AR079657A1 - Formulacion de liberacion sostenida - Google Patents

Formulacion de liberacion sostenida

Info

Publication number
AR079657A1
AR079657A1 ARP100104811A ARP100104811A AR079657A1 AR 079657 A1 AR079657 A1 AR 079657A1 AR P100104811 A ARP100104811 A AR P100104811A AR P100104811 A ARP100104811 A AR P100104811A AR 079657 A1 AR079657 A1 AR 079657A1
Authority
AR
Argentina
Prior art keywords
release formulation
salt
sustained release
compound
average molecular
Prior art date
Application number
ARP100104811A
Other languages
English (en)
Inventor
Tomomichi Futo
Hikaru Taira
Seitaro Mizukami
Naoyuki Murata
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of AR079657A1 publication Critical patent/AR079657A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una formulacion de liberacion sostenida que comprende un derivado de metastina y un copolímero de ácido láctico-ácido glicolico que tiene un peso molecular peso promedio de aproximadamente 5.000 a aproximadamente 40.000 o una sal del mismo. La formulacion de liberacion sostenida libera en forma lenta y estable el compuesto (1) o una sal del mismo durante mucho tiempo y ejerce un efecto medicinal del compuesto (1) o una sal del mismo durante un período de tiempo extenso. Además, la formulacion de liberacion sostenida que mejora la conveniencia del paciente reduciendo el numero de episodios de administracion. Reivindicacion 1: Una formulacion de liberacion sostenida caracterizado porque comprende un compuesto representado por la Formula: Ac-D--Tyr-Hyp-Asn-Thr-Phe--AzaGly-Leu-Arg (Me) -Trp-NH2 o una sal del mismo y un copolímero de ácido láctico-ácido glicolico que tiene un peso molecular peso promedio de aproximadamente 5.000 a aproximadamente 40.000 o una sal del mismo.
ARP100104811A 2009-12-22 2010-12-21 Formulacion de liberacion sostenida AR079657A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009290364 2009-12-22
JP2010144793 2010-06-25

Publications (1)

Publication Number Publication Date
AR079657A1 true AR079657A1 (es) 2012-02-08

Family

ID=43743497

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104811A AR079657A1 (es) 2009-12-22 2010-12-21 Formulacion de liberacion sostenida

Country Status (26)

Country Link
US (2) US20120302508A1 (es)
EP (1) EP2515878B1 (es)
JP (3) JP2013514968A (es)
KR (1) KR20120098906A (es)
CN (2) CN107412725A (es)
AR (1) AR079657A1 (es)
AU (1) AU2010336168A1 (es)
BR (1) BR112012014947A2 (es)
CA (1) CA2785021C (es)
CO (1) CO6551752A2 (es)
CR (1) CR20120290A (es)
DO (1) DOP2012000171A (es)
EA (1) EA020865B1 (es)
EC (1) ECSP12011992A (es)
ES (1) ES2434315T3 (es)
IL (1) IL219967A0 (es)
MA (1) MA33910B1 (es)
MX (1) MX2012006441A (es)
NZ (1) NZ600157A (es)
PE (1) PE20121481A1 (es)
SG (1) SG181436A1 (es)
TN (1) TN2012000255A1 (es)
TW (1) TW201125575A (es)
UY (1) UY33127A (es)
WO (1) WO2011078394A2 (es)
ZA (1) ZA201203775B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130210742A1 (en) * 2010-06-25 2013-08-15 Takeda Pharmaceutical Company Limited Sustained-release formulation
WO2016020901A1 (en) 2014-08-07 2016-02-11 Acerta Pharma B.V. Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate
EP3518952A1 (en) 2016-09-30 2019-08-07 Myovant Sciences GmbH Methods of treating female infertility

