AR075104A1 - Compuesto de piperazin-aril-purina, su uso para preparar un medicamento util para el tratamiento del dolor y composicion farmaceutica que lo comprende - Google Patents
Compuesto de piperazin-aril-purina, su uso para preparar un medicamento util para el tratamiento del dolor y composicion farmaceutica que lo comprendeInfo
- Publication number
- AR075104A1 AR075104A1 ARP090104628A ARP090104628A AR075104A1 AR 075104 A1 AR075104 A1 AR 075104A1 AR P090104628 A ARP090104628 A AR P090104628A AR P090104628 A ARP090104628 A AR P090104628A AR 075104 A1 AR075104 A1 AR 075104A1
- Authority
- AR
- Argentina
- Prior art keywords
- pain
- piperazin
- prepare
- treatment
- pharmaceutical composition
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- KVVMXWRFYAGASO-UHFFFAOYSA-N azetidine-1-carboxylic acid Chemical compound OC(=O)N1CCC1 KVVMXWRFYAGASO-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 230000003349 osteoarthritic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 abstract 1
- -1 tetrahydrothiophene-1,1-dioxide methyl ester Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13858908P | 2008-12-18 | 2008-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075104A1 true AR075104A1 (es) | 2011-03-09 |
Family
ID=41719189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090104628A AR075104A1 (es) | 2008-12-18 | 2009-12-01 | Compuesto de piperazin-aril-purina, su uso para preparar un medicamento util para el tratamiento del dolor y composicion farmaceutica que lo comprende |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8252798B2 (enExample) |
| EP (1) | EP2379555B1 (enExample) |
| JP (1) | JP5559812B2 (enExample) |
| KR (1) | KR101319630B1 (enExample) |
| CN (1) | CN102256977B (enExample) |
| AR (1) | AR075104A1 (enExample) |
| AU (1) | AU2009335997B2 (enExample) |
| BR (1) | BRPI0923195A2 (enExample) |
| CA (1) | CA2746740C (enExample) |
| CL (1) | CL2011001464A1 (enExample) |
| CO (1) | CO6390101A2 (enExample) |
| CR (1) | CR20110340A (enExample) |
| DO (1) | DOP2011000196A (enExample) |
| EA (1) | EA018386B1 (enExample) |
| EC (1) | ECSP11011151A (enExample) |
| ES (1) | ES2536880T3 (enExample) |
| HN (1) | HN2011001700A (enExample) |
| IL (1) | IL213167A (enExample) |
| MA (1) | MA32904B1 (enExample) |
| MX (1) | MX2011006442A (enExample) |
| NZ (1) | NZ593088A (enExample) |
| PA (1) | PA8851501A1 (enExample) |
| PE (1) | PE20110999A1 (enExample) |
| SG (1) | SG172253A1 (enExample) |
| TN (1) | TN2011000291A1 (enExample) |
| TW (1) | TWI376378B (enExample) |
| UA (1) | UA104010C2 (enExample) |
| WO (1) | WO2010080306A1 (enExample) |
| ZA (1) | ZA201103943B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2923734B1 (en) * | 2009-03-13 | 2018-01-10 | Katholieke Universiteit Leuven, K.U. Leuven R&D | Purine analogues and their use as immunosuppressive agents |
| EP2470508A1 (en) | 2009-08-28 | 2012-07-04 | Arena Pharmaceuticals, Inc. | Cannabinoid receptor modulators |
| US20130096104A1 (en) * | 2010-03-17 | 2013-04-18 | Genentech, Inc. | Imidazopyridine compounds, compositions and methods of use |
| AR080711A1 (es) | 2010-03-31 | 2012-05-02 | Lilly Co Eli | Compuesto de piperazin-purina composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento o prevencion del dolor |
