AR073675A1 - Metodos para determinar la eficacia de los ligandos de los intercambiadores de sodio-proton - Google Patents
Metodos para determinar la eficacia de los ligandos de los intercambiadores de sodio-protonInfo
- Publication number
- AR073675A1 AR073675A1 ARP090103681A ARP090103681A AR073675A1 AR 073675 A1 AR073675 A1 AR 073675A1 AR P090103681 A ARP090103681 A AR P090103681A AR P090103681 A ARP090103681 A AR P090103681A AR 073675 A1 AR073675 A1 AR 073675A1
- Authority
- AR
- Argentina
- Prior art keywords
- cell
- ionic channel
- sodium
- methods
- effectiveness
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Hospice & Palliative Care (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
La presente se refiere a métodos para determinar la eficacia de un ligando de canal ionico que comprende (a) poner en contacto una célula que expresa el canal ionico con (i) plasma de un animal y (ii) el ligando del canal ionico y (b) determinar el efecto del ligando del canal ionico sobre la célula. Reivindicacion 2: El método de la reivindicacion 1, en el que el canal ionico es un intercambiador de sodio-proton (NHE) o un cotransportador de sodio-bicarbonato. Reivindicacion 5: El método de cualquiera de las reivindicaciones 1 a 4, en el que la célula es una línea celular, particularmente una línea celular de un mamífero, particularmente una línea celular de un ser humano o de un raton, especialmente LAP1 de la línea celular LTK de raton. Reivindicacion 9: El método de cualquiera de las reivindicaciones 1 a 8, en el que el efecto es una alteracion del valor intracelular de pH. Reivindicacion 13: El método de cualquiera de las reivindicaciones 1 a 12, en el que el método se usa para el cribado de un medicamento para prevenir y/o tratar una enfermedad que implica una disfuncion de un canal ionico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290916A EP2175274A1 (en) | 2008-09-26 | 2008-09-26 | Methods for determining sodium-proton-exchanger ligand efficiency |
| EP09290028A EP2209004A1 (en) | 2009-01-12 | 2009-01-12 | Methods for determining sodium-proton-exchanger ligand efficiency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073675A1 true AR073675A1 (es) | 2010-11-24 |
Family
ID=41168404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103681A AR073675A1 (es) | 2008-09-26 | 2009-09-24 | Metodos para determinar la eficacia de los ligandos de los intercambiadores de sodio-proton |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8546102B2 (es) |
| EP (1) | EP2350666A1 (es) |
| JP (1) | JP5453435B2 (es) |
| KR (1) | KR20110076900A (es) |
| CN (1) | CN102227640A (es) |
| AR (1) | AR073675A1 (es) |
| AU (1) | AU2009295818A1 (es) |
| BR (1) | BRPI0920866A2 (es) |
| CA (1) | CA2738327A1 (es) |
| IL (1) | IL211882A0 (es) |
| MX (1) | MX2011002612A (es) |
| RU (1) | RU2519345C2 (es) |
| TW (1) | TW201024733A (es) |
| WO (1) | WO2010034801A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8694280B2 (en) * | 2009-09-28 | 2014-04-08 | International Business Machines Corporation | Servo control circuit for detecting analytes via nanoparticle-labeled substances with electromagnetic read-write heads |
| US9304130B2 (en) | 2010-12-16 | 2016-04-05 | International Business Machines Corporation | Trenched sample assembly for detection of analytes with electromagnetic read-write heads |
| US9435800B2 (en) | 2012-09-14 | 2016-09-06 | International Business Machines Corporation | Sample assembly with an electromagnetic field to accelerate the bonding of target antigens and nanoparticles |
