AR107494A1 - Proceso para la preparación de osimertinib (azd9291) o una sal del mismo, y “azd9291 anilina” o una sal de la misma - Google Patents

Proceso para la preparación de osimertinib (azd9291) o una sal del mismo, y “azd9291 anilina” o una sal de la misma

Info

Publication number
AR107494A1
AR107494A1 ARP170100246A ARP170100246A AR107494A1 AR 107494 A1 AR107494 A1 AR 107494A1 AR P170100246 A ARP170100246 A AR P170100246A AR P170100246 A ARP170100246 A AR P170100246A AR 107494 A1 AR107494 A1 AR 107494A1
Authority
AR
Argentina
Prior art keywords
azd9291
salt
aniline
preparation
formula
Prior art date
Application number
ARP170100246A
Other languages
English (en)
Spanish (es)
Inventor
Alexander Telford
Alistair John Boyd
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57984913&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR107494(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR107494A1 publication Critical patent/AR107494A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP170100246A 2016-02-01 2017-01-31 Proceso para la preparación de osimertinib (azd9291) o una sal del mismo, y “azd9291 anilina” o una sal de la misma AR107494A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662289390P 2016-02-01 2016-02-01

Publications (1)

Publication Number Publication Date
AR107494A1 true AR107494A1 (es) 2018-05-02

Family

ID=57984913

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170100246A AR107494A1 (es) 2016-02-01 2017-01-31 Proceso para la preparación de osimertinib (azd9291) o una sal del mismo, y “azd9291 anilina” o una sal de la misma

Country Status (18)

Country Link
US (1) US11180477B2 (enExample)
EP (1) EP3411038B1 (enExample)
JP (1) JP6812449B2 (enExample)
KR (1) KR102749892B1 (enExample)
CN (1) CN108495632B (enExample)
AR (1) AR107494A1 (enExample)
AU (1) AU2017214243B2 (enExample)
BR (1) BR112018014712B1 (enExample)
CA (1) CA3011809C (enExample)
CO (1) CO2018007008A2 (enExample)
ES (1) ES2834608T3 (enExample)
IL (1) IL260665B (enExample)
MX (1) MX378363B (enExample)
MY (1) MY185367A (enExample)
RU (1) RU2733376C2 (enExample)
TW (1) TWI745345B (enExample)
WO (1) WO2017134051A1 (enExample)
ZA (1) ZA201805790B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109311858B (zh) 2016-05-26 2021-12-03 里科瑞尔姆Ip控股有限责任公司 Egfr抑制剂化合物
CN107556293B (zh) * 2017-09-19 2019-12-03 福建省微生物研究所 一种奥西替尼的合成工艺
WO2021111462A1 (en) * 2019-12-02 2021-06-10 Natco Pharma Limited An improved process for the preparation of osimertinib mesylate
US11780824B2 (en) * 2020-12-16 2023-10-10 Scinopharm Taiwan, Ltd. Process for preparing osimertinib or a salt thereof
AU2022340897A1 (en) 2021-09-02 2024-03-14 Synthon B.V. A process for making osimertinib
WO2025124936A1 (en) 2023-12-15 2025-06-19 Synthon B.V. A process for making osimertinib

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4070401A (en) * 1972-02-19 1978-01-24 Mitsui Toatsu Chemicals Inc. Method for the preparation of a halogenated aromatic amine
EP2736895B1 (en) * 2011-07-27 2016-01-06 Astrazeneca AB 2-(2,4,5-substituted-anilino) pyrimidine derivatives as egfr modulators useful for treating cancer
PE20170268A1 (es) * 2014-06-19 2017-04-21 Ariad Pharma Inc Compuestos de heteroarilo para la inhibicion de cinasa
CN104817541B (zh) * 2015-05-11 2017-06-16 苏州东南药业股份有限公司 一种抗肿瘤药物的合成方法

Also Published As

Publication number Publication date
ZA201805790B (en) 2024-10-30
CA3011809A1 (en) 2017-08-10
TW201736364A (zh) 2017-10-16
MX2018008966A (es) 2018-09-03
AU2017214243A1 (en) 2018-09-06
JP6812449B2 (ja) 2021-01-13
BR112018014712A2 (pt) 2018-12-11
CN108495632B (zh) 2021-12-31
RU2018130327A (ru) 2020-03-04
US11180477B2 (en) 2021-11-23
RU2018130327A3 (enExample) 2020-03-26
MX378363B (es) 2025-03-10
IL260665B (en) 2021-08-31
JP2019508387A (ja) 2019-03-28
WO2017134051A1 (en) 2017-08-10
AU2017214243B2 (en) 2019-07-18
TWI745345B (zh) 2021-11-11
EP3411038B1 (en) 2020-09-09
EP3411038A1 (en) 2018-12-12
CN108495632A (zh) 2018-09-04
US20210122734A1 (en) 2021-04-29
BR112018014712B1 (pt) 2023-10-31
MY185367A (en) 2021-05-11
CO2018007008A2 (es) 2018-07-19
CA3011809C (en) 2024-02-27
ES2834608T3 (es) 2021-06-18
KR20180101610A (ko) 2018-09-12
KR102749892B1 (ko) 2025-01-07
RU2733376C2 (ru) 2020-10-01

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