AR113802A1 - Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo - Google Patents

Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo

Info

Publication number
AR113802A1
AR113802A1 ARP180103129A ARP180103129A AR113802A1 AR 113802 A1 AR113802 A1 AR 113802A1 AR P180103129 A ARP180103129 A AR P180103129A AR P180103129 A ARP180103129 A AR P180103129A AR 113802 A1 AR113802 A1 AR 113802A1
Authority
AR
Argentina
Prior art keywords
systems
methods
devices
ultra
low volume
Prior art date
Application number
ARP180103129A
Other languages
English (en)
Inventor
Jim Chauvapun
Paul Oeth
Mathias Ehrich
Den Boom Dirk Van
Original Assignee
Juno Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Diagnostics Inc filed Critical Juno Diagnostics Inc
Publication of AR113802A1 publication Critical patent/AR113802A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150061—Means for enhancing collection
    • A61B5/150099—Means for enhancing collection by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150755—Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2543/00—Reactions characterised by the reaction site, e.g. cell or chromosome
    • C12Q2543/10—Reactions characterised by the reaction site, e.g. cell or chromosome the purpose being "in situ" analysis
    • C12Q2543/101—Reactions characterised by the reaction site, e.g. cell or chromosome the purpose being "in situ" analysis in situ amplification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q

Abstract

Dispositivos, sistemas, kits y métodos para obtener información genética de ácidos nucleicos fetales sin células en cantidades ultra bajas de muestras biológicas. Dada la conveniencia de obtener cantidades ultra bajas de muestras, los dispositivos, sistemas, kits y métodos se pueden emplear, por lo menos parcialmente, donde se los necesita.
ARP180103129A 2017-10-27 2018-10-26 Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo AR113802A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762578179P 2017-10-27 2017-10-27

Publications (1)

Publication Number Publication Date
AR113802A1 true AR113802A1 (es) 2020-06-10

Family

ID=66247702

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180103129A AR113802A1 (es) 2017-10-27 2018-10-26 Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo

Country Status (9)

Country Link
US (3) US20200299677A1 (es)
EP (1) EP3700423A4 (es)
JP (1) JP2021500883A (es)
KR (1) KR20200085783A (es)
CN (1) CN111526793A (es)
AR (1) AR113802A1 (es)
AU (1) AU2018355575A1 (es)
CA (1) CA3080117A1 (es)
WO (1) WO2019084489A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR113802A1 (es) 2017-10-27 2020-06-10 Juno Diagnostics Inc Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo
EP3731959A4 (en) 2017-12-29 2021-10-13 Clear Labs Inc. AUTOMATED PRIMING AND LIBRARY LOADER
CA3162239A1 (en) * 2019-11-27 2021-06-03 Juno Diagnostics, Inc. Systems and devices for sample preparation and analyte detection
US20230183811A1 (en) * 2020-05-14 2023-06-15 Georgia Tech Research Corporation Methods of detecting the efficacy of anticancer agents
KR102573402B1 (ko) 2021-03-24 2023-09-04 재단법인대구경북과학기술원 액체생검 유래 생체물질 분석용 기판, 이의 제조방법 및 이를 이용한 분석방법
WO2024016016A1 (en) * 2022-07-15 2024-01-18 Life Magnetics, Inc. Stable composition for storing and transporting single strand nucleic acid material

