AR084222A1 - Derivados de amido-piridina como antagonistas del receptor ep4 - Google Patents
Derivados de amido-piridina como antagonistas del receptor ep4Info
- Publication number
- AR084222A1 AR084222A1 ARP110104603A ARP110104603A AR084222A1 AR 084222 A1 AR084222 A1 AR 084222A1 AR P110104603 A ARP110104603 A AR P110104603A AR P110104603 A ARP110104603 A AR P110104603A AR 084222 A1 AR084222 A1 AR 084222A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkane
- group
- amido
- alkanes
- halogens
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente relata un derivado de amido-piridina de fórmula (1) o una sal farmacéuticamente aceptada del mismo, donde R1 y R2 son independientemente hidrógenos, alcanos lineales o ramificados C1-3 o conectados formando un anillo de ciclopropano; R es independientemente seleccionado del grupo consistente en halógenos y trifluorometilo y p es 1, 2 ó 3; A es C o N; E es un grupo de fórmula (B) ó (C), donde B es C(O)OH, C(O)O-alcano C1-3, y C es seleccionado del grupo de fórmulas (2); m es 1, 2 ó 3, n es 0 ó 1; W es -O-, -O(alcano C1-3)-; -(alcano C1-3)O-; -C(O)-; -C(=N-O(alcano C1-3))-; -NH- o -NH(alcano C1-3)-; Ar es fenil, opcionalmente sustituido por uno o más sustitutos seleccionados del grupo consistente en halógenos, trifluorometilo, trifluorometoxilo, metilo, -NH(alcano C1-3)-; -N(alcano C1-3)(alcano C1-3)-, un anillo heterocíclico de 5 a 7 miembros que contiene un átomo de nitrógeno el cual está enlazado covalentemente a Ar y opcionalmente conteniendo uno o dos heteroátomos seleccionados de N, O y S; y un anillo heteroaromático de 5- ó 6- miembros que contiene 1 a 3 heteroátomos seleccionados de S, O y N, dicho anillo heteroaromático siendo sustituido por uno o más substitutos seleccionados del grupo consistente de alcanos C1-3, cicloalcoxi C3-5, alcano C1-3carbonilo. Los compuestos de la presente pueden ser usados para la producción de un medicamento para el tratamiento de patologías que requieren el uso de un antagonista de receptor EP4, tales como el tratamiento de dolor agudo y crónico, dolor inflamatorio, osteoartritis, desórdenes asociados a inflamaciones como artritis, artritis reumatoidea, cáncer, endometriosis y migraña.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2010/069355 WO2012076063A1 (en) | 2010-12-10 | 2010-12-10 | Pyridine amide derivatives as ep4 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
AR084222A1 true AR084222A1 (es) | 2013-05-02 |
Family
ID=43585625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110104603A AR084222A1 (es) | 2010-12-10 | 2011-12-12 | Derivados de amido-piridina como antagonistas del receptor ep4 |
Country Status (7)
Country | Link |
---|---|
US (1) | US8828987B2 (es) |
EP (1) | EP2649061B1 (es) |
AR (1) | AR084222A1 (es) |
CA (1) | CA2820109C (es) |
ES (1) | ES2545110T3 (es) |
TW (1) | TW201307314A (es) |
WO (1) | WO2012076063A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUE033587T2 (hu) * | 2013-05-17 | 2017-12-28 | Incyte Corp | Bipirazol-származékok mint JAK inhibitorok |
RS57406B1 (sr) | 2013-06-12 | 2018-09-28 | Kaken Pharmaceutical Co Ltd | Derivat 4-alkinil imidazola i lekovi koji ga sadrže kao aktivni sastojak |
EP3364958B1 (en) * | 2015-10-23 | 2023-01-04 | Navitor Pharmaceuticals, Inc. | Modulators of sestrin-gator2 interaction and uses thereof |
CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
CA2968836A1 (en) | 2016-06-13 | 2017-12-13 | Gilead Sciences, Inc. | Fxr (nr1h4) modulating compounds |
JP6906626B2 (ja) | 2017-03-28 | 2021-07-21 | ギリアード サイエンシーズ, インコーポレイテッド | 肝疾患を処置するための治療的組み合わせ |
