AR067056A1 - Compuesto de espiroindolina, sal farmaceuticamente aceptable del mismo, composicion que lo comprende y su uso para preparar un medicamento - Google Patents
Compuesto de espiroindolina, sal farmaceuticamente aceptable del mismo, composicion que lo comprende y su uso para preparar un medicamentoInfo
- Publication number
- AR067056A1 AR067056A1 ARP080102605A ARP080102605A AR067056A1 AR 067056 A1 AR067056 A1 AR 067056A1 AR P080102605 A ARP080102605 A AR P080102605A AR P080102605 A ARP080102605 A AR P080102605A AR 067056 A1 AR067056 A1 AR 067056A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- independently
- alkoxy
- hydroxy
- compound
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de espiroindolina de la siguiente formula (1), o una de sus sales farmacéuticamente aceptable o uno de sus enantiomeros; en la que cada R1 es independientemente halogeno, CF3, alquilo C1-4, alcoxi C1-4, OCF3, CN, alquil C1-6-C(O)-NH-, alquil C1-6NH-C(O)-, -CH2-N(R7)2, -CH2-O-R8, C1-4S(O)r-, COOH o heteroarilo; R2 es H, alquilo C1-4, -CH2C(O)OR9 o CH2C(O)N(R9)2; cada R3 es independientemente alquilo C1-6 o hidroxi-alquilo C1-6 cada R4 es independientemente OH, F, CI, CN, alquilo C1-4, hidroxi-alquilo C1-4, o alcoxi C1-4, Y es-NH-o como el resto de formula (2); R5 es H, OH, F, CI, CN, CF3, alquilo C1-6, hidroxi-alquilo C1-6 o alcoxi C1-6; cada R6 es independientemente halogeno, CF3, alquilo C1-4, alcoxi C1-4, OCF3, benciloxi o CN; cada R7 es independientemente H, alquilo C1-4 o junto con el átomo de nitrogeno al que están unidos, forman un grupo heterocicloalquilo de 5 o 6 miembros; R8 es H, alquilo C1-6, bencilo o fenilo; cada R9 es independientemente H, alquilo C1-6 o bencilo; cada R10 es independientemente OH, F, CI, CN, alquilo C1-4, hidroxi-alquilo C1-4 o alcoxi C1-4, n es 0, 1 o 2; m es 0, 1, 2 o 3; p es 0, 1 o2; q es 0, 1 o2; r es 0, 1 o 2; y s es 0, 1 o 2. La sal de benzoato de dicho compuesto. Composicion que lo comprende y uso de dicho compuesto para preparar un medicamento util para el tratamiento de enfermedades asociadas con la sobreexpresion de CCR2, tales como aterosclerosis, dolor inflamatorio, influenza, síndrome metabolico, esclerosis multiple, asma, enfermedad renal, insuficiencia cardiaca congestiva, enfermedad de Alzheimer, accidente cerebrovascular, enfermedad de Crohn, enfermedad inflamatoria del intestino, endometriosis o diabetes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94514707P | 2007-06-20 | 2007-06-20 | |
| US4315608P | 2008-04-08 | 2008-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR067056A1 true AR067056A1 (es) | 2009-09-30 |
Family
ID=40137143
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080102605A AR067056A1 (es) | 2007-06-20 | 2008-06-19 | Compuesto de espiroindolina, sal farmaceuticamente aceptable del mismo, composicion que lo comprende y su uso para preparar un medicamento |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7723350B2 (es) |
| EP (1) | EP2166848A4 (es) |
| JP (1) | JP5341076B2 (es) |
| AR (1) | AR067056A1 (es) |
| CL (1) | CL2008001810A1 (es) |
| PE (1) | PE20090829A1 (es) |
| TW (1) | TW200904423A (es) |
| UY (1) | UY31162A1 (es) |
| WO (1) | WO2008157741A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009089454A1 (en) * | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| WO2010065704A1 (en) * | 2008-12-04 | 2010-06-10 | Glaxo Group Limited | Method for preparing a spiroindoline and a precursor thereof |
| WO2010093578A1 (en) * | 2009-02-10 | 2010-08-19 | Glaxo Group Limited | Indolinyl-, benzofuranyl-, and benzothienyl- amides as modulators of chemokine receptors |
| WO2010099098A1 (en) * | 2009-02-24 | 2010-09-02 | Glaxo Group Limited | Stereoselective hydrogenation of a ketone |
| EP2531506B1 (en) | 2010-02-05 | 2014-05-14 | Intervet International B.V. | Spiroindoline compounds for use as anthelminthics |
| WO2013017678A1 (en) | 2011-08-04 | 2013-02-07 | Intervet International B.V. | Novel spiroindoline compounds |
| CN104067277A (zh) * | 2012-01-27 | 2014-09-24 | 皇家飞利浦有限公司 | 医学选择系统 |
| EP2881391A1 (en) | 2013-12-05 | 2015-06-10 | Bayer Pharma Aktiengesellschaft | Spiroindoline carbocycle derivatives and pharmaceutical compositions thereof |
| EP3570893A1 (en) | 2017-01-17 | 2019-11-27 | GlaxoSmithKline Intellectual Property Development Ltd | Non peptidic heterobivalent molecules for treating inflammatory diseases |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5803398A (en) * | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| US5962462A (en) * | 1996-12-13 | 1999-10-05 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| WO1998031364A1 (en) * | 1997-01-21 | 1998-07-23 | Merck & Co., Inc. | 3,3-disubstituted piperidines as modulators of chemokine receptor activity |
| JP2001278886A (ja) * | 2000-03-28 | 2001-10-10 | Dai Ichi Seiyaku Co Ltd | ベンゾオキサジン誘導体及びこれを含有する医薬 |
| GB0107907D0 (en) * | 2001-03-29 | 2001-05-23 | Smithkline Beecham Plc | Novel compounds |
| SE0202133D0 (sv) * | 2002-07-08 | 2002-07-08 | Astrazeneca Ab | Novel compounds |
| JP2006511500A (ja) * | 2002-10-30 | 2006-04-06 | メルク エンド カムパニー インコーポレーテッド | γ−アミノアミド系のケモカイン受容体活性調節剤 |
| AU2004309419A1 (en) | 2003-12-23 | 2005-07-14 | Arena Pharmaceuticals, Inc. | Novel spiroindoline or spiroisoquinoline compounds, methods of use and compositions thereof |
| CA2582225A1 (en) | 2004-09-28 | 2006-04-06 | Mingde Xia | Substituted dipiperdine ccr2 antagonists |
| EP1890696A4 (en) | 2005-06-02 | 2010-05-05 | Janssen Pharmaceutica Nv | Suitable as new ORL-1 receptor modulators are 3-pyrolytic indolyl derivatives |
| US20070197590A1 (en) | 2006-01-31 | 2007-08-23 | Demong Duane E | Substituted dipiperidine ccr2 antagonists |
| WO2009023754A1 (en) | 2007-08-14 | 2009-02-19 | Glaxo Group Limited | Spiroindenes and spiroindanes as modulators of chemokine receptors |
| EP2211618A1 (en) | 2007-10-11 | 2010-08-04 | Glaxo Group Limited | Piperidinylhydroxyethylpiperidines as modulators of chemokine receptors |
| WO2009061881A1 (en) | 2007-11-07 | 2009-05-14 | Glaxo Group Limited | Spirodihydrobenzofurans as modulators of chemokine receptors |
| MX2010014501A (es) * | 2008-06-23 | 2011-02-25 | Janssen Pharmaceutica Nv | Antagonistas de piperidil acrilamida de receptor 2 de citocina quimioatrayente. |
-
2008
- 2008-06-18 PE PE2008001039A patent/PE20090829A1/es not_active Application Discontinuation
- 2008-06-18 TW TW097122652A patent/TW200904423A/zh unknown
- 2008-06-18 UY UY31162A patent/UY31162A1/es unknown
- 2008-06-18 CL CL2008001810A patent/CL2008001810A1/es unknown
- 2008-06-19 AR ARP080102605A patent/AR067056A1/es unknown
- 2008-06-20 WO PCT/US2008/067589 patent/WO2008157741A1/en active Application Filing
- 2008-06-20 EP EP08771538A patent/EP2166848A4/en not_active Withdrawn
- 2008-06-20 US US12/142,899 patent/US7723350B2/en active Active
- 2008-06-20 US US12/665,335 patent/US8431590B2/en active Active
- 2008-06-20 JP JP2010513425A patent/JP5341076B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US7723350B2 (en) | 2010-05-25 |
| EP2166848A1 (en) | 2010-03-31 |
| EP2166848A4 (en) | 2011-08-03 |
| PE20090829A1 (es) | 2009-07-25 |
| JP5341076B2 (ja) | 2013-11-13 |
| WO2008157741A1 (en) | 2008-12-24 |
| JP2010530886A (ja) | 2010-09-16 |
| UY31162A1 (es) | 2008-11-28 |
| US8431590B2 (en) | 2013-04-30 |
| TW200904423A (en) | 2009-02-01 |
| US20110034499A1 (en) | 2011-02-10 |
| US20080318990A1 (en) | 2008-12-25 |
| CL2008001810A1 (es) | 2008-12-26 |
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Legal Events
| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |