AR076830A1 - Compuestos de carboxamidas de imidazol como moduladores de trpv3 - Google Patents

Compuestos de carboxamidas de imidazol como moduladores de trpv3

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Publication number
AR076830A1
AR076830A1 ARP090104861A ARP090104861A AR076830A1 AR 076830 A1 AR076830 A1 AR 076830A1 AR P090104861 A ARP090104861 A AR P090104861A AR P090104861 A ARP090104861 A AR P090104861A AR 076830 A1 AR076830 A1 AR 076830A1
Authority
AR
Argentina
Prior art keywords
ring
heteroaryl
substituted
cycloalkyl
alkenyl
Prior art date
Application number
ARP090104861A
Other languages
English (en)
Inventor
Abraham Thomas
Ashok Bhausaheb Kadam
Suresh Mahadev Kadam
Neelima Khairatkar-Joshi
Vidya Ganapati Kattige
Sachin Sundarlal Chaudhari
Sachin Vasantrao Dhone
Original Assignee
Glenmark Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa
Publication of AR076830A1 publication Critical patent/AR076830A1/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
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  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente provee un modulador de receptor vaniloide de potencial transitorio (TRPV) de formula (1). En particular, los compuestos aquí descriptos son utiles para el tratamiento o la prevencion de enfermedades, trastornos y/o desordenes modulados por TRPV3. También se proveen los procesos para preparar los compuestos descriptos, los intermediarios usados en su síntesis, sus composiciones farmacéuticas y métodos para el tratamiento o prevencion de enfermedades, trastornos y/o desordenes modulados por TRPV3. Reivindicacion 1: Un compuesto modulador de receptor vaniloide de potencial transitorio (TRPV) caracterizado por estar representado por la formula (1) en donde el anillo de formula (2) es un anillo heterocíclico o heteroaromático de 5 miembros o 6 miembros que contiene uno o dos enlaces dobles, en los que X y Z son elegidos en forma independiente de -N=, y -C(R1)-; e Y es -O-, -S-, =N-, -N(R1)-, -C(R1)=C(R1)-, o -C(R1)=N-; siendo Y -O-, -S- y -N(R1)- cuando el anillo de formula (2) es un anillo de 5 miembros que contiene un doble enlace; y siendo Y -C(R1)=C(R1)- o -C(R1)=N- cuando el anillo de formula (2) es un anillo de 6 miembros que contiene dos enlaces dobles; R1, que puede ser igual o diferente en cada ocurrencia, es independientemente hidrogeno, halogeno, nitro, ciano, alquilo substituido o no substituido, alquenilo, haloalquilo, alcoxi, cicloalquilo, cicloalquiloxi, arilo, ariloxi, arilalquilo, heterociclo, o heteroarilo; R2, que puede ser igual o diferente en cada ocurrencia, se elige en forma independiente del grupo que consiste en nitro, ciano, halogeno, -OR, alquilo substituido o no substituido, alquenilo, haloalquilo, cianoalquilo, cicloalquilo, arilo, anillo heterocíclico, y heteroarilo; R3 y R4, que pueden ser iguales o diferentes, son cada uno, independientemente, hidrogeno, álcali (incluyendo litio, sodio, o potasio), alquilo substituido o no substituido, haloalquilo, cianoalquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, arilo, heteroarilo, heterociclo, -S(O)NR5R6, -S(O)2NR5R6, -S(O)R5 o -S(O)2R5; o R3 y R4, junto con el átomo de nitrogeno al cual están adheridos, pueden formar un anillo cíclico opcionalmente substituido de 4 a 12 miembros; pudiendo el anillo cíclico ser heterociclo o heteroarilo; R se selecciona de hidrogeno, alquilo substituido o no substituido, haloalquilo, cianoalquilo, alquenilo, cicloalquilo, cicloalquilalquilo, alcoxialquilo, arilo, heteroarilo, anillo heterocíclico, arilalquilo, heteroarilalquilo, y heterocicloalquilo; en cada ocurrencia, R5 y R6, que pueden ser iguales o diferentes, son independientemente hidrogeno, alquilo substituido o no substituido, alquenilo, cicloalquilo, cicloalquilalquilo, cicloalquenilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, heterociclo, o heterocicloalquilo; y m es un entero comprendido en el rango que va de 0 a 5. ambos inclusive; o su sal farmacéuticamente aceptable.
ARP090104861A 2008-12-15 2009-12-15 Compuestos de carboxamidas de imidazol como moduladores de trpv3 AR076830A1 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
IN2610MU2008 2008-12-15
US14113308P 2008-12-29 2008-12-29
IN145MU2009 2009-01-22
US15024809P 2009-02-05 2009-02-05
IN1397MU2009 2009-06-10
US22161509P 2009-06-30 2009-06-30
IN1730MU2009 2009-07-29
US23745609P 2009-08-27 2009-08-27

Publications (1)

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AR076830A1 true AR076830A1 (es) 2011-07-13

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ARP090104861A AR076830A1 (es) 2008-12-15 2009-12-15 Compuestos de carboxamidas de imidazol como moduladores de trpv3

Country Status (12)

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US (1) US8318928B2 (es)
EP (1) EP2367825A1 (es)
JP (1) JP2012512151A (es)
AR (1) AR076830A1 (es)
AU (1) AU2009329192A1 (es)
CA (1) CA2746077A1 (es)
EA (1) EA201190004A1 (es)
GE (1) GEP20146099B (es)
MX (1) MX2011006132A (es)
NZ (1) NZ595777A (es)
TW (1) TW201022283A (es)
WO (1) WO2010070452A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2370425A4 (en) * 2008-12-26 2013-02-27 Glenmark Pharmaceuticals Sa IMIDAZOLE DERIVATIVES CONDENSED AS TRPV3 ANTAGONISTS
BR112013003121A2 (pt) * 2010-08-10 2016-06-28 Abbvie Inc moduladores de trpv3
WO2012072512A1 (en) * 2010-11-29 2012-06-07 Glaxo Group Limited N-cyclobutyl-imidazopyridine or -pyrazolopyridine carboxamides as trpv1 antagonists
DK2686303T3 (en) 2011-03-18 2016-03-29 Bayer Ip Gmbh N- (3-carbamoylphenyl) -1 H -pyrazole-5-carboxamide derivatives and their use for controlling animal pests
WO2012129491A1 (en) 2011-03-24 2012-09-27 Abbott Laboratories Trpv3 modulators
EP2697221A1 (en) 2011-04-11 2014-02-19 Glaxo Group Limited N- cyclobutyl - imidazopyridine - methylamine as trpv1 antagonists
EP2771322A2 (en) 2011-10-24 2014-09-03 AbbVie Inc. Novel trpv3 modulators
AU2013292529A1 (en) * 2012-07-18 2015-02-12 Marvin J. Miller 5,5-heteroaromatic anti-infective compounds
JP7208137B2 (ja) * 2016-12-09 2023-01-18 デナリ セラピューティクス インコーポレイテッド 化合物、組成物および方法
BR112022014933A2 (pt) * 2020-01-29 2022-09-20 Kamari Pharma Ltd Compostos e composições para uso no tratamento de distúrbios de pele

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4444770A (en) * 1980-05-29 1984-04-24 Bayer Aktiengesellschaft New imidazoazole-alkenoic acid amide compounds, intermediate products for their production, their production, and their medicinal use
US5204352A (en) * 1987-09-29 1993-04-20 The United States Of America As Represented By The Secretary Of The Army Compounds exhibiting anti-parasitic activity and a method for their use
GB8820231D0 (en) * 1988-08-25 1988-09-28 Fujisawa Pharmaceutical Co New benzazole compounds processes for preparation thereof & pharmaceutical composition comprising same
JPH02105085A (ja) 1988-10-14 1990-04-17 Komatsu Ltd 磁気センサ
JPH07242666A (ja) 1994-03-08 1995-09-19 Fujisawa Pharmaceut Co Ltd 複素環化合物
AU3053199A (en) * 1998-04-01 1999-10-25 Ono Pharmaceutical Co. Ltd. Fused thiophene derivatives and drugs containing the same as the active ingredient
US20040009537A1 (en) * 2002-01-11 2004-01-15 Jack Roos Methods of modulating and of identifying agents that modulate intracellular calcium
TWI372050B (en) * 2003-07-03 2012-09-11 Astex Therapeutics Ltd (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles
US20060074124A1 (en) * 2003-09-12 2006-04-06 Andrew Napper Methods of treating a disorder
PT1706057E (pt) 2004-08-18 2007-11-09 Robert Boettcher Implante dentário intra-ósseo aparafusável
US7576094B2 (en) 2004-12-13 2009-08-18 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
AP2008004432A0 (en) 2005-10-07 2008-04-30 Glenmark Pharmaceuticals Sa Substituted benzofused derivatives and their use as vanilloid receptor ligands
US7893260B2 (en) 2005-11-04 2011-02-22 Hydra Biosciences, Inc. Substituted quinazolin-4-one compounds for antagonizing TRPV3 function
US20110159111A1 (en) 2006-06-29 2011-06-30 Astex Therapeutics Limited Pharmaceutical combinations
WO2008001115A2 (en) 2006-06-29 2008-01-03 Astex Therapeutics Limited Pharmaceutical combinations of 1-cyclopropyl-3- [3- (5-m0rphoolin-4-ylmethyl-1h-benzoimidazol-2-yl) -lh-1-pyrazol- 4-yl] -urea
EP2049548A1 (en) 2006-07-27 2009-04-22 UCB Pharma, S.A. Fused oxazoles & thiazoles as histamine h3- receptor ligands
WO2008033564A1 (en) 2006-09-15 2008-03-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
WO2008114006A1 (en) 2007-03-19 2008-09-25 Astrazeneca Ab 9-substituted-8-oxo-adenine compounds as toll-like receptor (tlr7) modulators
WO2008140750A1 (en) 2007-05-10 2008-11-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function

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US20100152192A1 (en) 2010-06-17
EP2367825A1 (en) 2011-09-28
MX2011006132A (es) 2011-09-01
TW201022283A (en) 2010-06-16
WO2010070452A1 (en) 2010-06-24
EA201190004A1 (ru) 2012-11-30
CA2746077A1 (en) 2010-06-24
GEP20146099B (en) 2014-05-27
AU2009329192A2 (en) 2012-03-29
AU2009329192A1 (en) 2011-12-01
NZ595777A (en) 2013-07-26
US8318928B2 (en) 2012-11-27
JP2012512151A (ja) 2012-05-31

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