ES2896476T3 (es) * | 2017-05-18 | 2022-02-24 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina |
CA3063637A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | N-substituted indole derivatives |
EA201992677A1 (ru) | 2017-05-18 | 2020-04-23 | Идорсия Фармасьютиклз Лтд | Пиримидиновые производные в качестве модуляторов pge2 рецепторов |
CA3063632A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as pge2 receptor modulators |
LT3625222T (lt) | 2017-05-18 | 2021-11-10 | Idorsia Pharmaceuticals Ltd | Fenilo dariniai, kaip pge2 receptoriaus moduliatoriai |
PE20212186A1 (es) | 2018-02-16 | 2021-11-11 | Incyte Corp | Inhibidores de la via de jak1 para el tratamiento de trastornos relacionados con citoquinas |
MX2020010322A (es) | 2018-03-30 | 2022-11-30 | Incyte Corp | Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak). |
JP2021524494A (ja) * | 2018-07-12 | 2021-09-13 | ロッタファーム・バイオテック・エッセ・エッレ・エッレ | Ep4受容体アンタゴニストとしての(r)−4−(1−(1−(4−(トリフルオロメチル)ベンジル)ピロジリン−2−カルボキサミド)シクロプロピル)安息香酸 |
AU2020225225B2 (en) | 2019-02-19 | 2022-12-22 | Gilead Sciences, Inc. | Solid forms of FXR agonists |
AU2021283271A1 (en) | 2020-06-02 | 2022-12-15 | Incyte Corporation | Processes of preparing a JAK1 inhibitor |
TW202227447A (zh) * | 2020-08-18 | 2022-07-16 | 大陸商和記黃埔醫藥(上海)有限公司 | 嘧啶酮類化合物及其用途 |
EP4245301A1 (en) | 2020-11-13 | 2023-09-20 | ONO Pharmaceutical Co., Ltd. | Cancer treatment by combined use of ep4 antagonist and immune checkpoint inhibitor |
MX2023006542A (es) | 2020-12-08 | 2023-08-25 | Incyte Corp | Inhibidores de la vía cinasa jano 1 (jak1) para el tratamiento del vitiligo. |
CN117940420A (zh) * | 2021-09-14 | 2024-04-26 | 勃林格殷格翰国际有限公司 | 3-苯氧基氮杂环丁烷-1-基-杂芳基吡咯烷衍生物及其作为药物的用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020111495A1 (en) | 1997-04-04 | 2002-08-15 | Pfizer Inc. | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes |
US6211197B1 (en) * | 1998-10-07 | 2001-04-03 | Merck Frosst Canada & Co. | Prostaglandin receptor ligands |
MXPA06002551A (es) | 2003-09-03 | 2006-06-20 | Pfizer | Compuestos de aril o heteroaril amida. |
DE602005015215D1 (de) | 2004-05-04 | 2009-08-13 | Raqualia Pharma Inc | Orthosubstituierte aryl- oder heteroarylamidverbindungen |
WO2005105732A1 (en) | 2004-05-04 | 2005-11-10 | Pfizer Japan Inc. | Substituted methyl aryl or heteroaryl amide compounds |
ES2392192T3 (es) | 2006-04-24 | 2012-12-05 | Merck Canada Inc. | Derivados de indol amida como antagonistas del receptor EP4 |
AU2007283404B2 (en) | 2006-08-11 | 2013-04-18 | Merck Canada Inc. | Thiophenecarboxamide derivatives as EP4 receptor ligands |
JP5301469B2 (ja) | 2007-02-26 | 2013-09-25 | メルク カナダ インコーポレイテッド | Ep4受容体アンタゴニストとしてのインドール及びインドリンシクロプロピルアミド誘導体 |
US8598355B2 (en) | 2008-05-14 | 2013-12-03 | Astellas Pharma Inc. | Amide compound |
-
2010
- 2010-12-10 EP EP10798750.5A patent/EP2649061B1/en not_active Not-in-force
- 2010-12-10 ES ES10798750.5T patent/ES2545110T3/es active Active
- 2010-12-10 CA CA2820109A patent/CA2820109C/en not_active Expired - Fee Related
- 2010-12-10 WO PCT/EP2010/069355 patent/WO2012076063A1/en active Application Filing
- 2010-12-10 US US13/992,258 patent/US8828987B2/en not_active Expired - Fee Related
-
2011
- 2011-12-08 TW TW100145246A patent/TW201307314A/zh unknown
- 2011-12-12 AR ARP110104603A patent/AR084222A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2649061A1 (en) | 2013-10-16 |
EP2649061B1 (en) | 2015-05-13 |
US8828987B2 (en) | 2014-09-09 |
CA2820109A1 (en) | 2012-06-14 |
TW201307314A (zh) | 2013-02-16 |
CA2820109C (en) | 2018-01-09 |
US20130261100A1 (en) | 2013-10-03 |
ES2545110T3 (es) | 2015-09-08 |
WO2012076063A1 (en) | 2012-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |