AR075898A1 - Derivados de amida como ligandos del receptor y5 del neuropeptido. - Google Patents

Derivados de amida como ligandos del receptor y5 del neuropeptido.

Info

Publication number
AR075898A1
AR075898A1 ARP100100893A ARP100100893A AR075898A1 AR 075898 A1 AR075898 A1 AR 075898A1 AR P100100893 A ARP100100893 A AR P100100893A AR P100100893 A ARP100100893 A AR P100100893A AR 075898 A1 AR075898 A1 AR 075898A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
phenyl
neuropeptide
ligands
Prior art date
Application number
ARP100100893A
Other languages
English (en)
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US16180209P priority Critical
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of AR075898A1 publication Critical patent/AR075898A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Se describe una serie de ligandos del receptor Y5 del neuropéptido Y, y como tales son utiles para tratar trastornos relacionados con el ánimo, estrés, ADHD, cognicion y demencia. Composicion farmacéutica y usos. Reivindicacion 1: Un compuesto de formula (1) donde R1 es alquilo C1-7, perfluoroalquilo C1-7, alcoxi C1-7 o halogeno; donde R2 es alquilo C1-7; donde R3 es H, alquilo C1-7, alcoxi C1-7, -(CH2)uOH, -N(R4)C(O)alquilo C1-7 o -N(R4)C(O)alcoxi C1-7; donde R4 es H o alquilo C1-7; donde X es -CH2-, -O-, -CH2O-, -NR5- o -CH2NR5-; donde R5 es H, alquilo C1-7, fenilo o piridilo, donde el fenilo y piridilo son opcionalmente sustituidos con alquilo C1-7, perfluoroalquilo C1-7, alcoxi C1-7 o halogeno; donde Ar es una porcion aromática divalente seleccionada del grupo formado por fenilo, piridina, pirimidina piridazina, pirazina, imidazol, pirazol, triazol, oxazol e isoxazol; donde cada m y n es independientemente un numero entero de 0 a 5 inclusive; donde u es 0 o 1; y donde cada t y s es independientemente un numero entero de 0 a 2 inclusive; o su sal farmacéuticamente aceptable.
ARP100100893A 2009-03-20 2010-03-19 Derivados de amida como ligandos del receptor y5 del neuropeptido. AR075898A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US16180209P true 2009-03-20 2009-03-20

Publications (1)

Publication Number Publication Date
AR075898A1 true AR075898A1 (es) 2011-05-04

Family

ID=42740244

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100893A AR075898A1 (es) 2009-03-20 2010-03-19 Derivados de amida como ligandos del receptor y5 del neuropeptido.

Country Status (19)

Country Link
US (1) US20120101078A1 (es)
EP (1) EP2408767B1 (es)
JP (1) JP2012521350A (es)
KR (1) KR20110136818A (es)
CN (1) CN102356079A (es)
AR (1) AR075898A1 (es)
AU (1) AU2010226553B2 (es)
BR (1) BRPI1014526A2 (es)
CA (1) CA2756003A1 (es)
CL (1) CL2011002319A1 (es)
CO (1) CO6430464A2 (es)
EA (1) EA201171149A1 (es)
IL (1) IL215226D0 (es)
MX (1) MX2011009886A (es)
NZ (1) NZ595265A (es)
SG (1) SG174472A1 (es)
TW (1) TW201103907A (es)
WO (1) WO2010108052A2 (es)
ZA (1) ZA201106812B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9968574B2 (en) 2009-05-15 2018-05-15 The University Of Kentucky Research Foundation Treatment of MCI and Alzheimer's disease
CN102984938A (zh) * 2010-05-13 2013-03-20 肯塔基大学研究基金会 轻度认知障碍(mci)和阿尔茨海默氏症的治疗方法
HU1700521A2 (en) 2017-12-15 2019-06-28 Richter Gedeon Nyrt Triazolobenzazepines

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399631B1 (en) * 1999-07-23 2002-06-04 Pfizer Inc. Carbazole neuropeptide Y5 antagonists
EP1202986B1 (en) * 1999-07-28 2005-10-12 Ortho-McNeil Pharmaceutical, Inc. Amine and amide derivatives as ligands for the neuropeptide y y5 receptor useful in the treatment of obesity and other disorders
WO2004089919A1 (ja) * 2003-04-02 2004-10-21 Banyu Pharmaceutical Co., Ltd. シクロヘキサンカルボキサミド誘導体
JP2006298909A (ja) * 2005-03-25 2006-11-02 Tanabe Seiyaku Co Ltd 医薬組成物

Also Published As

Publication number Publication date
EA201171149A1 (ru) 2012-03-30
CN102356079A (zh) 2012-02-15
EP2408767A4 (en) 2012-08-22
EP2408767A2 (en) 2012-01-25
MX2011009886A (es) 2011-09-30
WO2010108052A3 (en) 2011-02-24
BRPI1014526A2 (pt) 2016-04-05
US20120101078A1 (en) 2012-04-26
ZA201106812B (en) 2012-11-28
JP2012521350A (ja) 2012-09-13
AU2010226553B2 (en) 2012-05-31
NZ595265A (en) 2013-02-22
WO2010108052A2 (en) 2010-09-23
CL2011002319A1 (es) 2012-08-31
TW201103907A (en) 2011-02-01
EP2408767B1 (en) 2013-07-10
CO6430464A2 (es) 2012-04-30
AU2010226553A1 (en) 2011-10-13
KR20110136818A (ko) 2011-12-21
CA2756003A1 (en) 2010-09-23
SG174472A1 (en) 2011-10-28
IL215226D0 (en) 2011-12-29

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