AR072624A1 - Derivados de estreptospirol, un metodo para su preparacion, una composicion farmaceutica que lo comprende, su uso en la fabricacion de un medicamento para el tratamiento de infecciones bacterianas y una cepa de streptomyces sp.st 108140 (dsm 19369) - Google Patents

Derivados de estreptospirol, un metodo para su preparacion, una composicion farmaceutica que lo comprende, su uso en la fabricacion de un medicamento para el tratamiento de infecciones bacterianas y una cepa de streptomyces sp.st 108140 (dsm 19369)

Info

Publication number
AR072624A1
AR072624A1 ARP090102887A ARP090102887A AR072624A1 AR 072624 A1 AR072624 A1 AR 072624A1 AR P090102887 A ARP090102887 A AR P090102887A AR P090102887 A ARP090102887 A AR P090102887A AR 072624 A1 AR072624 A1 AR 072624A1
Authority
AR
Argentina
Prior art keywords
alkyl
dsm
preparation
streptomyces
pharmaceutical composition
Prior art date
Application number
ARP090102887A
Other languages
English (en)
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR072624A1 publication Critical patent/AR072624A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un procedimeinto para la preparacion de dichos compuestos fermentando el microorganismo Streptomyces sp. ST 108140 (DSM 19369) y opcionalmente derivando los compuestos producidos por dicho microorganismo, una composicion farmacéutica que comprende al menos un compuesto de la formula (1), y el uso de un compuesto de la formula (1) para la preparacion de un medicamento para el tratamiento y/o profilaxis de infecciones bacterianas. Cepa del microorganismo Streptomyces sp. ST 108140 (DSM 19369). Reivindicacion 1: Un compuesto de la formula (1) en la que R1 es alquilo (C6-7), R2 es H, alquilo (C1-6) o alquileno (C1-6)-OH, R3 es H o alquilo (C1-6), X1 es halogeno, O-alquilo (C1-6), NH[alquilo (C1-6)], NH[alquilen (C1-4)-arilo (C6-10)], NH[alquilen (C1-4)-heteroarilo (C6-10)] o S-alquilen (C1-4)-N[alquilo (C1-4)]2, X2 es halogeno, e Y1 e Y2 son independientemente uno de otro H; OH; NH[alquilo (C1-6)]; NH[alquilen (C1-4)-arilo (C6-10)] en el que el grupo arilo (C610) se sustituye opcionalmente por halogeno; NH[alquilen (C1-4)-heteroarilo (C610)]; un sistema anular heterocíclico saturado o insaturado que contiene 5 a 6 átomos de anillo opcionalmente sustituidos por alquilo (C1-6) en el que uno o 2 átomos de anillo son N, O o S; o Y1 e Y2 juntos son =O, o una sal fisiologicamente tolerada de un compuesto de la formula (1).
ARP090102887A 2008-07-31 2009-07-29 Derivados de estreptospirol, un metodo para su preparacion, una composicion farmaceutica que lo comprende, su uso en la fabricacion de un medicamento para el tratamiento de infecciones bacterianas y una cepa de streptomyces sp.st 108140 (dsm 19369) AR072624A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08167138 2008-07-31

Publications (1)

Publication Number Publication Date
AR072624A1 true AR072624A1 (es) 2010-09-08

Family

ID=40054222

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102887A AR072624A1 (es) 2008-07-31 2009-07-29 Derivados de estreptospirol, un metodo para su preparacion, una composicion farmaceutica que lo comprende, su uso en la fabricacion de un medicamento para el tratamiento de infecciones bacterianas y una cepa de streptomyces sp.st 108140 (dsm 19369)

Country Status (5)

Country Link
US (1) US8765799B2 (es)
EP (1) EP2321322B1 (es)
JP (1) JP5619001B2 (es)
AR (1) AR072624A1 (es)
WO (1) WO2010012381A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103667073B (zh) * 2013-09-27 2016-04-13 浙江工业大学 蛇足石杉内生真菌及其在制备吡咯类护肝药中的应用
CN112979665B (zh) * 2021-02-07 2021-11-19 南通大学 一种灰黄霉素施密特重排衍生物及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10146910A1 (de) 2001-09-24 2003-04-10 Bayer Cropscience Ag Spirocyclische 3-Phenyl-3-substituierte-4-ketolaktame und -laktone
US7250438B2 (en) 2004-06-08 2007-07-31 Nereus Pharmaceuticals, Inc. Anti-bacterial and anti-cancer spiro beta-lactone/gamma-lactams

Also Published As

Publication number Publication date
JP2011529457A (ja) 2011-12-08
US20110295009A1 (en) 2011-12-01
EP2321322A1 (en) 2011-05-18
WO2010012381A8 (en) 2010-05-06
JP5619001B2 (ja) 2014-11-05
EP2321322B1 (en) 2012-12-19
WO2010012381A1 (en) 2010-02-04
US8765799B2 (en) 2014-07-01

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