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5977356A (ja) 1982-06-30 1984-05-02 Fuji Photo Film Co Ltd 螢光アツセイ用多層分析要素およびそれを用いる螢光アツセイ法
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US20010051341A1 (en) 1997-03-04 2001-12-13 Isis Innovation Limited Non-invasive prenatal diagnosis
WO1999001531A1 (en) 1997-07-02 1999-01-14 The Procter & Gamble Company Dishwashing compositions comprising a phospholipase and an amylase
WO1999049079A1 (en) 1998-03-25 1999-09-30 Ulf Landegren Rolling circle replication of padlock probes
US6156879A (en) 1998-06-03 2000-12-05 The Regents Of The University Of California Human minor vault protein p193
DE1020534T1 (de) 1998-11-09 2001-03-01 Eiken Chemical Verfahren zur synthetisieren von nukleinsäure
US7955794B2 (en) 2000-09-21 2011-06-07 Illumina, Inc. Multiplex nucleic acid reactions
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6749575B2 (en) 2001-08-20 2004-06-15 Alza Corporation Method for transdermal nucleic acid sampling
CA2367636C (en) 2001-04-12 2010-05-04 Lisa Mckerracher Fusion proteins
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US6977162B2 (en) 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
US7442506B2 (en) 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US7727720B2 (en) 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
WO2004035066A1 (ja) 2002-10-16 2004-04-29 Asahi Kasei Pharma Corporation 血漿製剤または血清製剤、及びその製造方法
DE10252223A1 (de) 2002-11-11 2004-05-27 Roche Diagnostics Gmbh Vorrichtung zur Separierung und Ausgabe von Plasma
DE10305050A1 (de) 2003-02-07 2004-08-19 Roche Diagnostics Gmbh Analytisches Testelement und Verfahren für Blutuntersuchungen
WO2004081533A2 (en) 2003-03-10 2004-09-23 The Regents Of The University Of California Vault and vault-like carrier molecules
WO2004112602A1 (en) 2003-06-13 2004-12-29 Pelikan Technologies, Inc. Method and apparatus for a point of care device
CN100515568C (zh) 2003-08-05 2009-07-22 贝克顿·迪金森公司 收集生物流体样品及处理选定成分的装置和方法
EP1524321B2 (en) 2003-10-16 2014-07-23 Sequenom, Inc. Non-invasive detection of fetal genetic traits
US20100216153A1 (en) * 2004-02-27 2010-08-26 Helicos Biosciences Corporation Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
DE102004027422A1 (de) 2004-06-04 2005-12-29 Boehringer Ingelheim Microparts Gmbh Vorrichtung zur Aufnahme von Blut und Abtrennung von Blutbestandteilen
CA2507323A1 (en) 2005-05-13 2006-11-13 Chromedx Inc. Diagnostic whole blood and plasma apparatus
GB2428093A (en) 2005-07-06 2007-01-17 Christopher Paul Hancock A non-invasive monitoring system
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US8532930B2 (en) 2005-11-26 2013-09-10 Natera, Inc. Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals
US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
EP3591068A1 (en) 2006-02-02 2020-01-08 The Board of Trustees of the Leland Stanford Junior University Non-invasive fetal genetic screening by digital analysis
US20080113357A1 (en) 2006-06-29 2008-05-15 Millipore Corporation Filter device for the isolation of a nucleic acid
NL1033365C2 (nl) 2007-02-09 2008-08-12 Medavinci Dev B V Inrichting en werkwijze voor scheiden en analyseren van bloed.
EP2527471B1 (en) 2007-07-23 2020-03-04 The Chinese University of Hong Kong Diagnosing cancer using genomic sequencing
US9218449B2 (en) 2007-07-23 2015-12-22 The Chinese University Of Hong Kong Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
FR2923151B1 (fr) 2007-11-02 2010-09-03 Commissariat Energie Atomique Dispositif de prelevement sanguin comportant au moins un filtre .
US8969070B2 (en) 2008-01-21 2015-03-03 Samsung Electronics Co., Ltd. Thin-film layered centrifuge device and analysis method using the same
WO2009114543A2 (en) 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
