AR111178A1 - Inhibidor de la quinasa reguladora de la señal de apoptosis - Google Patents

Inhibidor de la quinasa reguladora de la señal de apoptosis

Info

Publication number
AR111178A1
AR111178A1 ARP180100585A ARP180100585A AR111178A1 AR 111178 A1 AR111178 A1 AR 111178A1 AR P180100585 A ARP180100585 A AR P180100585A AR P180100585 A ARP180100585 A AR P180100585A AR 111178 A1 AR111178 A1 AR 111178A1
Authority
AR
Argentina
Prior art keywords
inhibitor
apoptosis signal
regulatory kinase
compound
formula
Prior art date
Application number
ARP180100585A
Other languages
English (en)
Spanish (es)
Inventor
Gregory Notte
Julie Farand
Kassibla Eloide Dempah
Jennifer Lynne Alleva
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR111178A1 publication Critical patent/AR111178A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP180100585A 2017-03-14 2018-03-14 Inhibidor de la quinasa reguladora de la señal de apoptosis AR111178A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762471300P 2017-03-14 2017-03-14

Publications (1)

Publication Number Publication Date
AR111178A1 true AR111178A1 (es) 2019-06-12

Family

ID=61750538

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180100585A AR111178A1 (es) 2017-03-14 2018-03-14 Inhibidor de la quinasa reguladora de la señal de apoptosis

Country Status (6)

Country Link
AR (1) AR111178A1 (fr)
BR (1) BR102018004862A2 (fr)
JO (1) JOP20180017A1 (fr)
TW (1) TW201840551A (fr)
UY (1) UY37631A (fr)
WO (1) WO2018169742A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
KR102629267B1 (ko) 2017-05-12 2024-01-25 이난타 파마슈티칼스, 인코포레이티드 아폽토시스 신호 조절 키나아제 １ 억제제 및 이의 사용 방법
US10597382B2 (en) 2017-08-28 2020-03-24 Enanta Pharmaceuticals, Inc. Tetrazole containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2019213239A1 (fr) 2018-05-02 2019-11-07 Enanta Pharmaceuticals Inc. Inhibiteurs de la kinase 1 régulant le signal d'apoptose et leurs méthodes d'utilisation
BR112020022114A2 (pt) 2018-05-02 2021-01-26 Enanta Pharmaceuticals, Inc. tetrazol contendo inibidores de quinase-1 reguladora de sinal de apoptose e métodos de uso do mesmo
CN110818683B (zh) * 2018-08-10 2023-04-14 中国科学院上海药物研究所 2-吡啶取代脲结构小分子化合物及其合成和应用
US10968199B2 (en) 2018-08-22 2021-04-06 Enanta Pharmaceuticals, Inc. Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
US11345699B2 (en) 2018-11-19 2022-05-31 Enanta Pharmaceuticals, Inc. Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
WO2020198214A1 (fr) 2019-03-25 2020-10-01 Enanta Pharmaceuticals, Inc. Inhibiteurs de la kinase 1 régulant le signal d'apoptose et leurs procédés d'utilisation
WO2023125904A1 (fr) * 2021-12-30 2023-07-06 苏州晶云药物科技股份有限公司 Forme cristalline d'un composé d'acide azacyclobutyl nicotinique et son procédé de préparation
CN117503932A (zh) * 2022-07-30 2024-02-06 中国医学科学院阜外医院 Jun抑制剂在制备用于治疗射血分数保留的心衰的药物中的用途
CN117054652B (zh) * 2023-08-04 2024-05-17 南京医科大学 一种用于辅助检测心肌肥厚的生物标志物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
EP2545964A1 (fr) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Nouveaux composés se liant au fxr (nr1 h4) et modulant son activité
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
WO2015187499A1 (fr) 2014-06-03 2015-12-10 Gilead Sciences, Inc. Utilisation d'un inhibiteur d'ask1, éventuellement associé à un inhibiteur de loxl2, pour le traitement d'une maladie du foie
TW201618781A (zh) 2014-08-13 2016-06-01 吉李德科學股份有限公司 治療肺高血壓之方法
MA41252A (fr) * 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1

Also Published As

Publication number Publication date
WO2018169742A1 (fr) 2018-09-20
BR102018004862A2 (pt) 2019-01-02
UY37631A (es) 2018-09-28
JOP20180017A1 (ar) 2019-01-30
TW201840551A (zh) 2018-11-16

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