AR120221A1 - Tienopirimidonas - Google Patents

Tienopirimidonas

Info

Publication number
AR120221A1
AR120221A1 ARP200102838A ARP200102838A AR120221A1 AR 120221 A1 AR120221 A1 AR 120221A1 AR P200102838 A ARP200102838 A AR P200102838A AR P200102838 A ARP200102838 A AR P200102838A AR 120221 A1 AR120221 A1 AR 120221A1
Authority
AR
Argentina
Prior art keywords
alkyl
fluoro
formula
group
thienopyrimidones
Prior art date
Application number
ARP200102838A
Other languages
English (en)
Inventor
Martin Thomas Fleck
Florian Paul Christian Binder
Georg Dahmann
Joerg P Hehn
Annekatrin Charlotte Heimann
Uta Friederike Lessel
Jens Willwacher
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR120221A1 publication Critical patent/AR120221A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Reivindicación 1: Un compuesto caracterizado por la fórmula (1) en donde A se selecciona del grupo que consiste en fenilo, naftilo, tiofenilo, benzotiofenilo o benzofuranilo, opcionalmente sustituido con uno o dos miembros del grupo que consiste en H, F, Cl, Br, C₁₋₄-alquilo, F₁₋₃-fluoro-C₁₋₄-alquilo, -CN, -OCH₃, ciclopropilo y ciclobutilo, o A se selecciona de los compuestos de fórmula (2) ó (3); y R¹ se selecciona de H, C₁₋₄-alquilo, F₁₋₃-fluoro-C₁₋₄-alquilo, C₁₋₄-alquilo-OH o C₁₋₄-alquilo-CN; R² se selecciona de C₁₋₂-alquilo o Cl; o R¹ y R² son cada uno CH₂ unido por un enlace que forma un anillo de 6 miembros; R³ se selecciona de H o C₁₋₄-alquilo.
ARP200102838A 2019-10-15 2020-10-14 Tienopirimidonas AR120221A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19203173 2019-10-15

Publications (1)

Publication Number Publication Date
AR120221A1 true AR120221A1 (es) 2022-02-02

Family

ID=68289874

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP200102838A AR120221A1 (es) 2019-10-15 2020-10-14 Tienopirimidonas

Country Status (14)

Country Link
US (2) US20210107919A1 (es)
EP (1) EP4045144A1 (es)
JP (1) JP7354438B2 (es)
KR (1) KR20220084127A (es)
CN (1) CN114945408B (es)
AR (1) AR120221A1 (es)
AU (1) AU2020366678A1 (es)
BR (1) BR112022003729A2 (es)
CA (1) CA3153115A1 (es)
CL (1) CL2022000757A1 (es)
IL (1) IL292095A (es)
MX (1) MX2022004564A (es)
TW (1) TW202128705A (es)
WO (1) WO2021074197A1 (es)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7754709B2 (en) 2003-06-10 2010-07-13 Solvay Pharmaceuticals Bv Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds
UA109916C2 (uk) * 2010-12-20 2015-10-26 Гленмарк Фармасьютікалс С.А. 2-аміно-4-арилтіазольні сполуки як антагоністи trра1
CN103826637A (zh) * 2011-06-13 2014-05-28 格兰马克药品股份有限公司 使用trpa1拮抗剂治疗呼吸疾患
EP3180345B1 (en) 2014-08-11 2018-10-10 Hydra Biosciences, Inc. Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders
WO2016081649A1 (en) 2014-11-18 2016-05-26 Emory University Thieno[2,3-d]pyrimidin-4-one derivatives as nmdar modulators and uses related thereto
WO2016133888A1 (en) * 2015-02-16 2016-08-25 Biota Pharmaceuticals, Inc. Compounds for treating respiratory syncytial virus infections
WO2017060488A1 (en) 2015-10-09 2017-04-13 Almirall, S.A. New trpa1 antagonists

Also Published As

Publication number Publication date
CL2022000757A1 (es) 2023-01-20
US11578080B2 (en) 2023-02-14
TW202128705A (zh) 2021-08-01
CA3153115A1 (en) 2021-04-22
EP4045144A1 (en) 2022-08-24
AU2020366678A1 (en) 2022-03-31
JP2022551956A (ja) 2022-12-14
CN114945408B (zh) 2024-04-16
US20210395267A1 (en) 2021-12-23
BR112022003729A2 (pt) 2022-05-31
WO2021074197A1 (en) 2021-04-22
CN114945408A (zh) 2022-08-26
US20210107919A1 (en) 2021-04-15
JP7354438B2 (ja) 2023-10-02
KR20220084127A (ko) 2022-06-21
MX2022004564A (es) 2022-05-06
IL292095A (en) 2022-06-01

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