AR066868A1 - 4-fenil-imidazol-2-tionas como inhibidoras de la tirosinasa, su procedimiento de preparacion y su utilizacion en medicina humana como tambien en cosmetica - Google Patents

4-fenil-imidazol-2-tionas como inhibidoras de la tirosinasa, su procedimiento de preparacion y su utilizacion en medicina humana como tambien en cosmetica

Info

Publication number
AR066868A1
AR066868A1 ARP080102384A ARP080102384A AR066868A1 AR 066868 A1 AR066868 A1 AR 066868A1 AR P080102384 A ARP080102384 A AR P080102384A AR P080102384 A ARP080102384 A AR P080102384A AR 066868 A1 AR066868 A1 AR 066868A1
Authority
AR
Argentina
Prior art keywords
radical
eventually
cycle
replaced
oxygen
Prior art date
Application number
ARP080102384A
Other languages
English (en)
Inventor
Jean-Guy Boiteau
Barbuis Corinne Millois
Sandrine Talano
Original Assignee
Galderma Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Res & Dev filed Critical Galderma Res & Dev
Publication of AR066868A1 publication Critical patent/AR066868A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/42—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Birds (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Formula general (1) siguiente: su utilizacion en composiciones farmacéuticas o cosméticas destinadas al tratamiento o a la prevencion de los trastornos pigmentarios. Reivindicacion 1: Compuesto de formula general (1) en la cual: a) cuando R2=H, entonces, R1 representa: - un radical alquilo C2-7, a excepcion de isopropilo, de n-propilo y de tercbutilo, - un radical hidroximetilo, triflulorometoxi, difluorometoxi, - un radical cicloalquilo C3-7, donde uno de los átomos de carbono del ciclo puede, eventualmente, ser reemplazado por un átomo de oxígeno, o de azufre, - un radical cicloalquilalquilo C4-9, - un grupo morfolinilo, tiomorfolinilo, piperazinilo, N-metilpiperazinilo - un carboxi, - un alcoxicarbonilo C1-4, o - un alcoxi C2-6, a excepcion de n-butoxi, b) cuando R1=H, entonces, R2 representa: - un radical alquilo C1-7, - un radical triflulorometoxi, difluorometoxi o ciano, - un radical cicloalquilo C3-7, donde uno de los átomos de carbono del ciclo puede, eventualmente, ser reemplazado por un átomo de oxígeno, o de azufre, - un radical cicloalquilalquilo C4-9, - un alcoxicarbonilo C1-4, - un alcoxi C1-6, a excepcion de n-propoxi, c) y cuando R2 está en posicion orto- con respecto a R1, entonces R1 y R2, idénticos o diferentes, representan un radical alquilo C1-5, o pueden formar un ciclo hidrocarbonato de 5 o 6 lados, en el que 1 o 2 átomo(s) de carbono pueden, eventualmente, ser reemplazados por 1 o 2 átomo(s) de oxígeno, así como sus sales y sus formas tautoméricas.
ARP080102384A 2007-06-05 2008-06-05 4-fenil-imidazol-2-tionas como inhibidoras de la tirosinasa, su procedimiento de preparacion y su utilizacion en medicina humana como tambien en cosmetica AR066868A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0755470A FR2917087B1 (fr) 2007-06-05 2007-06-05 Nouveaux 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique.

Publications (1)

Publication Number Publication Date
AR066868A1 true AR066868A1 (es) 2009-09-16

Family

ID=38468821

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080102384A AR066868A1 (es) 2007-06-05 2008-06-05 4-fenil-imidazol-2-tionas como inhibidoras de la tirosinasa, su procedimiento de preparacion y su utilizacion en medicina humana como tambien en cosmetica

Country Status (13)

Country Link
US (1) US8119674B2 (es)
EP (1) EP2155693A1 (es)
JP (1) JP2010529096A (es)
KR (1) KR20100017631A (es)
CN (1) CN101679296A (es)
AR (1) AR066868A1 (es)
AU (1) AU2008263666A1 (es)
BR (1) BRPI0810960A2 (es)
CA (1) CA2688235A1 (es)
FR (1) FR2917087B1 (es)
MX (1) MX2009012712A (es)
RU (1) RU2009148791A (es)
WO (1) WO2008152331A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2917089B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux 4-heteroaryl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique.
FR2916976B1 (fr) * 2007-06-05 2009-09-04 Galderma Res & Dev Utilisation de 4-phenyl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, pour la preparation de composition pharmaceutiques ou cosmetiques destinees au traitement ou a la prevention des desordres pigmentaires.
FR2939136B1 (fr) * 2008-12-02 2010-12-03 Galderma Res & Dev Nouveaux composes 4-(heterocycloalkyl)-benzene-1,3-diol comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique
TWI619710B (zh) * 2012-07-17 2018-04-01 高雄醫學大學 ３－ｐｅｄ４ｈｐｔ衍生物之合成與抗光老化活性之評估

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1206498B (it) 1983-07-18 1989-04-27 Angeli Inst Spa Derivati amidinici del4-fenilmidazolo 2-sostituto processi per la loro preparazione e loro uso farmaceutico.
US4798843A (en) 1987-07-09 1989-01-17 Smithkline Beckman Corporation 2-mercaproimidazole dopamine-β-hydroxylase inhibitors
JPH05132422A (ja) * 1991-04-09 1993-05-28 Sansho Seiyaku Co Ltd メラニン生成抑制外用剤
JPH05124923A (ja) * 1991-04-09 1993-05-21 Sansho Seiyaku Co Ltd メラニン生成抑制外用剤
US7928132B2 (en) 2004-08-06 2011-04-19 Ohio University Methods for the amelioration of episodes of acute or chronic ulcerative colitis
WO2007039821A2 (en) * 2005-08-31 2007-04-12 Galderma Research & Development Novel inhibitors of tyrosinase, their method of preparation and their use in human medicine and in cosmetics
FR2917089B1 (fr) * 2007-06-05 2009-07-17 Galderma Res & Dev Nouveaux 4-heteroaryl-imidazole-2-thiones comme inhibiteurs de la tyrosinase, leur procede de preparation et leur utilisation en medecine humaine ainsi qu'en cosmetique.

Also Published As

Publication number Publication date
BRPI0810960A2 (pt) 2015-01-27
MX2009012712A (es) 2009-12-08
JP2010529096A (ja) 2010-08-26
US20100144814A1 (en) 2010-06-10
WO2008152331A1 (fr) 2008-12-18
CN101679296A (zh) 2010-03-24
WO2008152331A9 (fr) 2009-12-23
FR2917087B1 (fr) 2012-09-21
EP2155693A1 (fr) 2010-02-24
US8119674B2 (en) 2012-02-21
CA2688235A1 (fr) 2008-12-18
KR20100017631A (ko) 2010-02-16
RU2009148791A (ru) 2011-07-20
AU2008263666A1 (en) 2008-12-18
FR2917087A1 (fr) 2008-12-12

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