AR116400A1 - Compuesto de imidazopiridinona - Google Patents
Compuesto de imidazopiridinonaInfo
- Publication number
- AR116400A1 AR116400A1 ARP190102601A ARP190102601A AR116400A1 AR 116400 A1 AR116400 A1 AR 116400A1 AR P190102601 A ARP190102601 A AR P190102601A AR P190102601 A ARP190102601 A AR P190102601A AR 116400 A1 AR116400 A1 AR 116400A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen atom
- group
- unsubstituted
- substituted
- Prior art date
Links
- -1 IMIDAZOPYRIDINONE COMPOUND Chemical class 0.000 title abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 13
- 125000001424 substituent group Chemical group 0.000 abstract 9
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 5
- 125000005843 halogen group Chemical group 0.000 abstract 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 3
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 2
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006719 (C6-C10) aryl (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005553 heteroaryloxy group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018171839 | 2018-09-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR116400A1 true AR116400A1 (es) | 2021-05-05 |
Family
ID=69777067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP190102601A AR116400A1 (es) | 2018-09-13 | 2019-09-13 | Compuesto de imidazopiridinona |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US12077531B2 (https=) |
| EP (1) | EP3808747B1 (https=) |
| JP (1) | JP7458987B2 (https=) |
| KR (1) | KR102830577B1 (https=) |
| CN (1) | CN112689637B (https=) |
| AR (1) | AR116400A1 (https=) |
| AU (1) | AU2019340173B2 (https=) |
| BR (1) | BR112021004730A2 (https=) |
| CA (1) | CA3106385A1 (https=) |
| DK (1) | DK3808747T3 (https=) |
| ES (1) | ES3016010T3 (https=) |
| FI (1) | FI3808747T3 (https=) |
| HU (1) | HUE069830T2 (https=) |
| IL (1) | IL281391B2 (https=) |
| MX (1) | MX2021003027A (https=) |
| MY (1) | MY207239A (https=) |
| NZ (1) | NZ773786A (https=) |
| PH (1) | PH12021550512A1 (https=) |
| PL (1) | PL3808747T3 (https=) |
| PT (1) | PT3808747T (https=) |
| SG (1) | SG11202102441VA (https=) |
| TW (1) | TWI814903B (https=) |
| WO (1) | WO2020054788A1 (https=) |
| ZA (1) | ZA202101671B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7414550B2 (ja) * | 2020-01-23 | 2024-01-16 | キッセイ薬品工業株式会社 | （ヘテロ）アリールイミダゾロン化合物 |
| US20230107927A1 (en) | 2020-02-28 | 2023-04-06 | First Wave Bio, Inc. | Methods of treating iatrogenic autoimmune colitis |
| CA3169000A1 (en) * | 2020-03-11 | 2021-09-16 | Hideki Takeuchi | Crystal of imidazopyridinone compound or salt thereof |
| JP7654426B2 (ja) * | 2020-03-12 | 2025-04-01 | キッセイ薬品工業株式会社 | イミダゾピリジノン化合物の製造方法 |
| CN117402178B (zh) * | 2023-12-15 | 2024-03-08 | 英矽智能科技(上海)有限公司 | 作为jak抑制剂和phd抑制剂的嘧啶类化合物 |
| WO2025264818A1 (en) * | 2024-06-20 | 2025-12-26 | Raythera, Inc. | Stat6 modulators and methods of uses thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0650961B1 (de) * | 1993-11-02 | 1997-03-05 | Hoechst Aktiengesellschaft | Substituierte heterocyclische Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| CA2344249A1 (en) * | 1998-09-18 | 2000-03-30 | Basf Aktiengesellschaft | Pyrrolopyrimidines as protein kinase inhibitors |
| WO2001072751A1 (en) | 2000-03-29 | 2001-10-04 | Knoll Gesellschaft Mit Beschraenkter Haftung | Pyrrolopyrimidines as tyrosine kinase inhibitors |
| WO2003037890A2 (en) | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Piperidines |
| MXPA06000700A (es) * | 2003-07-23 | 2006-04-11 | Wyeth Corp | Compuestos de sulfonildihidroimidazopiridinona como ligandos de 5-hidroxitriptamina-6. |
| US7749999B2 (en) | 2003-09-11 | 2010-07-06 | Itherx Pharmaceuticals, Inc. | Alpha-ketoamides and derivatives thereof |
| ATE531705T1 (de) * | 2004-05-18 | 2011-11-15 | Schering Corp | Substituierte 2-chinolyloxazole geeignet als pde4 inhibitoren |
| EP1861377B1 (en) | 2005-03-15 | 2010-12-29 | Pfizer, Inc. | Benzimidazolone derivatives as cb2 receptor ligands |
| DE102005019712A1 (de) | 2005-04-28 | 2006-11-09 | Bayer Healthcare Ag | Dipyridyl-dihydropyrazolone und ihre Verwendung |
| WO2007015877A2 (en) * | 2005-07-20 | 2007-02-08 | Kalypsys, Inc. | Inhibitors of p38 kinase and methods of treating inflammatory disorders |
| US20070142369A1 (en) | 2005-12-21 | 2007-06-21 | Margaret Van Heek | Combination of an H3 antagonist/inverse agonist and an appetite suppressant |
| US20090298811A1 (en) | 2006-09-12 | 2009-12-03 | Pfizer Inc | Benzimidazolone derivatives |
| EP2160187B1 (en) | 2007-05-16 | 2013-05-22 | Merck Sharp & Dohme Corp. | Spiroindalones |
| CA2686485A1 (en) * | 2007-05-23 | 2008-11-27 | Pharmacopeia, Llc | Purinones and 1h-imidazopyridinones as pkc-theta inhibitors |
| CA2698071A1 (en) | 2007-08-27 | 2009-03-05 | Wyeth Llc | Imidazopyridine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system |
| CN101951777A (zh) * | 2008-02-25 | 2011-01-19 | 默沙东公司 | 四氢呋喃并吡啶酮 |
| EP2294066B9 (en) | 2008-04-28 | 2015-03-11 | Janssen Pharmaceutica, N.V. | Benzoimidazoles as prolyl hydroxylase inhibitors |
| EP2285375B1 (en) | 2008-05-08 | 2013-04-10 | Merck Sharp & Dohme Corp. | spiroazaindole compounds as HIF propylhydroxylase inhibitors |
| EP2364313B1 (en) | 2008-09-09 | 2014-01-08 | Boehringer Ingelheim International GmbH | Aza-benzimidazolone chymase inhibitors |
| SI2455381T1 (sl) * | 2009-07-17 | 2014-08-29 | Japan Tobacco Inc. | Triazolopiridinova spojina in njeno delovanje kot zaviralec prolil-hidroksilaze in induktor produkcije eritropoietina |
| JP2011037814A (ja) | 2009-08-14 | 2011-02-24 | Synstar Japan Co Ltd | マラリア原虫疾患予防又は治療用の５−ヘテロ環置換イミノ−９−ジアルキルアミノベンゾ［ａ］フェノキサチン化合物又はその塩とアーテミシニン誘導体との組み合わせ |
| WO2011096490A1 (ja) | 2010-02-04 | 2011-08-11 | 第一三共株式会社 | イミダゾピリジン－２－オン誘導体 |
| FR2967355B1 (fr) * | 2010-11-17 | 2013-09-27 | Jouvin Jean Luc | Seringue dentaire securisee |
| WO2014181813A1 (ja) | 2013-05-10 | 2014-11-13 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3056975B1 (en) | 2013-10-08 | 2020-08-12 | Maxell, Ltd. | Projection type image display device, manipulation detection device and projection type image display method |
| WO2015052675A1 (en) | 2013-10-10 | 2015-04-16 | Glenmark Pharmaceuticals S.A. | Substituted dihydro-benzimidazole compounds as ror gamma modulators |
| CN104926733B (zh) | 2014-03-18 | 2019-05-10 | 北京韩美药品有限公司 | 作为RORγ调节剂的化合物 |
| GB201504565D0 (en) * | 2015-03-18 | 2015-05-06 | Takeda Pharmaceutical | Novel compounds |
| UA124090C2 (uk) * | 2015-06-03 | 2021-07-21 | Прінсіпіа Байофарма Інк. | Інгібітори тирозинкінази |
| EP3414234B1 (en) | 2015-10-14 | 2022-06-29 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
| RU2743126C9 (ru) | 2016-08-22 | 2021-04-27 | Шицзячжуан Сагесити Нью Драг Дивелопмент Ко., Лтд. | Ингибитор pde4 |
| US10899758B2 (en) * | 2016-09-16 | 2021-01-26 | Vitae Pharmaceuticals, Llc | Inhibitors of the menin-MLL interaction |
| CA3087886A1 (en) * | 2018-01-19 | 2019-07-25 | Idorsia Pharmaceuticals Ltd | C5a receptor modulators |
-
2019
- 2019-09-12 JP JP2020546064A patent/JP7458987B2/ja active Active
- 2019-09-12 US US17/268,011 patent/US12077531B2/en active Active
- 2019-09-12 NZ NZ773786A patent/NZ773786A/en unknown
- 2019-09-12 CA CA3106385A patent/CA3106385A1/en active Pending
- 2019-09-12 SG SG11202102441VA patent/SG11202102441VA/en unknown
- 2019-09-12 KR KR1020217004504A patent/KR102830577B1/ko active Active
- 2019-09-12 EP EP19859445.9A patent/EP3808747B1/en active Active
- 2019-09-12 ES ES19859445T patent/ES3016010T3/es active Active
- 2019-09-12 HU HUE19859445A patent/HUE069830T2/hu unknown
- 2019-09-12 BR BR112021004730-1A patent/BR112021004730A2/pt unknown
- 2019-09-12 DK DK19859445.9T patent/DK3808747T3/da active
- 2019-09-12 CN CN201980059004.8A patent/CN112689637B/zh active Active
- 2019-09-12 FI FIEP19859445.9T patent/FI3808747T3/fi active
- 2019-09-12 MX MX2021003027A patent/MX2021003027A/es unknown
- 2019-09-12 MY MYPI2021001303A patent/MY207239A/en unknown
- 2019-09-12 IL IL281391A patent/IL281391B2/en unknown
- 2019-09-12 AU AU2019340173A patent/AU2019340173B2/en not_active Ceased
- 2019-09-12 WO PCT/JP2019/035792 patent/WO2020054788A1/ja not_active Ceased
- 2019-09-12 PT PT198594459T patent/PT3808747T/pt unknown
- 2019-09-12 PL PL19859445.9T patent/PL3808747T3/pl unknown
- 2019-09-12 TW TW108133054A patent/TWI814903B/zh active
- 2019-09-13 AR ARP190102601A patent/AR116400A1/es unknown
-
2021
- 2021-03-10 PH PH12021550512A patent/PH12021550512A1/en unknown
- 2021-03-11 ZA ZA2021/01671A patent/ZA202101671B/en unknown
-
2024
- 2024-07-24 US US18/782,102 patent/US20240425504A1/en active Pending
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