AR118750A1 - UN PROCESO PARA PREPARAR UNA FORMA CRISTALINA DE 2-(3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-1-(CICLOPROPILSULFONILO)AZETIDIN-3-IL)ACETONITRILO QUE POSEE ACTIVIDAD INHIBIDORA DE JAK - Google Patents
UN PROCESO PARA PREPARAR UNA FORMA CRISTALINA DE 2-(3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-1-(CICLOPROPILSULFONILO)AZETIDIN-3-IL)ACETONITRILO QUE POSEE ACTIVIDAD INHIBIDORA DE JAKInfo
- Publication number
- AR118750A1 AR118750A1 ARP200101129A ARP200101129A AR118750A1 AR 118750 A1 AR118750 A1 AR 118750A1 AR P200101129 A ARP200101129 A AR P200101129A AR P200101129 A ARP200101129 A AR P200101129A AR 118750 A1 AR118750 A1 AR 118750A1
- Authority
- AR
- Argentina
- Prior art keywords
- cyclopropylsulfonyl
- azetidin
- pyrimidin
- acetonitrile
- crystalline form
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente descripción proporciona un método para preparar una forma cristalina de 2-(3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-1-(ciclopropilsulfonil)azetidin-3-il)acetonitrilo y su utilización en el tratamiento de afecciones dermatológicas tales como dermatitis atópica y prurito. Reivindicación 1: Un proceso para preparar 2-(3-(4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il)-1-(ciclopropilsulfonilo)azetidin-3-il)acetonitrilo cristalino sustancialmente polimórficamente puro caracterizado por el patrón de difracción de rayos X en polvo que comprende un pico a 5,34º, 10,68º, 14,26º, 16,06º, 16,39º, 16,48º, 18,26º, 18,65º, 21,05º, 21,76º, 22,68º, o 26,75º (± 0,2º 2q), cuyo proceso comprende la cristalización de un solvente seleccionado del grupo que consiste en un alcohol C₁₋₅, un alquiléter C₂₋₈, un acetato de alquilo C₂₋₈, un cianuro de alquilo C₂₋₅, una alquilcetona C₃₋₉ y un solvente aromático, o una mezcla de los mismos; en donde el solvente o la mezcla de solventes tienen una actividad de agua de menos de 0,7.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962837972P | 2019-04-24 | 2019-04-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR118750A1 true AR118750A1 (es) | 2021-10-27 |
Family
ID=70614675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200101129A AR118750A1 (es) | 2019-04-24 | 2020-04-22 | UN PROCESO PARA PREPARAR UNA FORMA CRISTALINA DE 2-(3-(4-(7H-PIRROLO[2,3-d]PIRIMIDIN-4-IL)-1H-PIRAZOL-1-IL)-1-(CICLOPROPILSULFONILO)AZETIDIN-3-IL)ACETONITRILO QUE POSEE ACTIVIDAD INHIBIDORA DE JAK |
Country Status (11)
Country | Link |
---|---|
US (2) | US11548895B2 (es) |
EP (1) | EP3958968A1 (es) |
JP (2) | JP7241916B2 (es) |
KR (1) | KR20210141634A (es) |
CN (1) | CN114466681A (es) |
AR (1) | AR118750A1 (es) |
AU (2) | AU2020262100B2 (es) |
BR (1) | BR112021020508A2 (es) |
CA (1) | CA3134750A1 (es) |
MX (1) | MX2021012849A (es) |
WO (1) | WO2020219524A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3958968A1 (en) | 2019-04-24 | 2022-03-02 | Elanco Us Inc. | A 7h-pyrrolo[2,3-d]pyrimidine jak-inhibitor |
US20230404925A1 (en) * | 2020-10-23 | 2023-12-21 | Elanco Us Inc. | Jak inhibitors having a specific particle size distribution |
CA3201608A1 (en) | 2020-12-18 | 2022-06-23 | Boehringer Ingelheim Animal Health USA Inc. | Boron containing pyrazole compounds, compositions comprising them, methods and uses thereof |
AU2022331122A1 (en) | 2021-08-20 | 2024-02-15 | Intervet International B.V. | Homodimer fusion proteins for treating atopic dermatitis |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE030235T2 (en) | 2005-12-13 | 2017-04-28 | Incyte Holdings Corp | Heteroaryl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors |
ES2602577T3 (es) * | 2008-03-11 | 2017-02-21 | Incyte Holdings Corporation | Derivados de azetidina y ciclobutano como inhibidores de JAK |
US20130310340A1 (en) | 2012-05-16 | 2013-11-21 | Rigel Pharmaceuticals, Inc. | Method of treating muscular degradation |
WO2016141891A1 (zh) | 2015-03-11 | 2016-09-15 | 苏州晶云药物科技有限公司 | Jak抑制剂的晶型及其制备方法 |
AR104918A1 (es) | 2015-06-19 | 2017-08-23 | Lilly Co Eli | Procesos e intermediarios para la preparación de {1-(etilsulfonil)-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo |
WO2019003249A1 (en) * | 2017-06-28 | 2019-01-03 | Mylan Laboratories Limited | POLYMORPHIC FORMS OF BARICITINIB |
EP3958968A1 (en) | 2019-04-24 | 2022-03-02 | Elanco Us Inc. | A 7h-pyrrolo[2,3-d]pyrimidine jak-inhibitor |
-
2020
- 2020-04-22 EP EP20724705.7A patent/EP3958968A1/en active Pending
- 2020-04-22 WO PCT/US2020/029283 patent/WO2020219524A1/en active Application Filing
- 2020-04-22 JP JP2021563159A patent/JP7241916B2/ja active Active
- 2020-04-22 AU AU2020262100A patent/AU2020262100B2/en active Active
- 2020-04-22 US US16/855,471 patent/US11548895B2/en active Active
- 2020-04-22 MX MX2021012849A patent/MX2021012849A/es unknown
- 2020-04-22 CA CA3134750A patent/CA3134750A1/en active Pending
- 2020-04-22 CN CN202080028291.9A patent/CN114466681A/zh active Pending
- 2020-04-22 AR ARP200101129A patent/AR118750A1/es unknown
- 2020-04-22 BR BR112021020508A patent/BR112021020508A2/pt unknown
- 2020-04-22 KR KR1020217033869A patent/KR20210141634A/ko not_active Application Discontinuation
-
2022
- 2022-06-02 US US17/830,898 patent/US20230056365A1/en active Pending
-
2023
- 2023-03-07 JP JP2023034772A patent/JP2023071922A/ja active Pending
- 2023-06-09 AU AU2023203627A patent/AU2023203627A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3958968A1 (en) | 2022-03-02 |
US20200339585A1 (en) | 2020-10-29 |
JP7241916B2 (ja) | 2023-03-17 |
JP2023071922A (ja) | 2023-05-23 |
BR112021020508A2 (pt) | 2021-12-07 |
US11548895B2 (en) | 2023-01-10 |
US20230056365A1 (en) | 2023-02-23 |
WO2020219524A1 (en) | 2020-10-29 |
KR20210141634A (ko) | 2021-11-23 |
MX2021012849A (es) | 2022-02-24 |
JP2022530441A (ja) | 2022-06-29 |
AU2020262100A1 (en) | 2021-11-11 |
AU2023203627A1 (en) | 2023-07-06 |
CN114466681A (zh) | 2022-05-10 |
CA3134750A1 (en) | 2020-10-29 |
AU2020262100B2 (en) | 2023-03-16 |
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