AR096346A1 - Composiciones antiparasitarias de espiro-isoxazolina de acción prolongada - Google Patents
Composiciones antiparasitarias de espiro-isoxazolina de acción prolongadaInfo
- Publication number
- AR096346A1 AR096346A1 ARP140101988A ARP140101988A AR096346A1 AR 096346 A1 AR096346 A1 AR 096346A1 AR P140101988 A ARP140101988 A AR P140101988A AR P140101988 A ARP140101988 A AR P140101988A AR 096346 A1 AR096346 A1 AR 096346A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition
- solvent
- optionally
- animal
- precipitation inhibitor
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A61K9/0017—Non-human animal skin, e.g. pour-on, spot-on
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Abstract
También, un procedimiento de tratamiento de un animal con una infestación parasitaria administrando la composición de acción prolongada al animal que la necesita. Reivindicación 1: Una composición de acción prolongada, caracterizada porque comprende: a) una espiro-azetidin-isoxazolina seleccionada de la fórmula (1) ó (2) en la que R¹ᵃ, R¹ᵇ y R¹ᶜ son cada uno independientemente hidrógeno, cloro, bromo, flúor o trifluorometilo; y R² es etilo, propilo, isopropilo, isobutilo, ciclopropilo, -C(OH)(CH₃)₂, -CH₂-ciclopropilo, -CH₂CF₃, -CH₂OH, -CH₂SCH₃, -CH₂S(O)CH₃, -CH₂S(O)₂CH₃, -CH₂SCF₃, 2,2-difluorociclopropilo, 1,1-dioxidotietano, y -CH₂-1H-pirazol, y estereoisómeros de los mismos; b) un éter glicólico; c) al menos un disolvente veterinariamente aceptable; d) opcionalmente, al menos un inhibidor de precipitación; y e) opcionalmente, al menos un antioxidante. Reivindicación 2: La composición de la reivindicación 1, caracterizada porque la espiro-azetidina es un compuesto de fórmula (1), y en la que R¹ᵃ, R¹ᵇ y R¹¹ᶜ son cada uno independientemente hidrógeno, flúor o cloro, y R² es -CH₂S(O)₂CH₃, y estereoisómeros del mismo. Reivindicación 5: Una composición tópica de acción prolongada, caracterizada porque comprende: a) (S)-1-(5-(5-(3,5-dicloro-4-fluorofenil)-5-(trifluorometil)-4,5-dihidroisoxazol-3-il)-3H-espiro[azetidin-3,1-isobenzofuran]-1-il)-2-(metiIsuIfoniI)etanona; b) monobutiléter dietilenglicólico o monoetiléter dietilenglicólico; c) al menos un disolvente veterinariamente aceptable; d) opcionalmente, al menos un inhibidor de precipitación; y e) opcionalmente, al menos un antioxidante. Reivindicación 6: La composición de la reivindicación 5, caracterizada porque el disolvente está seleccionado de dimetilisosorbida, triglicérido caprilico/cáprico, miristato de isopropilo, ácido oleico, eucaliptol, alcohol bencílico, benzoato de bencilo, etanol, caprilato de propilenglicol, Iaurato de propilenglicol, caprilocaproil macrogol-8 glicérido e isopropanol, y cualquier mezcla de los mismos. Reivindicación 7: La composición de la reivindicación 6, caracterizada porque el disolvente está seleccionado de dimetilisosorbida, Iaurato de propilenglicol y caprilocaproil macrogol-8 glicérido, o una mezcla de los mismos, y que comprende además al menos un inhibidor de precipitación. Reivindicación 8: La composición de la reivindicación 5, caracterizada porque el disolvente está seleccionado de miristato de isopropilo, ácido oleico, eucaliptol, alcohol bencílico, benzoato de bencilo, etanol e isopropanol, y cualquier mezcla de los mismos, y que comprende además al menos un inhibidor de precipitación. Reivindicación 15: El procedimiento de una cualquiera de las reivindicaciones 11 a 14, caracterizada porque el animal es un animal de compañía o ganado y la composición se administra por vía tópica al menos una vez cada 3 o más meses.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361825177P | 2013-05-20 | 2013-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR096346A1 true AR096346A1 (es) | 2015-12-23 |
Family
ID=50981866
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140101988A AR096346A1 (es) | 2013-05-20 | 2014-05-19 | Composiciones antiparasitarias de espiro-isoxazolina de acción prolongada |
Country Status (6)
Country | Link |
---|---|
US (3) | US20160081986A1 (es) |
EP (1) | EP2999339B1 (es) |
AR (1) | AR096346A1 (es) |
HK (1) | HK1219623A1 (es) |
UY (1) | UY35579A (es) |
WO (1) | WO2014189837A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2892902A1 (en) * | 2012-09-07 | 2015-07-15 | Zoetis LLC | Spirocyclic derivatives as antiparasitic agents |
UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
SG11201708068PA (en) | 2015-04-08 | 2017-10-30 | Merial Inc | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
UY37137A (es) * | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
BR112019007605A2 (pt) | 2016-10-14 | 2019-09-17 | Boehringer Ingelheim Animal Health Usa Inc | compostos pesticidas e parasiticidas de vinil isoxazolina |
EP3668866B1 (en) | 2017-08-14 | 2023-01-18 | Boehringer Ingelheim Animal Health USA Inc. | Pesticidal and parasiticidal pyrazole-isoxazoline compounds |
AU2021278871A1 (en) | 2020-05-28 | 2023-01-19 | Boehringer Ingelheim Animal Health USA Inc. | Bi-modal release intra-ruminal capsule device and methods of use thereof |
CN116897044A (zh) | 2020-12-21 | 2023-10-17 | 勃林格殷格翰动物保健有限公司 | 包含异噁唑啉化合物的杀寄生虫环 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9825402D0 (en) * | 1998-11-19 | 1999-01-13 | Pfizer Ltd | Antiparasitic formulations |
RU2497364C2 (ru) * | 2007-11-26 | 2013-11-10 | Мериал Лимитед | Системы растворителей для жидких наружных композиций для борьбы с паразитами |
AU2010212672B2 (en) * | 2009-02-16 | 2015-04-09 | Cipla Limited | Topical composition |
US20100322875A1 (en) * | 2009-06-18 | 2010-12-23 | Advanced Bio-Technologies, Inc. | Silicone scar treatment preparation |
UA108641C2 (uk) * | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
DK178277B1 (da) * | 2010-06-18 | 2015-10-26 | Novartis Tiergesundheit Ag | Diaryloxazolinforbindelser til bekæmpelse af fiskelus |
BR112013023068B8 (pt) * | 2011-03-10 | 2022-11-22 | Zoetis Llc | Derivados de isoxazolina espirocíclica, seu uso e seu processo de preparação, e composições veterinárias |
MX351463B (es) * | 2012-08-31 | 2017-10-16 | Zoetis Services Llc | Formas cristalinas de 1-(5'-(5-(3,5-dicloro-4-fluorofenil)-5-(trif luorometil)-4,5-dihidroisoxazol-3-il)-3'h-espiro[azetidin-3,1'-is obenzofuran]-1-il)-2-(metilsulfonil)etanona. |
EP2892902A1 (en) * | 2012-09-07 | 2015-07-15 | Zoetis LLC | Spirocyclic derivatives as antiparasitic agents |
CA2882546A1 (en) * | 2012-09-07 | 2014-03-13 | Zoetis Llc | Spirocyclic isoxazolines as antiparasitic agents |
EP2892347B1 (en) * | 2012-09-07 | 2019-08-14 | Zoetis Services LLC | Spirocyclic isoxazoline parasiticidal combinations |
-
2014
- 2014-05-19 WO PCT/US2014/038602 patent/WO2014189837A1/en active Application Filing
- 2014-05-19 AR ARP140101988A patent/AR096346A1/es unknown
- 2014-05-19 EP EP14732490.9A patent/EP2999339B1/en active Active
- 2014-05-19 US US14/888,972 patent/US20160081986A1/en not_active Abandoned
- 2014-05-20 UY UY0001035579A patent/UY35579A/es not_active Application Discontinuation
-
2016
- 2016-07-06 HK HK16107869.5A patent/HK1219623A1/zh unknown
-
2021
- 2021-08-03 US US17/392,569 patent/US20210379023A1/en not_active Abandoned
-
2023
- 2023-09-07 US US18/462,535 patent/US20230414576A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2014189837A1 (en) | 2014-11-27 |
HK1219623A1 (zh) | 2017-04-13 |
US20160081986A1 (en) | 2016-03-24 |
EP2999339A1 (en) | 2016-03-30 |
UY35579A (es) | 2014-12-31 |
US20210379023A1 (en) | 2021-12-09 |
US20230414576A1 (en) | 2023-12-28 |
EP2999339B1 (en) | 2019-06-19 |
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