UA99492C2 - Производные 1,3-дигидро-5-изобензофуранкарбонитрила и его фармацевтическая композиция для лечения преждевременной эякуляции - Google Patents

Производные 1,3-дигидро-5-изобензофуранкарбонитрила и его фармацевтическая композиция для лечения преждевременной эякуляции

Info

Publication number
UA99492C2
UA99492C2 UAA201006496A UAA201006496A UA99492C2 UA 99492 C2 UA99492 C2 UA 99492C2 UA A201006496 A UAA201006496 A UA A201006496A UA A201006496 A UAA201006496 A UA A201006496A UA 99492 C2 UA99492 C2 UA 99492C2
Authority
UA
Ukraine
Prior art keywords
dihydro
premature ejaculation
treatment
pharmaceutical composition
isobenzofurancarbonitrile
Prior art date
Application number
UAA201006496A
Other languages
English (en)
Ukrainian (uk)
Inventor
Еонг Геон Ли
Су-Джунг Чой
Тае-Кюн Канг
Ми-Джеонг Сео
Чанг-Йонг ШИН
Кюн-Сеок Ли
Гук-Джун Ан
Сеул-Минь Чой
Йонг-Дак Ким
Донг-хван КИМ
Кюн-Ку Кан
Хюн-Джу Шим
Донг-сунг КИМ
Бьянг-Ок Ан
Му-Хи Ю
Original Assignee
Донг-А Фармацевтикал. Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Донг-А Фармацевтикал. Ко., Лтд. filed Critical Донг-А Фармацевтикал. Ко., Лтд.
Publication of UA99492C2 publication Critical patent/UA99492C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

В данной заявке раскрыты новые производные 1,3-дигидро-5-изобензофуранкарбонитрила, представленные Формулой 1, или их фармацевтически приемлемые соли.Также раскрыта фармацевтическая композиция для лечения или предупреждения преждевременной эякуляции, которая содержит данное соединение.Производные 1,3-дигидро-5-изобензофуранкарбонитрила имеют короткий период полураспада и задерживают процесс эякуляции селективным ингибированием обратного захвата серотонина с помощью переносчика обратного захвата серотонина, присутствующего в пресинаптическом нейроне. Таким образом, соединения можно применять при лечении и предупреждении преждевременной эякуляции.
UAA201006496A 2007-11-02 2008-10-31 Производные 1,3-дигидро-5-изобензофуранкарбонитрила и его фармацевтическая композиция для лечения преждевременной эякуляции UA99492C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20070111783 2007-11-02

Publications (1)

Publication Number Publication Date
UA99492C2 true UA99492C2 (ru) 2012-08-27

Family

ID=40855892

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201006496A UA99492C2 (ru) 2007-11-02 2008-10-31 Производные 1,3-дигидро-5-изобензофуранкарбонитрила и его фармацевтическая композиция для лечения преждевременной эякуляции

Country Status (20)

Country Link
US (1) US8242159B2 (ru)
EP (1) EP2215070A4 (ru)
JP (1) JP5281649B2 (ru)
KR (1) KR101103118B1 (ru)
CN (1) CN101910146A (ru)
AR (1) AR069166A1 (ru)
AU (1) AU2008319628B2 (ru)
BR (1) BRPI0818267A2 (ru)
CA (1) CA2703783C (ru)
CL (1) CL2008003231A1 (ru)
CO (1) CO6280531A2 (ru)
IL (1) IL205350A0 (ru)
MX (1) MX2010004727A (ru)
NZ (1) NZ585091A (ru)
PE (1) PE20091018A1 (ru)
RU (1) RU2448963C2 (ru)
TW (1) TWI365741B (ru)
UA (1) UA99492C2 (ru)
WO (1) WO2009057974A2 (ru)
ZA (1) ZA201003794B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013026455A1 (en) * 2011-08-24 2013-02-28 Aarhus Universitet Permanently positively charged antidepressants
US9169237B1 (en) * 2014-10-24 2015-10-27 Medi Synergics, LLC Antiprotozoal amidine compounds
KR101637177B1 (ko) * 2014-03-14 2016-07-07 건일제약 주식회사 8-히드록시클로미프라민 또는 이의 약학적으로 허용가능한 염의 제조방법
UA122222C2 (uk) 2015-02-11 2020-10-12 Суновіон Фармасьютикалз Інк. Сполуки 1-гетероцикліл-ізохроманілу і аналоги для лікування розладів цнс
KR20190065246A (ko) 2016-07-29 2019-06-11 선오비온 파마슈티컬스 인코포레이티드 화합물 및 조성물 및 이들의 용도
MX2019000980A (es) 2016-07-29 2019-07-04 Sunovion Pharmaceuticals Inc Compuestos y composiciones y usos de los mismos.
WO2019028165A1 (en) 2017-08-02 2019-02-07 Sunovion Pharmaceuticals Inc. ISOCHROMAN COMPOUNDS AND USES THEREOF
CN109111415B (zh) * 2018-10-25 2022-08-23 安徽中医药大学 一类石斛生物碱衍生物、制备方法和医药用途
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
WO2002074241A2 (en) * 2001-03-16 2002-09-26 Dmi Biosciences Inc. Method of delaying ejaculation
HUP0401934A3 (en) * 2001-11-08 2007-05-29 Sepracor Inc Methods for treating depression and other cns disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram
IN192863B (ru) 2001-11-13 2004-05-22 Ranbaxy Lab Ltd
US6764200B1 (en) * 2003-01-15 2004-07-20 Hsiang Lan Wu Liu Decorative lantern
BRPI0408454A (pt) * 2003-03-21 2006-04-04 Nexmed Holdings Inc composição tópica, método de tratar a ejaculação precoce, e, uso da composição
GB0409744D0 (en) * 2004-04-30 2004-06-09 Pfizer Ltd Novel compounds

Also Published As

Publication number Publication date
JP5281649B2 (ja) 2013-09-04
CL2008003231A1 (es) 2009-11-27
RU2448963C2 (ru) 2012-04-27
IL205350A0 (en) 2010-12-30
MX2010004727A (es) 2010-05-20
ZA201003794B (en) 2011-02-23
US20100240725A1 (en) 2010-09-23
JP2011502981A (ja) 2011-01-27
TWI365741B (en) 2012-06-11
PE20091018A1 (es) 2009-08-17
CA2703783C (en) 2012-12-04
NZ585091A (en) 2012-04-27
WO2009057974A3 (en) 2009-07-16
CA2703783A1 (en) 2009-05-07
US8242159B2 (en) 2012-08-14
WO2009057974A2 (en) 2009-05-07
CO6280531A2 (es) 2011-05-20
AR069166A1 (es) 2010-01-06
EP2215070A4 (en) 2011-11-02
AU2008319628B2 (en) 2012-03-29
RU2010122320A (ru) 2011-12-10
BRPI0818267A2 (pt) 2015-04-14
KR20090045855A (ko) 2009-05-08
CN101910146A (zh) 2010-12-08
AU2008319628A1 (en) 2009-05-07
KR101103118B1 (ko) 2012-01-04
EP2215070A2 (en) 2010-08-11
TW200934481A (en) 2009-08-16

Similar Documents

Publication Publication Date Title
UA99492C2 (ru) Производные 1,3-дигидро-5-изобензофуранкарбонитрила и его фармацевтическая композиция для лечения преждевременной эякуляции
RS20080533A (en) Triazolopyrazine derivatives useful as anticancer agents
TW201000473A (en) Benzene or thiophene derivative and use thereof as VAP-1 inhibitor
WO2007138472A3 (en) Triazolopyridazine derivatives
CY1109970T1 (el) Παραγωγα 6-11 δικυκλικου κετολιδιου
HK1121440A1 (en) Biphenyl derivatives and their use in treating hepatitis c
MX2008002061A (es) Derivados de tiazolil piperidina utiles como moduladores del receptor h3.
MXPA02012034A (es) Derivados de tiofeno utiles como agentes anticancerosos.
EA201001669A1 (ru) Замещенные пиримидин-5-карбоксамиды 281
TW200716547A (en) Piperidin-4-yl-amide derivatives
TW200626158A (en) Naphthaline derivatives
TW200700069A (en) Benzothiazole, thiazolopyridine, benzooxazole and oxazolopyridine derivatives
EP2639229A3 (en) Thiazole Derivative and use thereof as VAP-1 Inhibitor
MX2010001020A (es) Derivados de pirimidina utiles para el tratamiento de condiciones inflamatorias o alergicas.
MX2009001660A (es) Compuestos de 2,5-dihidroxibenceno para el tratamiento de psoriasis.
TW200634021A (en) 3,6-bicyclolides
MX2007006387A (es) Derivados de piridina 3-substituidos como antagonistas h3.
TW200637817A (en) 5-aminoindole derivatives
TW200740827A (en) Benzooxazole, oxazolopyridine, benzothiazole and thiazolopyridine derivatives
PL1682528T3 (pl) Pochodne benzo[b][1,4]dioksepiny
WO2005000863A3 (en) 6, 11-4c-bicyclic 9a-azalide derivatives
PL1745010T3 (pl) Podstawione pochodne cykloheksylo-1,4-diaminy
MX2009007038A (es) Derivados de mononitrato de isosorbida para el tratamiento de trastornos intestinales.
MX2009012518A (es) Derivados de piperidina 4,4-disubstituidos.
WO2006065721A3 (en) 11, 12-lactone bicyclolides