AR089144A1 - Formas solidas de (1r,4r)-6-fluoro-(n,n-dimetil)-4-fenil-4,9-dihidro-3h-espiro-[ciclohexano-1,1-pirano-[3,4-b]indol]-4-amina y acido sulfurico - Google Patents

Formas solidas de (1r,4r)-6-fluoro-(n,n-dimetil)-4-fenil-4,9-dihidro-3h-espiro-[ciclohexano-1,1-pirano-[3,4-b]indol]-4-amina y acido sulfurico

Info

Publication number
AR089144A1
AR089144A1 ARP120104641A ARP120104641A AR089144A1 AR 089144 A1 AR089144 A1 AR 089144A1 AR P120104641 A ARP120104641 A AR P120104641A AR P120104641 A ARP120104641 A AR P120104641A AR 089144 A1 AR089144 A1 AR 089144A1
Authority
AR
Argentina
Prior art keywords
fluoro
solid forms
sulfuric acid
ciclohexano
pirano
Prior art date
Application number
ARP120104641A
Other languages
English (en)
Inventor
Dr Gruss Michael
Dr Kluge Stefan
Dr Prhs Stefan
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of AR089144A1 publication Critical patent/AR089144A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)

Abstract

Se refiere a formas sólidas de (1r,4r)-6-fluoro-N,N-dimetil-4-fenil-4,9dihidro-3H-espiro[ciclohexano-1,1-pirano[3,4-b]indol]-4-amina y ácido sulfúrico tal como sulfato o hemi-sulfato de (1r,4r)-6-fluoro-N,N-dimetil-4-fenil-4,9-dihidro-3H-espiro[ciclohexano-1,1-pirano[3,4-b]indol]-4-amina, en particular formas cristalinas y/o formas amorfas particulares de la misma, composiciones farmacéuticas y medicamentos que comprenden estas formas sólidas, el uso de estas formas sólidas así como también a un proceso para obtenerlas.
ARP120104641A 2011-12-12 2012-12-11 Formas solidas de (1r,4r)-6-fluoro-(n,n-dimetil)-4-fenil-4,9-dihidro-3h-espiro-[ciclohexano-1,1-pirano-[3,4-b]indol]-4-amina y acido sulfurico AR089144A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11009774 2011-12-12

Publications (1)

Publication Number Publication Date
AR089144A1 true AR089144A1 (es) 2014-07-30

Family

ID=47324171

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104641A AR089144A1 (es) 2011-12-12 2012-12-11 Formas solidas de (1r,4r)-6-fluoro-(n,n-dimetil)-4-fenil-4,9-dihidro-3h-espiro-[ciclohexano-1,1-pirano-[3,4-b]indol]-4-amina y acido sulfurico

Country Status (23)

Country Link
US (1) US8912343B2 (es)
EP (1) EP2797924B1 (es)
JP (1) JP6276703B2 (es)
CN (1) CN104114560B (es)
AR (1) AR089144A1 (es)
AU (1) AU2012350763B2 (es)
BR (1) BR112014014164A2 (es)
CA (1) CA2858769C (es)
CY (1) CY1117873T1 (es)
DK (1) DK2797924T3 (es)
EA (1) EA029975B1 (es)
ES (1) ES2589259T3 (es)
HK (1) HK1199256A1 (es)
HR (1) HRP20161105T1 (es)
HU (1) HUE029806T2 (es)
IL (1) IL233049A (es)
MX (1) MX354688B (es)
PL (1) PL2797924T3 (es)
PT (1) PT2797924T (es)
RS (1) RS54960B1 (es)
SI (1) SI2797924T1 (es)
TW (1) TWI567078B (es)
WO (1) WO2013087591A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201642853A (zh) 2015-01-23 2016-12-16 歌林達有限公司 用於治療肝功能之損傷及／或腎功能之損傷個體疼痛之西博帕多（Ｃｅｂｒａｎｏｐａｄｏｌ）

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006046745A1 (de) 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
BR112013002696A2 (pt) * 2010-08-04 2016-05-31 Gruenenthal Gmbh forma de dosagem farmacêutica compreendendo 6'-fluor-(n-metil- ou n,n-dimetil-)4-fenil-4',9'-diidro-3'h-espiro[cicloexano-1,-1'-pirano[3,4-b]indol]-4 amina 13''
WO2012016703A2 (en) * 2010-08-04 2012-02-09 Grünenthal GmbH Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine

Also Published As

Publication number Publication date
CA2858769C (en) 2017-10-24
IL233049A (en) 2017-09-28
MX2014007012A (es) 2014-07-14
CY1117873T1 (el) 2017-05-17
HK1199256A1 (zh) 2015-06-26
PL2797924T3 (pl) 2016-10-31
TW201329081A (zh) 2013-07-16
EP2797924A1 (en) 2014-11-05
US20130150589A1 (en) 2013-06-13
EA029975B1 (ru) 2018-06-29
HRP20161105T1 (hr) 2016-11-04
CN104114560B (zh) 2018-05-04
RS54960B1 (sr) 2016-11-30
HUE029806T2 (hu) 2017-03-28
EA201400684A1 (ru) 2014-12-30
IL233049A0 (en) 2014-07-31
JP2015500311A (ja) 2015-01-05
TWI567078B (zh) 2017-01-21
BR112014014164A2 (pt) 2017-06-13
DK2797924T3 (en) 2016-08-01
SI2797924T1 (sl) 2016-08-31
WO2013087591A1 (en) 2013-06-20
MX354688B (es) 2018-03-15
ES2589259T3 (es) 2016-11-11
JP6276703B2 (ja) 2018-02-07
AU2012350763B2 (en) 2017-03-30
PT2797924T (pt) 2016-09-08
US8912343B2 (en) 2014-12-16
CN104114560A (zh) 2014-10-22
AU2012350763A1 (en) 2014-07-31
EP2797924B1 (en) 2016-06-01
CA2858769A1 (en) 2013-06-20

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