AR121573A1 - Moduladores de nlrp3 - Google Patents
Moduladores de nlrp3Info
- Publication number
- AR121573A1 AR121573A1 ARP210100650A ARP210100650A AR121573A1 AR 121573 A1 AR121573 A1 AR 121573A1 AR P210100650 A ARP210100650 A AR P210100650A AR P210100650 A ARP210100650 A AR P210100650A AR 121573 A1 AR121573 A1 AR 121573A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- haloalkyl
- halogen
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Amplifiers (AREA)
- Burglar Alarm Systems (AREA)
Abstract
Reivindicación 1: Un compuesto de la fórmula (1) o una sal o solvato farmacéuticamente aceptable de este, caracterizado por que: X¹ es O, S o N(R³); X² es -N(R⁴)- o -C(R⁴)₂-; X³ es -N(R⁵)- o -C(R⁵)₂-; Y¹ es O, S o N(R⁸); Y² es N o C(R⁹); Z¹ es O, S, N(R³), o -C(R¹⁷)=C(R¹⁷)-; Z² es N o C(R¹⁹); R¹ es un compuesto del grupo de fórmulas (2); R² es un compuesto del grupo de fórmulas (3); R³ es hidrógeno, -OR¹⁴, -CN, -NO₂ o -S(=O)₂R¹⁵; cada R⁴ se selecciona independientemente de hidrógeno, alquilo C₁₋₆, alquilo -C₁₋₆-OR⁷ y alquilo -C₁₋₆-N(R⁷)₂; cada R⁵ se selecciona independientemente de hidrógeno, alquilo C₁₋₆, alquilo -C₁₋₆-OR⁷ y alquilo -C₁₋₆-N(R⁷)₂; cada R⁶ se selecciona independientemente de alquilo C₁₋₆, alquilo -C₁₋₆-CO₂R¹⁸, haloalquilo C₁₋₆, alquilo -C₁₋₆-OR⁷ y alquilo C₁₋₆-N(R⁷)₂; cada R⁷ se selecciona de independientemente de hidrógeno y alquilo C₁₋₆; R⁸ es hidrógeno, alquilo C₁₋₆, alquilo -C₁₋₆-OR⁷, alquilo -C₁₋₆-N(R⁷)₂ o cicloalquilo C₃₋₆; R⁹ es hidrógeno, halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆ y cicloalquilo C₃₋₆; R¹⁰ es hidrógeno, halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alquilo -C₁₋₆-OR⁷ o alquilo -C₁₋₆-N(R⁷)₂; R¹¹ y R¹² se seleccionan independientemente de hidrógeno, halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alquilo -C₁₋₆-OR⁷ y alquilo C₁₋₆-N(R⁷)₂; o R¹¹ y R¹² se combinan para formar un anillo cicloalquilo de 5 ó 6 miembros; R¹³ es hidrógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₅, heterocicloalquilo C₂₋₉, fenilo o heteroarilo C₂₋₉, donde el cicloalquilo C₃₋₅, heterocicloalquilo C₂₋₉, fenilo y heteroarilo C₂₋₉ están opcionalmente sustituidos con 1, 2, 3 ó 4 R¹⁶; R¹⁴ es hidrógeno o alquilo C₁₋₆; R¹⁵ es alquilo C₁₋₆; o cada R¹⁶ se selecciona independientemente de halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆, haloalcoxi C₁₋₆, cicloalquilo C₃₋₆, heterocicloalquilo C₂₋₉, arilo C₆₋₁₀, heteroarilo C₂₋₉, donde el cicloalquilo C₃₋₆, heterocicloalquilo C₂₋₉, arilo C₆₋₁₀ y el heteroarilo C₂₋₉ están opcionalmente sustituidos con 1, 2 ó 3 grupos seleccionados entre halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alcoxi C₁₋₆ y haloalcoxi C₁₋₆; cada R¹⁷ se selecciona independientemente de hidrógeno, halógeno, alquilo C₁₋₆, haloalquilo C₁₋₆, alquilo -C₁₋₆-OR⁷ y alquilo -C₁₋₆-N(R⁷)₂; R¹⁸ es hidrógeno o alquilo C₁₋₆; R¹⁹ es hidrógeno, halógeno, -CN, alquilo C₁₋₆, haloalquilo C₁₋₆, alquilo -C₁₋₆-OR⁷ o alquilo -C₁₋₆-N(R⁷)₂; m es 0, 1 ó 2; n es 1, 2 ó 3; p es 0, 1 ó 2; q es 0, 1, 2, 3 ó 4; s es 1, 2 ó 3; y t es 1, 2 ó 3.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062990363P | 2020-03-16 | 2020-03-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR121573A1 true AR121573A1 (es) | 2022-06-15 |
Family
ID=77747550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP210100650A AR121573A1 (es) | 2020-03-16 | 2021-03-15 | Moduladores de nlrp3 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11603375B2 (es) |
| EP (1) | EP4121059A4 (es) |
| JP (1) | JP2023518044A (es) |
| KR (1) | KR20220154165A (es) |
| CN (1) | CN115605209A (es) |
| AR (1) | AR121573A1 (es) |
| AU (1) | AU2021237477A1 (es) |
| BR (1) | BR112022018480A2 (es) |
| CA (1) | CA3175729A1 (es) |
| CL (1) | CL2022002531A1 (es) |
| CO (1) | CO2022014499A2 (es) |
| IL (1) | IL296488A (es) |
| MX (1) | MX2022011576A (es) |
| TW (1) | TW202200584A (es) |
