CL2014002220A1 - Compuesto 1-(3,3-dimetilbutil)-3-(2-fluoro-4-metil-5-(7-metil-2-(metilamino)pirido[2,3-d]pirimidin-6-il)fenil)urea, inhibidor de la cinasa raf; forma cristalina del compuesto; composicion farmaceutica que lo comprende; y metodo para tratar el cancer. - Google Patents

Compuesto 1-(3,3-dimetilbutil)-3-(2-fluoro-4-metil-5-(7-metil-2-(metilamino)pirido[2,3-d]pirimidin-6-il)fenil)urea, inhibidor de la cinasa raf; forma cristalina del compuesto; composicion farmaceutica que lo comprende; y metodo para tratar el cancer.

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Publication number
CL2014002220A1
CL2014002220A1 CL2014002220A CL2014002220A CL2014002220A1 CL 2014002220 A1 CL2014002220 A1 CL 2014002220A1 CL 2014002220 A CL2014002220 A CL 2014002220A CL 2014002220 A CL2014002220 A CL 2014002220A CL 2014002220 A1 CL2014002220 A1 CL 2014002220A1
Authority
CL
Chile
Prior art keywords
methyl
compound
pyrido
dimethylbutyl
pyrimidin
Prior art date
Application number
CL2014002220A
Other languages
English (en)
Inventor
Matthew Carl Allgeier
Daniel L Flynn
Michael D Kaufman
Phenil J Patel
Craig D Wolfangel
Original Assignee
Lilly Co Eli
Deciphera Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47884613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014002220(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli, Deciphera Pharmaceuticals Llc filed Critical Lilly Co Eli
Publication of CL2014002220A1 publication Critical patent/CL2014002220A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
CL2014002220A 2012-03-07 2014-08-21 Compuesto 1-(3,3-dimetilbutil)-3-(2-fluoro-4-metil-5-(7-metil-2-(metilamino)pirido[2,3-d]pirimidin-6-il)fenil)urea, inhibidor de la cinasa raf; forma cristalina del compuesto; composicion farmaceutica que lo comprende; y metodo para tratar el cancer. CL2014002220A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261607702P 2012-03-07 2012-03-07

Publications (1)

Publication Number Publication Date
CL2014002220A1 true CL2014002220A1 (es) 2015-06-05

Family

ID=47884613

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014002220A CL2014002220A1 (es) 2012-03-07 2014-08-21 Compuesto 1-(3,3-dimetilbutil)-3-(2-fluoro-4-metil-5-(7-metil-2-(metilamino)pirido[2,3-d]pirimidin-6-il)fenil)urea, inhibidor de la cinasa raf; forma cristalina del compuesto; composicion farmaceutica que lo comprende; y metodo para tratar el cancer.

Country Status (39)

Country Link
US (2) US8741911B2 (es)
EP (1) EP2850082B1 (es)
JP (1) JP2015509536A (es)
KR (1) KR20140129087A (es)
CN (1) CN104302646B (es)
AP (1) AP2014007899A0 (es)
AR (1) AR090151A1 (es)
AU (1) AU2013230146B2 (es)
BR (1) BR112014018528A8 (es)
CA (1) CA2863673A1 (es)
CL (1) CL2014002220A1 (es)
CO (1) CO7010837A2 (es)
CR (1) CR20140378A (es)
CY (1) CY1117846T1 (es)
DK (1) DK2850082T3 (es)
DO (1) DOP2014000200A (es)
EA (1) EA024824B1 (es)
EC (1) ECSP14017584A (es)
ES (1) ES2584387T3 (es)
HK (1) HK1202541A1 (es)
HR (1) HRP20160654T1 (es)
HU (1) HUE028095T2 (es)
IL (1) IL234052A (es)
IN (1) IN2014MN01575A (es)
LT (1) LT2850082T (es)
MA (1) MA37316B1 (es)
ME (1) ME02423B (es)
MX (1) MX2014010701A (es)
NZ (1) NZ627454A (es)
PE (1) PE20142338A1 (es)
PH (1) PH12014501986B1 (es)
PT (1) PT2850082T (es)
RS (1) RS54840B1 (es)
SG (1) SG11201404969YA (es)
SI (1) SI2850082T1 (es)
TN (1) TN2014000375A1 (es)
TW (1) TW201348233A (es)
UA (1) UA112340C2 (es)
WO (2) WO2013134252A1 (es)

