AR098333A1 - Una composición en forma de polvo - Google Patents

Una composición en forma de polvo

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Publication number
AR098333A1
AR098333A1 ARP140104181A ARP140104181A AR098333A1 AR 098333 A1 AR098333 A1 AR 098333A1 AR P140104181 A ARP140104181 A AR P140104181A AR P140104181 A ARP140104181 A AR P140104181A AR 098333 A1 AR098333 A1 AR 098333A1
Authority
AR
Argentina
Prior art keywords
weight
particles
primary
high dispersion
cationic surfactant
Prior art date
Application number
ARP140104181A
Other languages
English (en)
Inventor
Gerashchenko Igor
Chepliaka Oleksii
Original Assignee
Invenres Gmbh
Gerashchenko Igor
Chepliaka Oleksii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invenres Gmbh, Gerashchenko Igor, Chepliaka Oleksii filed Critical Invenres Gmbh
Publication of AR098333A1 publication Critical patent/AR098333A1/es

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    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
    • C08G77/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract

Composición en forma de polvo que comprende partículas de sílice de alta dispersión, partículas de polimetilsiloxano, un tensioactivo catiónico y una sustancia antimicrobiana, en la que por lo menos 25% en peso del tensioactivo catiónico está presente en las partículas de polimetilsiloxano primarias que llevan el tensioactivo catiónico en su superficie y/o en aglomerados de estas partículas primarias, y por lo menos 25% en peso de la sustancia antimicrobiana está presente en partículas de sílice de alta dispersión primarias que llevan la sustancia antimicrobiana en su superficie y/o en aglomerados de estas partículas primarias. Reivindicación 3: Una composición en forma de polvo que comprende: 21,0 a 75,0% en peso de sílice de alta dispersión; 16,0 a 70,0% en peso de polimetilsiloxano; por lo menos uno de un tensioactivo catiónico en una cantidad de 0,2 a 4,0% en peso; y una sustancia antimicrobiana en una cantidad de 0,5 a 10% en peso; y en forma adicional por lo menos uno de los siguientes agentes: 0,01 a 10,0% en peso de por lo menos una sustancia con actividad de crecimiento de tejido, 0,01 a 5,0% en peso de lidocaína, 0,01 a 5,0% en peso de por lo menos un derivado de fenotiazina, y 0,01 a 3,0% en peso de por lo menos una enzima proteolítica, con base en el peso total de la composición. Reivindicación 4: Un procedimiento para la producción de una composición en forma de polvo que comprende los siguientes pasos (a) a (c): (a) la proporción de partículas de sílice de alta dispersión, partículas de polimetilsiloxano, y uno o ambos de un tensioactivo catiónico, y una sustancia antimicrobiana; (b) la puesta en práctica de por lo menos uno de los siguientes pasos(b1) y (b2): (b1) la formación de partículas de polimetilsiloxano primarias que llevan el tensioactivo catiónico en su superficie y/o aglomerados de estas partículas primarias, (b2) la formación de partículas de sílice de alta dispersión primarias que llevan la sustancia antimicrobiana en su superficie y/o aglomerados de estas partículas primarias por el uso de una parte menor de las partículas de sílice de alta dispersión, y (c) la mezcla de la mayor parte de las partículas de sílice de alta dispersión con los productos obtenidos en el paso (b). Reivindicación 17: La composición de acuerdo con cualquiera de las reivindicaciones 1 a 3, 6, 7, 13 ó 14 o la preparación farmacéutica de acuerdo con la reivindicación 15 para su uso en el tratamiento de heridas purulentas y heridas necróticas.
ARP140104181A 2013-11-06 2014-11-06 Una composición en forma de polvo AR098333A1 (es)

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US20210106531A1 (en) * 2018-01-29 2021-04-15 Pathelen Health Care Ag Hydrophilic/hydrophobic pharmaceutical composition and method of its production and use
US20190255223A1 (en) 2018-02-16 2019-08-22 American Nano, LLC Silica fiber compositions and methods of use
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UA32088C2 (en) * 1998-12-23 2004-07-15 Yurii Mykolaiovych Shevchenko Wound healing preparation and method for its manufacture
JP4276179B2 (ja) * 2002-11-04 2009-06-10 ザ プロクター アンド ギャンブル カンパニー 改善された安定性を有し、クレンジング相と別個の効能相（ａｂｅｎｅｆｉｔｐｈａｓｅ）とを含有する、ストライプ模様の液体パーソナルクレンジング組成物
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UA82774C2 (uk) 2006-09-20 2008-05-12 Tolcheiev Yurii Zakharovych Спосіб одержання сорбенту на основі гідрогелю метилкремнієвої кислоти
WO2008051513A2 (en) * 2006-10-23 2008-05-02 Allan Pronovost Compositions and methods for treating lacerations, abrasions, avulsions, burns, ulcers, and cases of excessive bleeding
UA28103U (uk) 2007-07-12 2007-11-26 Ольга Олександрівна Біляєва Комплексний сорбційно-протеолітичний препарат сертасил для лікування гнійних ран, трофічних виразок, опіків
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US10226425B2 (en) 2019-03-12
US20170312221A1 (en) 2017-11-02
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