| WO (1) | WO2021188450A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR121573A1 (es) | 2020-03-16 | 2022-06-15 | Zomagen Biosciences Ltd | Moduladores de nlrp3 |
| CN117279903A (zh) * | 2021-02-10 | 2023-12-22 | 杭州英创医药科技有限公司 | 作为nlrp3抑制剂的化合物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3578547T3 (pl) | 2015-02-16 | 2021-12-20 | The University Of Queensland | Pochodne sulfonylomocznika i związki pokrewne oraz ich zastosowanie |
| US11858922B2 (en) | 2016-02-16 | 2024-01-02 | The University Of Queensland | Sulfonylureas and related compounds and use of same |
| MA44734A (fr) | 2016-04-18 | 2021-05-19 | Novartis Ag | Composés et compositions destinés au traitement d'états associés à une activité de nlrp |
| EP3571187B1 (en) * | 2017-01-23 | 2023-11-22 | Genentech, Inc. | Chemical compounds as inhibitors of interleukin-1 activity |
| JP7072586B2 (ja) * | 2017-05-24 | 2022-05-20 | ザ ユニバーシティ オブ クィーンズランド | 新規な化合物及び使用 |
| PL3661925T3 (pl) * | 2017-07-07 | 2022-02-28 | Inflazome Limited | Nowe związki sulfonamidowo karboksyamidowe |
| US11542255B2 (en) | 2017-08-15 | 2023-01-03 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors |
| KR20200041919A (ko) | 2017-08-15 | 2020-04-22 | 인플라좀 리미티드 | Nlrp3 저해제로서의 설포닐유레아 및 설포닐티오유레아 |
| CN111417622A (zh) | 2017-10-17 | 2020-07-14 | 诺华炎症研究公司 | 用于治疗与nlrp活性相关的病症的磺胺类及其组合物 |
| GB201721185D0 (en) * | 2017-12-18 | 2018-01-31 | Nodthera Ltd | Sulphonyl urea derivatives |
| CN112513048A (zh) * | 2018-07-20 | 2021-03-16 | 豪夫迈·罗氏有限公司 | 作为白细胞介素-1活性抑制剂的磺酰亚胺酰胺类化合物 |
| WO2020086732A1 (en) | 2018-10-24 | 2020-04-30 | Novartis Inflammasome Research, Inc. | Compounds and compositions for treating conditions associated with nlrp activity |
| JP2022541254A (ja) | 2019-07-17 | 2022-09-22 | ズーマゲン バイオサイエンシーズ エルティーディー | 多発性硬化症（ＭＳ）の治療のためのＮＬＰＲ３モジュレーターとしてのＮ－（（１，２，３，５，６，７－ヘキサヒドロ－ｓ－インダセン－４－イル）カルバモイル）－４，５，６，７－テトラヒドロベンゾフラン－２－スルホンアミド誘導体および関連化合物 |
| US20220259170A1 (en) | 2019-07-17 | 2022-08-18 | Zomagen Biosciences Ltd | Nlrp3 modulators |
| AR121573A1 (es) | 2020-03-16 | 2022-06-15 | Zomagen Biosciences Ltd | Moduladores de nlrp3 |
-
2021
- 2021-03-15 AR ARP210100650A patent/AR121573A1/es unknown
- 2021-03-15 WO PCT/US2021/022397 patent/WO2021188450A1/en unknown
- 2021-03-15 MX MX2022011576A patent/MX2022011576A/es unknown
- 2021-03-15 JP JP2022555714A patent/JP2023518044A/ja active Pending
- 2021-03-15 CA CA3175729A patent/CA3175729A1/en active Pending
- 2021-03-15 KR KR1020227035334A patent/KR20220154165A/ko active Search and Examination
- 2021-03-15 IL IL296488A patent/IL296488A/en unknown
- 2021-03-15 AU AU2021237477A patent/AU2021237477A1/en active Pending
- 2021-03-15 CN CN202180035570.2A patent/CN115605209A/zh active Pending
- 2021-03-15 BR BR112022018480A patent/BR112022018480A2/pt not_active Application Discontinuation
- 2021-03-15 EP EP21770604.3A patent/EP4121059A4/en active Pending
- 2021-03-15 US US17/202,047 patent/US11603375B2/en active Active
- 2021-03-16 TW TW110109276A patent/TW202200584A/zh unknown
-
2022
- 2022-09-15 CL CL2022002531A patent/CL2022002531A1/es unknown
- 2022-10-12 CO CONC2022/0014499A patent/CO2022014499A2/es unknown
-
2023
- 2023-02-02 US US18/163,680 patent/US20230183258A1/en not_active Abandoned
- 2023-10-09 US US18/483,397 patent/US20240101571A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20240101571A1 (en) | 2024-03-28 |
| EP4121059A1 (en) | 2023-01-25 |
| MX2022011576A (es) | 2022-10-18 |
| WO2021188450A1 (en) | 2021-09-23 |
| IL296488A (en) | 2022-11-01 |
| KR20220154165A (ko) | 2022-11-21 |
| CL2022002531A1 (es) | 2023-03-31 |
| CO2022014499A2 (es) | 2023-02-16 |
| EP4121059A4 (en) | 2023-12-13 |
| CA3175729A1 (en) | 2021-09-23 |
| AU2021237477A1 (en) | 2022-10-13 |
| JP2023518044A (ja) | 2023-04-27 |
| CN115605209A (zh) | 2023-01-13 |
| US20210292336A1 (en) | 2021-09-23 |
| BR112022018480A2 (pt) | 2022-11-29 |
| US11603375B2 (en) | 2023-03-14 |
| TW202200584A (zh) | 2022-01-01 |
| US20230183258A1 (en) | 2023-06-15 |
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