| EP3370737B1 (en) | 2015-11-04 | 2021-09-22 | Prescient Pharma LLC | Anti-aging compositions and methods for using same |
| BR112018008928A2 (pt) * | 2015-11-04 | 2019-04-30 | Vivia Biotech, S.L | um método ex vivo para testar a capacidade de resposta celular de populações de células primárias a um fármaco ou combinação de fármacos |
| US20220057405A1 (en) * | 2019-02-25 | 2022-02-24 | Absorption Systems Llc | Cells and methods for evaluating the activity of organic anion transporting polypeptide 2a1 (oatp2a1) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5380649A (en) | 1987-04-10 | 1995-01-10 | Boehringer Mannheim Gmbh | Enzymatic determination of analyte ions in fluids by optimizing measurement levels |
| US5334507A (en) | 1991-09-20 | 1994-08-02 | Toyo Boseki Kabushiki Kaisha | Composition for measurement of potassium ion concentration and composition for elimination of ammonium ions |
| JPH07203991A (ja) | 1994-01-24 | 1995-08-08 | Kyowa Medex Co Ltd | カリウムイオンの定量方法 |
| AUPQ223999A0 (en) * | 1999-08-16 | 1999-09-09 | University Of Sydney, The | Intracellular feedback controls in the diagnosis and treatment of human disease |
| AU2001284974A1 (en) * | 2000-08-16 | 2002-02-25 | The Trustees Of Columbia University In The City Of New York | Quantitative assessment of erbb/her receptors in biological fluids |
| JP2002223762A (ja) * | 2001-01-30 | 2002-08-13 | Takeda Chem Ind Ltd | 新規タンパク質およびそのｄｎａ |
| CA2549303A1 (en) * | 2003-12-12 | 2005-06-30 | Wyeth | Novel sodium channel |
| DE102004059781A1 (de) * | 2004-12-10 | 2006-06-22 | Sanofi-Aventis Deutschland Gmbh | Verwendung der Serum-/Glucocorticoid regulierten Kinase |
-
2009
- 2009-09-24 AR ARP090103681A patent/AR073675A1/es not_active Application Discontinuation
- 2009-09-24 TW TW098132201A patent/TW201024733A/zh unknown
- 2009-09-25 MX MX2011002612A patent/MX2011002612A/es not_active Application Discontinuation
- 2009-09-25 JP JP2011528335A patent/JP5453435B2/ja not_active Expired - Fee Related
- 2009-09-25 KR KR1020117006987A patent/KR20110076900A/ko not_active Application Discontinuation
- 2009-09-25 CA CA2738327A patent/CA2738327A1/en not_active Abandoned
- 2009-09-25 RU RU2011116421/15A patent/RU2519345C2/ru not_active IP Right Cessation
- 2009-09-25 BR BRPI0920866A patent/BRPI0920866A2/pt not_active IP Right Cessation
- 2009-09-25 US US13/063,497 patent/US8546102B2/en not_active Expired - Fee Related
- 2009-09-25 EP EP09815690A patent/EP2350666A1/en not_active Withdrawn
- 2009-09-25 CN CN2009801473601A patent/CN102227640A/zh active Pending
- 2009-09-25 AU AU2009295818A patent/AU2009295818A1/en not_active Abandoned
- 2009-09-25 WO PCT/EP2009/062428 patent/WO2010034801A1/en active Application Filing
-
2011
- 2011-03-23 IL IL211882A patent/IL211882A0/en unknown
-
2013
- 2013-09-04 US US14/017,854 patent/US20140106366A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0920866A2 (pt) | 2015-12-22 |
| EP2350666A1 (en) | 2011-08-03 |
| US8546102B2 (en) | 2013-10-01 |
| RU2519345C2 (ru) | 2014-06-10 |
| US20110262955A1 (en) | 2011-10-27 |
| KR20110076900A (ko) | 2011-07-06 |
| JP2012503765A (ja) | 2012-02-09 |
| AU2009295818A1 (en) | 2010-04-01 |
| WO2010034801A1 (en) | 2010-04-01 |
| US20140106366A1 (en) | 2014-04-17 |
| CN102227640A (zh) | 2011-10-26 |
| JP5453435B2 (ja) | 2014-03-26 |
| IL211882A0 (en) | 2011-06-30 |
| MX2011002612A (es) | 2011-04-07 |
| RU2011116421A (ru) | 2012-11-10 |
| CA2738327A1 (en) | 2010-04-01 |
| TW201024733A (en) | 2010-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |