AR066899A1 - Metodos y disposiciones para el tratamiento de trastornos de proliferacion celular - Google Patents

Metodos y disposiciones para el tratamiento de trastornos de proliferacion celular

Info

Publication number
AR066899A1
AR066899A1 ARP080101438A ARP080101438A AR066899A1 AR 066899 A1 AR066899 A1 AR 066899A1 AR P080101438 A ARP080101438 A AR P080101438A AR P080101438 A ARP080101438 A AR P080101438A AR 066899 A1 AR066899 A1 AR 066899A1
Authority
AR
Argentina
Prior art keywords
subject
cellular change
pharmaceutical agent
energy
predetermined cellular
Prior art date
Application number
ARP080101438A
Other languages
English (en)
Original Assignee
Inmunolight Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39827110&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR066899(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Inmunolight Llc filed Critical Inmunolight Llc
Publication of AR066899A1 publication Critical patent/AR066899A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H23/00—Percussion or vibration massage, e.g. using supersonic vibration; Suction-vibration massage; Massage with moving diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0066—Psoralene-activated UV-A photochemotherapy (PUVA-therapy), e.g. for treatment of psoriasis or eczema, extracorporeal photopheresis with psoralens or fucocoumarins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/008—Two-Photon or Multi-Photon PDT, e.g. with upconverting dyes or photosensitisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0656—Chemical light sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
    • A61N2005/1089—Electrons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Un kit para ejecutar el método, un sistema implementado por computacion para ejecutar el método, una composicion farmacéutica ventajosa para el método, y un método y para causar un efecto de autovacuna en un sujeto. Reivindicacion 1: El uso de por lo menos un agente farmacéutico activable con capacidad para efectuar un cambio celular predeterminado al activarse, en la elaboracion de un medicamento para el tratamiento de un trastorno de proliferacion celular en un sujeto, donde el tratamiento comprende: (1) administrar al sujeto el por lo menos un agente farmacéutico activable con capacidad de efectuar un cambio celular predeterminado al activarse, y (2) aplicar al sujeto una energía iniciadora desde una fuente de energía iniciadora, donde la energía de iniciacion tiene capacidad para penetrar por completo a través del sujeto y donde la energía de iniciacion aplicada activa el agente activable in situ, - causando así que se produzca el cambio celular predeterminado, donde dicho cambio celular predeterminado trata el trastorno de proliferacion celular. Reivindicacion 2: El uso de acuerdo con la reivindicacion 1, en el cual la fuente de energía de iniciacion es rayos x, rayos gamma, un haz de electrones, microondas u ondas de radio. Reivindicacion 3: El uso de acuerdo con la reivindicacion 1, en el cual el trastorno de proliferacion celular es por lo menos un miembro seleccionado del grupo que consiste en cáncer, infeccion bacteriana, infeccion viral, respuesta inmune de rechazo, trastornos autoinmunes, condiciones aplásicas y combinaciones de los mismos. Reivindicacion 5: EI uso de acuerdo con la reivindicacion 1, en el cual el por lo menos un agente farmacéutico activable es seleccionado entre psoralens, colesteriloleato de pireno, acridina, porfirina, fluoresceína, rodamina, 16-diazorcortisona, etidio, complejos de bleomicina con metales de transicion, complejos de deglicobleomicina con metales de transicion, complejos de organoplatino, aloxazinas, vitamina Ks, vitamina L, metabolitos de vitaminas, precursores de vitaminas, naftoquinonas, naftalenos, naftoles y derivados de los mismos con conformaciones moleculares planas, porfiroporfirinas, tinturas y derivados de fenotiazina, cumarinas, quinolonas, quinonas y antroquinonas. Reivindicacion 7: El uso de acuerdo con la reivindicacion 5, en el cual el por lo menos un agente farmacéutico activable es 8-MOP o AMT. Reivindicacion 8: El uso de acuerdo con la reivindicacion 5, en el cual el por lo menos un agente farmacéutico activable es uno seleccionado entre 7,8-dimetil-10-ribitil isoalloxazina, 7,8,10-trimetilisoaloxazina, 7,8-dimetilaloxazina, isoaloxazinaadenina dinucleotido, aloxazina mononucleotido tetrasulfonato de ftalocianina de aluminio (III), hematoporfirina y ftalocianina. Reivindicacion 10: El uso de acuerdo con la reivindicacion 9, en el cual el portador es seleccionado entre insulina, interleuquina, timopoyetina o transferrina. Reivindicacion 18: El uso de acuerdo con la reivindicacion 1, en el cual el por lo menos un agente farmacéutico activable es un intercalador de ADN o un derivado halogenado del mismo. Reivindicacion 24: El uso de por lo menos un agente farmacéutico activable con capacidad para efectuar un cambio celular predeterminado al activarse, en la elaboracion de un medicamento para el tratamiento de un trastorno de proliferacion celular en un sujeto, donde el tratamiento comprende: (1) administrar al sujeto por lo menos un agente modulador de la energía y el por lo menos un agente farmacéutico activable con capacidad de efectuar un cambio celular predeterminado al activarse, y (2) aplicar al sujeto una energía iniciadora desde una fuente de energía iniciadora, donde el agente modulador de la energía convierte la energía de iniciacion aplicada a energía de UV-A o visible, que luego activa al agente activable in situ, - causando así que se produzca el cambio celular predeterminado, donde dicho cambio celular predeterminado trata el trastorno de proliferacion celular. Reivindicacion 26: El uso de acuerdo con la reivindicacion 24, en el cual el agente modulador de la energía es uno o más seleccionados entre una nanopartícula de metal fluorescente biocompatible, una molécula de tintura fluorescente, una nanopartícula de oro, un punto cuántico hidrosoluble encapsulado por dendrímeros de poliamidina, una luciferasa, una molécula fosforescente biocompatible, una molécula cosechadora de energía electromagnética combinada y un quelato de lántanido con capacidad de luminiscencia intensa. Reivindicacion 52: El uso de por lo menos un agente farmacéutico activable con capacidad para efectuar un cambio celular predeterminado al activarse, en la elaboracion de un medicamento para el tratamiento de un trastorno de proliferacion celular en un sujeto, donde el tratamiento comprende: (1) administrar al sujeto el por lo menos un agente farmacéutico activable con capacidad para efectuar un cambio celular predeterminado al (2) aplicar al sujeto una energía iniciadora desde una fuente de energía iniciadora, donde la energía de iniciacion aplicada y el agente farmacéutico activable, ante la activacion, producen una cantidad insuficiente de oxígeno singlete para producir la lisis celular y donde la energía de iniciacion activa el agente farmacéutico activable in situ, -causando así que se produzca el cambio celular predeterminado, donde dicho cambio celular predeterminado trata el trastorno de proliferacion celular. Reivindicacion 77: El uso de por lo menos un agente farmacéutico activable con capacidad para efectuar un cambio celular predeterminado al activarse, en la elaboracion de un medicamento para el tratamiento de un trastorno de proliferacion celular en un sujeto, donde el tratamiento comprende: (1) modificar una o más células para incorporar una modificacion o sustancia emisora de fotones; (2) insertar las células modificadas en un sitio objetivo del sujeto y (3) administrar el por lo menos un agente farmacéutico activable con capacidad para ser activado por los fotones emitidos por las células modificadas para causar un cambio celular predeterminado. Reivindicacion 83: El uso de un psoralen o un derivado del mismo en la elaboracion de un medicamento para la generacion de una autovacuna para un sujeto, donde la generacion comprende: (1) producir una poblacion de células blanco; (2) tratar a las células ex vivo, en un ambiente separado y aislado del sujeto, con un psoralen o un derivado del mismo, (3) activar el psoralem o derivado del mismo con una fuente de UV-A para inducir un cambio celular predeterminado en las células blanco; (4) restituir las células así cambiadas al sujeto a fin de inducir en el sujeto un efecto de autovacuna contra la célula objetivo, donde las células cambiadas actuan como autovacuna.
ARP080101438A 2007-04-08 2008-04-07 Metodos y disposiciones para el tratamiento de trastornos de proliferacion celular AR066899A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91066307P 2007-04-08 2007-04-08
US11/935,655 US9358292B2 (en) 2007-04-08 2007-11-06 Methods and systems for treating cell proliferation disorders

