AR120221A1 - Tienopirimidonas - Google Patents
TienopirimidonasInfo
- Publication number
- AR120221A1 AR120221A1 ARP200102838A ARP200102838A AR120221A1 AR 120221 A1 AR120221 A1 AR 120221A1 AR P200102838 A ARP200102838 A AR P200102838A AR P200102838 A ARP200102838 A AR P200102838A AR 120221 A1 AR120221 A1 AR 120221A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- fluoro
- formula
- group
- thienopyrimidones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en donde A se selecciona del grupo que consiste en fenilo, naftilo, tiofenilo, benzotiofenilo o benzofuranilo, opcionalmente sustituido con uno o dos miembros del grupo que consiste en H, F, Cl, Br, C₁₋₄-alquilo, F₁₋₃-fluoro-C₁₋₄-alquilo, -CN, -OCH₃, ciclopropilo y ciclobutilo, o A se selecciona de los compuestos de fórmula (2) ó (3); y R¹ se selecciona de H, C₁₋₄-alquilo, F₁₋₃-fluoro-C₁₋₄-alquilo, C₁₋₄-alquilo-OH o C₁₋₄-alquilo-CN; R² se selecciona de C₁₋₂-alquilo o Cl; o R¹ y R² son cada uno CH₂ unido por un enlace que forma un anillo de 6 miembros; R³ se selecciona de H o C₁₋₄-alquilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19203173 | 2019-10-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR120221A1 true AR120221A1 (es) | 2022-02-02 |
Family
ID=68289874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200102838A AR120221A1 (es) | 2019-10-15 | 2020-10-14 | Tienopirimidonas |
Country Status (14)
Country | Link |
---|---|
US (2) | US20210107919A1 (es) |
EP (1) | EP4045144A1 (es) |
JP (1) | JP7354438B2 (es) |
KR (1) | KR20220084127A (es) |
CN (1) | CN114945408B (es) |
AR (1) | AR120221A1 (es) |
AU (1) | AU2020366678A1 (es) |
BR (1) | BR112022003729A2 (es) |
CA (1) | CA3153115A1 (es) |
CL (1) | CL2022000757A1 (es) |
IL (1) | IL292095A (es) |
MX (1) | MX2022004564A (es) |
TW (1) | TW202128705A (es) |
WO (1) | WO2021074197A1 (es) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7754709B2 (en) * | 2003-06-10 | 2010-07-13 | Solvay Pharmaceuticals Bv | Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds |
MY159059A (en) * | 2010-12-20 | 2016-12-15 | Glenmark Pharmaceuticals Sa | 2-amino-4-arylthiazole compounds as trpa1 antagonists |
JP2014517031A (ja) * | 2011-06-13 | 2014-07-17 | グレンマーク ファーマシューティカルズ, エセ.アー. | Trpa1アンタゴニストを使用した呼吸器疾患の治療 |
WO2016023832A1 (en) * | 2014-08-11 | 2016-02-18 | Hydra Biosciences, Inc. | Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders |
US12006328B2 (en) * | 2014-11-18 | 2024-06-11 | Emory University | Thieno[2,3-d]pyrimidin-4-one derivatives as NMDAR modulators and uses related thereto |
WO2016133888A1 (en) * | 2015-02-16 | 2016-08-25 | Biota Pharmaceuticals, Inc. | Compounds for treating respiratory syncytial virus infections |
WO2017060488A1 (en) * | 2015-10-09 | 2017-04-13 | Almirall, S.A. | New trpa1 antagonists |
-
2020
- 2020-10-14 CN CN202080071930.XA patent/CN114945408B/zh active Active
- 2020-10-14 WO PCT/EP2020/078855 patent/WO2021074197A1/en unknown
- 2020-10-14 CA CA3153115A patent/CA3153115A1/en active Pending
- 2020-10-14 AR ARP200102838A patent/AR120221A1/es unknown
- 2020-10-14 TW TW109135461A patent/TW202128705A/zh unknown
