AR113802A1 - Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo - Google Patents

Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo

Info

Publication number
AR113802A1
AR113802A1 ARP180103129A ARP180103129A AR113802A1 AR 113802 A1 AR113802 A1 AR 113802A1 AR P180103129 A ARP180103129 A AR P180103129A AR P180103129 A ARP180103129 A AR P180103129A AR 113802 A1 AR113802 A1 AR 113802A1
Authority
AR
Argentina
Prior art keywords
systems
methods
devices
ultra
low volume
Prior art date
Application number
ARP180103129A
Other languages
English (en)
Inventor
Jim Chauvapun
Paul Oeth
Mathias Ehrich
Den Boom Dirk Van
Original Assignee
Juno Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Diagnostics Inc filed Critical Juno Diagnostics Inc
Publication of AR113802A1 publication Critical patent/AR113802A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2543/00—Reactions characterised by the reaction site, e.g. cell or chromosome
    • C12Q2543/10—Reactions characterised by the reaction site, e.g. cell or chromosome the purpose being "in situ" analysis
    • C12Q2543/101—Reactions characterised by the reaction site, e.g. cell or chromosome the purpose being "in situ" analysis in situ amplification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • General Physics & Mathematics (AREA)
  • Hydrology & Water Resources (AREA)
  • Pain & Pain Management (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

Dispositivos, sistemas, kits y métodos para obtener información genética de ácidos nucleicos fetales sin células en cantidades ultra bajas de muestras biológicas. Dada la conveniencia de obtener cantidades ultra bajas de muestras, los dispositivos, sistemas, kits y métodos se pueden emplear, por lo menos parcialmente, donde se los necesita.
ARP180103129A 2017-10-27 2018-10-26 Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo AR113802A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762578179P 2017-10-27 2017-10-27

Publications (1)

Publication Number Publication Date
AR113802A1 true AR113802A1 (es) 2020-06-10

Family

ID=66247702

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180103129A AR113802A1 (es) 2017-10-27 2018-10-26 Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo

Country Status (10)

Country Link
US (3) US20200299677A1 (es)
EP (1) EP3700423A4 (es)
JP (1) JP2021500883A (es)
KR (1) KR20200085783A (es)
CN (1) CN111526793A (es)
AR (1) AR113802A1 (es)
AU (1) AU2018355575A1 (es)
CA (1) CA3080117A1 (es)
TW (1) TWI833715B (es)
WO (1) WO2019084489A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018355575A1 (en) 2017-10-27 2020-05-21 Juno Diagnostics, Inc. Devices, systems and methods for ultra-low volume liquid biopsy
GB2589159B (en) 2017-12-29 2023-04-05 Clear Labs Inc Nucleic acid sequencing apparatus
EP4065730A4 (en) * 2019-11-27 2023-12-20 Juno Diagnostics, Inc. SYSTEMS AND DEVICES FOR SAMPLE PREPARATION AND ANALYTE DETECTION
US20230183811A1 (en) * 2020-05-14 2023-06-15 Georgia Tech Research Corporation Methods of detecting the efficacy of anticancer agents
KR102573402B1 (ko) 2021-03-24 2023-09-04 재단법인대구경북과학기술원 액체생검 유래 생체물질 분석용 기판, 이의 제조방법 및 이를 이용한 분석방법
WO2024016016A1 (en) * 2022-07-15 2024-01-18 Life Magnetics, Inc. Stable composition for storing and transporting single strand nucleic acid material
WO2024091509A1 (en) * 2022-10-24 2024-05-02 Definitive Biotechnologies Llc Rapid, microfluidic diagnostic device and method for biological sex determination