Publications (1)

Publication Number Publication Date
AR066899A1 true AR066899A1 (es) 2009-09-23

Family

ID=39827110

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101438A AR066899A1 (es) 2007-04-08 2008-04-07 Metodos y disposiciones para el tratamiento de trastornos de proliferacion celular

Country Status (12)

Country Link
US (5) US9358292B2 (es)
EP (2) EP3299031B1 (es)
JP (1) JP2010523690A (es)
KR (6) KR20170127045A (es)
CN (2) CN104027809B (es)
AR (1) AR066899A1 (es)
AU (1) AU2008237121B2 (es)
CA (2) CA2935870C (es)
CL (3) CL2008000997A1 (es)
IN (2) IN2015DN03080A (es)
TW (2) TWI654008B (es)
WO (1) WO2008124681A2 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8951561B2 (en) 2007-08-06 2015-02-10 Duke University Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP)
US9358292B2 (en) 2007-04-08 2016-06-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
WO2015195896A1 (en) * 2014-06-19 2015-12-23 Immunolight, Llc Methods and systems for treating cell proliferation disorders with psoralen derivatives
US9488916B2 (en) 2007-04-08 2016-11-08 Immunolight, Llc. Interior energy-activation of photo-reactive species inside a medium or body
US8376013B2 (en) * 2008-03-11 2013-02-19 Duke University Plasmonic assisted systems and methods for interior energy-activation from an exterior source
US8383836B2 (en) * 2009-04-21 2013-02-26 Duke University Methods and systems for treating cell proliferation disorders with psoralen derivatives
US20090104212A1 (en) * 2007-08-06 2009-04-23 Immunolight Methods and systems for treating cell proliferation disorders using two-photon simultaneous absorption
US9439897B2 (en) * 2007-11-06 2016-09-13 Immunolight, Llc Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders
US9662389B2 (en) * 2008-03-31 2017-05-30 Duke University Functionalized metal-coated energy converting nanoparticles, methods for production thereof and methods for use
US9907976B2 (en) * 2011-07-08 2018-03-06 Immunolight, Llc Phosphors and scintillators for light stimulation within a medium
JP5967935B2 (ja) * 2008-04-04 2016-08-10 イミュノライト・エルエルシー ｉｎｓｉｔｕでのフォトバイオモデュレーションのための非侵襲性システムおよび方法
WO2010009106A1 (en) 2008-07-14 2010-01-21 Bourke Frederic A Jr Advanced methods and systems for treating cell proliferation disorders
EP2403539A2 (en) * 2009-03-02 2012-01-11 Massachusetts Institute of Technology Methods and systems for treatment and/or diagnosis
EP2421376A4 (en) 2009-04-21 2016-04-27 Immunolight Llc NON-INVASIVE ENERGY UPGRADING METHODS AND SYSTEMS FOR IN-SITU PHOTO BODY MODULATION
WO2010144531A1 (en) * 2009-06-09 2010-12-16 Gary Wayne Jones Method for selective photodynamic therapy and light source for implementation thereof
CN107149689A (zh) * 2009-11-10 2017-09-12 免疫之光有限责任公司 对可辐射固化介质进行固化的系统和产生光的方法
EP3673893A1 (en) 2010-08-27 2020-07-01 Sienna Biopharmaceuticals, Inc. Compositions and methods for targeted thermomodulation
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
CN103533934B (zh) * 2011-03-17 2016-03-30 特尔汗什莫尔医学基础设施研究和服务公司 用于治疗自身免疫性疾病的喹诺酮类似物
WO2013006176A1 (en) * 2011-07-07 2013-01-10 Empire Technology Development Llc Microwave induced photodynamic therapy
KR102154207B1 (ko) 2012-10-11 2020-09-10 나노콤포식스, 인크. 은 나노플레이트 조성물 및 방법
KR101536325B1 (ko) * 2013-10-16 2015-07-14 주식회사 지니스 전자기파를 이용한 암 온열치료용 감작제 조성물 및 이를 이용한 암 치료 방법
WO2015079411A1 (en) 2013-11-28 2015-06-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof
WO2016028680A1 (en) * 2014-08-18 2016-02-25 Immunolight, Llc. Non-invasive systems and methods for selective activation of photoreactive responses
US20180071024A1 (en) * 2015-03-20 2018-03-15 Sienna Biopharmaceuticals, Inc. Enhanced efficacy and targeted topical delivery of drugs to skin with nanoparticles
US10383939B2 (en) 2015-03-20 2019-08-20 The Regents Of The University Of Colorado, A Body Corporate Light-activated compositions and methods using the same
EP3331575A4 (en) * 2015-08-04 2019-03-27 Vaxiion Therapeutics, LLC STERILIZATION USING IONIZING RADIATION OF BIOPHARMAZEUTIKA BASED ON BACTERIAL MINIMIZES AND METHODS OF USE
US10407399B2 (en) 2015-09-01 2019-09-10 Howard Hughes Medical Institute Ion-activated photolabile compounds
KR102465104B1 (ko) * 2016-04-25 2022-11-10 이뮤노라이트, 엘엘씨 삽입 디바이스들 및 매질 내부에 방출 광의 생산을 위한 시스템들 및 이들의 사용 방법들
KR102692689B1 (ko) * 2016-12-21 2024-08-06 나노비오?笭? 뉴런 장애의 치료에 사용하기 위한 나노입자
KR20210135559A (ko) 2019-03-04 2021-11-15 이뮤노라이트, 엘엘씨 에너지 방출기 및 수집기와 함께 사용하기 위한 에너지 증강 구조
CN110115761B (zh) * 2019-05-09 2023-06-16 英诺激光科技股份有限公司 一种利用激光和载体技术制备疫苗的方法
WO2022072095A2 (en) * 2020-06-30 2022-04-07 Board Of Regents, The University Of Texas System Cancer radiosensitization by in situ formation of gold nanoparticles and/or gold nanoclusters
US20220096634A1 (en) * 2020-09-30 2022-03-31 David A. Jernigan Method of manipulating phages within the body to attack infectious target cells
CN115414354A (zh) * 2022-08-29 2022-12-02 西南医科大学 花椒毒素在制备治疗血小板减少症药物中的应用
CN116925997B (zh) * 2023-07-27 2024-04-02 湖北医药学院 左氧氟沙星在制备促进细胞增殖中的药物的用途

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US124A (en) 1837-02-10 Improvement in the machine for weighing heavy bodies
US7045A (en) 1850-01-22 Chitck foe
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4748120A (en) 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
US4838852A (en) 1987-03-27 1989-06-13 Therakos, Inc. Active specific immune suppression
US5177073A (en) 1988-09-30 1993-01-05 Baylor Research Institute Therapeutic compositions derived from photoactive compounds
US5091385A (en) 1988-09-30 1992-02-25 Baylor Research Institute Pre-activated therapeutic agents derived from photoactive compounds
US5216176A (en) 1989-01-23 1993-06-01 Lehigh University 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor
US4979935A (en) 1989-02-21 1990-12-25 Quantex Corporation Method of photodynamic therapy employing electron trapping material
US5120649A (en) 1990-05-15 1992-06-09 New York Blood Center, Inc. Photodynamic inactivation of viruses in blood cell-containing compositions
US5658722A (en) 1990-05-15 1997-08-19 New York Blood Center, Inc. Process for the sterilization of biological compositions using UVA1 irradiation
US6669965B2 (en) 1992-02-07 2003-12-30 Vasogen Ireland Limited Method of treating atherosclerosis
US6204058B1 (en) 1992-02-07 2001-03-20 Vasogen Ireland Limited Treatment of autoimmune diseases
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
US5807881A (en) 1992-05-27 1998-09-15 Quadra Logic Technologies, Inc. Method for selectively reducing activated leukocyte cell population
AU5959994A (en) 1992-12-23 1994-07-19 Iowa State University Research Foundation Inc. Molecular flashlight
US6121425A (en) 1994-07-29 2000-09-19 Nanoprobes, Inc. Metal-lipid molecules
US5728590A (en) 1994-07-29 1998-03-17 Nanoprobes, Inc. Small organometallic probes
US5521289A (en) 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
US6235508B1 (en) 1995-06-07 2001-05-22 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants
IT1275571B (it) 1995-07-19 1997-08-07 Consiglio Nazionale Ricerche Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori
JP3689939B2 (ja) 1995-07-28 2005-08-31 豊田合成株式会社 光触媒装置
US20030022105A1 (en) * 1995-09-06 2003-01-30 Paras N. Prasad Two -photon upconverting dyes and applications
DE69733826T2 (de) 1996-03-29 2006-05-24 Therakos, Inc. Behandlung von leukocyten durch photopheresis
CA2250920A1 (en) 1996-03-29 1997-10-09 Bruce C. Stouch Photopheresis treatment of chronic hcv infections
JPH09299937A (ja) 1996-05-09 1997-11-25 Daikin Ind Ltd 被処理体処理装置
US7390668B2 (en) 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US5957960A (en) 1997-05-05 1999-09-28 Light Sciences Limited Partnership Internal two photon excitation device for delivery of PDT to diffuse abnormal cells
US6071944A (en) 1997-11-12 2000-06-06 Bowling Green State University Method of treatment of pigmented cancer cells utilizing photodynamic therapy
US20030022170A1 (en) 1998-03-06 2003-01-30 Millenium Pharmaceuticals, Inc. Novel fibroblast growth factors and therapeutic and diagnostic uses therefor