- 2020-10-14 BR BR112022003729A patent/BR112022003729A2/pt not_active Application Discontinuation
- 2020-10-14 JP JP2022522350A patent/JP7354438B2/ja active Active
- 2020-10-14 KR KR1020227016330A patent/KR20220084127A/ko unknown
- 2020-10-14 AU AU2020366678A patent/AU2020366678A1/en active Pending
- 2020-10-14 MX MX2022004564A patent/MX2022004564A/es unknown
- 2020-10-14 EP EP20789985.7A patent/EP4045144A1/en active Pending
- 2020-10-15 US US17/071,092 patent/US20210107919A1/en not_active Abandoned
-
2021
- 2021-09-01 US US17/463,942 patent/US11578080B2/en active Active
-
2022
- 2022-03-25 CL CL2022000757A patent/CL2022000757A1/es unknown
- 2022-04-10 IL IL292095A patent/IL292095A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20220084127A (ko) | 2022-06-21 |
EP4045144A1 (en) | 2022-08-24 |
CL2022000757A1 (es) | 2023-01-20 |
JP2022551956A (ja) | 2022-12-14 |
WO2021074197A1 (en) | 2021-04-22 |
CN114945408B (zh) | 2024-04-16 |
JP7354438B2 (ja) | 2023-10-02 |
TW202128705A (zh) | 2021-08-01 |
IL292095A (en) | 2022-06-01 |
CA3153115A1 (en) | 2021-04-22 |
MX2022004564A (es) | 2022-05-06 |
CN114945408A (zh) | 2022-08-26 |
US20210395267A1 (en) | 2021-12-23 |
BR112022003729A2 (pt) | 2022-05-31 |
US11578080B2 (en) | 2023-02-14 |
US20210107919A1 (en) | 2021-04-15 |
AU2020366678A1 (en) | 2022-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR116628A1 (es) | Compuestos microbiocidas | |
AR108395A1 (es) | Moduladores de la vía de estrés integrada | |
AR107519A1 (es) | Compuestos de piperidina sustituido y su uso | |
AR099177A1 (es) | Determinadas (2s)-n-[(1s)-1-ciano-2-feniletil]-1,4-oxazepan-2-carboxamidas como inhibidores de dipeptidil peptidasa 1 | |
AR110599A1 (es) | Moduladores de la vía de estrés integrada | |
AR110405A1 (es) | Compuestos | |
AR100809A1 (es) | Inhibidores de fosfatidilinositol 3-quinasa | |
AR103138A1 (es) | Compuestos de heteroarilo como inhibidores de la irak y usos de los mismos | |
AR099995A1 (es) | Piridilamidinas fungicidas | |
AR094299A1 (es) | Derivados de ftalazin-1(2h)-ona sustituidos | |
AR106486A1 (es) | Antagonistas de receptores de cgrp | |
AR098721A1 (es) | Inhibidores de biarilo de tirosina quinasa de bruton | |
ES2590489T3 (es) | Compuestos de benceno sustituidos | |
AR112338A2 (es) | Arilciclohexiléteres de dihidro-tetraazabenzoazuleno | |
AR102731A1 (es) | Compuestos espiroisoquinolin-1,4-piperidínicos con actividad multimodal contra el dolor | |
AR105991A1 (es) | Heteroarilos sustituidos con pirazolilo y su uso como medicamentos | |
AR097253A1 (es) | Derivado de pirazolilpirazol sustituido y el uso del mismo como herbicida | |
AR101255A1 (es) | Derivados de isoindolinona | |
AR109711A1 (es) | Inhibidores de fosfatidilinositol 3-quinasa | |
AR101222A1 (es) | Derivados de piridona | |
AR109296A1 (es) | Derivados de oxadiazolopiridina para el uso como inhibidores de ghrelin o-aciltransferasa (goat) | |
AR102222A1 (es) | Compuestos de indolinona, composiciones farmacéuticas que los comprende y usos de los mismos | |
AR114496A1 (es) | Compuestos antiproliferación y usos de los mismos | |
AR101798A1 (es) | Quinolinas herbicidas | |
AR117472A1 (es) | Inhibidores de tienopiridina de ripk2 |