AR069166A1 - Derivados de 1,3- dihidro-5- isobenzofurancarbonitrilo, composicion farmaceutica de los mismos para el tratamiento de la eyaculacion precoz prematura y procedimiento para obtener dichos productos - Google Patents
Derivados de 1,3- dihidro-5- isobenzofurancarbonitrilo, composicion farmaceutica de los mismos para el tratamiento de la eyaculacion precoz prematura y procedimiento para obtener dichos productosInfo
- Publication number
- AR069166A1 AR069166A1 ARP080104804A ARP080104804A AR069166A1 AR 069166 A1 AR069166 A1 AR 069166A1 AR P080104804 A ARP080104804 A AR P080104804A AR P080104804 A ARP080104804 A AR P080104804A AR 069166 A1 AR069166 A1 AR 069166A1
- Authority
- AR
- Argentina
- Prior art keywords
- thienyl
- pharmaceutical composition
- treatment
- derivatives
- ejaculation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
También se describe una composicion farmacéutica para tratar o prevenir eyaculacion prematura que incluye el compuesto. Los derivados de 1,3-dihidro-5-isobenzofurancarbonitrilo tienen una vida media corta e inhiben el proceso de eyaculacion inhibiendo selectivamente la recaptacion de serotonina por medio de un transportador de recaptacion de serotonina presente en una neurona presináptica. Por consiguiente, los compuestos son utiles en el tratamiento y prevencion de la eyaculacion prematura. Reivindicacion 1: Un derivado representado por la formula 1 o su sal aceptable para uso farmacéutico, donde, R1 es un fenilo sustituido o no sustituido, o heterociclilo seleccionado entre piridinilo, isoxazolilo, tiazolilo, pirimidinilo, indanilo, benztiazolilo, pirazolilo, tiadiazolilo, oxazolilo, piperidinilo, morfolinilo, imidazolilo, pirrolidinilo, tienilo, triazolilo, pirrolilo y furilo; R2 es dialquilamino C1-6, o un heterociclilo sustituido o no sustituido seleccionado entre piridinilo, isoxazolilo, tiazolilo, pirimidinilo, indanilo, benztiazolilo, pirazolilo, tiadiazolilo, oxazolilo, piperidinilo, morfolinilo, imidazolilo, pirrolidinilo, tienilo, triazolilo, pirrolilo y furilo; y n es un numero entero de 1 a 3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20070111783 | 2007-11-02 | ||
KR1020080105439A KR101103118B1 (ko) | 2007-11-02 | 2008-10-27 | 신규한 1,3-디히드로-5-이소벤조퓨란카르보니트릴 유도체 화합물 및 이를 함유하는 조루증 치료용 약학조성물 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR069166A1 true AR069166A1 (es) | 2010-01-06 |
Family
ID=40855892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080104804A AR069166A1 (es) | 2007-11-02 | 2008-11-03 | Derivados de 1,3- dihidro-5- isobenzofurancarbonitrilo, composicion farmaceutica de los mismos para el tratamiento de la eyaculacion precoz prematura y procedimiento para obtener dichos productos |
Country Status (20)
Country | Link |
---|---|
US (1) | US8242159B2 (es) |
EP (1) | EP2215070A4 (es) |
JP (1) | JP5281649B2 (es) |
KR (1) | KR101103118B1 (es) |
CN (1) | CN101910146A (es) |
AR (1) | AR069166A1 (es) |
AU (1) | AU2008319628B2 (es) |
BR (1) | BRPI0818267A2 (es) |
CA (1) | CA2703783C (es) |
CL (1) | CL2008003231A1 (es) |
CO (1) | CO6280531A2 (es) |
IL (1) | IL205350A0 (es) |
MX (1) | MX2010004727A (es) |
NZ (1) | NZ585091A (es) |
PE (1) | PE20091018A1 (es) |
RU (1) | RU2448963C2 (es) |
TW (1) | TWI365741B (es) |
UA (1) | UA99492C2 (es) |
WO (1) | WO2009057974A2 (es) |
ZA (1) | ZA201003794B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013026455A1 (en) * | 2011-08-24 | 2013-02-28 | Aarhus Universitet | Permanently positively charged antidepressants |
US9169237B1 (en) * | 2014-10-24 | 2015-10-27 | Medi Synergics, LLC | Antiprotozoal amidine compounds |
KR101637177B1 (ko) * | 2014-03-14 | 2016-07-07 | 건일제약 주식회사 | 8-히드록시클로미프라민 또는 이의 약학적으로 허용가능한 염의 제조방법 |
SG11201706515QA (en) | 2015-02-11 | 2017-09-28 | Sunovion Pharmaceuticals Inc | 1-heterocyclyl isochromanyl compounds and analogs for treating cns disorders |
EA201990400A1 (ru) | 2016-07-29 | 2019-07-31 | Суновион Фармасьютикалз, Инк. | Соединения и композиции и их применение |
MA45795A (fr) | 2016-07-29 | 2019-06-05 | Sunovion Pharmaceuticals Inc | Composés et compositions, et utilisations associées |
EP3661929B1 (en) | 2017-08-02 | 2021-07-14 | Sunovion Pharmaceuticals Inc. | Isochroman compounds and uses thereof |
CN109111415B (zh) * | 2018-10-25 | 2022-08-23 | 安徽中医药大学 | 一类石斛生物碱衍生物、制备方法和医药用途 |
US11136304B2 (en) | 2019-03-14 | 2021-10-05 | Sunovion Pharmaceuticals Inc. | Salts of a heterocyclic compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
GB0105627D0 (en) * | 2001-03-07 | 2001-04-25 | Cipla Ltd | Preparation of phthalanes |
EP1397126B9 (en) * | 2001-03-16 | 2007-02-21 | DMI Biosciences, Inc. | Use of tramadol for delaying ejaculation |
EP1446396A1 (en) * | 2001-11-08 | 2004-08-18 | Sepracor, Inc. | Methods for treating depression and other cns disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram |
IN192863B (es) | 2001-11-13 | 2004-05-22 | Ranbaxy Lab Ltd | |
US6764200B1 (en) * | 2003-01-15 | 2004-07-20 | Hsiang Lan Wu Liu | Decorative lantern |
JP4667369B2 (ja) * | 2003-03-21 | 2011-04-13 | ネックスメド ホールディングス インコーポレイテッド | 早漏を治療するための組成物および方法 |
GB0409744D0 (en) * | 2004-04-30 | 2004-06-09 | Pfizer Ltd | Novel compounds |
-
2008
- 2008-10-27 KR KR1020080105439A patent/KR101103118B1/ko not_active IP Right Cessation
- 2008-10-29 CL CL2008003231A patent/CL2008003231A1/es unknown
- 2008-10-31 BR BRPI0818267-1A patent/BRPI0818267A2/pt not_active IP Right Cessation
- 2008-10-31 TW TW097142052A patent/TWI365741B/zh not_active IP Right Cessation
- 2008-10-31 NZ NZ585091A patent/NZ585091A/en not_active IP Right Cessation
- 2008-10-31 CA CA2703783A patent/CA2703783C/en not_active Expired - Fee Related
- 2008-10-31 RU RU2010122320/04A patent/RU2448963C2/ru not_active IP Right Cessation
- 2008-10-31 EP EP08846179A patent/EP2215070A4/en not_active Withdrawn
- 2008-10-31 UA UAA201006496A patent/UA99492C2/ru unknown
- 2008-10-31 CN CN2008801224430A patent/CN101910146A/zh active Pending
- 2008-10-31 US US12/739,870 patent/US8242159B2/en not_active Expired - Fee Related
- 2008-10-31 MX MX2010004727A patent/MX2010004727A/es active IP Right Grant
- 2008-10-31 PE PE2008001868A patent/PE20091018A1/es not_active Application Discontinuation
- 2008-10-31 WO PCT/KR2008/006445 patent/WO2009057974A2/en active Application Filing
- 2008-10-31 AU AU2008319628A patent/AU2008319628B2/en not_active Ceased
- 2008-10-31 JP JP2010531967A patent/JP5281649B2/ja not_active Expired - Fee Related
- 2008-11-03 AR ARP080104804A patent/AR069166A1/es not_active Application Discontinuation
-
2010
- 2010-04-26 IL IL205350A patent/IL205350A0/en unknown
- 2010-05-27 ZA ZA2010/03794A patent/ZA201003794B/en unknown
- 2010-06-02 CO CO10066630A patent/CO6280531A2/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP2215070A4 (en) | 2011-11-02 |
EP2215070A2 (en) | 2010-08-11 |
RU2010122320A (ru) | 2011-12-10 |
JP2011502981A (ja) | 2011-01-27 |
CL2008003231A1 (es) | 2009-11-27 |
WO2009057974A3 (en) | 2009-07-16 |
US20100240725A1 (en) | 2010-09-23 |
KR101103118B1 (ko) | 2012-01-04 |
KR20090045855A (ko) | 2009-05-08 |
JP5281649B2 (ja) | 2013-09-04 |
ZA201003794B (en) | 2011-02-23 |
MX2010004727A (es) | 2010-05-20 |
TW200934481A (en) | 2009-08-16 |
PE20091018A1 (es) | 2009-08-17 |
CN101910146A (zh) | 2010-12-08 |
CA2703783A1 (en) | 2009-05-07 |
CO6280531A2 (es) | 2011-05-20 |
US8242159B2 (en) | 2012-08-14 |
AU2008319628B2 (en) | 2012-03-29 |
IL205350A0 (en) | 2010-12-30 |
RU2448963C2 (ru) | 2012-04-27 |
CA2703783C (en) | 2012-12-04 |
TWI365741B (en) | 2012-06-11 |
WO2009057974A2 (en) | 2009-05-07 |
NZ585091A (en) | 2012-04-27 |
AU2008319628A1 (en) | 2009-05-07 |
BRPI0818267A2 (pt) | 2015-04-14 |
UA99492C2 (ru) | 2012-08-27 |
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Legal Events
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