| CN102803263B (zh) * | 2010-03-31 | 2014-12-17 | 伊莱利利公司 | 用作cb2激动剂的嘌呤化合物 |
| RU2013114352A (ru) | 2010-09-15 | 2014-10-20 | Ф. Хоффманн-Ля Рош Аг | Азабензотиазолы, композиции и способы применения |
| KR20140009259A (ko) | 2010-11-19 | 2014-01-22 | 에프. 호프만-라 로슈 아게 | 피라졸로피리딘 및 tyk2 억제제로서 이의 용도 |
| JP5945554B2 (ja) | 2011-02-25 | 2016-07-05 | アリーナ ファーマシューティカルズ， インコーポレイテッド | 縮合型アザ環の結晶形およびその調製プロセス（カンナビノイド受容体モジュレーター） |
| MX392150B (es) | 2011-02-25 | 2025-03-21 | Arena Pharm Inc | Moduladores de receptores canabinoides. |
| US9597340B2 (en) | 2011-02-25 | 2017-03-21 | Arena Pharmaceuticals, Inc. | Cannabinoid receptor modulators |
| BR112014006643A2 (pt) * | 2011-09-20 | 2017-04-04 | Hoffmann La Roche | compostos de imidazopiridina, composições e métodos de uso dos mesmos |
| US9067943B2 (en) * | 2011-11-25 | 2015-06-30 | Hoffmann-La Roche Inc. | [1,2,3]triazolo[4,5-D]pyrimidine derivatives |
| PE20151140A1 (es) * | 2012-08-16 | 2015-08-07 | Janssen Pharmaceutica Nv | Pirazoles sustituidos como bloqueadores del canal de calcio tipo n |
| WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
| BR112015027394A8 (pt) * | 2013-05-02 | 2018-01-30 | Hoffmann La Roche | derivados de pirrolo[2,3-d]pirimidina como agonistas de receptor cb2 |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| WO2017052394A1 (en) * | 2015-09-23 | 2017-03-30 | Uniwersytet Jagielloński | Imidazopyridine compounds and their use as 5-ht6 receptor ligands |
| WO2018137176A1 (en) * | 2017-01-25 | 2018-08-02 | Eli Lilly And Company | Treatment for nonalcoholic steatohepatitis and fibrosis |
| WO2017181317A1 (en) * | 2016-04-18 | 2017-10-26 | Eli Lilly And Company | Treatment for nonalcoholic steatohepatitis and fibrosis |
| WO2017184412A1 (en) | 2016-04-18 | 2017-10-26 | Eli Lilly And Company | Purine cannabinoid agonist for treating nonalcoholic steatohepatitis and fibrosis |
| EP3558996A4 (en) * | 2016-12-21 | 2020-08-05 | Research Triangle Institute, International | DIARYLPURINE DERIVATIVES WITH ENHANCED BIOAVAILABILITY |
| US20200078358A1 (en) | 2017-05-08 | 2020-03-12 | Arena Pharmaceuticals, Inc. | Compounds and Methods for Treatment of Visceral Pain |
| WO2024017227A1 (zh) * | 2022-07-21 | 2024-01-25 | 长春金赛药业有限责任公司 | 取代的稠环大麻素受体化合物及其应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60260579A (ja) * | 1984-01-13 | 1985-12-23 | Yoshitomi Pharmaceut Ind Ltd | プリン誘導体 |
| NZ225447A (en) | 1987-07-20 | 1991-12-23 | Merck & Co Inc | Piperazinyl derivatives of purine and purine isosteres and pharmaceutical compositions |
| US5057517A (en) * | 1987-07-20 | 1991-10-15 | Merck & Co., Inc. | Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents |
| GB0003960D0 (en) * | 2000-02-18 | 2000-04-12 | Pfizer Ltd | Purine derivatives |
| WO2003022214A2 (en) | 2001-09-06 | 2003-03-20 | Millennium Pharmaceuticals, Inc. | Piperazine and homopiperazine compounds |
| US20030139427A1 (en) * | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
| US7129239B2 (en) * | 2002-10-28 | 2006-10-31 | Pfizer Inc. | Purine compounds and uses thereof |
| US20040224962A1 (en) * | 2003-05-09 | 2004-11-11 | Pfizer Inc | Pharmaceutical composition for the treatment of obesity or to facilitate or promote weight loss |
| US20050043327A1 (en) * | 2003-08-21 | 2005-02-24 | Pfizer Inc | Pharmaceutical composition for the prevention and treatment of addiction in a mammal |
| US20050153989A1 (en) | 2004-01-13 | 2005-07-14 | Ambit Biosciences Corporation | Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases |
| CN101044143A (zh) * | 2004-10-22 | 2007-09-26 | 辉瑞产品公司 | 制备嘌呤化合物的方法 |
| WO2006128172A2 (en) | 2005-05-26 | 2006-11-30 | Synta Pharmaceuticals Corp. | Method for treating b cell regulated autoimmune disorders |
| HRP20120786T1 (hr) * | 2006-02-02 | 2012-11-30 | Millennium Pharmaceuticals, Inc. | Inhibitori aktivirajuä†eg enzima e1 |
| JP2013512245A (ja) * | 2009-11-24 | 2013-04-11 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 脂肪酸合成酵素阻害剤としてのアザベンズイミダゾール |
| AR080711A1 (es) * | 2010-03-31 | 2012-05-02 | Lilly Co Eli | Compuesto de piperazin-purina composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para el tratamiento o prevencion del dolor |
-
2009
- 2009-09-12 UA UAA201107563A patent/UA104010C2/ru unknown
- 2009-12-01 AR ARP090104628A patent/AR075104A1/es not_active Application Discontinuation
- 2009-12-01 PA PA20098851501A patent/PA8851501A1/es unknown
- 2009-12-04 TW TW098141555A patent/TWI376378B/zh not_active IP Right Cessation
- 2009-12-09 JP JP2011542246A patent/JP5559812B2/ja not_active Expired - Fee Related
- 2009-12-09 MX MX2011006442A patent/MX2011006442A/es active IP Right Grant
- 2009-12-09 CN CN200980150689.3A patent/CN102256977B/zh not_active Expired - Fee Related
- 2009-12-09 EP EP09768474.0A patent/EP2379555B1/en not_active Not-in-force
- 2009-12-09 CA CA2746740A patent/CA2746740C/en not_active Expired - Fee Related
- 2009-12-09 SG SG2011044773A patent/SG172253A1/en unknown
- 2009-12-09 US US12/633,812 patent/US8252798B2/en not_active Expired - Fee Related
- 2009-12-09 AU AU2009335997A patent/AU2009335997B2/en not_active Ceased
- 2009-12-09 ES ES09768474.0T patent/ES2536880T3/es active Active
- 2009-12-09 KR KR1020117014000A patent/KR101319630B1/ko not_active Expired - Fee Related
- 2009-12-09 NZ NZ593088A patent/NZ593088A/xx not_active IP Right Cessation
- 2009-12-09 PE PE2011001219A patent/PE20110999A1/es not_active Application Discontinuation
- 2009-12-09 WO PCT/US2009/067249 patent/WO2010080306A1/en not_active Ceased
- 2009-12-09 EA EA201170832A patent/EA018386B1/ru not_active IP Right Cessation
- 2009-12-09 BR BRPI0923195A patent/BRPI0923195A2/pt not_active Application Discontinuation
-
2011
- 2011-05-26 IL IL213167A patent/IL213167A/en not_active IP Right Cessation
- 2011-05-27 ZA ZA2011/03943A patent/ZA201103943B/en unknown
- 2011-06-09 TN TN2011000291A patent/TN2011000291A1/fr unknown
- 2011-06-14 MA MA33947A patent/MA32904B1/fr unknown
- 2011-06-16 CL CL2011001464A patent/CL2011001464A1/es unknown
- 2011-06-17 HN HN2011001700A patent/HN2011001700A/es unknown
- 2011-06-17 EC EC2011011151A patent/ECSP11011151A/es unknown
- 2011-06-17 CR CR20110340A patent/CR20110340A/es unknown
- 2011-06-17 DO DO2011000196A patent/DOP2011000196A/es unknown
- 2011-06-23 CO CO11079298A patent/CO6390101A2/es active IP Right Grant
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |