AR071280A1 - Complejo de inclusion formado por disulfiram y una ciclodextrina, util en el tratamiento de la dependencia de alcohol y cocaina , procedimiento de preparacion , composicion farmaceutica y uso de dicho complejo - Google Patents

Complejo de inclusion formado por disulfiram y una ciclodextrina, util en el tratamiento de la dependencia de alcohol y cocaina , procedimiento de preparacion , composicion farmaceutica y uso de dicho complejo

Info

Publication number
AR071280A1
AR071280A1 ARP080105738A ARP080105738A AR071280A1 AR 071280 A1 AR071280 A1 AR 071280A1 AR P080105738 A ARP080105738 A AR P080105738A AR P080105738 A ARP080105738 A AR P080105738A AR 071280 A1 AR071280 A1 AR 071280A1
Authority
AR
Argentina
Prior art keywords
inclusion complex
dsf
complex according
beta
inclusion
Prior art date
Application number
ARP080105738A
Other languages
English (en)
Inventor
Cabrera Edson Freddy Montero
Carreno Maria Jacqueline Sepulveda
Plessing Rossel Carlos Guillermo Von
Original Assignee
Andromaco Lab
Univ Concepcion
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Andromaco Lab, Univ Concepcion filed Critical Andromaco Lab
Publication of AR071280A1 publication Critical patent/AR071280A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/145Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14Dithiocarbamic acids; Derivatives thereof
    • C07C333/30Dithiocarbamic acids; Derivatives thereof having sulfur atoms of dithiocarbamic groups bound to other sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C333/00Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C333/14Dithiocarbamic acids; Derivatives thereof
    • C07C333/18Esters of dithiocarbamic acids
    • C07C333/20Esters of dithiocarbamic acids having nitrogen atoms of dithiocarbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16Cyclodextrin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicacion 1: Un complejo de inclusion caracterizado porque está formado por Disulfiram (DSF) y Ciclodextrina (CD) en proporciones 1:1 a 1:2 respectivamente. Reivindicacion 5: El complejo de inclusion de acuerdo a la reivindicacion 3 caracterizado porque es de formula 1 Reivindicacion 6: El complejo de inclusion de acuerdo a la reivindicacion 2 y 3 caracterizado porque en el difractograma de calorimetría diferencial de barrido el pico endotérmico esta desplazado a temperaturas mayores de 250sC. Reivindicacion 7: El complejo de inclusion de acuerdo a la reivindicacion 2 caracterizado porque los desplazamientos químicos en 1H-RMN para el DSF y la HP-beta-CD en forma de complejo 1:1 son: DSF: 1,292; 1,454; y HP-beta-CD: 1,115; 1,135. Reivindicacion 9: El complejo de inclusion de acuerdo a la reivindicacion 2 caracterizado porque los desplazamientos químicos en 13C-RMN para el complejo DSF-HP-beta-CD en proporcion 1:1 son: 14,016 (-0,009), 11,909 (+0,002), 53,087 (+0,935), 48,662 (+0,994). Reivindicacion 11: El complejo de inclusion de acuerdo a la reivindicacion 1 caracterizado porque el espectro de difraccion de rayos X para un complejo 1:1 se presenta con ausencia de picos. Reivindicacion 17: Un procedimiento para preparar un complejo de inclusion de acuerdo a la reivindicacion 1 caracterizado porque se lleva a cabo en un rotavapor con una temperatura del bano de 60°C a una velocidad de 160 rpm y con un vacío de 80 mm Hg, mediante las siguientes etapas: a) se mezcla en forma física hidroxipropil-beta-ciclodextrina y DSF; b) se disuelve dicha mezcla en alcohol absoluto; c) se evapora completamente el solvente en estufa a 45°C por 48 horas. Reivindicacion 20: Composicion farmacéutica caracterizada porque comprende un complejo de inclusion formado por DSF y CD de acuerdo a la reivindicacion 1. Reivindicacion 23: Uso de un complejo de inclusion de acuerdo a la reivindicacion 1 caracterizado porque sirve para preparar un medicamento destinado a tratar la dependencia de alcohol.
ARP080105738A 2007-12-28 2008-12-23 Complejo de inclusion formado por disulfiram y una ciclodextrina, util en el tratamiento de la dependencia de alcohol y cocaina , procedimiento de preparacion , composicion farmaceutica y uso de dicho complejo AR071280A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CL200703876A CL2007003876A1 (es) 2007-12-28 2007-12-28 Complejo de inclusion que esta formado por disulfiram y ciclodextrina; procedimiento de preparacion; composicion farmaceutica; y uso en el tratamiento de la dependencia de alcohol y cocaina.

Publications (1)

Publication Number Publication Date
AR071280A1 true AR071280A1 (es) 2010-06-09

Family

ID=40261621

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080105738A AR071280A1 (es) 2007-12-28 2008-12-23 Complejo de inclusion formado por disulfiram y una ciclodextrina, util en el tratamiento de la dependencia de alcohol y cocaina , procedimiento de preparacion , composicion farmaceutica y uso de dicho complejo

Country Status (5)

Country Link
KR (1) KR101131296B1 (es)
AR (1) AR071280A1 (es)
CL (1) CL2007003876A1 (es)
ES (1) ES2348887B2 (es)
WO (1) WO2009083793A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2462235C1 (ru) * 2011-05-10 2012-09-27 Государственное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова Федерального агентства по здравоохранению и социальному развитию" Лекарственная форма дисульфирама пролонгированного действия и способ ее получения
RU2592625C1 (ru) * 2015-02-03 2016-07-27 Станислав Анатольевич Кедик Комплекс включения дисульфирама с циклодекстрином
KR20220010855A (ko) 2020-07-20 2022-01-27 재단법인 제주테크노파크 디설피람 및 그 유도체를 이용한 지방세포의 분화억제 효과를 갖는 비만 개선 및 치료용 약학적 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196033B (it) * 1984-02-22 1988-11-10 Chiesi Farma Spa Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche
HU213200B (en) * 1993-05-12 1997-03-28 Chinoin Gyogyszer Es Vegyeszet The cyclodextrin or cyclodextrin derivative cluster complexes of taxol, taxotere, or taxus, pharmaceutical preparations containing them and process for their production
KR20030041577A (ko) * 2001-11-20 2003-05-27 디디에스텍주식회사 난용성 약물과 치환된 시클로덱스트린을 함유하는고체분산체 및 이를 함유하는 약제학적 조성물

Also Published As

Publication number Publication date
KR101131296B1 (ko) 2012-03-30
ES2348887B2 (es) 2012-01-23
ES2348887A1 (es) 2010-12-16
KR20090073025A (ko) 2009-07-02
CL2007003876A1 (es) 2008-03-07
WO2009083793A1 (es) 2009-07-09

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