AR073056A1 - Mejoras relacionadas a composiciones nanodispersas. - Google Patents

Mejoras relacionadas a composiciones nanodispersas.

Info

Publication number
AR073056A1
AR073056A1 ARP090103143A ARP090103143A AR073056A1 AR 073056 A1 AR073056 A1 AR 073056A1 AR P090103143 A ARP090103143 A AR P090103143A AR P090103143 A ARP090103143 A AR P090103143A AR 073056 A1 AR073056 A1 AR 073056A1
Authority
AR
Argentina
Prior art keywords
asset
carrier
water
solvent
water insoluble
Prior art date
Application number
ARP090103143A
Other languages
English (en)
Inventor
Dong Wang
Alison Jayne Foster
Steven Paul Rannard
David John Duncalf
Doris Angus
Original Assignee
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Nv filed Critical Unilever Nv
Publication of AR073056A1 publication Critical patent/AR073056A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Colloid Chemistry (AREA)

Abstract

Un procedimiento para la produccion de una composicion hidrosoluble que comprende un activo insoluble en agua que comprende las siguientes etapas: a) proporcionar una mezcla líquida que comprende: i) un activo insoluble en agua disuelto, ii) un portador hidrosoluble disuelto, iii) un solvente para cada uno de los activos y el portador, y b) granular por pulverizacion la mezcla para remover el solvente, o cada solvente, y obtener una nanodispersion sustancialmente libre de solvente del activo insoluble en agua en el portador, dicho activo insoluble en agua se encuentra en nanopartículas que tienen un rango de tamano que oscila entre 999 y 20 nm; o las siguientes etapas: a) proporcionar un polvo sustancialmente libre de solvente que comprende un activo insoluble en agua disperso en el portador soluble en agua, dicho activo insoluble en agua se presenta como nanopartículas que tienen un rango de tamano que oscila entre 999 y 20 nm, y b) granular por pulverizacion el polvo para obtener partículas más grandes y más densas. La solicitud también se refiere a productos granulados libres de solvente con un tamano de partícula que oscila entre 20 micrones y 10 mm y una densidad aparente superior a 0,4 g/cm3 que comprende un material portador hidrosoluble, el material portador tiene allí disperso un activo insoluble en agua, donde tras la adicion de agua el portador se disuelve para formar una dispersion acuosa del activo con un tamano de partícula pico (promedio Z) inferior a 800 nm, preferentemente, inferior a 500 nm, y con mayor preferencia, inferior a 200 nm. La solicitud también se refiere a un procedimiento ôinversoö en el cual el activo es hidrosoluble y el portador es soluble en aceite.
ARP090103143A 2008-08-18 2009-08-14 Mejoras relacionadas a composiciones nanodispersas. AR073056A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0814953.6A GB0814953D0 (en) 2008-08-18 2008-08-18 Improvements relating to nanodisperse compositions

Publications (1)

Publication Number Publication Date
AR073056A1 true AR073056A1 (es) 2010-10-13

Family

ID=39812108

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103143A AR073056A1 (es) 2008-08-18 2009-08-14 Mejoras relacionadas a composiciones nanodispersas.

Country Status (12)

Country Link
US (1) US20110217340A1 (es)
EP (1) EP2326309A2 (es)
CN (1) CN102149367A (es)
AR (1) AR073056A1 (es)
AU (1) AU2009284226A1 (es)
BR (1) BRPI0917336A2 (es)
CA (1) CA2734356A1 (es)
GB (1) GB0814953D0 (es)
IL (1) IL210992A0 (es)
MX (1) MX2011001882A (es)
WO (1) WO2010020518A2 (es)
ZA (1) ZA201101730B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201006038D0 (en) * 2010-04-12 2010-05-26 Unilever Plc Improvements relating to antiviral compositions
JP2012197243A (ja) * 2011-03-22 2012-10-18 Sumitomo Chemical Co Ltd 除草組成物および雑草の防除方法
CN104739771A (zh) * 2014-10-31 2015-07-01 合肥平光制药有限公司 一种不含溶剂的纳米分散体及其制备方法、应用
EP3165218A1 (en) * 2015-11-06 2017-05-10 INDENA S.p.A. Water dispersible granulates containing oxidized or reduced forms of coenzyme q10
US20210252467A1 (en) * 2018-08-30 2021-08-19 Boehringer Ingelheim International Gmbh Novel, lean and environment-friendly granulation method
US11433070B2 (en) 2019-06-28 2022-09-06 The Procter & Gamble Company Synergistic anti-inflammatory compositions
US11980612B2 (en) 2020-06-26 2024-05-14 The Procter & Gamble Company Synergistic anti-inflammatory compositions
CN112426373B (zh) * 2020-11-27 2021-07-27 佛山市南海东方澳龙制药有限公司 一种具有治疗体外寄生虫皮肤病和抗菌功能的宠物香波及制备方法
US11701316B2 (en) 2020-12-18 2023-07-18 The Procter & Gamble Company Synergistic anti-inflammatory compositions
CN114854088B (zh) * 2022-06-01 2023-08-11 江苏极易新材料有限公司 一种复合抗氧剂颗粒化的制备方法

