AR116312A1 - Método mejorado para la fabricación de 3-[(1s)-1-imidazo[1,2-a]piridin-6-iletil]-5-(1-metilpirazol-4-il)triazolo[4,5-b]pirazina y formas polimórficas de la misma - Google Patents

Método mejorado para la fabricación de 3-[(1s)-1-imidazo[1,2-a]piridin-6-iletil]-5-(1-metilpirazol-4-il)triazolo[4,5-b]pirazina y formas polimórficas de la misma

Info

Publication number
AR116312A1
AR116312A1 ARP190102586A ARP190102586A AR116312A1 AR 116312 A1 AR116312 A1 AR 116312A1 AR P190102586 A ARP190102586 A AR P190102586A AR P190102586 A ARP190102586 A AR P190102586A AR 116312 A1 AR116312 A1 AR 116312A1
Authority
AR
Argentina
Prior art keywords
manufacture
triazolo
imidazo
pyridin
improved method
Prior art date
Application number
ARP190102586A
Other languages
English (en)
Inventor
Gareth Paul Howell
Andrew Timothy Turner
Andrew Roy Turner
Neil Keith Adlington
Keith Raymond Mulholland
Malcolm Allan Young Gall
Zhenping Tian
Wei Yu
Qisun Gong
Bo Liu
Original Assignee
Hutchison Medipharma Ltd
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchison Medipharma Ltd, Astrazeneca Ab filed Critical Hutchison Medipharma Ltd
Publication of AR116312A1 publication Critical patent/AR116312A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta memoria descripta se refiere generalmente a un método mejorado para la fabricación de 3-[(1S)-1-imidazo[1,2-a]piridin-6-iletil]-5-(1-metilpirazol-4-il)triazolo[4,5-b]pirazina, de fórmula (1), o sales farmacéuticamente aceptables de la misma; formas polimórficas de la misma; e intermedios útiles en la fabricación de dichos compuestos y sales de los mismos.
ARP190102586A 2018-09-11 2019-09-11 Método mejorado para la fabricación de 3-[(1s)-1-imidazo[1,2-a]piridin-6-iletil]-5-(1-metilpirazol-4-il)triazolo[4,5-b]pirazina y formas polimórficas de la misma AR116312A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2018104941 2018-09-11

Publications (1)

Publication Number Publication Date
AR116312A1 true AR116312A1 (es) 2021-04-21

Family

ID=67988964

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190102586A AR116312A1 (es) 2018-09-11 2019-09-11 Método mejorado para la fabricación de 3-[(1s)-1-imidazo[1,2-a]piridin-6-iletil]-5-(1-metilpirazol-4-il)triazolo[4,5-b]pirazina y formas polimórficas de la misma

Country Status (15)

Country Link
US (1) US20220048904A1 (es)
EP (1) EP3849977B1 (es)
JP (1) JP2022500494A (es)
KR (1) KR20210057777A (es)
CN (1) CN112930348B (es)
AR (1) AR116312A1 (es)
AU (1) AU2019340569B2 (es)
BR (1) BR112021003814A2 (es)
CA (1) CA3110762A1 (es)
CO (1) CO2021004130A2 (es)
EA (1) EA202190643A1 (es)
ES (1) ES2956847T3 (es)
IL (1) IL281283B2 (es)
MX (1) MX2021002794A (es)
WO (1) WO2020053198A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3193755A1 (en) 2020-09-28 2022-03-31 Codexis, Inc. Engineered biocatalysts and methods for synthesizing chiral amines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2966075B1 (en) * 2009-12-31 2019-02-27 Hutchison Medipharma Limited Certain triazolopyridines, compositions thereof and their use in the treatment of cancer.

Also Published As

Publication number Publication date
AU2019340569A1 (en) 2021-05-13
KR20210057777A (ko) 2021-05-21
IL281283A (en) 2021-04-29
JP2022500494A (ja) 2022-01-04
ES2956847T3 (es) 2023-12-29
CO2021004130A2 (es) 2021-04-30
IL281283B2 (en) 2024-01-01
BR112021003814A2 (pt) 2021-05-18
TW202026295A (zh) 2020-07-16
CN112930348B (zh) 2023-12-05
WO2020053198A1 (en) 2020-03-19
EP3849977B1 (en) 2023-07-19
CA3110762A1 (en) 2020-03-19
US20220048904A1 (en) 2022-02-17
EP3849977A1 (en) 2021-07-21
CN112930348A (zh) 2021-06-08
IL281283B1 (en) 2023-09-01
MX2021002794A (es) 2021-08-11
AU2019340569B2 (en) 2022-06-09
EA202190643A1 (ru) 2021-07-09

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