AR065799A1 - Moduladores cannabinoides hexahidrocicloheptapirazol - Google Patents
Moduladores cannabinoides hexahidrocicloheptapirazolInfo
- Publication number
- AR065799A1 AR065799A1 ARP080101147A ARP080101147A AR065799A1 AR 065799 A1 AR065799 A1 AR 065799A1 AR P080101147 A ARP080101147 A AR P080101147A AR P080101147 A ARP080101147 A AR P080101147A AR 065799 A1 AR065799 A1 AR 065799A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydroxy
- halogen
- positions
- optionally substituted
- alkyl
- Prior art date
Links
- 229930003827 cannabinoid Natural products 0.000 title 1
- 239000003557 cannabinoid Substances 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 28
- 150000002367 halogens Chemical class 0.000 abstract 28
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 28
- 125000003545 alkoxy group Chemical group 0.000 abstract 20
- 125000000217 alkyl group Chemical group 0.000 abstract 17
- 125000003118 aryl group Chemical group 0.000 abstract 16
- 125000000623 heterocyclic group Chemical group 0.000 abstract 15
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 abstract 11
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000002947 alkylene group Chemical group 0.000 abstract 6
- 125000004043 oxo group Chemical group O=* 0.000 abstract 6
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 4
- 125000004104 aryloxy group Chemical group 0.000 abstract 4
- 125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 4
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 4
- 125000005102 carbonylalkoxy group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- 125000004471 alkyl aminosulfonyl group Chemical group 0.000 abstract 3
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 3
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 lower-amino alkyl Chemical group 0.000 abstract 2
- 102000018208 Cannabinoid Receptor Human genes 0.000 abstract 1
- 108050007331 Cannabinoid receptor Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000028774 intestinal disease Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A61P11/00—Drugs for disorders of the respiratory system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/36—Opioid-abuse
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Addiction (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
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- Communicable Diseases (AREA)
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Abstract
Estos compuestos son utiles para tratar, mejorar o prevenir un síndrome, trastorno o enfermedad mediado por el receptor cannabinoide, tales como obesidad, trastornos metabolicos, enfermedades intestinales e infarto de miocardio. Reivindicacion 1:Un compuesto que tiene una estructura de acuerdo con la formula (1), o una sal, isomero, profármaco, metabolito o polimorfo del mismo donde las líneas discontinuas entre las posiciones 2-3 y posiciones 3a-8a en la formula (1) representan ubicacionespara cada uno de los dos dobles enlaces presentes cuando X1R1 está presente; las líneas discontinuas entre las posiciones 3-3a y posiciones 8a-1 en formula (1) representan ubicaciones para cada uno de los dos dobles enlaces presentes cuando X2R2está presente; la línea discontinua entre la posicion 8 y X4R4 en la formula (1) representa una ubicacion para un doble enlace; X1 está ausente o es alquileno inferior; X2 está ausente o es alquileno inferior; donde solo uno de X1R1 y X2R2 estánpresentes; X3 está ausente, es alquileno inferior, alquilideno inferior o -NH-; cuando la línea discontinua entre la posicion 8 y X4R4 está ausente, X4 está ausente, o es alquileno inferior, cuando la línea discontinua entre la posicion 8 y X4R4está presente, X4 está ausente; X5 está ausente o es alquileno inferior; R1 se selecciona entre hidrogeno, alquilo (opcionalmente sustituido en una o más posiciones con halogeno, hidroxi o alcoxi inferior), alquilo inferior-sulfonilo, arilo,cicloalquilo C3-12 o heterociclilo, donde cada arilo, cicloalquilo C3-12 o heterociclilo está opcionalmente sustituido en una o más posiciones con halogeno, aminosulfonilo, alquilo inferior-aminosulfonilo, alquilo (opcionalmente sustituido en una omás posiciones con halogeno, hidroxi o alcoxi inferior), hidroxi o alcoxi inferior (opcionalmente sustituido en una o más posiciones con halogeno o hidroxi); R2 se selecciona entre hidrogeno, alquilo (opcionalmente sustituido en una o más posicionescon halogeno, hidroxi o alcoxi inferior), alquilo inferior-sulfonilo, arilo, cicloalquilo C3-12 o heterociclilo, donde cada arilo, cicloalquilo C3-12 o heterociclilo está opcionalmente sustituido en una o más posiciones con halogeno, aminosulfonilo,alquilo inferior-aminosulfonilo, alquilo (opcionalmente sustituido en una o más posiciones con halogeno, hidroxi o alcoxi inferior), hidroxi o alcoxi inferior (opcionalmente sustituido en una o más posiciones con halogeno o hidroxi); R3 es -C(O)-Z1(R6), -SO2-NR7-Z2(R8) o -C(O)-NR9-Z3(R10); cuando la línea discontinua entre la posicion 8 y X4R4 está ausente, X4 está ausente o es alquileno inferior y R4 es hidroxi, alquilo inferior, alcoxi inferior, halogeno, arilo, cicloalquilo C3-12 oheterociclilo, donde cada arilo, cicloalquilo C3-12 o heterociclilo está opcionalmente sustituido en una o más posiciones con hidroxi, oxo, alquilo inferior (opcionalmente sustituido en una o más posiciones con halogeno, hidroxi o alcoxi inferior),alcoxi inferior (opcionalmente sustituido en una o más posiciones con halogeno o hidroxi) o halogeno; cuando la línea discontinua entre la posicion 8 y X4R4 está presente, X4. está ausente y R4, es CH-arilo o CH-heterociclilo, donde cada arilo oheterociclilo está opcionalmente sustituido en una o más posiciones con hidroxi, oxo, alquilo inferior (opcionalmente sustituido en una o más posiciones con halogeno, hidroxi o alcoxi inferior), alcoxi inferior (opcionalmente sustituido en una o másposiciones con halogeno o hidroxi) o halogeno; R5 es hidrogeno, hidroxi, oxo, halogeno, amino, alquilo inferior-amino, alquilo (opcionalmente sustituido en una o más posiciones con halogeno, hidroxi o alcoxi inferior), alcoxi inferior (opcionalmentesustituido en una o más posiciones con halogeno o hidroxi), carboxi carbonilalcoxi, carbamoilo, carbamoilalquilo, arilo, ariloxi, arilalcoxi o heterociclilo; R6 es arilo, cicloalquilo C3-12 o heterociclilo cada uno opcionalmente sustituido con uno omás hidroxi, oxo, halogeno, amino, alquilo inferior-amino, alquilo (opcionalmente sustituido en una o más posiciones con halogeno, hidroxi o alcoxi inferior), alcoxi inferior (opcionalmente sustituido en una o más posiciones con halogeno o hidroxi),carboxi, carbonilalcoxi, carbamoilo, carbamoilalquilo, arilo, ariloxi, arilalcoxi o heterociclilo; R7 es hidrogeno o alquilo inferior; R8 es hidrogeno, arilo, cicloalquilo C3-12 o heterociclilo, donde arilo, cicloalquilo C3-12 o heterociclilo estáncada uno opcionalmente sustituido con uno o más hidroxi, oxo, halogeno, amino, alquilo inferior-amino, alquilo (opcionalmente sustituido en una o más posiciones con halogeno, hidroxi o alcoxi inferior), alcoxi inferior (opcionalmente sustituido enuna o más posiciones con halogeno o hidroxi), carboxi, carbonilalcoxi, carbamoilo, carbamoilalquilo, arilo, ariloxi, arilalcoxi o heterociclilo; R9 es hidrogeno o alquilo inferior; R10 es hidrogeno, arilo, cicloalquilo C3-12 o heterociclilo, dondecada arilo, cicloalquilo C3-12 o heterociclilo está opcionalmente sustituido con uno o más hidroxi, oxo, halogeno, amino, alquilo inferior-amino, alquilo (opcionalmente sustituido en una o más posiciones con halogeno, hidroxi o alcoxi inferior),alcoxi inferior (opcionalmente sustituido en una o más posiciones con halogeno o hidroxi), carboxi, carbonilalcoxi, carbamoilo, carbamoilalquilo, aminosulfonilo, alquilo inferior-aminosulfonilo, arilo, ariloxi, arilalcoxi o heterociclilo; Z1 y Z2están ausentes o son alquilo; y Z3 está ausente, -NH-, -SO2- o alquilo (donde alquilo está opcionalmente sustituido en una o más posiciones con halogeno, hidroxi, alquilo inferior, alcoxi inferior, carboxi o carbonilalcoxi).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/688,552 US8378117B2 (en) | 2005-09-23 | 2007-03-20 | Hexahydro-cycloheptapyrazole cannabinoid modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065799A1 true AR065799A1 (es) | 2009-07-01 |
Family
ID=39189452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101147A AR065799A1 (es) | 2007-03-20 | 2008-03-19 | Moduladores cannabinoides hexahidrocicloheptapirazol |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8378117B2 (es) |
| EP (1) | EP2139328A4 (es) |
| JP (1) | JP2010529949A (es) |
| KR (1) | KR20100015602A (es) |
| CN (1) | CN101677557A (es) |
| AR (1) | AR065799A1 (es) |
| AU (1) | AU2008229202A1 (es) |
| BR (1) | BRPI0809037A2 (es) |
| CA (1) | CA2681468A1 (es) |
| CL (1) | CL2008000799A1 (es) |
| CO (1) | CO6220909A2 (es) |
| IL (1) | IL200957A0 (es) |
| MX (1) | MX2009010157A (es) |
| NZ (1) | NZ579649A (es) |
| PE (1) | PE20090061A1 (es) |
| TW (1) | TW200901976A (es) |
| UA (1) | UA98487C2 (es) |
| WO (1) | WO2008115705A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090120499A (ko) * | 2007-03-21 | 2009-11-24 | 얀센 파마슈티카 엔.브이. | Ｃｂ２ 수용체 매개 통증의 치료 방법 |
| JP6062633B2 (ja) * | 2009-01-28 | 2017-01-18 | カラ セラピューティクス インコーポレイテッド | 二環式ピラゾロ複素環類 |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN105492011A (zh) | 2013-04-08 | 2016-04-13 | 丹尼斯·M·布朗 | 不理想给药化学化合物的治疗增效 |
| EP4262815A1 (en) * | 2020-12-15 | 2023-10-25 | Merck Sharp & Dohme LLC | Fused [7,5] bicyclic pyrazole derivatives and methods of use thereof for the treatment of herpesviruses |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2948718A (en) | 1960-08-09 | New n-heterocyclic compounds | ||
| DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| IT1147087B (it) | 1979-06-01 | 1986-11-19 | Wellcome Found | Nuovi preparati farmaceutici per il trattamento dei disordini del sistema nervoso centrale e procedimento per la loro preparazione |
| LU83729A1 (fr) | 1981-11-04 | 1983-09-01 | Galephar | Sels d'acide valproique,leur preparation et leur utilisation |
| US4513006A (en) | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US5164381A (en) | 1986-05-29 | 1992-11-17 | Ortho Pharmaceutical Corporation | Pharmacologically active 1,5-diaryl-3-substituted pyrazoles and method for synthesizing the same |
| US5242942A (en) | 1992-04-28 | 1993-09-07 | Mcneilab, Inc. | Anticonvulsant fructopyranose cyclic sulfites and sulfates |
| US5384327A (en) | 1992-12-22 | 1995-01-24 | Mcneilab, Inc. | Anticonvulsant sorbopyranose sulfamates |
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| FR2800372B1 (fr) | 1999-11-03 | 2001-12-07 | Sanofi Synthelabo | Derives tricycliques d'acide 1-benzylpyrazole-3- carboxylique, leur preparation, les medicaments en contenant |
