AR086427A1 - Deteccion de los canceres colorrectales con deficiencias en la reparacion de las faltas de coincidencia en el adn - Google Patents

Deteccion de los canceres colorrectales con deficiencias en la reparacion de las faltas de coincidencia en el adn

Info

Publication number
AR086427A1
AR086427A1 ARP120101742A ARP120101742A AR086427A1 AR 086427 A1 AR086427 A1 AR 086427A1 AR P120101742 A ARP120101742 A AR P120101742A AR P120101742 A ARP120101742 A AR P120101742A AR 086427 A1 AR086427 A1 AR 086427A1
Authority
AR
Argentina
Prior art keywords
marker
msh6
deficiencies
pcr
cancers
Prior art date
Application number
ARP120101742A
Other languages
English (en)
Inventor
C Richard Boland
Takeshi Nagasaka
Ajay Goel
Original Assignee
Baylor Res Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor Res Inst filed Critical Baylor Res Inst
Publication of AR086427A1 publication Critical patent/AR086427A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Uso del mononucleótido marcador CAT25 en un método basado en una PCR cuádruple con el que pueden detectarse los cánceres colorrectales (CRC) con deficiencias en MSH6. La PCR cuádruple de la presente solicitud es un ensayo sencillo, robusto, más económico (en comparación con la PCR quíntuple habitual), altamente sensible y específico con el que puede identificarse la inestabilidad a nivel de los microsatélites (MSI) en los CRC.Reivindicación 1: Un sistema para detectar la inestabilidad a nivel de los microsatélites (MSl) en una muestra biológica obtenida de un sujeto humano o de un animal, caracterizado porque comprende una cantidad de mononucleótidos marcadores que es suficiente para detectar un cambio en la expresión del gen MSH6, en la expresión de la proteína MSH6 o en ambas, donde los mononucleótidos marcadores comprenden CAT25, BAT25, BAT26, NR21, NR22, NR24, NR27 o cualquier combinación de éstos.
ARP120101742A 2011-05-16 2012-05-17 Deteccion de los canceres colorrectales con deficiencias en la reparacion de las faltas de coincidencia en el adn AR086427A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161486610P 2011-05-16 2011-05-16

Publications (1)

Publication Number Publication Date
AR086427A1 true AR086427A1 (es) 2013-12-11

Family

ID=47175185

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120101742A AR086427A1 (es) 2011-05-16 2012-05-17 Deteccion de los canceres colorrectales con deficiencias en la reparacion de las faltas de coincidencia en el adn

Country Status (4)

Country Link
US (1) US20120295267A1 (es)
AR (1) AR086427A1 (es)
TW (1) TW201300544A (es)
WO (1) WO2012158385A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2813374T3 (es) * 2014-08-28 2021-03-23 The Provost Fellows Found Scholars & The Other Members Of Board Of The College Of Holy And Undiv Procedimientos y kit para la identificación del cáncer
GB201614474D0 (en) 2016-08-24 2016-10-05 Univ Of Newcastle Upon Tyne The Methods of identifying microsatellite instability
KR101969971B1 (ko) * 2017-03-24 2019-04-18 주식회사 시선바이오머티리얼스 양기능성 pna 프로브를 이용한 융해곡선 분석방법, 및 이를 이용한 현미부수체 불안정성의 진단방법 및 현미부수체 불안정성 진단용 키트
WO2019041045A1 (en) 2017-09-01 2019-03-07 The Hospital For Sick Children PROFILING AND TREATMENT OF HYPERMUTANT CANCER
CN109593847B (zh) * 2017-09-29 2023-04-11 中山大学附属第六医院 检测微卫星nr24位点稳定性的引物对、试剂盒及方法
US10699802B2 (en) 2017-10-09 2020-06-30 Strata Oncology, Inc. Microsatellite instability characterization
NZ759171A (en) * 2017-11-16 2022-05-27 Illumina Inc Systems and methods for determining microsatellite instability
CN108441558A (zh) * 2018-02-12 2018-08-24 杭州和壹基因科技有限公司 肿瘤细胞微卫星不稳定性的复合扩增体系及检测试剂盒
CN108866190B (zh) * 2018-07-12 2022-01-28 吉林大学 一种卵巢恶性肿瘤易感性预测试剂盒及系统
CN110343763A (zh) * 2019-06-11 2019-10-18 浙江中创生物医药有限公司 一种人类微卫星不稳定性状态msi检测位点及检测方法和应用
WO2021019197A1 (en) * 2019-07-31 2021-02-04 University Of Newcastle Upon Tyne Methods of identifying microsatellite instability
CN117471101B (zh) * 2023-12-28 2024-03-12 中国科学院烟台海岸带研究所 基于多通道拉曼探针肿瘤msi错配修复蛋白的检测方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1650311B1 (en) * 2004-10-19 2009-12-09 MTM Laboratories AG Compounds and methods for assessment of Microsatellite Instability (MSI) status
CN102230004B (zh) * 2011-06-08 2012-12-26 北京阅微基因技术有限公司 肿瘤细胞微卫星不稳定状态的复合扩增体系及检测试剂盒

Also Published As

Publication number Publication date
TW201300544A (zh) 2013-01-01
WO2012158385A1 (en) 2012-11-22
US20120295267A1 (en) 2012-11-22

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