AR063059A1 - Derivados de quinolinona y 1,8-naftiridinona, composiciones farmaceuticas que los contienen y usos como agentes anti-vih. - Google Patents
Derivados de quinolinona y 1,8-naftiridinona, composiciones farmaceuticas que los contienen y usos como agentes anti-vih.Info
- Publication number
- AR063059A1 AR063059A1 ARP070104318A ARP070104318A AR063059A1 AR 063059 A1 AR063059 A1 AR 063059A1 AR P070104318 A ARP070104318 A AR P070104318A AR P070104318 A ARP070104318 A AR P070104318A AR 063059 A1 AR063059 A1 AR 063059A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- mono
- amino
- hydroxy
- Prior art date
Links
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 title 1
- 229940124411 anti-hiv antiviral agent Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- -1 hydroxy, amino Chemical group 0.000 abstract 5
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 125000004193 piperazinyl group Chemical group 0.000 abstract 4
- 125000004076 pyridyl group Chemical group 0.000 abstract 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000002883 imidazolyl group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- ASSKVPFEZFQQNQ-UHFFFAOYSA-N 2-benzoxazolinone Chemical group C1=CC=C2OC(O)=NC2=C1 ASSKVPFEZFQQNQ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002757 morpholinyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 1
- SLLFVLKNXABYGI-UHFFFAOYSA-N 1,2,3-benzoxadiazole Chemical group C1=CC=C2ON=NC2=C1 SLLFVLKNXABYGI-UHFFFAOYSA-N 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65685—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine oxide or thioxide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
Abstract
Reivindicacion 1: Un compuesto de formula (1); incluidas las formas estereoisoméricas, las sales farmacéuticamente aceptables y los solvatos farmacéuticamente aceptables de dicho compuesto; donde R1 es ciano; R2 es H, aIquilo C1-6, trifluorometilo, amino, mono- o di-alquil C1-6amino, alquilC1-6amino donde el grupo alquilo C1-6 está sustituido con hidroxi, amino, alquil C1-6-carbonilamino-, mono- o dialquil C1-6amino-, piridilo, imidazolilo, pirrolidinilo, piperidinilo, morfolinilo, piperazinilo, 4-alquil C1-6piperazinilo, o con 4-(alquil C1-6-carbonil)piperazinilo; X1 es CH o N; R3 es fenilo o piridilo, cada uno de los cuales puede no estar sustituido o estar sustituido con uno o dos sustituyentes, cada uno de los cuales se selecciona independientemente de alquilo C1-6, alcoxi C1-6, nitro, ciano, halo, trifluorometilo, o R3 es benzoxadiazol, o benzoxazolona N-sustituida con alquilo C1-6; R4 es H, alquilo C1-6, (alquil C1-6carbonilamino)alquilo C1-6-, Ar, tienilo, tienilo sustituido con carboxilo, furanilo, piridilo, pirimidilo, pirazinilo, pirrolilo, pirazolilo, imidazolilo, triazolilo, oxazolilo, tiazolilo, halo, trifluorometilo, hidroxi, alquiloxi C1-6, -OPO(OH)2, amino, aminocarbonilo, ciano, un radical de formula -Y1-R6, -Y1-Alq-R6, o de formula -Y1-Alq-Y2-R7; R5 es H, halo, hidroxi o alquiloxi C1-6 o R4 y R5 tomados juntos forman un radical bivalente -O-CH2-O-; Y1 es O o NR8; Y2 es O o NR9; Alq es alquilo C1-6 bivalente; R6 es pirrolidinilo, piperidinilo, morfolinilo, piperazinilo, 4-alquil C1-6piperazinilo, 4-(alquilC1-6carbonil)piperazinilo, piridilo o imidazolilo; R7 es H, alquilo C1-6, hidroxialquilo C1-6, alquil C1-6carbonilo; R8 es H o alquilo C1-6; R9 es H o alquilo C1-6; Ar es fenilo opcionalmente sustituido con uno, dos o tres sustituyentes, cada uno de los cuales se selecciona independientemente de alquilo C1-6, halo, hidroxi, amino mono- o dialquil C1-6amino, carboxilo, alquil C1-6carbonilamino, aminocarbonilo, mono- o dialquil C1-6aminocarbonilo, y alquilo C1-6 sustituido con amino, hidroxi, mono- o di-alquil C1-6amino, alquil C1-6carbonilamino, [(mono- o dialquil C1-6)amino-alquil C1-6]carbonilamino, o con alquil C1-6 sulfonilamino.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06121586 | 2006-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063059A1 true AR063059A1 (es) | 2008-12-23 |
Family
ID=37807936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104318A AR063059A1 (es) | 2006-09-29 | 2007-09-28 | Derivados de quinolinona y 1,8-naftiridinona, composiciones farmaceuticas que los contienen y usos como agentes anti-vih. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100087649A1 (es) |
| EP (1) | EP2074099A1 (es) |
| JP (1) | JP2010504945A (es) |
| CN (1) | CN101516853A (es) |
| AR (1) | AR063059A1 (es) |
| AU (1) | AU2007301958A1 (es) |
| BR (1) | BRPI0717089A2 (es) |
| CA (1) | CA2660377A1 (es) |
| CL (1) | CL2007002812A1 (es) |
| MX (1) | MX2009003051A (es) |
| RU (1) | RU2009116264A (es) |
| TW (1) | TW200829554A (es) |
| WO (1) | WO2008037784A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106187889B (zh) * | 2015-04-29 | 2021-11-05 | 中国科学院上海药物研究所 | 一种多官能团吖啶类化合物及其衍生物的制备方法 |
| CN107652198B (zh) * | 2017-10-09 | 2020-04-07 | 新乡市锦源化工有限公司 | 乙酰苯胺的制备方法 |
| CN110540553B (zh) * | 2019-09-23 | 2022-11-01 | 江西师范大学 | 含磷的喹啉类化合物及其制备方法和应用 |
| AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
| CN116406271A (zh) * | 2020-07-14 | 2023-07-07 | 江苏先声药业有限公司 | 双环类化合物 |
| TW202214630A (zh) * | 2020-09-12 | 2022-04-16 | 大陸商成都倍特藥業股份有限公司 | 甲硫胺酸腺苷轉移酶抑制劑、其製備方法及應用 |
| CN115960099A (zh) * | 2020-09-24 | 2023-04-14 | 上海凌达生物医药有限公司 | 一类芳环或芳基杂环并吡啶酮类化合物、药物组合物及其应用 |
| WO2023185811A1 (zh) * | 2022-03-29 | 2023-10-05 | 首药控股(北京)股份有限公司 | 一种新型杂环化合物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19613591A1 (de) * | 1996-04-04 | 1997-10-09 | Hoechst Ag | Substituierte-Chinolin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| JPH1171351A (ja) * | 1997-08-29 | 1999-03-16 | Ss Pharmaceut Co Ltd | 置換キノロン誘導体及びこれを含有する医薬 |
| GB9930061D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Quinolone compounds for use in treating viral infections |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
-
2007
- 2007-09-28 TW TW096136071A patent/TW200829554A/zh unknown
- 2007-09-28 MX MX2009003051A patent/MX2009003051A/es not_active Application Discontinuation
- 2007-09-28 WO PCT/EP2007/060289 patent/WO2008037784A1/en active Application Filing
- 2007-09-28 AU AU2007301958A patent/AU2007301958A1/en not_active Abandoned
- 2007-09-28 US US12/442,753 patent/US20100087649A1/en not_active Abandoned
- 2007-09-28 EP EP07820676A patent/EP2074099A1/en not_active Withdrawn
- 2007-09-28 CA CA002660377A patent/CA2660377A1/en not_active Abandoned
- 2007-09-28 AR ARP070104318A patent/AR063059A1/es unknown
- 2007-09-28 CN CNA200780035784XA patent/CN101516853A/zh active Pending
- 2007-09-28 JP JP2009529709A patent/JP2010504945A/ja not_active Withdrawn
- 2007-09-28 BR BRPI0717089-0A patent/BRPI0717089A2/pt not_active IP Right Cessation
- 2007-09-28 CL CL200702812A patent/CL2007002812A1/es unknown
- 2007-09-28 RU RU2009116264/04A patent/RU2009116264A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010504945A (ja) | 2010-02-18 |
| EP2074099A1 (en) | 2009-07-01 |
| AU2007301958A1 (en) | 2008-04-03 |
| CN101516853A (zh) | 2009-08-26 |
| CA2660377A1 (en) | 2008-04-03 |
| MX2009003051A (es) | 2009-04-01 |
| RU2009116264A (ru) | 2010-11-10 |
| TW200829554A (en) | 2008-07-16 |
| WO2008037784A1 (en) | 2008-04-03 |
| BRPI0717089A2 (pt) | 2013-11-26 |
| US20100087649A1 (en) | 2010-04-08 |
| CL2007002812A1 (es) | 2008-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |