AR094876A1 - Derivados de ácido betulínico modificados con alquilo c-3 y alquenilo - Google Patents
Derivados de ácido betulínico modificados con alquilo c-3 y alqueniloInfo
- Publication number
- AR094876A1 AR094876A1 ARP140100580A ARP140100580A AR094876A1 AR 094876 A1 AR094876 A1 AR 094876A1 AR P140100580 A ARP140100580 A AR P140100580A AR P140100580 A ARP140100580 A AR P140100580A AR 094876 A1 AR094876 A1 AR 094876A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- substituted
- cycloalkyl
- heteroaryl
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- FVWJYYTZTCVBKE-ROUWMTJPSA-N betulin Chemical class C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(CO)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C FVWJYYTZTCVBKE-ROUWMTJPSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 28
- 125000000217 alkyl group Chemical group 0.000 abstract 14
- 125000001072 heteroaryl group Chemical group 0.000 abstract 14
- 125000003118 aryl group Chemical group 0.000 abstract 8
- 150000001875 compounds Chemical class 0.000 abstract 8
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 8
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- -1 -OR2 Chemical group 0.000 abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 208000030507 AIDS Diseases 0.000 abstract 2
- 230000000840 anti-viral effect Effects 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 229940126154 HIV entry inhibitor Drugs 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 229960005475 antiinfective agent Drugs 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000002835 hiv fusion inhibitor Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361768630P | 2013-02-25 | 2013-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR094876A1 true AR094876A1 (es) | 2015-09-02 |
Family
ID=50288267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140100580A AR094876A1 (es) | 2013-02-25 | 2014-02-24 | Derivados de ácido betulínico modificados con alquilo c-3 y alquenilo |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9249180B2 (OSRAM) |
| EP (1) | EP2958930A1 (OSRAM) |
| JP (1) | JP6186012B2 (OSRAM) |
| KR (1) | KR20150121712A (OSRAM) |
| CN (1) | CN105102468A (OSRAM) |
| AR (1) | AR094876A1 (OSRAM) |
| AU (1) | AU2014218754B2 (OSRAM) |
| BR (1) | BR112015019590A2 (OSRAM) |
| CA (1) | CA2902513A1 (OSRAM) |
| EA (1) | EA027861B1 (OSRAM) |
| IL (1) | IL240739A0 (OSRAM) |
| MX (1) | MX2015010354A (OSRAM) |
| SG (1) | SG11201506445PA (OSRAM) |
| TW (1) | TW201444862A (OSRAM) |
| WO (1) | WO2014130810A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| US10221208B2 (en) * | 2015-04-14 | 2019-03-05 | ViiV Healthcare UK (No.4) Limited | Methods of producing an HIV maturation inhibitor |
| EA038890B1 (ru) | 2015-11-02 | 2021-11-03 | Блюпринт Медсинс Корпорейшн | Ингибиторы ret |
| AR107512A1 (es) | 2016-02-04 | 2018-05-09 | VIIV HEALTHCARE UK Nº 5 LTD | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 |
| AR107912A1 (es) | 2016-03-17 | 2018-06-28 | Blueprint Medicines Corp | Inhibidores de ret |
| WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
| WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
| WO2018044838A1 (en) * | 2016-08-31 | 2018-03-08 | Viiv Healthcare Company | Combinations and uses and treatments thereof |
| CN106749486A (zh) * | 2016-11-30 | 2017-05-31 | 沈阳化工大学 | 一种以乙二胺为连接臂的齐墩果酸衍生物及其应用 |
| RU2020113341A (ru) | 2017-09-14 | 2021-10-15 | Феникс Байотекнолоджи, Инк. | Способ и композиция для лечения вирусной инфекции |
| EP3681477A4 (en) | 2017-09-14 | 2021-06-09 | Phoenix Biotechnology, Inc. | PROCEDURES AND IMPROVED COMPOSITION FOR TREATMENT OF TREITERPEN RESPONSIBLE CONDITIONS, DISEASES, OR DISORDERS |
| CA3096043A1 (en) | 2018-04-03 | 2019-10-10 | Blueprint Medicines Corporation | Ret inhibitor for use in treating cancer having a ret alteration |
| HRP20231582T1 (hr) | 2019-02-11 | 2024-03-15 | Hetero Labs Limited | Novi derivati triterpena kao inhibitori hiv-a |
| CN111440151A (zh) * | 2020-03-25 | 2020-07-24 | 魏威 | 制备抗肿瘤药普拉赛替尼的方法 |
| CN111362923A (zh) * | 2020-03-25 | 2020-07-03 | 魏威 | 制备ret抑制剂普拉塞替尼的方法、以及普拉塞替尼的中间体及其制备方法 |
| JP7153083B2 (ja) | 2020-03-31 | 2022-10-13 | フェニックス・バイオテクノロジー・インコーポレイテッド | コロナウイルス感染を治療するための方法および組成物 |
| EP4295854A3 (en) | 2020-03-31 | 2024-04-03 | Phoenix Biotechnology, Inc. | Method and compositions for treating coronavirus infection |
| KR20230017234A (ko) | 2020-05-29 | 2023-02-03 | 블루프린트 메디신즈 코포레이션 | 프랄세티닙의 고체 형태 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5413999A (en) | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| US5679828A (en) | 1995-06-05 | 1997-10-21 | Biotech Research Labs, Inc. | Betulinic acid and dihydrobetulinic acid derivatives and uses therefor |
| US6369101B1 (en) * | 1999-02-26 | 2002-04-09 | Regents Of The University Of Minnesota | Therapeutic method to treat herpes virus infection |
| US20020137755A1 (en) | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7365221B2 (en) | 2002-09-26 | 2008-04-29 | Panacos Pharmaceuticals, Inc. | Monoacylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof |
| US7745625B2 (en) | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| MXPA06010592A (es) | 2004-03-17 | 2007-06-12 | Panacos Pharmaceuticals Inc | Sales farmaceuticas de acido 3-o-(3',3'-dimetilsuccinil) betulinico. |
| TW200628161A (en) | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
| US20110144069A1 (en) | 2006-10-16 | 2011-06-16 | Myriad Genetics, Incorporated | Compounds for treating viral infections |
| EP2257567A1 (en) | 2008-02-14 | 2010-12-08 | Virochem Pharma Inc. | Novel 17 beta lupane derivatives |
| US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
| CN103038245B (zh) * | 2010-06-04 | 2015-03-25 | 百时美施贵宝公司 | 作为hiv成熟抑制剂的c-3经修饰的桦木酸衍生物 |
| MX2012013628A (es) | 2010-06-04 | 2012-12-17 | Bristol Myers Squibb Co | Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih). |
| US8846647B2 (en) | 2011-01-31 | 2014-09-30 | Bristol-Myers Squibb Company | C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity |
| RS54352B1 (sr) | 2011-01-31 | 2016-02-29 | Bristol-Myers Squibb Company | C-28 amini c-3 modifikovanih derivata betulinske kiseline kao inhibitori sazrevanja hiv-a |
| US8889854B2 (en) | 2012-05-07 | 2014-11-18 | Bristol-Myers Squibb Company | C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity |
-
2014
- 2014-02-21 MX MX2015010354A patent/MX2015010354A/es unknown
- 2014-02-21 EA EA201591545A patent/EA027861B1/ru not_active IP Right Cessation
- 2014-02-21 BR BR112015019590A patent/BR112015019590A2/pt not_active Application Discontinuation
- 2014-02-21 AU AU2014218754A patent/AU2014218754B2/en not_active Ceased
- 2014-02-21 CN CN201480010426.3A patent/CN105102468A/zh active Pending
- 2014-02-21 KR KR1020157026070A patent/KR20150121712A/ko not_active Withdrawn
- 2014-02-21 EP EP14710687.6A patent/EP2958930A1/en not_active Withdrawn
- 2014-02-21 SG SG11201506445PA patent/SG11201506445PA/en unknown
- 2014-02-21 WO PCT/US2014/017688 patent/WO2014130810A1/en not_active Ceased
- 2014-02-21 CA CA2902513A patent/CA2902513A1/en not_active Abandoned
- 2014-02-21 US US14/186,533 patent/US9249180B2/en not_active Expired - Fee Related
- 2014-02-21 JP JP2015558996A patent/JP6186012B2/ja not_active Expired - Fee Related
- 2014-02-24 TW TW103106131A patent/TW201444862A/zh unknown
- 2014-02-24 AR ARP140100580A patent/AR094876A1/es unknown
-
2015
- 2015-08-20 IL IL240739A patent/IL240739A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL240739A0 (en) | 2015-10-29 |
| CN105102468A (zh) | 2015-11-25 |
| EP2958930A1 (en) | 2015-12-30 |
| SG11201506445PA (en) | 2015-09-29 |
| KR20150121712A (ko) | 2015-10-29 |
| EA027861B1 (ru) | 2017-09-29 |
| CA2902513A1 (en) | 2014-08-28 |
| TW201444862A (zh) | 2014-12-01 |
| US20140243298A1 (en) | 2014-08-28 |
| BR112015019590A2 (pt) | 2017-07-18 |
| EA201591545A1 (ru) | 2015-12-30 |
| WO2014130810A1 (en) | 2014-08-28 |
| AU2014218754A1 (en) | 2015-10-15 |
| MX2015010354A (es) | 2015-10-09 |
| JP6186012B2 (ja) | 2017-08-23 |
| US9249180B2 (en) | 2016-02-02 |
| AU2014218754B2 (en) | 2017-04-20 |
| JP2016509062A (ja) | 2016-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR094876A1 (es) | Derivados de ácido betulínico modificados con alquilo c-3 y alquenilo | |
| AR089996A1 (es) | Triterpenoides de c-3 cicloalquenilo con actividad inhibidora de la maduracion del hiv | |
| AR114164A1 (es) | Piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1 | |
| AR094684A1 (es) | Triterpenoides de c-19 modificados, con actividad inhibidora de la maduración del vih | |
| AR092742A1 (es) | Piridinonas antifibroticas | |
| AR090955A1 (es) | Aminas biciclicas c-17 de triterpenoides con actividad inhibidora de la maduracion del vih | |
| AR082886A1 (es) | Compuestos y composiciones farmaceuticas que los contienen | |
| AR100691A1 (es) | Esteroides neuroactivos, composiciones, y usos de los mismos | |
| AR096287A1 (es) | Pirrolobenzodiacepinas y conjugados | |
| AR101077A1 (es) | Triterpenoides con actividad inhibidora de la maduración de hiv | |
| PE20160501A1 (es) | Derivados de quinolizina sustituidos utiles como inhibidores de integrasa del vih | |
| MX2020011085A (es) | Compuestos de tiazolcarboxamidas y piridinacarboxamida útiles como inhibidores de cinasa pim. | |
| CL2015002520A1 (es) | Compuestos novedosos de pirimidina y piridina y su uso. | |
| AR094174A1 (es) | Lactamas fusionadas de arilo y heteroarilo | |
| AR100442A1 (es) | Derivados de pirido[1,2-a]pirimidin-4-ona para tratar atrofia muscular espinal | |
| AR103251A1 (es) | Compuestos policíclicos de carbamoilpiridona y su uso farmacéutico | |
| AR094262A1 (es) | Compuestos antivirales para el tratamiento de la hepatitis c | |
| AR089285A1 (es) | Derivados de betulina | |
| AR107512A1 (es) | Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1 | |
| AR098492A1 (es) | Derivados de purina | |
| AR097894A1 (es) | Inhibidores terapéuticos de cdk8 o uso de los mismos | |
| AR108046A1 (es) | Derivados de indolina sustituidos como inhibidores de la replicación viral del dengue | |
| PE20211769A1 (es) | Compuestos heteroaromaticos como inhibidores de vanina | |
| PE20190968A1 (es) | Compuestos de heterociclo tetraciclicos utiles como inhibidores de la integrasa del vih | |
| AR087915A1 (es) | N-(3-(2-amino-6,6-difluor-4,4a,5,6,7,7a-hexahidro-ciclopenta-[e][1,3]oxazin-4-il)-fenil)-amidas como inhibidores de la bace1 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |