MX2012012005A - Proceso para preparar amidas de acidos carboxilicos pirazolicos. - Google Patents

Proceso para preparar amidas de acidos carboxilicos pirazolicos.

Info

Publication number
MX2012012005A
MX2012012005A MX2012012005A MX2012012005A MX2012012005A MX 2012012005 A MX2012012005 A MX 2012012005A MX 2012012005 A MX2012012005 A MX 2012012005A MX 2012012005 A MX2012012005 A MX 2012012005A MX 2012012005 A MX2012012005 A MX 2012012005A
Authority
MX
Mexico
Prior art keywords
formula
compound
reacting
preparation
vii
Prior art date
Application number
MX2012012005A
Other languages
English (en)
Inventor
Stephan Trah
Raphael Dumeunier
Thomas Vettiger
Florian Schleth
Michael Rommel
Original Assignee
Syngenta Participations Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag filed Critical Syngenta Participations Ag
Publication of MX2012012005A publication Critical patent/MX2012012005A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/23—Preparation of halogenated hydrocarbons by dehalogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/30—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by a Diels-Alder synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/04—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups
    • C07C209/06—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms
    • C07C209/10—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of functional groups by amino groups by substitution of halogen atoms with formation of amino groups bound to carbon atoms of six-membered aromatic rings or from amines having nitrogen atoms bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/24—Halogenated aromatic hydrocarbons with unsaturated side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/48—Halogenated derivatives
    • C07C35/52—Alcohols with a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
    • C07D303/17—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals containing oxirane rings condensed with carbocyclic ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/60—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/66—Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Epoxy Compounds (AREA)

Abstract

La invención se refiere a un proceso para preparar el compuesto de fórmula (I) (Ver Formula) (I), comprendiendo el proceso a) hacer reaccionar un compuesto de fórmula (II) (Ver Formula) (II), donde X es cloro o bromo, con una especie organometálica en una atmósfera inerte para obtener un halobencino de fórmula (X) (Ver Formula) hacer reaccionar el halobencino de fórmula (X) formado de este modo con ciclopentadieno para obtener (III) (Ver Formula) b) hacer reaccionar (III) en presencia de un disolvente inerte con un oxidante para obtener (IV) (Ver Formula) c) hacer reaccionar (IV) en presencia de un ácido de Lewis y una fuente de hidruro para obtener (V) (Ver Formula) d) hacer reaccionar (V) en presencia de un agente oxidante, una base y un disolvente inerte para obtener (VI) (Ver Formula) e) convertir (VI) en presencia de un fosfano y CCl4 o CHCl3 en (VII) (Ver Formula) y o bien f1) hacer reaccionar (VII) con NH3 en presencia de un catalizador para obtener el compuesto de fórmula (VIII) (Ver Formula) y g) hacer reaccionar (VIII) en presencia de una base con un compuesto de fórmula (IX) (Ver Formula) (IX), para obtener el compuesto de fórmula (I); o f2) hacer reaccionar el compuesto de fórmula (VII) (Ver Formula) en presencia de un disolvente, una base, un catalizador de cobre y al menos un ligando, con el compuesto de fórmula (IXa) (Ver Formula) (IXa), para obtener el compuesto de fórmula (I).
MX2012012005A 2010-04-20 2011-04-14 Proceso para preparar amidas de acidos carboxilicos pirazolicos. MX2012012005A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10160438 2010-04-20
PCT/EP2011/055871 WO2011131545A1 (en) 2010-04-20 2011-04-14 Process for the preparation of pyrazole carboxylic acid amides

Publications (1)

Publication Number Publication Date
MX2012012005A true MX2012012005A (es) 2012-12-17

Family

ID=44072655

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012012005A MX2012012005A (es) 2010-04-20 2011-04-14 Proceso para preparar amidas de acidos carboxilicos pirazolicos.

Country Status (12)

Country Link
US (1) US8519152B2 (es)
EP (1) EP2560959B1 (es)
JP (1) JP5684896B2 (es)
CN (1) CN102906072B (es)
AR (1) AR080922A1 (es)
BR (1) BR112012026631B1 (es)
ES (1) ES2513540T3 (es)
IL (1) IL222398A (es)
MX (1) MX2012012005A (es)
TW (1) TWI428325B (es)
UY (1) UY33340A (es)
WO (1) WO2011131545A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011131544A1 (en) * 2010-04-20 2011-10-27 Syngenta Participations Ag Process for the preparation of pyrazole carboxylic acid amides
TWI534126B (zh) * 2011-01-25 2016-05-21 先正達合夥公司 用於製備吡唑羧酸醯胺之方法
GB201403438D0 (en) 2014-02-27 2014-04-16 Syngenta Participations Ag Polymorphs
WO2024017788A1 (en) 2022-07-22 2024-01-25 Syngenta Crop Protection Ag Solid form of a heterocyclic amide derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH075487B2 (ja) 1985-11-14 1995-01-25 住友化学工業株式会社 １―ブロモ―２―クロロ―４―フルオロベンゼンの製造法
US5093347A (en) 1991-01-28 1992-03-03 Monsanto Company 3-difluoromethylpyrazolecarboxamide fungicides, compositions and use
US7223879B2 (en) 1998-07-10 2007-05-29 Massachusetts Institute Of Technology Ligands for metals and improved metal-catalyzed processes based thereon
UA87416C2 (ru) 2005-10-25 2009-07-10 Syngenta Participations Ag Гетероциклические амиды, композиция на их основе и способ борьбы с заражением полезных растений фитопатогенными микроорганизмами и его предупреждение, промежуточные соединения
WO2007124907A2 (en) 2006-04-27 2007-11-08 Syngenta Participations Ag Heterocyclyl-carboxylic acid (benzonorbornene-5-yl)amide derivatives as fungicides for agrochemical use
CN101528034B (zh) 2006-10-25 2011-11-09 辛根塔有限公司 生产经取代的溴苯的方法
US20110257410A1 (en) * 2008-12-24 2011-10-20 Syngenta Crop Protection, Llc Methods for the preparation of fungicides

Also Published As

Publication number Publication date
BR112012026631A2 (pt) 2015-09-15
EP2560959A1 (en) 2013-02-27
CN102906072B (zh) 2014-07-02
BR112012026631B1 (pt) 2017-07-25
US20130035496A1 (en) 2013-02-07
JP2013525317A (ja) 2013-06-20
JP5684896B2 (ja) 2015-03-18
TW201204704A (en) 2012-02-01
TWI428325B (zh) 2014-03-01
EP2560959B1 (en) 2014-08-20
IL222398A (en) 2017-01-31
UY33340A (es) 2011-12-01
CN102906072A (zh) 2013-01-30
US8519152B2 (en) 2013-08-27
ES2513540T3 (es) 2014-10-27
AR080922A1 (es) 2012-05-16
WO2011131545A1 (en) 2011-10-27

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