US6075155A (en) 1998-06-22 2000-06-13 Rensselaer Polytechnic Institute Radiation-curable cycloaliphatic epoxy compounds, uses thereof, and compositions containing them
US6645464B1 (en) 1998-07-30 2003-11-11 James F. Hainfeld Loading metal particles into cell membrane vesicles and metal particular use for imaging and therapy
US7045124B1 (en) 1999-01-12 2006-05-16 Vasogen Irelend Limited Pre-conditioning against cell death
US6132958A (en) * 1999-05-27 2000-10-17 The Rockefeller University Fluorescent bead for determining the temperature of a cell and methods of use thereof
US7332344B2 (en) 1999-12-01 2008-02-19 Photonic Research Systems Limited Luminescence assays
EP1239795B1 (en) 1999-12-23 2006-12-06 Edwards Lifesciences Corporation Enhanced visualization of medical implants
US6719778B1 (en) * 2000-03-24 2004-04-13 Endovascular Technologies, Inc. Methods for treatment of aneurysms
CN1308961A (zh) 2001-02-16 2001-08-22 北京飞天兆业科技有限责任公司 一种光化学疗法治疗皮肤病用的药物
US20020127224A1 (en) 2001-03-02 2002-09-12 James Chen Use of photoluminescent nanoparticles for photodynamic therapy
US7364872B1 (en) 2001-03-30 2008-04-29 Nanoprobes Test methods using enzymatic deposition and alteration of metals
US6670113B2 (en) 2001-03-30 2003-12-30 Nanoprobes Enzymatic deposition and alteration of metals
EP1404334A4 (en) 2001-05-15 2005-02-02 Faulk Pharmaceuticals Inc TARGETED ADMINISTRATION OF BIOACTIVE COMPOUNDS FOR THE TREATMENT OF CANCER
US7008559B2 (en) 2001-06-06 2006-03-07 Nomadics, Inc. Manganese doped upconversion luminescence nanoparticles
GB0126236D0 (en) 2001-11-01 2002-01-02 Univ East Anglia Photosensitiser functionalised nanoparticles
US7303578B2 (en) 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
EP1465699A4 (en) 2001-12-12 2006-05-24 Leon J Lewandowski AUTOIMMUNE STIMULATION BY PHOTOPHORESIS
AU2002359870A1 (en) * 2001-12-28 2003-07-24 Oregon Health And Science University Agents that recognize src when phosphorylated at serine 17
US6908591B2 (en) 2002-07-18 2005-06-21 Clearant, Inc. Methods for sterilizing biological materials by irradiation over a temperature gradient
WO2004045547A2 (en) 2002-11-18 2004-06-03 Genospectra, Inc. Rnai-based sensors, caged interfering rnas, and methods of use thereof
US7695738B2 (en) * 2003-02-19 2010-04-13 Academia Sinica Carbohydrate encapsulated nanoparticles
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
CN1874789A (zh) 2003-09-23 2006-12-06 光科学公司 用于光动力疗法的缀合物
US20060067941A1 (en) 2003-12-05 2006-03-30 Secretary, Department Of Health & Human Services Nanotubes for cancer therapy and diagnostics
CN1893976A (zh) 2003-12-17 2007-01-10 皇家飞利浦电子股份有限公司 使用uv发射纳米微粒的放射治疗和医学成像
FR2869803B1 (fr) 2004-05-10 2006-07-28 Nanobiotix Sarl Particules activables, preparation et utilisations
US20060067889A1 (en) 2004-09-27 2006-03-30 Light Sciences Corporation Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted PDT agents
WO2006037081A2 (en) 2004-09-28 2006-04-06 The Regents Of The University Of California Nanoparticle radiosensitizers
JPWO2006038449A1 (ja) 2004-10-05 2008-07-31 日本板硝子株式会社 蛍光体微粒子が分散した発光体とその製造方法、およびこの発光体を含む材料または物品
FR2877571B1 (fr) 2004-11-05 2007-04-13 Nanobiotix Sarl Nanoparticules pourvues d'un element de ciblage intracellulaire, preparation et utilisations
NZ572334A (en) 2004-12-22 2010-02-26 Omj Ireland Ltd Phototherapy compositions comprising 8-methoxypsoralen and 2-ethylhexyl p-dimethylaminobenzoate
US7397043B2 (en) 2005-01-26 2008-07-08 Nomadics, Inc. Standoff optical detection platform based on surface plasmon-coupled emission
US7538329B2 (en) 2005-02-02 2009-05-26 Nomadics, Inc. Energy-transfer nanocomposite materials and methods of making and using same
US20070218049A1 (en) 2006-02-02 2007-09-20 Wei Chen Nanoparticle based photodynamic therapy and methods of making and using same
US20060222595A1 (en) * 2005-03-31 2006-10-05 Priyabrata Mukherjee Nanoparticles for therapeutic and diagnostic applications
WO2006113192A2 (en) * 2005-04-06 2006-10-26 Drexel University Functional nanoparticle filled carbon nanotubes and methods of their production
IL168184A (en) 2005-04-21 2011-11-30 Univ Ariel Res & Dev Co Ltd Use of a ligand-photosensitizer conjugate in combination with a chemiluminescent agent in the manufacture of a medicament for photodynamic therapy
EP1779891A1 (en) 2005-10-28 2007-05-02 Abdula Kurkayev Method of activating a photosensitizer
EP2003228A2 (en) 2006-03-22 2008-12-17 Kiichirou Sumi Process for producing metal coating material and metal coating material
US20070243137A1 (en) 2006-04-18 2007-10-18 Nanoprobes, Inc. Cell and sub-cell methods for imaging and therapy
GB0712287D0 (en) 2007-06-22 2007-08-01 Ucl Business Plc Antimicrobial Conjugates
US8328785B2 (en) 2006-09-18 2012-12-11 The University Of Houston System Use of nanoparticles in the photodynamic treatment of tumors
US7906147B2 (en) 2006-10-12 2011-03-15 Nanoprobes, Inc. Functional associative coatings for nanoparticles
US8951561B2 (en) * 2007-08-06 2015-02-10 Duke University Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP)
US8376013B2 (en) 2008-03-11 2013-02-19 Duke University Plasmonic assisted systems and methods for interior energy-activation from an exterior source
US9358292B2 (en) 2007-04-08 2016-06-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
US20090104212A1 (en) 2007-08-06 2009-04-23 Immunolight Methods and systems for treating cell proliferation disorders using two-photon simultaneous absorption
US9439897B2 (en) * 2007-11-06 2016-09-13 Immunolight, Llc Use of psoralen derivatives and combination therapy for treatment of cell proliferation disorders
US8236239B2 (en) 2007-11-16 2012-08-07 Bernstein Eric F Sterilizing compositions comprising phosphors for converting electromagnetic radiation to UVC radiation and methods for using the same
US8431041B2 (en) 2008-03-31 2013-04-30 Stc.Unm Halide-based scintillator nanomaterial
JP5967935B2 (ja) 2008-04-04 2016-08-10 イミュノライト・エルエルシー ｉｎｓｉｔｕでのフォトバイオモデュレーションのための非侵襲性システムおよび方法
WO2010009106A1 (en) * 2008-07-14 2010-01-21 Bourke Frederic A Jr Advanced methods and systems for treating cell proliferation disorders
EP3365017A4 (en) * 2015-10-19 2019-04-17 Immunolight, LLC X-PACT ACTIVATED ANTI-CANCER TREATMENT BASED ON X-RAY-ACTIVATED PSORALENE

Also Published As

Publication number Publication date
CN101711246B (zh) 2014-06-25
CN104027809B (zh) 2017-08-25
IN2015DN03077A (es) 2015-10-02
CA2682686C (en) 2016-12-20
TWI654008B (zh) 2019-03-21
WO2008124681A2 (en) 2008-10-16
US11103580B2 (en) 2021-08-31
TWI530308B (zh) 2016-04-21
EP2150549A2 (en) 2010-02-10
US20170258908A1 (en) 2017-09-14
US10398777B2 (en) 2019-09-03
EP3299031A1 (en) 2018-03-28
EP3299031B1 (en) 2022-06-08
US20140242035A1 (en) 2014-08-28
TW200902114A (en) 2009-01-16
KR20170127045A (ko) 2017-11-20
CA2935870C (en) 2021-07-20
CL2008000997A1 (es) 2008-10-03
TW201519929A (zh) 2015-06-01
EP2150549A4 (en) 2014-09-03
KR20170015570A (ko) 2017-02-08
KR102065832B1 (ko) 2020-01-13
CN104027809A (zh) 2014-09-10
JP2010523690A (ja) 2010-07-15
US20190336605A1 (en) 2019-11-07
US20080248001A1 (en) 2008-10-09
KR101925176B1 (ko) 2018-12-04
US9352040B2 (en) 2016-05-31
US9358292B2 (en) 2016-06-07
KR20170067904A (ko) 2017-06-16
WO2008124681A3 (en) 2009-02-05
KR20140141725A (ko) 2014-12-10
CL2015000383A1 (es) 2015-04-24
CA2935870A1 (en) 2008-10-16
US20140341845A1 (en) 2014-11-20
CL2015000382A1 (es) 2015-04-24
IN2015DN03080A (es) 2015-10-02
CN101711246A (zh) 2010-05-19
KR20100022951A (ko) 2010-03-03
WO2008124681A4 (en) 2009-12-23
US9682146B2 (en) 2017-06-20
AU2008237121A1 (en) 2008-10-16
CA2682686A1 (en) 2008-10-16
KR20200001607A (ko) 2020-01-06
AU2008237121B2 (en) 2013-10-10

Similar Documents

Publication Publication Date Title
AR066899A1 (es) Metodos y disposiciones para el tratamiento de trastornos de proliferacion celular
Xie et al. Emerging combination strategies with phototherapy in cancer nanomedicine
Yang et al. Enhancement of photodynamic cancer therapy by physical and chemical factors
AR068338A1 (es) Metodos y sistemas para tratar trastornos de proliferacion celular utilizando absorcion simultanea de dos fotones
Zhong et al. Biodegradable microalgae‐based carriers for targeted delivery and imaging‐guided therapy toward lung metastasis of breast cancer
AR070461A1 (es) Metodos y sistemas para tratar trastornos de proliferacion celular usando terapia fotoespectral mejorada con plasmonicos (pepst) y fototerapia mejorada con excitones plasmones (epep). composiciones.
Li et al. Exceptionally high payload of the IR780 iodide on folic acid-functionalized graphene quantum dots for targeted photothermal therapy
JP6824933B2 (ja) ｉｎ ｓｉｔｕフォトバイオモジュレーションのための非侵襲的エネルギーアップコンバージョン方法およびシステム
JP2011518781A5 (es)
He et al. Recent advances in aggregation‐induced emission materials and their biomedical and healthcare applications
Zhang et al. A comparison of TiO2 and ZnO nanoparticles as photosensitizers in photodynamic therapy for cancer
Tang et al. Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness
Cheng et al. Multifunctional polymeric nanoparticles for combined chemotherapeutic and near-infrared photothermal cancer therapy in vitro and in vivo
Badrigilan et al. Bismuth‐based nanomaterials: Recent advances in tumor targeting and synergistic cancer therapy techniques
Kusuzaki et al. Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?
US20090304803A1 (en) Compositions and methods relating to target-specific photodynamic therapy
Kim et al. Recent progress on photodynamic therapy and photothermal therapy
Li et al. Facile synthesis of a metal–organic framework nanocarrier for NIR imaging-guided photothermal therapy
Zhang et al. Photodynamic therapy of cancers with internal light sources: chemiluminescence, bioluminescence, and Cerenkov radiation
Maduray et al. The in vitro photodynamic effect of laser activated gallium, indium and iron phthalocyanine chlorides on human lung adenocarcinoma cells
Tapajós et al. In vitro photodynamic therapy on human oral keratinocytes using chloroaluminum-phthalocyanine
Duchi et al. Development of near-infrared photoactivable phthalocyanine-loaded nanoparticles to kill tumor cells: An improved tool for photodynamic therapy of solid cancers
Zhou et al. Water-soluble conjugated polymer with near-infrared absorption for synergistic tumor therapy using photothermal and photodynamic activity
Chen et al. Proof of concept for inhibiting metastasis: circulating tumor cell-triggered localized release of anticancer agent via a structure-switching aptamer
Maduray et al. In vitro photodynamic effect of aluminum tetrasulfophthalocyanines on melanoma skin cancer and healthy normal skin cells

Legal Events

Date Code Title Description
FB Suspension of granting procedure