AR115731A1 - Derivados de pirrolo[1,2-b]piridazina como inhibidores de quinasas irak4 - Google Patents

Derivados de pirrolo[1,2-b]piridazina como inhibidores de quinasas irak4

Info

Publication number
AR115731A1
AR115731A1 ARP190101944A ARP190101944A AR115731A1 AR 115731 A1 AR115731 A1 AR 115731A1 AR P190101944 A ARP190101944 A AR P190101944A AR P190101944 A ARP190101944 A AR P190101944A AR 115731 A1 AR115731 A1 AR 115731A1
Authority
AR
Argentina
Prior art keywords
pirrolo
pyridazine
inhibitors
derivatives
irak4
Prior art date
Application number
ARP190101944A
Other languages
English (en)
Inventor
Sheila M Zipfel
Zheng Yang
- Wright Nathan E Yu
James G Taylor
Marilyn Ndukwe
Jeromy J Cottell
Chienhung Chou
Elbert Chin
Gediminas J Brizgys
Elizabeth M Bacon
Stephen Ammann
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=67480334&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR115731(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR115731A1 publication Critical patent/AR115731A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un compuesto de fórmula (1), sus sales farmacéuticamente aceptables, análogos deuterados de los mismos, composiciones de los mismos, y métodos para tratar enfermedades usando un compuesto del mismo, donde los sustituyentes variables se describen en el presente documento.
ARP190101944A 2018-07-13 2019-07-10 Derivados de pirrolo[1,2-b]piridazina como inhibidores de quinasas irak4 AR115731A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862697533P 2018-07-13 2018-07-13

Publications (1)

Publication Number Publication Date
AR115731A1 true AR115731A1 (es) 2021-02-17

Family

ID=67480334

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190101944A AR115731A1 (es) 2018-07-13 2019-07-10 Derivados de pirrolo[1,2-b]piridazina como inhibidores de quinasas irak4

Country Status (30)

Country Link
US (3) US10875866B2 (es)
EP (2) EP4403174A3 (es)
JP (2) JP7167298B2 (es)
KR (2) KR102583817B1 (es)
CN (2) CN117683034A (es)
AR (1) AR115731A1 (es)
AU (3) AU2019302732B2 (es)
BR (1) BR112020026675A2 (es)
CA (1) CA3105485C (es)
CL (1) CL2021000086A1 (es)
CO (1) CO2021000153A2 (es)
CR (1) CR20210014A (es)
DK (1) DK3820872T3 (es)
EA (1) EA202092858A1 (es)
ES (1) ES2981798T3 (es)
FI (1) FI3820872T3 (es)
HR (1) HRP20240811T8 (es)
IL (2) IL309267A (es)
LT (1) LT3820872T (es)
MX (1) MX2021000462A (es)
NZ (1) NZ771681A (es)
PE (1) PE20210404A1 (es)
PH (1) PH12020552283A1 (es)
PL (1) PL3820872T3 (es)
PT (1) PT3820872T (es)
SG (1) SG11202013003VA (es)
TW (2) TWI842978B (es)
UA (1) UA127506C2 (es)
WO (1) WO2020014468A1 (es)
ZA (1) ZA202100259B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI842978B (zh) * 2018-07-13 2024-05-21 美商基利科學股份有限公司 衍生物
JP2023529877A (ja) * 2020-06-10 2023-07-12 シクソン エービー 結晶形のラベキシモドの調製方法
TW202315632A (zh) 2021-08-18 2023-04-16 美商新銳思生物製藥股份有限公司 介白素-1受體相關激酶之雙官能降解劑及其治療用途

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IL309267A (en) 2024-02-01
CL2021000086A1 (es) 2021-08-06
TW202019931A (zh) 2020-06-01
IL279654B2 (en) 2024-05-01
CR20210014A (es) 2021-02-26
EP4403174A3 (en) 2024-09-18
IL279654B1 (en) 2024-01-01
KR20230144100A (ko) 2023-10-13
ZA202100259B (en) 2023-06-28
US20210214363A1 (en) 2021-07-15
HRP20240811T8 (hr) 2024-10-11
AU2019302732B2 (en) 2022-07-07
KR20210031717A (ko) 2021-03-22
KR102583817B1 (ko) 2023-10-04
MX2021000462A (es) 2021-03-25
CO2021000153A2 (es) 2021-01-18
US20230257386A1 (en) 2023-08-17
CN112513044A (zh) 2021-03-16
FI3820872T3 (fi) 2024-06-24
US10875866B2 (en) 2020-12-29
DK3820872T3 (da) 2024-07-01
EP3820872B1 (en) 2024-05-29
JP7167298B2 (ja) 2022-11-08
TWI842978B (zh) 2024-05-21
WO2020014468A1 (en) 2020-01-16
TW202136268A (zh) 2021-10-01
NZ771681A (en) 2024-07-26
AU2022246450A1 (en) 2022-11-03
CN117683034A (zh) 2024-03-12
JP2022191496A (ja) 2022-12-27
EP4403174A2 (en) 2024-07-24
TWI721483B (zh) 2021-03-11
HRP20240811T1 (hr) 2024-09-27
ES2981798T3 (es) 2024-10-10
BR112020026675A2 (pt) 2021-03-30
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