AR080922A1 - Proceso para la preparacion de amidas del acido pirazolcarboxilico e intermediarios del mismo - Google Patents

Proceso para la preparacion de amidas del acido pirazolcarboxilico e intermediarios del mismo

Info

Publication number
AR080922A1
AR080922A1 ARP110101326A ARP110101326A AR080922A1 AR 080922 A1 AR080922 A1 AR 080922A1 AR P110101326 A ARP110101326 A AR P110101326A AR P110101326 A ARP110101326 A AR P110101326A AR 080922 A1 AR080922 A1 AR 080922A1
Authority
AR
Argentina
Prior art keywords
formula
compound
reacting
until
bromine
Prior art date
Application number
ARP110101326A
Other languages
English (en)
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of AR080922A1 publication Critical patent/AR080922A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/23—Preparation of halogenated hydrocarbons by dehalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/30—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by a Diels-Alder synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/10—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/24—Halogenated aromatic hydrocarbons with unsaturated side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/48—Halogenated derivatives
    • C07C35/52—Alcohols with a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C07D303/17—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals containing oxirane rings condensed with carbocyclic ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings

Abstract

Proceso para la preparacion del compuesto de formula (1), dicho proceso comprende a) hacer reaccionar un compuesto de la formula (2), donde X es cloro o bromo, con una especie organometálica en una atmosfera inerte hasta obtener un halobencino de formula (10), hacer reaccionar el halobencino de formula (10) así formado con ciclopentadieno hasta obtener el compuesto de formula (3); b) hacer reaccionar el compuesto de formula (3) en presencia de un solvente inerte con un oxidante hasta obtener el compuesto de formula (4); c) hacer reaccionar el compuesto de formula (4) en presencia de un ácido de Lewis y una fuente de hidruro hasta obtener el compuesto de formula (5); d) hacer reaccionar el compuesto de formula (5) en presencia de un agente de oxidacion, una base y un solvente inerte hasta obtener el compuesto de formula (6); (e) convertir el compuesto de formula (6) en presencia de un fosfano y CCI4 o CHCI3 hasta obtener el compuesto de formula (7); y ya sea f1) hacer reaccionar el compuesto de formula (7) con NH3 en presencia de un catalizador hasta obtener el compuesto de formula (8); y g) hacer reaccionar el compuesto de formula (8) en presencia de una base con un compuesto de formula (9), hasta obtener el compuesto de formula (1); o f2) hacer reaccionar el compuesto de formula (7) en presencia de un solvente, una base, un catalizador de cobre y por lo menos un ligando con el compuesto de formula (9a), hasta obtener el compuesto de formula (1). Reivindicacion 7: El compuesto de formula (4) donde X es cloro o bromo. Reivindicacion 8: El compuesto de formula (5) donde X es cloro o bromo. Reivindicacion 9: El compuesto de formula (7) donde X es cloro o bromo.
ARP110101326A 2010-04-20 2011-04-18 Proceso para la preparacion de amidas del acido pirazolcarboxilico e intermediarios del mismo AR080922A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP10160438 2010-04-20

Publications (1)

Publication Number Publication Date
AR080922A1 true AR080922A1 (es) 2012-05-16

Family

ID=44072655

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110101326A AR080922A1 (es) 2010-04-20 2011-04-18 Proceso para la preparacion de amidas del acido pirazolcarboxilico e intermediarios del mismo

Country Status (12)

Country Link
US (1) US8519152B2 (es)
EP (1) EP2560959B1 (es)
JP (1) JP5684896B2 (es)
CN (1) CN102906072B (es)
AR (1) AR080922A1 (es)
BR (1) BR112012026631B1 (es)
ES (1) ES2513540T3 (es)
IL (1) IL222398A (es)
MX (1) MX2012012005A (es)
TW (1) TWI428325B (es)
UY (1) UY33340A (es)
WO (1) WO2011131545A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2458935T3 (es) * 2010-04-20 2014-05-07 Syngenta Participations Ag Proceso para preparar amidas de ácidos carboxílicos pirazólicos
TWI534126B (zh) 2011-01-25 2016-05-21 先正達合夥公司 用於製備吡唑羧酸醯胺之方法
GB201403438D0 (en) * 2014-02-27 2014-04-16 Syngenta Participations Ag Polymorphs
WO2024017788A1 (en) 2022-07-22 2024-01-25 Syngenta Crop Protection Ag Solid form of a heterocyclic amide derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH075487B2 (ja) 1985-11-14 1995-01-25 住友化学工業株式会社 １―ブロモ―２―クロロ―４―フルオロベンゼンの製造法
US5093347A (en) 1991-01-28 1992-03-03 Monsanto Company 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use
US7223879B2 (en) 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
EP1940813B1 (en) * 2005-10-25 2010-11-24 Syngenta Participations AG Heterocyclic amide derivatives useful as microbiocides
WO2007124907A2 (en) * 2006-04-27 2007-11-08 Syngenta Participations Ag Heterocyclyl-carboxylic acid (benzonorbornene-5-yl)amide derivatives as fungicides for agrochemical use
TW200824566A (en) 2006-10-25 2008-06-16 Syngenta Ltd Process for the production of substituted bromobenzenes
MX2011006426A (es) * 2008-12-24 2011-07-20 Syngenta Ltd Metodos para la preparacion de arilamidas.

Also Published As

Publication number Publication date
UY33340A (es) 2011-12-01
EP2560959A1 (en) 2013-02-27
WO2011131545A1 (en) 2011-10-27
BR112012026631A2 (pt) 2015-09-15
MX2012012005A (es) 2012-12-17
EP2560959B1 (en) 2014-08-20
CN102906072A (zh) 2013-01-30
JP5684896B2 (ja) 2015-03-18
JP2013525317A (ja) 2013-06-20
US8519152B2 (en) 2013-08-27
US20130035496A1 (en) 2013-02-07
TW201204704A (en) 2012-02-01
TWI428325B (zh) 2014-03-01
ES2513540T3 (es) 2014-10-27
IL222398A (en) 2017-01-31
BR112012026631B1 (pt) 2017-07-25
CN102906072B (zh) 2014-07-02

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