AR111284A1 - Agonistas del receptor farnesoide x y usos de los mismos - Google Patents
Agonistas del receptor farnesoide x y usos de los mismosInfo
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- AR111284A1 AR111284A1 ARP180100608A ARP180100608A AR111284A1 AR 111284 A1 AR111284 A1 AR 111284A1 AR P180100608 A ARP180100608 A AR P180100608A AR P180100608 A ARP180100608 A AR P180100608A AR 111284 A1 AR111284 A1 AR 111284A1
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- alkyl
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- unsubstituted
- nr15c
- fluoroalkyl
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0029—Parenteral nutrition; Parenteral nutrition compositions as drug carriers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Compuestos que son antagonistas del receptor farnesoide X, métodos para hacer dichos compuestos, composiciones farmacéuticas y medicamentos que comprenden dichos compuestos y métodos para utilizar dichos compuestos en el tratamiento de afecciones, enfermedades o trastornos asociados con la actividad del receptor X farnesoide. Reivindicación 1: Un compuesto que tiene la estructura de la fórmula (1), o una sal o solvato farmacéuticamente aceptable del mismo, en la que, X¹ es CH o N; R¹ es H, D, halógeno, -CN, -OH, -SH, -N(R¹⁵)₂, -NR¹⁵S(=O)₂(alquilo C₁₋₄), -S(alquilo C₁₋₄), -S(=O)(alquilo C₁₋₄), -S(=O)₂(alquilo C₁₋₄), -S(=O)₂N(R¹⁵)₂, -OC(=O)(alquilo C₁₋₄), -CO₂H, -CO₂(alquilo C₁₋₄), -C(=O)N(R¹⁵)₂, -NR¹⁵C(=O)(alquilo C₁₋₄), -NR¹⁵C(=O)O(alquilo C₁₋₄), -OC(=O)N(R¹⁵)₂, -NR¹⁵C(=O)N(R¹⁵)₂, alquilo C₁₋₄, alquenilo C₂₋₄, alquinilo C₂₋₄, alcoxi C₁₋₄, deuteroalquilo C₁₋₄, deuteroalcoxi C₁₋₄, fluoroalquilo C₁₋₄,fluoroalcoxi C₁₋₄, heteroalquilo C₁₋₄, o heterocicloalquilo C₂₋₅ monocíclico sustituido o no sustituido; X² es CR² o N; R² es H, D, halógeno, -CN, -OH, -SH, -N(R¹⁵)₂, NR¹⁵S(=O)₂(alquilo C₁₋₄), -S(alquilo C₁₋₄), -S(=O)(alquilo C₁₋₄), -S(=O)₂(alquilo C₁₋₄), -S(=O)₂N(R¹⁵)₂, -OC(=O)(alquilo C₁₋₄), -CO₂H, -CO₂(alquilo C₁₋₄), -C(=O)N(R¹⁵)₂, -NR¹⁵C(=O)(alquilo C₁₋₄), -NR¹⁵C(=O)O(alquilo C₁₋₄), -OC(=O)N(R¹⁵)₂, -NR¹⁵C(=O)N(R¹⁵)₂, alquilo C₁₋₄, alquenilo C₂₋₄, alquinilo C₂₋₄, alcoxi C₁₋₄, deuteroalquilo C₁₋₄, deuteroalcoxi C₁₋₄, fluoroalquilo C₁₋₄, fluoroalcoxi C₁₋₄, o heteroalquilo C₁₋₄, o heterocicloalquilo C₂₋₅ monocíclico sustituido o no sustituido; o R¹ y R² se toman juntos con los átomos de intervención para formar un anillo de 5 miembros fusionado sustituido o no sustituido o anillo de 6 miembros fusionado sustituido o no sustituido con 0 - 3 átomos de N y 0 - 2 átomos de O ó S en el anillo; X³ es CR³ o N; R³ es H, D, halógeno, -CN, -OH, -SH, -N(R¹⁵)₂, -NR¹⁵S(=O)₂(alquilo C₁₋₄), -S(alquilo C₁₋₄), -S(=O)(alquilo C₁₋₄), -S(=O)₂(alquilo C₁₋₄), -S(=O)₂ N(R¹⁵)₂, -OC(=O)(alquilo C₁₋₄), -CO₂H, -CO₂(alquilo C₁₋₄), -C(=O)N(R¹⁵)₂, -NR¹⁵C(=O)(alquilo C₁₋₄), alquilo C₁₋₄, alquenilo C₂₋₄, alquinilo C₂₋₄, alcoxi C₁₋₄, deuteroalquilo C₁₋₄, deuteroalcoxi C₁₋₄, fluoroalquilo C₁₋₄, fluoroalcoxi C₁₋₄, heteroalquilo C₁₋₄, o heterocicloalquilo C₂₋₅ monocíclico sustituido o no sustituido; cada X⁴ es independientemente CH o N; R⁴ es H, D, F, o -CH₃; R⁵ es H, D, F, o -CH₃; o R⁴ y R⁵ se toman juntos para formar un puente que es -CH₂- o -CH₂CH₂-; cada R⁶ es independientemente H, D, F, -OH, o -CH₃; m es 0, 1, ó 2; R⁷ es H, D, halógeno, -CN, -OH, alquilo C₁₋₄, alquenilo C₂₋₄, alquinilo C₂₋₄, alcoxi C₁₋₄, deuteroalquilo C₁₋₄, deuteroalcoxi C₁₋₄, fluoroalquilo C₁₋₄, fluoroalcoxi C₁₋₄, o heteroalquilo C₁₋₄; L está ausente, es -Y²-L¹-, -L¹-Y²-, ciclopropileno, ciclobutileno o biciclo[1.1.1]pentileno; Y² está ausente, es -O-, -S-, -S(=O)-, -S(=O)₂-, -S(=O)₂NR¹⁵-, -CH₂-, -CH=CH-, -CºC-, -C(=O)-, -C(=O)O-, -OC(=O)-, -OC(=O)O-, -C(=O)NR¹⁵-, -NR¹⁵C(=O)-, -OC(=O)NR¹⁵-, -NR¹⁵C(=O)O-, -NR¹⁵C(=O)NR¹⁵-, -NR¹⁵S(=O)₂-, o -NR¹⁵-; L¹ está ausente o es alquileno C₁₋₄ sustituido o no sustituido; X⁵ es NR⁸ o N; R⁸ es H, D, alquilo C₁₋₆, deuteroalquilo C₁₋₆, fluoroalquilo C₁₋₆, heteroalquilo C₁₋₆, -C(=O)(alquilo C₁₋₄), -CO₂(alquilo C₁₋₄), -C(=O)N(R¹⁵)₂, -S(=O)₂(alquilo C₁₋₄), -S(=O)₂N(R¹⁵)₂, cicloalquilo C₃₋₆ sustituido o no sustituido, o heterocicloalquilo C₂₋₆ monocíclico sustituido o no sustituido, fenilo sustituido o no sustituido, o heteroarilo monocíclico sustituido o no sustituido; R⁹ es H, D, F o -CH₃; Y es -CR¹⁰R¹¹-, -O-, -S-, -S(=O)-, -S(=O)₂-, o -NR¹⁷-; R¹⁰ es H, D, halógeno, -CN, -OH, alquilo C₁₋₆, alquenilo C₂₋₄, alquinilo C₂₋₄, alcoxi C₁₋₆, fluoroalquilo C₁₋₆, -SR¹², -S(=O)R¹⁴, -S(=O)₂R¹⁴, o -N(R¹²)₂; R¹¹ es H, D, F o -CH₃; o R⁹ y R¹¹ se toman juntos para formar un puente que es -CH₂- o -CH₂CH₂-; cada R¹² es independientemente H, alquilo C₁₋₄, deuteroalquilo C₁₋₄, fluoroalquilo C₁₋₄, heteroalquilo C₁₋₄, cicloalquilo C₃₋₆ sustituido o no sustituido, heterocicloalquilo C₂₋₆ sustituido o no sustituido, fenilo sustituido o no sustituido, bencilo sustituido o no sustituido, heteroarilo monocíclico sustituido o no sustituido; R¹⁴ es alquilo C₁₋₄, deuteroalquilo C₁₋₄, fluoroalquilo C₁₋₄, heteroalquilo C₁₋₄, cicloalquilo C₃₋₆ sustituido o no sustituido, heterocicloalquilo C₂₋₆ sustituido o no sustituido, fenilo sustituido o no sustituido, bencilo sustituido o no sustituido, o heteroarilo monocíclico sustituido o no sustituido; R¹⁵ es H o alquilo C₁₋₆ sustituido o no sustituido; cada R¹⁶ es independientemente H, D, halógeno, -CN, -OH, -N(R¹⁵)₂, -NR¹⁵S(=O)₂(alquilo C₁₋₄), -S(alquilo C₁₋₄), -S(=O)(alquilo C₁₋₄), -S(=O)₂(alquilo C₁₋₄), -C(=O)(alquilo C₁₋₄), OC(=O)(alquilo C₁₋₄), -CO₂H, -CO₂(alquilo C₁₋₄), -NR¹⁵C(=O)(alquilo C₁₋₄), -C(=O)N(R¹⁵)₂, -NR¹⁵C(=O)O(alquilo