| FR2800375B1 (fr) | 1999-11-03 | 2004-07-23 | Sanofi Synthelabo | Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant |
| AU2001296402A1 (en) | 2000-09-28 | 2002-04-08 | Immugen Pharmaceuticals, Inc. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
| GB0205693D0 (en) | 2002-03-09 | 2002-04-24 | Astrazeneca Ab | Chemical compounds |
| US7271189B2 (en) | 2003-10-20 | 2007-09-18 | Solvay Pharmaceuticals, Inc. | 1H-imidazole derivatives as cannabinoid receptor modulators |
| US7151097B2 (en) * | 2003-11-07 | 2006-12-19 | Pfizer Inc. | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof |
| US20080249154A1 (en) | 2003-12-26 | 2008-10-09 | Ono Pharmaceutical Co., Ltd. | Preventive and/or Therapeutic Agent For Disease In Which Mitochondrial Benzodiazephine Receptor Participates |
| TW200602324A (en) | 2004-03-24 | 2006-01-16 | Janssen Pharmaceutica Nv | Tetrahydro-indazole cannabinoid modulators cross reference to related applications |
| FR2875230A1 (fr) | 2004-09-13 | 2006-03-17 | Sanofi Aventis Sa | Derives de pyrazole condense, leur preparation et leur application en therapeutique |
| EP1931336A1 (en) * | 2005-09-23 | 2008-06-18 | Janssen Pharmaceutica, N.V. | Tetrahydro-indazolyl cannabinoid modulators |
| AU2006295121B2 (en) * | 2005-09-23 | 2011-10-27 | Janssen Pharmaceutica, N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| EA200800889A1 (ru) * | 2005-09-23 | 2008-12-30 | Янссен Фармацевтика, Н. В. | Гексагидроциклооктилпиразольные каннабиноидные модуляторы |
-
2007
- 2007-03-20 US US11/688,552 patent/US8378117B2/en not_active Expired - Fee Related
-
2008
- 2008-03-06 JP JP2009554630A patent/JP2010529949A/ja active Pending
- 2008-03-06 AU AU2008229202A patent/AU2008229202A1/en not_active Abandoned
- 2008-03-06 MX MX2009010157A patent/MX2009010157A/es not_active Application Discontinuation
- 2008-03-06 WO PCT/US2008/056011 patent/WO2008115705A2/en active Application Filing
- 2008-03-06 CN CN200880016624A patent/CN101677557A/zh active Pending
- 2008-03-06 EP EP08731511A patent/EP2139328A4/en not_active Withdrawn
- 2008-03-06 KR KR1020097021528A patent/KR20100015602A/ko not_active Application Discontinuation
- 2008-03-06 CA CA002681468A patent/CA2681468A1/en not_active Abandoned
- 2008-03-06 NZ NZ579649A patent/NZ579649A/en not_active IP Right Cessation
- 2008-03-06 BR BRPI0809037-8A patent/BRPI0809037A2/pt not_active IP Right Cessation
- 2008-03-19 AR ARP080101147A patent/AR065799A1/es unknown
- 2008-03-19 PE PE2008000509A patent/PE20090061A1/es not_active Application Discontinuation
- 2008-03-19 CL CL200800799A patent/CL2008000799A1/es unknown
- 2008-03-19 TW TW097109566A patent/TW200901976A/zh unknown
- 2008-06-03 UA UAA200910591A patent/UA98487C2/ru unknown
-
2009
- 2009-09-15 IL IL200957A patent/IL200957A0/en unknown
- 2009-10-05 CO CO09109472A patent/CO6220909A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO6220909A2 (es) | 2010-11-19 |
| UA98487C2 (en) | 2012-05-25 |
| WO2008115705A3 (en) | 2009-01-15 |
| KR20100015602A (ko) | 2010-02-12 |
| CA2681468A1 (en) | 2008-09-25 |
| JP2010529949A (ja) | 2010-09-02 |
| CL2008000799A1 (es) | 2008-09-26 |
| EP2139328A4 (en) | 2010-07-07 |
| BRPI0809037A2 (pt) | 2014-09-16 |
| CN101677557A (zh) | 2010-03-24 |
| EP2139328A2 (en) | 2010-01-06 |
| US20080070968A1 (en) | 2008-03-20 |
| WO2008115705A2 (en) | 2008-09-25 |
| NZ579649A (en) | 2011-12-22 |
| US8378117B2 (en) | 2013-02-19 |
| TW200901976A (en) | 2009-01-16 |
| AU2008229202A1 (en) | 2008-09-25 |
| MX2009010157A (es) | 2009-10-12 |
| PE20090061A1 (es) | 2009-01-26 |
| IL200957A0 (en) | 2010-05-17 |
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