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
US4830858A (en) * 1985-02-11 1989-05-16 E. R. Squibb & Sons, Inc. Spray-drying method for preparing liposomes and products produced thereby
US5547683A (en) * 1992-10-09 1996-08-20 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Method for producing microgranulated particle
DE4407898A1 (de) * 1994-03-09 1995-09-14 Hoechst Ag Nanopartikel, enthaltend einen Wirkstoff und ein Polyketalweinsäureamid, Verfahren zu ihrer Herstellung und Verwendung derselben
AUPM855194A0 (en) * 1994-10-04 1994-10-27 Csl Limited Controlled-release pharmaceutical preparations
WO1997014407A1 (en) * 1995-10-17 1997-04-24 Research Triangle Pharmaceuticals Insoluble drug delivery
AU6014098A (en) * 1996-12-31 1998-07-31 Inhale Therapeutic Systems Aerosolized hydrophobic drug
UA74141C2 (uk) * 1998-12-09 2005-11-15 Дж.Д. Сірл Енд Ко. Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти)
EP1058539A1 (en) * 1999-01-06 2000-12-13 Korea Research Institute Of Chemical Technology Method of preparing pharmaceutical active ingredient comprising water-insoluble drug and pharmaceutical composition for oral administration comprising the same
KR100694667B1 (ko) * 1999-12-08 2007-03-14 동아제약주식회사 생체내이용률 향상과 개인간 및 개인내 흡수 편차를감소시킨 이트라코나졸 함유 항진균성 제제
AU2001282886A1 (en) * 2000-07-13 2002-01-30 Pharmacia Corporation Combination of a cox-2 inhibitor and a vasomodulator for treating pain and headache pain
KR20040055798A (ko) * 2001-11-07 2004-06-26 바스프 악티엔게젤샤프트 시니돈-에틸 함유 고체 작물보호 배합물 및 상응하는 분산액
US8268352B2 (en) * 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
US20070196471A1 (en) * 2004-04-02 2007-08-23 Thosar Shilpa S Micronized Eplerenone Compositions
WO2005117834A1 (en) * 2004-05-27 2005-12-15 Janssen Pharmaceutica N.V. Solid dispersions of a basic drug compound and a polymer containing acidic groups
RU2007120253A (ru) * 2004-12-02 2009-01-10 Вайет (Us) Составы, содержащие замещенные бензоксазолы
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
GB0501835D0 (en) * 2005-01-28 2005-03-09 Unilever Plc Improvements relating to spray dried compositions
GB0613925D0 (en) * 2006-07-13 2006-08-23 Unilever Plc Improvements relating to nanodispersions

Also Published As

Publication number Publication date
WO2010020518A2 (en) 2010-02-25
CA2734356A1 (en) 2010-02-25
ZA201101730B (en) 2012-05-30
IL210992A0 (en) 2011-04-28
WO2010020518A3 (en) 2010-10-14
BRPI0917336A2 (pt) 2015-11-17
CN102149367A (zh) 2011-08-10
GB0814953D0 (en) 2008-09-24
US20110217340A1 (en) 2011-09-08
EP2326309A2 (en) 2011-06-01
AU2009284226A1 (en) 2010-02-25
MX2011001882A (es) 2011-03-25

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