AR075718A1 - Compuestos heterociclicos antivirales - Google Patents
Compuestos heterociclicos antiviralesInfo
- Publication number
- AR075718A1 AR075718A1 ARP100100641A ARP100100641A AR075718A1 AR 075718 A1 AR075718 A1 AR 075718A1 AR P100100641 A ARP100100641 A AR P100100641A AR P100100641 A ARP100100641 A AR P100100641A AR 075718 A1 AR075718 A1 AR 075718A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- dihydro
- oxo
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Son inhibidores de la polimerasa NS5b del virus de la hepatitis C. Se describen también composiciones y métodos para tratar una infeccion del HCV y para inhibir la replicacion del HCV. Reivindicacion 1: Un compuesto de la formula (1): A-R (1), en la que A es un resto heteroarilo elegido entre el grupo formado por 2-oxo-1,2-dihidro-piridin-3-ilo, 3-oxo-3, 4-dihidro-pirazin-2-ilo, 3-oxo-2,3-dihidro-piridazin-4-ilo, 2-oxo-1,2-dihidro-pirimidin-4-ona-5-ilo y 6-oxo-1,6-dihidro-[1,2,4]triazin-5-ilo, dicho heteroarilo está opcionalmente sustituido por halogeno, alquilo C1-6, haloalquilo C1-3 o alcoxi C1-6; R es un resto de formula (la), (Ib) o (Ic); X es NR4 u O; si X es O, X1 y X2 juntos son oxo, o uno de X1 y X2 es OH o alcoxi C1-3 y el otro. de X1 y X2 es hidrogeno; o, si X es NR4, X1 y X2 juntos son oxo; R3a es hidrogeno y R3b es CH2Ar o R3a y R3b juntos son =CHAr; Ar es fenilo, piridinilo, pirimidinilo, pirazinilo o piridazinilo opcionalmente sustituidos con independencia de una a tres veces por sustituyentes elegidos entre el grupo formado por hidroxi, alcoxi C1-6, alquilo C1-6, hidroxialquilo C1-6, halogeno, ciano, CO2R5, CONRcRd, acilamino C1-3, (CH2)nNRaRb, (CH2)nCONRcRd, (CH2)nSO2NRcRd, -O(CH2)nCONRcRd; Ra y Rb son con independencia hidrogeno, alquilo C1-6, acilo C1-6, alquilsulfonilo C1-6, haloalquilsulfonilo C1-6, cicloalquilsulfonilo C3-7, (cicloalquil C3-7)-alquil-sulfonilo C1-3 o (alcoxi C1-6)-alquilsulfonilo C1-6, SO2-(CH2)nNRcRd, carbamoilo, (alquil C1-3)-carbamoilo, di(alquil C1-3)-carbamoilo o benzoilo, dicho benzoílo está opcionalmente sustituido con independencia por uno o dos restos elegidos con independencia entre el grupo formado por amino, halogeno, alquilo C1-6 y (alquil C1-3)-sulfonilamido; Rc y Rd son con independencia hidrogeno, alquilo C1-6, acilo C1-6, o una amina cíclica; R1 es hidrogeno, alquiloxi C1-6 o haloalquiloxi C1-6 o R1 y R2a juntos son CH2-O y junto con los átomos a los que están unidos forman un 2,3-dihidrobenzofurano; R6 es hidrogeno o R6 y R2a juntos son CH2-O y junto con los átomos a los que están unidos forman un 2,3-dihidro-benzofurano; R4 es hidrogeno o alquilo C1-6; R5 es hidrogeno, alquilo C1-6, haloalquilo C1-6, (alcoxi C1-3)-alquilo C1-3 o bencilo opcionalmente sustituido; R2a, R2b y R2c (i) si se toman por separado se eligen con independencia entre alquilo C1-3, alcoxi C1-2, halogeno y fluoroalquilo C1-2 o (ii) si se toman juntos, R2a y R2b juntos son metileno C2-4 y R2c es alquilo C1-3, alcoxi C1-2, halogeno, ciano, carboxilo o fluoroalquilo C1-2; o (iii) o bien R1 o bien R6 y R2a juntos son CH2-O y junto con los átomos a los que están unidos forman un 2,3-dihidro-benzofurano y R2b y R2c son alquilo C1-3; n es con independencia de su aparicion un numero entero de cero a tres; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15820709P | 2009-03-06 | 2009-03-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR075718A1 true AR075718A1 (es) | 2011-04-20 |
Family
ID=42102526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100100641A AR075718A1 (es) | 2009-03-06 | 2010-03-04 | Compuestos heterociclicos antivirales |
Country Status (14)
Country | Link |
---|---|
US (1) | US8168792B2 (es) |
EP (1) | EP2403844A1 (es) |
JP (1) | JP2012519661A (es) |
KR (1) | KR20110122874A (es) |
CN (1) | CN102341382A (es) |
AR (1) | AR075718A1 (es) |
AU (1) | AU2010220374A1 (es) |
BR (1) | BRPI1016266A2 (es) |
CA (1) | CA2752443A1 (es) |
IL (1) | IL214288A0 (es) |
MX (1) | MX2011008641A (es) |
SG (1) | SG174252A1 (es) |
TW (1) | TW201035083A (es) |
WO (1) | WO2010100178A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2454966T3 (es) | 2007-02-01 | 2014-04-14 | Resverlogix Corp. | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
WO2010079431A2 (en) | 2009-01-08 | 2010-07-15 | Resverlogix Corp. | Compounds for the prevention and treatment of cardiovascular disease |
US10752611B2 (en) | 2009-02-27 | 2020-08-25 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
NZ595747A (en) * | 2009-03-18 | 2015-06-26 | Resverlogix Corp | Novel quinazolinones and related compounds for use as anti-inflammatory agents |
KR20190091564A (ko) | 2009-04-22 | 2019-08-06 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
ES2477342T3 (es) * | 2010-08-13 | 2014-07-16 | F. Hoffmann-La Roche Ag | Compuestos heteroc�clicos antivirales |
PT2773354T (pt) | 2011-11-01 | 2019-07-17 | Resverlogix Corp | Formulações orais de libertação imediata para quinazolinonas substituídas |
ES2611504T3 (es) | 2012-03-07 | 2017-05-09 | Institute Of Cancer Research: Royal Cancer Hospital (The) | Compuestos de isoquinolin-1-ona 3-aril-5-sustituida y sus usos terapéuticos |
WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
WO2014096965A2 (en) | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
TW201536789A (zh) | 2013-07-29 | 2015-10-01 | Enanta Pharm Inc | C型肝炎病毒抑制劑 |
AU2014320149A1 (en) | 2013-09-11 | 2016-04-07 | Institute Of Cancer Research: Royal Cancer Hospital (The) | 3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use |
JO3789B1 (ar) | 2015-03-13 | 2021-01-31 | Resverlogix Corp | التراكيب والوسائل العلاجية المعتمدة لمعالجة الامراض المتعلقة بالمتممة |
CN106810557B (zh) * | 2015-11-27 | 2021-05-04 | 南京圣和药物研发有限公司 | 杂环化合物及其应用 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
ATE357421T1 (de) | 1999-12-24 | 2007-04-15 | Asahi Glass Co Ltd | Siliziumnitrid filter und verfahren zu dessen herstellung |
WO2001085172A1 (en) | 2000-05-10 | 2001-11-15 | Smithkline Beecham Corporation | Novel anti-infectives |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
AR036081A1 (es) | 2001-06-07 | 2004-08-11 | Smithkline Beecham Corp | Compuesto de 1,2-dihidroquinolina, su uso para preparar una composicion farmaceutica, metodos para prepararlo y compuestos del acido 2-aminobenzoico n-alquilado de utilidad como intermediarios en dichos metodos |
AR035543A1 (es) | 2001-06-26 | 2004-06-16 | Japan Tobacco Inc | Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con |
WO2003007945A1 (en) | 2001-07-20 | 2003-01-30 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
US6899700B2 (en) | 2001-08-29 | 2005-05-31 | Kimberly-Clark Worldwide, Inc. | Therapeutic agent delivery tampon |
WO2003037262A2 (en) | 2001-10-29 | 2003-05-08 | Smithkline Beecham Corporation | Novel anit-infectives |
WO2003059356A2 (en) | 2001-10-30 | 2003-07-24 | Smithkline Beecham Corporation | Novel anti-infectives |
AU2003248566A1 (en) | 2002-05-24 | 2003-12-12 | Smithkline Beecham Corporation | Novel anti-infectives |
US20040097492A1 (en) * | 2002-11-01 | 2004-05-20 | Pratt John K | Anti-infective agents |
BR0315897A (pt) | 2002-11-01 | 2008-05-13 | Abbott Lab | agentes antiinfecciosos |
JP4738172B2 (ja) * | 2002-11-01 | 2011-08-03 | アボット・ラボラトリーズ | 抗感染薬 |
TWI332507B (en) | 2002-11-19 | 2010-11-01 | Hoffmann La Roche | Antiviral nucleoside derivatives |
AU2003300956A1 (en) | 2002-12-11 | 2004-06-30 | Smithkline Beecham Corporation | Anti-infectives |
WO2004052313A2 (en) | 2002-12-11 | 2004-06-24 | Smithkline Beecham Corporation | Anti-infectives |
AU2003297235A1 (en) | 2002-12-17 | 2004-07-22 | Smithkline Beecham Corporation | Anti-infectives |
WO2005019191A2 (en) | 2003-08-25 | 2005-03-03 | Abbott Laboratories | 1, 1-dioxido-4h-1,2,4-benzothiadiazine derivate und verwandte verbindungen als inhibitoren der hcv polymerase zur behandlung von hepatitis c |
RU2007110531A (ru) | 2004-08-23 | 2008-09-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Гетероциклические противовирусные соединения |
US20070163927A1 (en) | 2006-01-05 | 2007-07-19 | M-I L.L.C. | Vapor extracting and separator cleaning apparatus |
US8557848B2 (en) * | 2006-12-22 | 2013-10-15 | Merck Sharp & Dohme Corp. | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
ATE512954T1 (de) | 2007-09-17 | 2011-07-15 | Abbott Lab | Als inhibitoren des hepatitis-c-virus (hcv) geeignete n-phenyldioxohydropyrimidine |
PE20110409A1 (es) * | 2008-07-23 | 2011-06-22 | Hoffmann La Roche | Compuestos heterociclicos antiviricos |
MX2011010058A (es) | 2009-03-25 | 2011-10-11 | Abbott Lab | Compuestos antivirales y usos de los mismos. |
WO2010111437A1 (en) | 2009-03-25 | 2010-09-30 | Abbott Laboratories | Antiviral compounds and uses thereof |
AR077004A1 (es) * | 2009-06-09 | 2011-07-27 | Hoffmann La Roche | Compuestos heterociclicos antivirales |
-
2010
- 2010-03-03 MX MX2011008641A patent/MX2011008641A/es not_active Application Discontinuation
- 2010-03-03 BR BRPI1016266A patent/BRPI1016266A2/pt not_active IP Right Cessation
- 2010-03-03 WO PCT/EP2010/052661 patent/WO2010100178A1/en active Application Filing
- 2010-03-03 AU AU2010220374A patent/AU2010220374A1/en not_active Abandoned
- 2010-03-03 TW TW099106187A patent/TW201035083A/zh unknown
- 2010-03-03 SG SG2011063781A patent/SG174252A1/en unknown
- 2010-03-03 CN CN2010800106504A patent/CN102341382A/zh active Pending
- 2010-03-03 EP EP10706244A patent/EP2403844A1/en not_active Withdrawn
- 2010-03-03 CA CA2752443A patent/CA2752443A1/en not_active Abandoned
- 2010-03-03 KR KR1020117023397A patent/KR20110122874A/ko not_active Application Discontinuation
- 2010-03-03 JP JP2011552427A patent/JP2012519661A/ja active Pending
- 2010-03-04 AR ARP100100641A patent/AR075718A1/es unknown
- 2010-03-05 US US12/718,207 patent/US8168792B2/en not_active Expired - Fee Related
-
2011
- 2011-07-26 IL IL214288A patent/IL214288A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
SG174252A1 (en) | 2011-10-28 |
TW201035083A (en) | 2010-10-01 |
US8168792B2 (en) | 2012-05-01 |
US20100226879A1 (en) | 2010-09-09 |
WO2010100178A1 (en) | 2010-09-10 |
EP2403844A1 (en) | 2012-01-11 |
CA2752443A1 (en) | 2010-09-10 |
JP2012519661A (ja) | 2012-08-30 |
KR20110122874A (ko) | 2011-11-11 |
BRPI1016266A2 (pt) | 2019-09-24 |
IL214288A0 (en) | 2011-09-27 |
MX2011008641A (es) | 2011-09-06 |
AU2010220374A1 (en) | 2011-09-01 |
CN102341382A (zh) | 2012-02-01 |
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