C₁₋₄), -OC(=O)N(R¹⁵)₂, alquilo C₁₋₄, alquenilo C₂₋₄, alquinilo C₂₋₄, alcoxi C₁₋₄, deuteroalquilo C₁₋₄, deuteroalcoxi C₁₋₄, fluoroalquilo C₁₋₄, fluoroalcoxi C₁₋₄, heteroalquilo C₁₋₄, cicloalquilo C₃₋₆ sustituido o no sustituido, heterocicloalquilo C₂₋₆ monocíclico sustituido o no sustituido, fenilo sustituido o no sustituido, o heteroarilo monocíclico sustituido o no sustituido; n es 0, 1, ó 2; R¹⁷ es L⁵-R¹⁴; y L⁵ está ausente, es -S(=O)₂-, -C(=O)-, -CO₂-, o -C(=O)N(R¹⁵).
Applications Claiming Priority (1)
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US201762471517P | 2017-03-15 | 2017-03-15 |
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AR111284A1 true AR111284A1 (es) | 2019-06-26 |
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ARP180100608A AR111284A1 (es) | 2017-03-15 | 2018-03-15 | Agonistas del receptor farnesoide x y usos de los mismos |
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US (3) | US10961198B2 (es) |
EP (1) | EP3596053B1 (es) |
JP (1) | JP7174709B2 (es) |
CN (1) | CN110637011B (es) |
AR (1) | AR111284A1 (es) |
CA (1) | CA3055990A1 (es) |
DK (1) | DK3596053T3 (es) |
IL (1) | IL269068B (es) |
TW (1) | TWI803482B (es) |
WO (1) | WO2018170166A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3350166A4 (en) | 2015-09-16 | 2019-05-01 | Metacrine, Inc. | FARNESOID-X RECEPTOR AGONISTS AND USES THEREOF |
EA201890725A1 (ru) | 2015-09-16 | 2018-08-31 | Метакрайн, Инк. | Агонисты фарнезоидного х-рецептора и их применение |
WO2017049172A1 (en) | 2015-09-16 | 2017-03-23 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
DK3596053T3 (da) | 2017-03-15 | 2023-09-25 | Organovo Inc | Farnesoid-x-receptoragonister og anvendelser deraf |
KR102588982B1 (ko) * | 2017-03-15 | 2023-10-12 | 오가노보, 인크. | 파네소이드 x 수용체 효능제 및 이의 용도 |
WO2019089664A1 (en) | 2017-11-01 | 2019-05-09 | Bristol-Myers Squibb Company | Multicyclic compounds as farnesoid x receptor modulators |
CN111630051B (zh) | 2017-11-01 | 2023-12-26 | 百时美施贵宝公司 | 作为法尼醇x受体调节剂的烯烃螺环化合物 |
TWI833805B (zh) | 2018-09-18 | 2024-03-01 | 美商奧加諾沃公司 | 類法尼醇x(farnesoid x)受體促效劑及其用途 |
EA202190661A1 (ru) * | 2018-09-18 | 2021-08-13 | Метакрайн, Инк. | Агонисты фарнезоидного х-рецептора для лечения заболевания |
US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
CN113677666A (zh) * | 2019-02-15 | 2021-11-19 | 百时美施贵宝公司 | 作为类法尼醇x受体调节剂的经取代的双环化合物 |
BR112021015688A2 (pt) * | 2019-02-15 | 2021-10-26 | Bristol-Myers Squibb Company | Compostos de amida substituídos úteis como moduladores do receptor do farnesoide x |
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JP7174709B2 (ja) | 2022-11-17 |
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DK3596053T3 (da) | 2023-09-25 |
CA3055990A1 (en) | 2018-09-20 |
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