AR079442A1 - Derivados (heterociclo-tetrahidro-piridin)-(piperazinil)-1-alcanona y (hete-rociclo-dihidro-pirrolidin)-(piperazinil)-1-alcanona y su utilizacion como in-hibidores de p75 - Google Patents

Derivados (heterociclo-tetrahidro-piridin)-(piperazinil)-1-alcanona y (hete-rociclo-dihidro-pirrolidin)-(piperazinil)-1-alcanona y su utilizacion como in-hibidores de p75

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Publication number
AR079442A1
AR079442A1 ARP100104602A ARP100104602A AR079442A1 AR 079442 A1 AR079442 A1 AR 079442A1 AR P100104602 A ARP100104602 A AR P100104602A AR P100104602 A ARP100104602 A AR P100104602A AR 079442 A1 AR079442 A1 AR 079442A1
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Argentina
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group
formula
atom
nucleus
represent
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ARP100104602A
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Sandrine Delbary-Gossart
Valentina Vercesi
Marco Baroni
Francoise Bono
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Sanofi Aventis
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Publication of AR079442A1 publication Critical patent/AR079442A1/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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Abstract

Composicion farmacéutica, así como a su procedimiento de preparacion y su aplicacion en terapéutica. Reivindicacion 1: Un compuesto que responde a la formula (1): en la que: - n representa 1 o 2; - m representa 0 o 1; - A representa un grupo heterocíclico condensado de la formula (2) y B representa un átomo de hidrogeno; o A representa un átomo de hidrogeno; y B representa un grupo heterocíclico condensado de la formula (2) pudiendo estar unido el heterociclo condensado de la formula 2 al resto de la molécula, por uno cualquiera de los átomos de carbono disponibles y en el cual: - U completa: - o bien un nucleo de 6 átomos, aromático o saturado, que contiene 1 o 2 átomos de nitrogeno, pudiendo estar sustituido el nucleo con uno o dos átomos de halogeno, uno o dos grupos alquilo (C1-4) o alcoxi (C1-4), uno o dos radicales perfluoroalquilo; - o bien un nucleo de 5 átomos, aromático o saturado, que contiene un átomo de nitrogeno, de oxígeno o de azufre, pudiendo estar sustituido el nucleo con uno o dos grupos alquilo (C1-4); - X y X1 representan CH o N; - R y R1 situados sobre una cualquiera de las posiciones disponibles, representan independientemente un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo (C1-4), alcoxi (C1-4), un radical perfluoroalquilo, trifluorometoxi, un grupo ciano, un grupo COOH, COOalquilo, CONR3R4 o NHCOR3; - -W- es un heterociclo nitrogenado elegido entre: (3); - 1-2 representa 1 o 2; - 1-3 representa 1, 2 o 3; - R2 representa un grupo de la formula: (4); - en la que R5 y R6, situados sobre una cualquiera de las posiciones disponibles, representan independientemente un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo (C1-4), alcoxi (C1-4), un radical trifluorometilo, trifluorometoxi, un grupo ciano, un grupo COOH, COOalquilo, COOcicloalquilo, SOalquilo, SO2alquilo, CONR3R4, NR3R4 o NHCOR3; o uno de R5 y R6 puede representar también un heterociclo elegido entre: (5); - Z representa un átomo de oxígeno o de azufre; - R3 y R4 representan un hidrogeno o un grupo alquilo C1-6; en estado de base o de sal de adicion a un ácido.
ARP100104602A 2009-12-14 2010-12-13 Derivados (heterociclo-tetrahidro-piridin)-(piperazinil)-1-alcanona y (hete-rociclo-dihidro-pirrolidin)-(piperazinil)-1-alcanona y su utilizacion como in-hibidores de p75 AR079442A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0906025A FR2953836B1 (fr) 2009-12-14 2009-12-14 Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75

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AR079442A1 true AR079442A1 (es) 2012-01-25

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US (2) US8518947B2 (es)
EP (1) EP2513088B1 (es)
JP (1) JP5760005B2 (es)
KR (1) KR101730205B1 (es)
CN (1) CN102656162B (es)
AR (1) AR079442A1 (es)
AU (1) AU2010338111B2 (es)
BR (1) BR112012014310B1 (es)
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FR2953839A1 (fr) * 2009-12-14 2011-06-17 Sanofi Aventis Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75
EP2606894A1 (en) 2011-12-20 2013-06-26 Sanofi Novel therapeutic use of p75 receptor antagonists

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JP2003514508A (ja) 1997-07-01 2003-04-15 ノボ ノルディスク アクティーゼルスカブ グルカゴン拮抗剤／逆作用剤
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FR2932482B1 (fr) * 2008-06-13 2010-10-08 Sanofi Aventis Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75
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HUE027940T2 (en) 2016-11-28
CY1116960T1 (el) 2017-04-05
NI201200103A (es) 2012-08-21
EA024403B1 (ru) 2016-09-30
TN2012000166A1 (fr) 2013-12-12
DOP2012000146A (es) 2012-07-31
HRP20151036T1 (hr) 2015-11-06
TW201130827A (en) 2011-09-16
PT2513088E (pt) 2015-10-23
FR2953836B1 (fr) 2012-03-16
PL2513088T3 (pl) 2015-12-31
AU2010338111A1 (en) 2012-07-05
CN102656162B (zh) 2015-07-22
CA2784153A1 (fr) 2011-07-07
CN102656162A (zh) 2012-09-05
CL2012001580A1 (es) 2012-12-14
DK2513088T3 (en) 2015-10-05
IL220273A0 (en) 2012-07-31
FR2953836A1 (fr) 2011-06-17
ZA201204339B (en) 2013-08-28
MX2012006863A (es) 2012-06-27
PE20121683A1 (es) 2012-12-06
US20130303520A1 (en) 2013-11-14
BR112012014310A2 (pt) 2016-07-05
CA2784153C (fr) 2019-04-16
UY33104A (es) 2011-07-29
ES2548872T3 (es) 2015-10-21
KR101730205B1 (ko) 2017-04-25
EP2513088B1 (fr) 2015-07-01
MA33916B1 (fr) 2013-01-02
NZ600576A (en) 2014-06-27
US8906924B2 (en) 2014-12-09
SI2513088T1 (sl) 2015-11-30
US20120245150A1 (en) 2012-09-27
WO2011080445A1 (fr) 2011-07-07
CO6501125A2 (es) 2012-08-15
GT201200178A (es) 2013-12-18
IL220273A (en) 2015-01-29
AU2010338111B2 (en) 2015-12-03
TWI475021B (zh) 2015-03-01
JP5760005B2 (ja) 2015-08-05
EP2513088A1 (fr) 2012-10-24
JP2013513650A (ja) 2013-04-22
SG181711A1 (en) 2012-07-30
CR20120315A (es) 2012-07-27
US8518947B2 (en) 2013-08-27
KR20120101068A (ko) 2012-09-12
EA201290513A1 (ru) 2012-12-28
ECSP12011971A (es) 2012-07-31
BR112012014310B1 (pt) 2021-09-28

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