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KR20190017767A (ko) * 2016-06-10 2019-02-20 노파르티스 아게 C-raf 억제제의 치료적 용도
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CA3085835A1 (en) 2017-12-21 2019-06-27 Boehringer Ingelheim International Gmbh Novel benzylamino substituted pyridopyrimidinones and derivatives as sos1 inhibitors
JP7161849B2 (ja) * 2018-01-24 2022-10-27 株式会社クラレ 第一級アミンの製造方法
CA3089630A1 (en) 2018-01-31 2019-08-08 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of mastocytosis
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JP2022500385A (ja) 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
EP4303583A3 (en) 2018-12-28 2024-03-27 Deciphera Pharmaceuticals, LLC Methods of treating disorders using csf1r inhibitors cross-reference to related applications
LT3921030T (lt) 2019-02-06 2024-01-25 Eli Lilly And Company 1-((2-(2,2,2-trifluoroetoksi)piridin-4-il)metil)karbamido dariniai, kaip kcnq stiprikliai
EP3962484A4 (en) * 2019-05-03 2023-01-18 Kinnate Biopharma Inc. RAF KINASE INHIBITORS
JP2022531932A (ja) 2019-05-10 2022-07-12 デシフェラ・ファーマシューティカルズ，エルエルシー ヘテロアリールアミノピリミジンアミドオートファジー阻害剤およびその使用方法
EP3966207B1 (en) 2019-05-10 2023-11-01 Deciphera Pharmaceuticals, LLC Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
MX2021015628A (es) 2019-06-17 2022-04-18 Deciphera Pharmaceuticals Llc Inhibidores de la autofagia de la amida aminopirimidina y sus metodos de uso.
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
EP4013412A1 (en) 2019-08-12 2022-06-22 Deciphera Pharmaceuticals, LLC Ripretinib for treating gastrointestinal stromal tumors
EP4084778B1 (en) 2019-12-30 2023-11-01 Deciphera Pharmaceuticals, LLC Amorphous kinase inhibitor formulations and methods of use thereof
EP4084779B1 (en) 2019-12-30 2024-10-09 Deciphera Pharmaceuticals, LLC Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
AU2021285032A1 (en) 2020-06-02 2022-12-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2022060996A1 (en) 2020-09-18 2022-03-24 Kinnate Biopharma Inc. Inhibitors of raf kinases
WO2022081469A1 (en) 2020-10-12 2022-04-21 Kinnate Biopharma Inc. Inhibitors of raf kinases
CN116507627A (zh) 2020-11-02 2023-07-28 勃林格殷格翰国际有限公司 作为egfr抑制剂的经取代1h-吡唑并[4,3-c]吡啶及衍生物
BR112023009531A2 (pt) 2020-11-18 2023-10-03 Deciphera Pharmaceuticals Llc Gcn2 e inibidores de perk quinase e métodos de uso dos mesmos
AU2021409816A1 (en) 2020-12-22 2023-07-06 Qilu Regor Therapeutics Inc. Sos1 inhibitors and uses thereof
JP2024516972A (ja) 2021-04-23 2024-04-18 キネート バイオファーマ インク． Ｒａｆ阻害薬による癌の処置
US12065427B2 (en) 2021-04-29 2024-08-20 Boehringer Ingelheim International Gmbh Heterocyclic compounds capable of activating STING
EP4441056A1 (en) 2021-12-01 2024-10-09 Boehringer Ingelheim International GmbH Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
EP4441050A1 (en) 2021-12-01 2024-10-09 Boehringer Ingelheim International GmbH Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
EP4441053A1 (en) 2021-12-01 2024-10-09 Boehringer Ingelheim International GmbH Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
IL312905A (en) 2021-12-01 2024-07-01 Boehringer Ingelheim Int 2-amino-3-cyano ring thiophenes and history for cancer therapy
CN118574836A (zh) 2021-12-01 2024-08-30 勃林格殷格翰国际有限公司 用于治疗癌症的环状2-胺基-3-氰基噻吩及衍生物
EP4441051A1 (en) 2021-12-01 2024-10-09 Boehringer Ingelheim International GmbH Kras degrading compounds comprising annulated 2-amino-3-cyano thiophenes
EP4444430A1 (en) 2021-12-09 2024-10-16 Deciphera Pharmaceuticals, LLC Raf kinase inhibitors and methods of use thereof
WO2023118250A1 (en) 2021-12-23 2023-06-29 Boehringer Ingelheim International Gmbh 8-aza quinazolines as brain-penetrant sos1-inhibitors
WO2023173017A1 (en) * 2022-03-09 2023-09-14 Blossomhill Therapeutics, Inc. Kras inhibitors for treating disease
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors
US20240174641A1 (en) 2022-10-26 2024-05-30 Boehringer Ingelheim International Gmbh Heterocyclic compounds capable of activating sting
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EP1447405A4 (en) * 2001-10-17 2005-01-12 Kirin Brewery QUINOLINE OR QUINAZOLINE DERIVATIVES INHIBITING THE AUTOPHOSPHORYLATION OF FIBROBLAST GROWTH FACTOR RECEPTORS
AU2003280599A1 (en) * 2002-10-29 2004-05-25 Kirin Beer Kabushiki Kaisha QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF Flt3 AND MEDICINAL COMPOSITIONS CONTAINING THE SAME
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Also Published As

Publication number Publication date
BR112014018528A8 (pt) 2017-07-11
CO7010837A2 (es) 2014-07-31
ME02423B (me) 2016-09-20
MX2014010701A (es) 2015-03-10
MA37316A1 (fr) 2016-06-30
CN104302646B (zh) 2016-05-04
HRP20160654T1 (hr) 2016-07-01
IL234052A (en) 2016-05-31
US9334267B2 (en) 2016-05-10
RS54840B1 (sr) 2016-10-31
EA024824B1 (ru) 2016-10-31
DK2850082T3 (en) 2016-08-15
PH12014501986A1 (en) 2014-11-24
KR20140129087A (ko) 2014-11-06
AU2013230146B2 (en) 2015-09-10
CR20140378A (es) 2014-11-27
DOP2014000200A (es) 2014-10-15
MA37316B1 (fr) 2017-03-31
TN2014000375A1 (en) 2015-12-21
US20150119392A1 (en) 2015-04-30
LT2850082T (lt) 2016-09-12
AU2013230146A1 (en) 2014-08-14
JP2015509536A (ja) 2015-03-30
PH12014501986B1 (en) 2014-11-24
BR112014018528A2 (es) 2017-06-20
TW201348233A (zh) 2013-12-01
US8741911B2 (en) 2014-06-03
WO2013134252A1 (en) 2013-09-12
NZ627454A (en) 2016-09-30
SG11201404969YA (en) 2014-10-30
EA201491456A1 (ru) 2014-12-30
PT2850082T (pt) 2016-07-15
SI2850082T1 (sl) 2016-07-29
EP2850082A1 (en) 2015-03-25
AP2014007899A0 (en) 2014-08-31
IN2014MN01575A (es) 2015-05-08
CA2863673A1 (en) 2013-09-12
EP2850082B1 (en) 2016-05-18
PE20142338A1 (es) 2015-01-10
CN104302646A (zh) 2015-01-21
ECSP14017584A (es) 2016-01-29
ES2584387T3 (es) 2016-09-27
AR090151A1 (es) 2014-10-22
HK1202541A1 (en) 2015-10-02
WO2013134243A1 (en) 2013-09-12
UA112340C2 (uk) 2016-08-25
HUE028095T2 (en) 2016-11-28
CY1117846T1 (el) 2017-05-17
US20130252977A1 (en) 2013-09-26

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