EP2113574A1 (en) 2008-04-28 2009-11-04 Biotype AG Substances and methods for a DNA based profiling assay
US8124109B2 (en) 2008-05-15 2012-02-28 The Regents Of The University Of California Vault compositions for immunization against chlamydia genital infection
US8895240B2 (en) * 2008-05-19 2014-11-25 E I Du Pont De Nemours And Company Method, kit and system for collecting and processing samples for DNA and RNA detection
US20110086359A1 (en) 2008-06-10 2011-04-14 Rapid Pathogen Screening, Inc. Lateral flow assays
HUE031849T2 (en) 2008-09-20 2017-08-28 Univ Leland Stanford Junior Non-invasive diagnosis of fetal aneuploidy by sequencing
WO2010065470A2 (en) * 2008-12-01 2010-06-10 Consumer Genetics, Inc. Compositions and methods for detecting background male dna during fetal sex determination
EP3586945A3 (en) 2009-06-05 2020-03-04 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
EP2264453B1 (en) 2009-06-17 2013-04-03 Leukocare Ag Method for filtering blood
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
AU2010308329B2 (en) 2009-10-19 2016-10-13 Labrador Diagnostics Llc Integrated health data capture and analysis system
WO2011053790A2 (en) 2009-10-30 2011-05-05 Fluidigm Corporation Assay of closely linked targets in fetal diagnosis and coincidence detection assay for genetic analysis
JP5907877B2 (ja) 2009-11-02 2016-04-26 ザ、リージェンツ、オブ、ザ、ユニバーシティ、オブ、カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ サイトカイン送達のためのヴォールト（ｖａｕｌｔ）複合体
DK2496720T3 (da) 2009-11-06 2020-09-28 Univ Leland Stanford Junior Ikke-invasiv diagnose af transplantatafstødning i organ-transplanterede patienter
WO2011063324A2 (en) 2009-11-20 2011-05-26 The General Hospital Corporation Microfluidic systems for isolating microvesicles
EP2516677B1 (en) 2009-12-23 2014-11-26 Genetic Technologies Limited Methods of enriching and detecting fetal nucleic acids
EP2366031B1 (en) 2010-01-19 2015-01-21 Verinata Health, Inc Sequencing methods in prenatal diagnoses
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
US8720036B2 (en) 2010-03-09 2014-05-13 Netbio, Inc. Unitary biochip providing sample-in to results-out processing and methods of manufacture
US20120003201A1 (en) 2010-04-21 2012-01-05 Nicholas Susanne B Vault agents for chronic kidney disease
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
ES2565805T3 (es) 2010-11-09 2016-04-07 Seventh Sense Biosystems, Inc. Sistemas e interfaces para el muestreo de sangre
EP2656263B1 (en) 2010-12-22 2019-11-06 Natera, Inc. Methods for non-invasive prenatal paternity testing
CN103384725A (zh) * 2010-12-23 2013-11-06 塞昆纳姆股份有限公司 胎儿遗传变异的检测
JP6105485B2 (ja) 2011-01-05 2017-04-05 ザ・チャイニーズ・ユニバーシティー・オブ・ホンコンＴｈｅ Ｃｈｉｎｅｓｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｈｏｎｇ Ｋｏｎｇ 胎児の性染色体遺伝子型の非侵襲的出生前同定
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
US20120219950A1 (en) 2011-02-28 2012-08-30 Arnold Oliphant Assay systems for detection of aneuploidy and sex determination
GB2484764B (en) 2011-04-14 2012-09-05 Verinata Health Inc Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies
US20130022974A1 (en) 2011-06-17 2013-01-24 The Regents Of The University Of Michigan Dna methylation profiles in cancer
DE102011078961B4 (de) 2011-07-11 2021-02-18 Robert Bosch Gmbh System zum Separieren von Körperflüssigkeitsbestandteilen und Verfahren zum Herstellen eines derartigen Systems
WO2013052907A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20130252835A1 (en) * 2012-01-27 2013-09-26 Lian Chye Winston Koh Methods for profiling and quantitating cell-free rna
US9892230B2 (en) 2012-03-08 2018-02-13 The Chinese University Of Hong Kong Size-based analysis of fetal or tumor DNA fraction in plasma
US11360076B2 (en) 2012-03-30 2022-06-14 Weavr Health Corp. Methods and systems to collect a biological sample
