AR076123A1 - Dispositivo de suministro de droga zootecnica. metodo. - Google Patents

Dispositivo de suministro de droga zootecnica. metodo.

Info

Publication number
AR076123A1
AR076123A1 ARP100100818A ARP100100818A AR076123A1 AR 076123 A1 AR076123 A1 AR 076123A1 AR P100100818 A ARP100100818 A AR P100100818A AR P100100818 A ARP100100818 A AR P100100818A AR 076123 A1 AR076123 A1 AR 076123A1
Authority
AR
Argentina
Prior art keywords
zootechnical
drug delivery
delivery system
active compound
layer
Prior art date
Application number
ARP100100818A
Other languages
English (en)
Inventor
Marc Antoine Driancourt
Raymond Zeeman
Graaff Wouter De
Original Assignee
Intervet Int Bv
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intervet Int Bv, Organon Nv filed Critical Intervet Int Bv
Publication of AR076123A1 publication Critical patent/AR076123A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Sistema (dispositivo) de suministro de droga zootécnica veterinaria para la liberacion simultánea de dos o más sustancias activas, dicho sistema libera las sustancias activas en una relacion sustancialmente constante, durante un período prolongado. El sistema de suministro de droga puede estar bajo diferentes formas, tales como, por ejemplo, un implante o un dispositivo intravaginal, tal como un rollo helicoidal, un resorte o un anillo. Reivindicacion 1: Un sistema de suministro de droga zootécnica caracterizada porque comprende (i) una capa central polimérica termoplástica medicada, (ii) una capa intermedia polimérica termoplástica medicada y (iii) una capa de revestimiento polimérica termoplástica no medicada que cubre la capa intermedia, en el cual dicha capa central está cargada con cristales de un primer compuesto activo zootécnico y en el cual, dicha capa intermedia está cargada con cristales de un segundo compuesto activo. Reivindicacion 3: Un sistema de suministro de droga de acuerdo con las reivindicaciones 1 a [SIC] 3, en el cual dicho primer compuesto activo zootécnico es trembolona o las sales del mismo, y dicho segundo compuesto activo es un estrogeno, seleccionado entre el grupo que consiste en estradiol, etinil estradiol, estriol, estetrol y ésteres de los mismos. Reivindicacion 4: Un sistema de suministro de droga de acuerdo con las reivindicaciones 1 o 2, en el cual dicho primer compuesto activo a nivel zootécnico es trembolona o sales del mismo, y dicho segundo compuesto activo a nivel zootécnico es un progestogeno. Reivindicacion 5: Un sistema de suministro de droga de acuerdo con la reivindicacion 4, en el cual el progestogeno es altrenogest o acetato de melengestrol. Reivindicacion 7: Un sistema de suministro de droga de acuerdo con la reivindicacion 1, caracterizado porque al menos la capa de revestimiento -pero además también la capa central y la capa intermedia- comprenden copolímero de etileno y acetato de vinilo como el polímero termoplástico.
ARP100100818A 2009-03-17 2010-03-16 Dispositivo de suministro de droga zootecnica. metodo. AR076123A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16093909P 2009-03-17 2009-03-17
EP09155385 2009-03-17

Publications (1)

Publication Number Publication Date
AR076123A1 true AR076123A1 (es) 2011-05-18

Family

ID=42115744

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100818A AR076123A1 (es) 2009-03-17 2010-03-16 Dispositivo de suministro de droga zootecnica. metodo.

Country Status (10)

Country Link
US (2) US9198857B2 (es)
EP (1) EP2408423A2 (es)
AR (1) AR076123A1 (es)
AU (1) AU2010224957B2 (es)
BR (1) BRPI1009586A2 (es)
CA (1) CA2755828A1 (es)
MX (1) MX2011009679A (es)
UY (1) UY32492A (es)
WO (1) WO2010105995A2 (es)
ZA (1) ZA201106668B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2547332B1 (en) * 2010-03-16 2018-08-29 Titan Pharmaceuticals, Inc. Heterogeneous implantable devices for drug delivery
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
WO2019210066A1 (en) * 2018-04-27 2019-10-31 Evestra, Inc. Estrogen prodrugs and methods of administering estrogen prodrugs
CN112137975A (zh) * 2020-10-30 2020-12-29 厦门汇承药业有限公司 一种烯丙孕素片及其干法制备方法

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US3417182A (en) 1963-03-25 1968-12-17 Upjohn Co Compositions and treatments using 6-methyl - 16 - methylene - 17alpha - hydroxy-4,6-pregnadiene-3,20-dione 17-acetate
US4472394A (en) 1983-09-19 1984-09-18 G. D. Searle & Co. Method for increasing weight in domestic animals
EP0169894A4 (en) 1984-01-31 1986-11-21 Int Found Biochem Endocrino METHOD FOR PROMOTING GROWTH AND IMPROVING THE QUALITY OF THE MEAT OF BEEF ANIMALS WITH FEMALE STEROID HORMONES.
US5147869A (en) 1986-12-11 1992-09-15 Roussel Uclaf Zootechnical compositions
IE60964B1 (en) 1986-12-11 1994-09-07 Roussel Uclaf Zootechnical compositions containing a beta-adrenergic
TW358031B (en) 1997-04-11 1999-05-11 Akze Nobel N V Drug delivery system for 2 or more active substances
US7001609B1 (en) * 1998-10-02 2006-02-21 Regents Of The University Of Minnesota Mucosal originated drug delivery systems and animal applications
TWI336627B (en) * 2003-05-23 2011-02-01 Organon Nv Drug delivery system,and use and manufacturing method thereof
CA2559224C (en) 2004-03-24 2011-12-13 N.V. Organon Drug delivery system based on polyethylene vinylacetate copolymers
BRPI0719050A2 (pt) 2006-11-20 2013-11-05 Organon Nv Sistema veterinário medicado de forma helicoidal, e, métodos para controlar a função reprodutiva em um mamífero não humano fêmea, para otimizar o desempenho reprodutivo em um mamífero não humano fêmea e para fabricar o sistema de liberação de medicamento de três camadas.
TW200930343A (en) 2007-09-21 2009-07-16 Organon Nv Drug delivery system

Also Published As

Publication number Publication date
US9198857B2 (en) 2015-12-01
EP2408423A2 (en) 2012-01-25
ZA201106668B (en) 2014-03-26
CA2755828A1 (en) 2010-09-23
US20160038430A1 (en) 2016-02-11
UY32492A (es) 2010-10-29
AU2010224957B2 (en) 2016-07-21
MX2011009679A (es) 2011-09-30
AU2010224957A1 (en) 2011-09-29
WO2010105995A3 (en) 2011-01-20
WO2010105995A2 (en) 2010-09-23
BRPI1009586A2 (pt) 2016-03-08
US20120058171A1 (en) 2012-03-08

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