁷²), -CO-N(R⁷³)(R⁷⁴), -N(R⁷⁵)-CO-R⁶², -N(R⁷⁶)-COO-R⁵³ y -O-S(O)₂-R⁶³, R⁵¹, R⁵² y R⁵³ son cada uno, de modo independiente, (1) hidrógeno, (2) alquilo C₁₋₄ o (3) aril C₆₋₁₄-alquilo C₁₋₄, R⁶¹, R⁶² y R⁶³ son cada uno, de modo independiente, (1) alquilo C₁₋₄, R⁷¹, R⁷², R⁷³, R⁷⁴, R⁷⁵ y R⁷⁶ son cada uno, de modo independiente, (1) hidrógeno o (2) alquilo C₁₋₄, R¹¹ es (1) -CO-R¹¹¹ o (2) -COO-R¹¹², R¹¹¹ es (1) alquilo C₁₋₄, R¹¹² es (1) alquilo C₁₋₄ o una de sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018035601 | 2018-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR123121A1 true AR123121A1 (es) | 2022-11-02 |
Family
ID=67805013
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190100481A AR123121A1 (es) | 2018-02-28 | 2019-02-27 | Compuestos de dihidropirimidinona o dihidrotriazinona fusionados con anillo saturado y su uso farmacéutico |
Country Status (18)
Country | Link |
---|---|
US (2) | US20190300490A1 (es) |
EP (1) | EP3760619B1 (es) |
JP (1) | JP7200005B2 (es) |
KR (1) | KR20200127177A (es) |
CN (1) | CN111741948B (es) |
AR (1) | AR123121A1 (es) |
AU (1) | AU2019228916A1 (es) |
BR (1) | BR112020016784A2 (es) |
CA (1) | CA3088000A1 (es) |
CL (1) | CL2020002188A1 (es) |
IL (1) | IL276326A (es) |
MX (1) | MX2020008929A (es) |
PE (1) | PE20210447A1 (es) |
PH (1) | PH12020551342A1 (es) |
RU (1) | RU2020131405A (es) |
SG (1) | SG11202007119UA (es) |
TW (1) | TW202000652A (es) |
WO (1) | WO2019167982A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
JP7065989B2 (ja) | 2018-02-28 | 2022-05-12 | ノバルティス アーゲー | インフルエンザを処置するためのオルソミクソウイルス複製の阻害剤としての10-(ジ(フェニル)メチル)-4-ヒドロキシ-8,9,9a,10-テトラヒドロ-7H-ピロロ[1’,2’:4,5]ピラジノ[1,2-b]ピリダジン-3,5-ジオン誘導体および関連化合物 |
CN111741948B (zh) | 2018-02-28 | 2023-11-10 | 日本烟草产业株式会社 | 饱和环稠合的二氢嘧啶酮或二氢三嗪酮化合物及其药物用途 |
WO2023232870A1 (en) | 2022-05-31 | 2023-12-07 | Immunic Ag | Rorg/rorgt modulators for the treatment of virus infections like covid-19 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080029965A (ko) | 2005-06-14 | 2008-04-03 | 쉐링 코포레이션 | 아스파르틸 프로테아제 억제제 |
AU2008263207B2 (en) | 2007-06-01 | 2013-10-03 | Merck Sharp & Dohme Corp. | Gamma secretase modulators |
MX2010011563A (es) | 2008-04-22 | 2010-11-12 | Schering Corp | Compuestos 2-imino-3-metil pirrolo pirimidinona fenil-sustituidos como inhibidores de enzima de escision de proteina precursora amiloide sitio beta-1, composiciones y su uso. |
WO2013064231A1 (en) | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
EP2931731A1 (en) | 2012-12-11 | 2015-10-21 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1 |
EP3102576B8 (en) | 2014-02-03 | 2019-06-19 | Vitae Pharmaceuticals, LLC | Dihydropyrrolopyridine inhibitors of ror-gamma |
EP3223820B1 (en) | 2014-11-25 | 2020-07-22 | Merck Sharp & Dohme Corp. | 3-methyl-2-imino-hexahydro-1h-pyrano[3,4-d]pyrimidin-4-one compounds as bace inhibitors, compositions, and their use |
AR102972A1 (es) | 2014-12-12 | 2017-04-05 | Japan Tobacco Inc | Compuestos de dihidropirimidin-2-ona y su uso médico |
MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
CN111741948B (zh) | 2018-02-28 | 2023-11-10 | 日本烟草产业株式会社 | 饱和环稠合的二氢嘧啶酮或二氢三嗪酮化合物及其药物用途 |
-
2019
- 2019-02-27 CN CN201980015796.9A patent/CN111741948B/zh active Active
- 2019-02-27 BR BR112020016784-3A patent/BR112020016784A2/pt not_active Application Discontinuation
- 2019-02-27 PE PE2020001290A patent/PE20210447A1/es unknown
- 2019-02-27 KR KR1020207024427A patent/KR20200127177A/ko not_active Application Discontinuation
- 2019-02-27 WO PCT/JP2019/007435 patent/WO2019167982A1/ja unknown
- 2019-02-27 EP EP19761273.2A patent/EP3760619B1/en active Active
- 2019-02-27 RU RU2020131405A patent/RU2020131405A/ru unknown
- 2019-02-27 TW TW108106804A patent/TW202000652A/zh unknown
- 2019-02-27 MX MX2020008929A patent/MX2020008929A/es unknown
- 2019-02-27 AU AU2019228916A patent/AU2019228916A1/en not_active Abandoned
- 2019-02-27 SG SG11202007119UA patent/SG11202007119UA/en unknown
- 2019-02-27 US US16/287,871 patent/US20190300490A1/en not_active Abandoned
- 2019-02-27 CA CA3088000A patent/CA3088000A1/en active Pending
- 2019-02-27 AR ARP190100481A patent/AR123121A1/es not_active Application Discontinuation
- 2019-02-27 JP JP2019033423A patent/JP7200005B2/ja active Active
-
2020
- 2020-07-27 IL IL276326A patent/IL276326A/en unknown
- 2020-08-25 CL CL2020002188A patent/CL2020002188A1/es unknown
- 2020-08-27 PH PH12020551342A patent/PH12020551342A1/en unknown
-
2021
- 2021-05-28 US US17/334,517 patent/US11834421B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
PE20210447A1 (es) | 2021-03-08 |
KR20200127177A (ko) | 2020-11-10 |
CL2020002188A1 (es) | 2020-12-18 |
TW202000652A (zh) | 2020-01-01 |
EP3760619A4 (en) | 2021-07-07 |
JP2019151624A (ja) | 2019-09-12 |
US11834421B2 (en) | 2023-12-05 |
JP7200005B2 (ja) | 2023-01-06 |
CA3088000A1 (en) | 2019-09-06 |
US20190300490A1 (en) | 2019-10-03 |
WO2019167982A1 (ja) | 2019-09-06 |
MX2020008929A (es) | 2020-10-01 |
AU2019228916A1 (en) | 2020-07-02 |
US20220119355A1 (en) | 2022-04-21 |
EP3760619B1 (en) | 2023-10-25 |
BR112020016784A2 (pt) | 2021-01-12 |
PH12020551342A1 (en) | 2021-06-21 |
IL276326A (en) | 2020-09-30 |
EP3760619A1 (en) | 2021-01-06 |
RU2020131405A (ru) | 2022-03-24 |
SG11202007119UA (en) | 2020-08-28 |
CN111741948B (zh) | 2023-11-10 |
CN111741948A (zh) | 2020-10-02 |
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