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211268D0 (en) * 1992-05-28 1992-07-15 Ici Plc Salts of basic peptides with carboxyterminated polyesters
FR2693905B1 (fr) * 1992-07-27 1994-09-02 Rhone Merieux Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues.
EP1187602A4 (en) * 2000-04-18 2004-09-15 Peptron Inc SUSTAINABLE RELEASE INJECTABLE PHARMACEUTICAL COMPOSITION AND METHODS OF PREPARING THE SAME
AR023940A1 (es) * 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
CA2420854C (en) * 2000-09-01 2013-07-30 Palmaya Pty Ltd Slow release pharmaceutical preparation and method of administering of same
US7090869B2 (en) * 2000-12-01 2006-08-15 Takeda Pharmaceutical Company Limited Method for producing preparation containing bioactive substance
WO2002085399A1 (en) 2001-04-20 2002-10-31 Takeda Chemical Industries, Ltd. Peptide-containing preparations
JP2003002841A (ja) * 2001-04-20 2003-01-08 Takeda Chem Ind Ltd ペプチド含有製剤
US20060241051A1 (en) * 2002-12-26 2006-10-26 Chieko Kitada Metastin derivatives and use thereof
AR049938A1 (es) 2004-06-25 2006-09-13 Takeda Pharmaceutical Derivados de metastina y utilizacion de los mismos
TW200613012A (en) * 2004-07-02 2006-05-01 Takeda Pharmaceuticals Co Sustained-release composition, process for producing the same and use of the same
CN1923284A (zh) * 2005-08-30 2007-03-07 孔庆忠 抗癌药物缓释注射剂及其应用
CN101341168B (zh) * 2005-12-22 2013-01-16 武田药品工业株式会社 肿瘤迁移抑制素衍生物及其用途
AR058584A1 (es) * 2005-12-22 2008-02-13 Takeda Pharmaceutical Derivados de metastina y uso de los mismos
US8404643B2 (en) * 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
BRPI0720582B1 (pt) * 2006-12-18 2021-08-24 Takeda Pharmaceutical Company Limited Composição de liberação prolongada, processo para a preparação da mesma, composição farmacêutica, agente profilático ou terapêutico, e, uso de uma substância fisiologicamente ativa
US20110118172A1 (en) * 2008-04-24 2011-05-19 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
WO2010076896A1 (en) * 2008-12-29 2010-07-08 Takeda Pharmaceutical Company Limited Prophylactic/therapeutic agent for cancer
WO2012021874A1 (en) * 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with thioether linkers

Also Published As

Publication number Publication date
US20120302508A1 (en) 2012-11-29
IL219967A0 (en) 2012-07-31
BR112012014947A2 (pt) 2019-09-24
CN102665690A (zh) 2012-09-12
CA2785021C (en) 2019-03-05
WO2011078394A2 (en) 2011-06-30
JP2016029045A (ja) 2016-03-03
AU2010336168A1 (en) 2012-06-14
CN107412725A (zh) 2017-12-01
JP2013514968A (ja) 2013-05-02
ECSP12011992A (es) 2012-07-31
NZ600157A (en) 2013-07-26
CO6551752A2 (es) 2012-10-31
US20180228732A1 (en) 2018-08-16
DOP2012000171A (es) 2012-08-31
CA2785021A1 (en) 2011-06-30
PE20121481A1 (es) 2012-11-12
EA201290372A1 (ru) 2012-12-28
EP2515878A2 (en) 2012-10-31
MX2012006441A (es) 2012-06-28
JP2017160201A (ja) 2017-09-14
MA33910B1 (fr) 2013-01-02
ZA201203775B (en) 2013-08-28
UY33127A (es) 2011-07-29
KR20120098906A (ko) 2012-09-05
SG181436A1 (en) 2012-07-30
EP2515878B1 (en) 2013-10-30
TW201125575A (en) 2011-08-01
TN2012000255A1 (en) 2013-12-12
CR20120290A (es) 2012-09-06
ES2434315T3 (es) 2013-12-16
JP6472730B2 (ja) 2019-02-20
EA020865B1 (ru) 2015-02-27
WO2011078394A3 (en) 2012-03-15

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Legal Events

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