EP2676606B1 (en) 2012-06-20 2017-05-03 Fabpulous B.V. Quick test device and method
US20150150821A1 (en) 2012-07-09 2015-06-04 The Regents Of The University Of California Vault Immunotherapy
WO2014051998A1 (en) 2012-09-28 2014-04-03 Clontech Laboratories, Inc. Lateral flow assays for tagged analytes
US20140342371A1 (en) * 2012-12-05 2014-11-20 Theranos, Inc. Bodily Fluid Sample Collection and Transport
CA2904593A1 (en) 2013-03-14 2014-10-02 Instrumentation Laboratory Company Plasma separation from blood using a filtration device and methods thereof
AU2014233373B2 (en) * 2013-03-15 2019-10-24 Verinata Health, Inc. Generating cell-free DNA libraries directly from blood
WO2014172244A1 (en) 2013-04-15 2014-10-23 Becton, Dickinson And Company Biological fluid separation device and biological fluid separation and testing system
WO2014170497A2 (en) * 2013-04-19 2014-10-23 Epiontis Gmbh Method for identifying the quantitative cellular composition in a biological sample
US11358138B2 (en) 2013-07-19 2022-06-14 Boston Microfluidics Inc. Fluid sample collection device
US9644232B2 (en) 2013-07-26 2017-05-09 General Electric Company Method and device for collection and amplification of circulating nucleic acids
DE102013012677A1 (de) 2013-07-31 2015-02-05 Mann + Hummel Gmbh Verfahren zum abtrennen von blutplasma/serum von vollblut
US10262755B2 (en) 2014-04-21 2019-04-16 Natera, Inc. Detecting cancer mutations and aneuploidy in chromosomal segments
US9499870B2 (en) 2013-09-27 2016-11-22 Natera, Inc. Cell free DNA diagnostic testing standards
EP3110977B1 (en) 2014-02-28 2018-05-16 Exosome Sciences Inc. Brain specific exosome based diagnostics and extracorporeal therapies
CN111849955A (zh) 2014-03-18 2020-10-30 凯杰有限公司 胞外核酸的固定和分离
EP3598452B1 (en) 2014-05-30 2023-07-26 Sequenom, Inc. Chromosome representation determinations
EP3152559B1 (en) 2014-06-04 2020-12-02 Pepex Biomedical, Inc. Electrochemical sensors made using advanced printing technology
US10472620B2 (en) 2014-07-01 2019-11-12 General Electric Company Method, substrate and device for separating nucleic acids
WO2016004539A1 (en) 2014-07-11 2016-01-14 Advanced Theranostics Inc. Point of care polymerase chain reaction device for disease detection
EP3760739A1 (en) 2014-07-30 2021-01-06 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
MX2017001368A (es) 2014-08-01 2017-05-11 Siemens Healthcare Diagnostics Inc Separacion de plasma asistido por vacio.
US10335078B2 (en) 2014-08-04 2019-07-02 General Electric Company Device for separation and collection of plasma
US20170342500A1 (en) 2014-12-19 2017-11-30 Danmarks Tekniske Universitet Method for identification of tissue or organ localization of a tumour
WO2016105508A2 (en) 2014-12-23 2016-06-30 California Institute Of Technology Devices and methods for autonomous measurements
US10913068B2 (en) 2015-03-13 2021-02-09 Nanyang Technological University Testing device, microfluidic chip and nucleic acid testing method
CN104830986B (zh) * 2015-05-07 2018-08-03 深圳承启生物科技有限公司 一种检测胎儿基因信息的方法、装置和系统
AU2016273418A1 (en) 2015-06-02 2017-12-07 Ecocraft Systems Pty Ltd Personal safety device
US20160371428A1 (en) 2015-06-19 2016-12-22 Natera, Inc. Systems and methods for determining aneuploidy risk using sample fetal fraction
CN108463279B (zh) 2015-07-24 2021-02-12 奥斯龙-明士克公司 用于血液样品的血液分离介质和侧向流动设备
EP3334834B1 (en) * 2015-08-12 2020-05-13 Circulogene Theranostics, LLC Method of preparing cell free nucleic acid molecules by in situ amplification
EP3754011B1 (en) * 2015-09-09 2022-02-16 Drawbridge Health, Inc. Devices for sample collection, stabilization and preservation
US11756655B2 (en) 2015-10-09 2023-09-12 Guardant Health, Inc. Population based treatment recommender using cell free DNA
KR20180113973A (ko) 2015-11-11 2018-10-17 레졸루션 바이오사이언스, 인크. Dna 라이브러리의 고효율 작제
US11073511B2 (en) 2016-02-01 2021-07-27 The Board Of Trustees Of The Leland Stanford Junior University Exosome-Total-Isolation-Chip (ExoTIC) device for isolation of exosome-based biomarkers
US10095831B2 (en) 2016-02-03 2018-10-09 Verinata Health, Inc. Using cell-free DNA fragment size to determine copy number variations
US10808239B2 (en) 2016-04-06 2020-10-20 Wayne State University Isolation and analysis of fetal DNA from extravillous trophoblast cells retrieved from the endocervical canal
RU2742355C2 (ru) 2016-04-07 2021-02-05 Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити Неинвазивная диагностика путем секвенирования 5-гидроксиметилированной бесклеточной днк
WO2017214338A1 (en) 2016-06-07 2017-12-14 Drawbridge Health, Inc. Metods and devices for strong or stabilizing molecules
US11399755B2 (en) 2016-08-24 2022-08-02 Becton, Dickinson And Company Device for obtaining a blood sample
TW201816645A (zh) 2016-09-23 2018-05-01 美商德萊福公司 用於生物樣本的自動化處理及分析、臨床資訊處理及臨床試驗配對之整合系統及方法
EP3518974A4 (en) 2016-09-29 2020-05-27 Myriad Women's Health, Inc. NON-INVASIVE PRENATAL SCREENING USING DYNAMIC ITERATIVE DEEP OPTIMIZATION
JP1754773S (ja) 2017-01-10 2023-10-06 サンプル採取器具
PT3596233T (pt) 2017-03-17 2022-08-22 Sequenom Inc Métodos e processos para avaliação de mosaicismo genético
US20180300450A1 (en) 2017-04-17 2018-10-18 Counsyl, Inc. Systems and methods for performing and optimizing performance of dna-based noninvasive prenatal screens
CN110998333B (zh) 2017-05-16 2023-08-25 Sk电信有限公司 使用盒的核酸分析设备
WO2019016080A1 (en) 2017-07-17 2019-01-24 Boehringer Ingelheim Vetmedica Gmbh MODIFIED FILTERING MEMBRANE AND USE THEREOF
WO2019067567A1 (en) 2017-09-26 2019-04-04 Juno Diagnostics, Inc. DEVICES, SYSTEMS AND METHODS FOR BIOMARKER ANALYSIS
AR113802A1 (es) 2017-10-27 2020-06-10 Juno Diagnostics Inc Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo
RU2020117208A (ru) 2017-10-27 2021-11-29 Бостон Майкрофлюидикс, Инк. Устройство для сбора образцов жидкостей
US20210020314A1 (en) 2018-03-30 2021-01-21 Juno Diagnostics, Inc. Deep learning-based methods, devices, and systems for prenatal testing
DE102018111834A1 (de) 2018-05-16 2019-11-21 Mildendo Gesellschaft für mikrofluidische Systeme mbH Mikrofluidische Vorrichtung und Verfahren zur Nutzung derselben zur Trennung, Aufreinigung und Konzentration von Komponenten von fluidischen Medien,
US20200015725A1 (en) 2018-05-24 2020-01-16 Boston Microfluidics, Inc. Cassette for blood sample measurement collection and storage
US20210327538A1 (en) 2018-07-17 2021-10-21 Natera, Inc. Methods and systems for calling ploidy states using a neural network
US20210340601A1 (en) 2018-09-03 2021-11-04 Ramot At Tel-Aviv University Ltd. Method and system for identifying gene disorder in maternal blood
WO2020086396A1 (en) 2018-10-23 2020-04-30 Boston Microfluidics, Inc. Blood sample collection device with time stamp and simultaneous environmental sample
CN109971846A (zh) 2018-11-29 2019-07-05 时代基因检测中心有限公司 使用双等位基因snp靶向下一代测序的非侵入性产前测定非整倍体的方法
AU2020245532A1 (en) 2019-03-27 2021-11-11 Juno Diagnostics, Inc. Optimized ultra-low volume liquid biopsy methods, systems, and devices
EP4025129A4 (en) 2019-09-06 2024-02-14 Renegadexbio Pbc HYDROPHOBIC PATTERNED MEDIUM AND RUPTURE LINES DEFINING A BLOOD COLLECTION VOLUME
CA3155419A1 (en) 2019-09-23 2021-04-01 Gateway Genomics, Llc Methods, compositions, and kits for determining the sex of a fetus
CA3162239A1 (en) 2019-11-27 2021-06-03 Juno Diagnostics, Inc. Systems and devices for sample preparation and analyte detection
WO2021188594A1 (en) 2020-03-18 2021-09-23 Drawbridge Health, Inc. Systems and methods for sample collection

Also Published As

Publication number Publication date
TW201923090A (zh) 2019-06-16
JP2021500883A (ja) 2021-01-14
CA3080117A1 (en) 2019-05-02
KR20200085783A (ko) 2020-07-15
US20230051179A1 (en) 2023-02-16
EP3700423A1 (en) 2020-09-02
EP3700423A4 (en) 2021-08-18
US20200299677A1 (en) 2020-09-24
AU2018355575A1 (en) 2020-05-21
WO2019084489A1 (en) 2019-05-02
CN111526793A (zh) 2020-08-11
US20220098575A1 (en) 2022-03-31
US11525134B2 (en) 2022-12-13

Similar Documents

Publication Publication Date Title
AR113802A1 (es) Dispositivos, sistemas y métodos para la biopsia líquida de un volumen ultra bajo
CL2017001940A1 (es) Dispositivo de medición de la calidad del suelo
GB2568608A (en) Personalized genetic testing
CL2017000235A1 (es) Instrumento para analizar las muestras biológicas y reactivos
MX2021008472A (es) Dispositivos, sistemas, metodos y equipos para recibir un hisopo.
CL2018001156A1 (es) Preparación de muestras para muestras difíciles.
CR20170240A (es) Anticuerpos anti-interleucina-33 y sus usos
EP3800253A3 (en) Prostate cancer detection kit or device, and detection method
BR112018069849A2 (pt) kit, dispositivo e método para a detecção de câncer pancreático precoce ou de lesão precursora do câncer pancreático
EA201690731A1 (ru) Анализ igfbp7, имеющий улучшенную характеристику в биологических образцах
CL2017002101A1 (es) Dispositivo, plataforma y ensayo para evaluación de células
EA201692157A1 (ru) Синтез двухцепочечных нуклеиновых кислот
MX364554B (es) Procedimiento para determinar la morfologia, tridimensional y cuantitativa, de las micro y nanocavidades producidas por corrosion quimica y/o microbiologica en materiales metalicos.
EA201791300A1 (ru) Флюидные системы, содержащие канал инкубации, включающие в себя флюидные системы, образованные литьевым формованием
EA201690185A1 (ru) Анализ timp2, обладающий улучшенной эффективностью в биологическом образце
MX2015012319A (es) Sistemas de instrumento analitico.
GB2545850A (en) System and method using a combined modality optical probe
BR112017008351A2 (pt) recipiente de suabe para dispositivos microfluídicos
BR112016028838A2 (pt) anticorpos, ácido nucleico, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, métodos de detecção de lgr5 humano em uma amostra biológica, de detecção de um câncer, de identificação de um paciente com câncer, de seleção de um paciente com câncer para tratamento com um imunoconjugado e de tratamento de um paciente com câncer
MX2019000592A (es) Dispositivo dispensador de reactivos analiticos liquidos, y kits analiticos y metodos de uso relacionados.
MX2019000591A (es) Tira mejorada de ensayo de analisis de orina de bajo volumen de muestra, kits analiticos y metodos de uso relacionados con la misma.
SA518391425B1 (ar) طرق لاستخلاص حمض بدون خلية لفحص غير باضع قبل الولادة dna
MX2018015140A (es) Firmas de biomarcadores de lupus eritematoso sistemico y sus usos.
CL2013003628A1 (es) Metodo para la determinacion microbiologica de trazas de antibioticos en muestra biologicas de bajo volumen
EA201692223A1 (ru) Композиции и способы жидкостной биопсии меланомы