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5977356A (ja) 1982-06-30 1984-05-02 Fuji Photo Film Co Ltd 螢光アツセイ用多層分析要素およびそれを用いる螢光アツセイ法
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US20010051341A1 (en) 1997-03-04 2001-12-13 Isis Innovation Limited Non-invasive prenatal diagnosis
EP0994936A1 (en) 1997-07-02 2000-04-26 The Procter & Gamble Company Dishwashing compositions comprising a phospholipase and an amylase
EP1997909B1 (en) 1998-03-25 2012-02-01 Olink AB Rolling circle replication of circularised target nucleic acid fragments
US6156879A (en) 1998-06-03 2000-12-05 The Regents Of The University Of California Human minor vault protein p193
EP1873260B1 (en) 1998-11-09 2009-03-18 Eiken Kagaku Kabushiki Kaisha Process for synthesizing nucleic acid
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
CA2367636C (en) 2001-04-12 2010-05-04 Lisa Mckerracher Fusion proteins
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
WO2004035066A1 (ja) 2002-10-16 2004-04-29 Asahi Kasei Pharma Corporation 血漿製剤または血清製剤、及びその製造方法
DE10252223A1 (de) 2002-11-11 2004-05-27 Roche Diagnostics Gmbh Vorrichtung zur Separierung und Ausgabe von Plasma
DE10305050A1 (de) 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
EP1610809A4 (en) 2003-03-10 2008-02-20 Univ California WOVEN AND CROCHETED CARRIER MOLECULES
WO2004112602A1 (en) 2003-06-13 2004-12-29 Pelikan Technologies, Inc. Method and apparatus for a point of care device
KR20060070536A (ko) 2003-08-05 2006-06-23 벡톤 디킨슨 앤드 컴퍼니 생물학적 액체 샘플의 수집과 선택된 성분들의 처리를 위한장치 및 방법
EP1524321B2 (en) 2003-10-16 2014-07-23 Sequenom, Inc. Non-invasive detection of fetal genetic traits
US20100216153A1 (en) * 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
DE102004027422A1 (de) 2004-06-04 2005-12-29 Boehringer Ingelheim Microparts Gmbh Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen
CA2507323A1 (en) 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
GB2428093A (en) 2005-07-06 2007-01-17 Christopher Paul Hancock A non-invasive monitoring system
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
PL3002338T3 (pl) 2006-02-02 2019-12-31 The Board Of Trustees Of The Leland Stanford Junior University Nieinwazyjne badania przesiewowe płodu poprzez analizę cyfrową
US20080113357A1 (en) 2006-06-29 2008-05-15 Millipore Corporation Filter device for the isolation of a nucleic acid
NL1033365C2 (nl) 2007-02-09 2008-08-12 Medavinci Dev B V Inrichting en werkwijze voor scheiden en analyseren van bloed.
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
EP3770275A1 (en) 2007-07-23 2021-01-27 The Chinese University of Hong Kong Determining a fetal aneuploidy
FR2923151B1 (fr) 2007-11-02 2010-09-03 Commissariat Energie Atomique Dispositif de prelevement sanguin comportant au moins un filtre .
KR101608749B1 (ko) 2008-01-21 2016-04-06 삼성전자주식회사 박막 원심분리 분석 장치 및 이를 이용한 분석 방법
AU2009223671B2 (en) 2008-03-11 2014-11-27 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
EP2113574A1 (en) 2008-04-28 2009-11-04 Biotype AG Substances and methods for a DNA based profiling assay
US8124109B2 (en) 2008-05-15 2012-02-28 The Regents Of The University Of California Vault compositions for immunization against chlamydia genital infection
US8895240B2 (en) * 2008-05-19 2014-11-25 E I Du Pont De Nemours And Company Method, kit and system for collecting and processing samples for DNA and RNA detection
US20110086359A1 (en) 2008-06-10 2011-04-14 Rapid Pathogen Screening, Inc. Lateral flow assays
LT2562268T (lt) 2008-09-20 2017-04-25 The Board Of Trustees Of The Leland Stanford Junior University Neinvazinis fetalinės aneuploidijos diagnozavimas sekvenavimu
WO2010065470A2 (en) * 2008-12-01 2010-06-10 Consumer Genetics, Inc. Compositions and methods for detecting background male dna during fetal sex determination
WO2010141921A1 (en) 2009-06-05 2010-12-09 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
EP2264453B1 (en) 2009-06-17 2013-04-03 Leukocare Ag Method for filtering blood
NZ599873A (en) 2009-10-19 2014-09-26 Theranos Inc Integrated health data capture and analysis system
WO2011053790A2 (en) 2009-10-30 2011-05-05 Fluidigm Corporation Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis
CN105031618A (zh) 2009-11-02 2015-11-11 加利福尼亚大学董事会 用于细胞因子递送的穹窿体复合物
DK2496720T3 (da) 2009-11-06 2020-09-28 Univ Leland Stanford Junior Ikke-invasiv diagnose af transplantatafstødning i organ-transplanterede patienter
WO2011063324A2 (en) 2009-11-20 2011-05-26 The General Hospital Corporation Microfluidic systems for isolating microvesicles
US20120315633A1 (en) 2009-12-23 2012-12-13 Genetic Technologies Limited Methods of enriching and detecting fetal nucleic acids
ES2704701T3 (es) 2010-01-19 2019-03-19 Verinata Health Inc Nuevo protocolo de preparación de bibliotecas de secuenciación
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
US8720036B2 (en) 2010-03-09 2014-05-13 Netbio, Inc. Unitary biochip providing sample-in to results-out processing and methods of manufacture
US20120003201A1 (en) 2010-04-21 2012-01-05 Nicholas Susanne B Vault agents for chronic kidney disease
EP2854057B1 (en) 2010-05-18 2018-03-07 Natera, Inc. Methods for non-invasive pre-natal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
CN103370007B (zh) 2010-11-09 2018-12-18 第七感生物系统有限公司 用于采血的系统和界面
CA2821906C (en) 2010-12-22 2020-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
CA2822439A1 (en) * 2010-12-23 2012-06-28 Sequenom, Inc. Fetal genetic variation detection
CN103459614B (zh) 2011-01-05 2015-12-02 香港中文大学 胎儿性染色体的非侵入性产前基因分型
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
WO2012118745A1 (en) 2011-02-28 2012-09-07 Arnold Oliphant Assay systems for detection of aneuploidy and sex determination
GB2484764B (en) 2011-04-14 2012-09-05 Verinata Health Inc Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
US20130022974A1 (en) 2011-06-17 2013-01-24 The Regents Of The University Of Michigan Dna methylation profiles in cancer
DE102011078961B4 (de) 2011-07-11 2021-02-18 Robert Bosch Gmbh System zum Separieren von Körperflüssigkeitsbestandteilen und Verfahren zum Herstellen eines derartigen Systems
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
AU2013211850B8 (en) * 2012-01-27 2017-06-29 The Board Of Trustees Of The Leland Stanford Junior University Methods for profiling and quantitating cell-free RNA
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
EP3573066B1 (en) 2012-03-13 2023-09-27 The Chinese University Of Hong Kong Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis
US11360076B2 (en) 2012-03-30 2022-06-14 Weavr Health Corp. Methods and systems to collect a biological sample
PL2676606T3 (pl) 2012-06-20 2017-10-31 Fabpulous B V Szybko testujące urządzenie i sposób
EP2869828B1 (en) 2012-07-09 2018-01-03 The Regents of The University of California Vault immunotherapy
US9423399B2 (en) 2012-09-28 2016-08-23 Takara Bio Usa, Inc. Lateral flow assays for tagged analytes
US20140342371A1 (en) * 2012-12-05 2014-11-20 Theranos, Inc. Bodily Fluid Sample Collection and Transport
JP2016520796A (ja) 2013-03-14 2016-07-14 インストゥルメンテーション ラボラトリー カンパニー 濾過装置を使用した血液からの血漿分離及びその方法
WO2014145078A1 (en) * 2013-03-15 2014-09-18 Verinata Health, Inc. Generating cell-free dna libraries directly from blood
EP2986383B1 (en) 2013-04-15 2020-08-26 Becton, Dickinson and Company Biological fluid separation device and biological fluid separation and testing system
US10208346B2 (en) * 2013-04-19 2019-02-19 Epiontis Gmbh Method for identifying the quantitative cellular composition in a biological sample
US11358138B2 (en) 2013-07-19 2022-06-14 Boston Microfluidics Inc. Fluid sample collection device
US9644232B2 (en) 2013-07-26 2017-05-09 General Electric Company Method and device for collection and amplification of circulating nucleic acids
DE102013012677A1 (de) 2013-07-31 2015-02-05 Mann + Hummel Gmbh Verfahren zum abtrennen von blutplasma/serum von vollblut
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
DK3110977T3 (en) 2014-02-28 2018-07-23 Exosome Sciences Inc BRAIN SPECIFIC EXOSOME-BASED DIAGNOSTIC AND EXTRACORPORAL THERAPIES
EP3119197A1 (en) 2014-03-18 2017-01-25 Qiagen GmbH Stabilization and isolation of extracellular nucleic acids
WO2015183872A1 (en) 2014-05-30 2015-12-03 Sequenom, Inc. Chromosome representation determinations
WO2015187959A1 (en) 2014-06-04 2015-12-10 Pepex Biomedical, Inc. Electrochemical sensors and methods for making electrochemical sensors using advanced printing technology
US10472620B2 (en) 2014-07-01 2019-11-12 General Electric Company Method, substrate and device for separating nucleic acids
EP3167045A4 (en) 2014-07-11 2018-01-17 Advanced Theranostics Inc. Point of care polymerase chain reaction device for disease detection
EP3175000B1 (en) 2014-07-30 2020-07-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
MX2017001368A (es) 2014-08-01 2017-05-11 Siemens Healthcare Diagnostics Inc Separacion de plasma asistido por vacio.
US10335078B2 (en) 2014-08-04 2019-07-02 General Electric Company Device for separation and collection of plasma
WO2016097251A1 (en) 2014-12-19 2016-06-23 Danmarks Tekniske Universitet Method for identification of tissue or organ localization of a tumour
US20190111423A1 (en) 2014-12-23 2019-04-18 California Institute Of Technology Devices and methods for autonomous measurements
WO2016148646A1 (en) 2015-03-13 2016-09-22 Nanyang Technological University Testing device, microfluidic chip and nucleic acid testing method
CN104830986B (zh) * 2015-05-07 2018-08-03 深圳承启生物科技有限公司 一种检测胎儿基因信息的方法、装置和系统
EP3303118A4 (en) 2015-06-02 2019-02-13 Ecocraft Systems Pty Ltd PERSONAL SECURITY DEVICE
US20160371428A1 (en) 2015-06-19 2016-12-22 Natera, Inc. Systems and methods for determining aneuploidy risk using sample fetal fraction
EP3325126B1 (en) 2015-07-24 2019-11-20 Ahlstrom-Munksjö Oyj Blood separation media and lateral flow devices for blood samples
CA2995468A1 (en) * 2015-08-12 2017-02-16 Circulogene Theranostics, Llc Method of preparing cell free nucleic acid molecules by in situ amplification
CN108473932B (zh) * 2015-09-09 2022-07-15 集联健康有限公司 用于样品收集、稳定化和保存的系统、方法和装置
JP6991134B2 (ja) 2015-10-09 2022-01-12 ガーダント ヘルス， インコーポレイテッド 無細胞ｄｎａを使用する集団ベースの処置レコメンダ
MX2018005858A (es) 2015-11-11 2019-02-20 Resolution Bioscience Inc Construccion de alta eficacia de bibliotecas de adn.
WO2017136430A1 (en) 2016-02-01 2017-08-10 The Board Of Trustees Of The Leland Stanford Junior University Exosome-total-isoloation-chip (exotic) device for isolation of exosome-based biomarkers
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
CN109312332B (zh) 2016-04-06 2022-07-08 韦恩州立大学 自子宫颈内管获取的绒毛外滋养层细胞的胎儿dna的分离与分析
WO2017176630A1 (en) 2016-04-07 2017-10-12 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnostics by sequencing 5-hydroxymethylated cell-free dna
WO2017214338A1 (en) 2016-06-07 2017-12-14 Drawbridge Health, Inc. Metods and devices for strong or stabilizing molecules
EP3811865B1 (en) 2016-08-24 2022-05-11 Becton, Dickinson and Company A device for the attached flow of blood
TW201816645A (zh) 2016-09-23 2018-05-01 美商德萊福公司 用於生物樣本的自動化處理及分析、臨床資訊處理及臨床試驗配對之整合系統及方法
CA3037366A1 (en) 2016-09-29 2018-04-05 Myriad Women's Health, Inc. Noninvasive prenatal screening using dynamic iterative depth optimization
TW202425920A (zh) 2017-01-10 2024-07-01 美商集聯健康有限公司 筒匣組裝件
EP3998350A1 (en) 2017-03-17 2022-05-18 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
WO2018194757A1 (en) 2017-04-17 2018-10-25 Counsyl, Inc. Systems and methods for performing and optimizing performance of dna-based noninvasive prenatal screens
EP3611508B1 (en) 2017-05-16 2022-08-03 SK Telecom Co., Ltd. Nucleic acid analysis apparatus using catridge
CN110785220A (zh) 2017-07-17 2020-02-11 勃林格殷格翰维特梅迪卡有限公司 改性滤膜及其用途
WO2019067567A1 (en) 2017-09-26 2019-04-04 Juno Diagnostics, Inc. DEVICES, SYSTEMS AND METHODS FOR BIOMARKER ANALYSIS
EP3701261A4 (en) 2017-10-27 2021-08-04 Boston Microfluidics, Inc. FLUID SAMPLE COLLECTION DEVICE
AU2018355575A1 (en) 2017-10-27 2020-05-21 Juno Diagnostics, Inc. Devices, systems and methods for ultra-low volume liquid biopsy
US20210020314A1 (en) 2018-03-30 2021-01-21 Juno Diagnostics, Inc. Deep learning-based methods, devices, and systems for prenatal testing
DE102018111834A1 (de) 2018-05-16 2019-11-21 Mildendo Gesellschaft für mikrofluidische Systeme mbH Mikrofluidische Vorrichtung und Verfahren zur Nutzung derselben zur Trennung, Aufreinigung und Konzentration von Komponenten von fluidischen Medien,
US20200015725A1 (en) 2018-05-24 2020-01-16 Boston Microfluidics, Inc. Cassette for blood sample measurement collection and storage
CN112639982A (zh) 2018-07-17 2021-04-09 纳特拉公司 使用神经网络调用倍性状态的方法和系统
WO2020049558A1 (en) 2018-09-03 2020-03-12 Ramot At Tel-Aviv University Ltd. Method and system for identifying gene disorder in maternal blood
US20200121234A1 (en) 2018-10-23 2020-04-23 Boston Microfluidics, Inc. Blood sample collection device with time stamp and simultaneous environmental sample
CN109971846A (zh) 2018-11-29 2019-07-05 时代基因检测中心有限公司 使用双等位基因snp靶向下一代测序的非侵入性产前测定非整倍体的方法
JP2022525953A (ja) 2019-03-27 2022-05-20 ジュノ ダイアグノスティックス，インク． 最適化された超微量リキッドバイオプシーの方法、システム、およびデバイス
WO2021046391A2 (en) 2019-09-06 2021-03-11 Boston Microfluidics, Inc. Medium with hydrophobic patterns and break lines defining a blood collection volume
WO2021061751A1 (en) 2019-09-23 2021-04-01 Gateway Genomics, Llc Methods, compositions, and kits for determining the sex of a fetus
EP4065730A4 (en) 2019-11-27 2023-12-20 Juno Diagnostics, Inc. SYSTEMS AND DEVICES FOR SAMPLE PREPARATION AND ANALYTE DETECTION
WO2021188594A1 (en) 2020-03-18 2021-09-23 Drawbridge Health, Inc. Systems and methods for sample collection

Also Published As

Publication number Publication date
US20230051179A1 (en) 2023-02-16
TWI833715B (zh) 2024-03-01
WO2019084489A1 (en) 2019-05-02
CA3080117A1 (en) 2019-05-02
AU2018355575A1 (en) 2020-05-21
TW201923090A (zh) 2019-06-16
CN111526793A (zh) 2020-08-11
JP2021500883A (ja) 2021-01-14
US20200299677A1 (en) 2020-09-24
US20220098575A1 (en) 2022-03-31
EP3700423A4 (en) 2021-08-18
US11525134B2 (en) 2022-12-13
EP3700423A1 (en) 2020-09-02
KR20200085783A (ko) 2020-07-15

Similar Documents

Publication Publication Date Title
AR113802A1 (es) Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo
GB2569252A (en) Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
CL2017001940A1 (es) Dispositivo de medición de la calidad del suelo
GB2568608A (en) Personalized genetic testing
CL2018001156A1 (es) Preparación de muestras para muestras difíciles.
MX2021008472A (es) Dispositivos, sistemas, metodos y equipos para recibir un hisopo.
WO2017181135A3 (en) METHODS, SYSTEMS AND KITS FOR IN PEN ASSAYS
EP3800253A3 (en) Prostate cancer detection kit or device, and detection method
CL2017002101A1 (es) Dispositivo, plataforma y ensayo para evaluación de células
EP3816303A3 (en) Breast cancer detection kit or device, and method for detecting breast cancer
EA201692157A1 (ru) Синтез двухцепочечных нуклеиновых кислот
BR112015022490A2 (pt) métodos e composições para classificação de amostras
EP3636769A4 (en) TEST KIT FOR SAMPLE NUCLEIC ACID MEASUREMENT, REAGENT AND USE OF IT
MX364554B (es) Procedimiento para determinar la morfologia, tridimensional y cuantitativa, de las micro y nanocavidades producidas por corrosion quimica y/o microbiologica en materiales metalicos.
BR112016010106A2 (pt) ensaios para igfbp7 com melhor desempenho em amostras biológicas
BR112016002685A2 (pt) ensaios para timp2 que apresentam melhor desempenho em amostras biológicas
EA201791300A1 (ru) Флюидные системы, содержащие канал инкубации, включающие в себя флюидные системы, образованные литьевым формованием
EP4220158A3 (en) Urine specimen analysis device and urine specimen analysis method
BR112017008351A2 (pt) recipiente de suabe para dispositivos microfluídicos
GB2545850A (en) System and method using a combined modality optical probe
MX2019000591A (es) Tira mejorada de ensayo de analisis de orina de bajo volumen de muestra, kits analiticos y metodos de uso relacionados con la misma.
MX2018015140A (es) Firmas de biomarcadores de lupus eritematoso sistemico y sus usos.
MX2018005386A (es) Metodos para extraccion de adn libre de celulas para diagnostico prenatal no invasivo.
CL2013003628A1 (es) Metodo para la determinacion microbiologica de trazas de antibioticos en muestra biologicas de bajo volumen
MX2014015162A (es) Dispositivo lector y metodo de amplificacion de señal.