AR062482A1 - Identificacion y caracterizacion de variantes de replicon de vhc con menor suceptibilidad a vhc 796, y metodos relacionados - Google Patents

Identificacion y caracterizacion de variantes de replicon de vhc con menor suceptibilidad a vhc 796, y metodos relacionados

Info

Publication number
AR062482A1
AR062482A1 ARP070103727A ARP070103727A AR062482A1 AR 062482 A1 AR062482 A1 AR 062482A1 AR P070103727 A ARP070103727 A AR P070103727A AR P070103727 A ARP070103727 A AR P070103727A AR 062482 A1 AR062482 A1 AR 062482A1
Authority
AR
Argentina
Prior art keywords
hepatitis
rna
hcv
individual
ns5b
Prior art date
Application number
ARP070103727A
Other languages
English (en)
Original Assignee
Viropharma Inc
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viropharma Inc, Wyeth Corp filed Critical Viropharma Inc
Publication of AR062482A1 publication Critical patent/AR062482A1/es

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5767Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/18Togaviridae; Flaviviridae

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Métodos para disminuir la frecuencia de aparicion, disminuir el nivel de resistencia y retardar la aparicion de una infeccion viral de hepatitis C resistente al tratamiento, mediante la administracion a un sujeto, ya sea en forma combinada o en serie, de un inhibidor de la polimerasa NS5B de ARN dependiente del ARN de la hepatitis C, por ejemplo, un benzofurano, tal como 5-ciclopropil-2-(4-fluorofenil)-6-[(2-hidroxietil)(metilsulfonil)amino]-N-metil-1-benzofuran-3-carboxamida (VHC-796), y al menos un agente anti-hepatitis C adicional, por ejemplo, un producto de ribavirina o un inmunomodulador, tal como un producto de interferon. Además se refiere a métodos para monitorear el curso de tratamiento de una infeccion viral de hepatitis C, métodos para monitorear y pronosticar una infeccion viral de hepatitis C, y métodos para identificar un individuo con menor probabilidad de responder a un tratamiento contra la hepatitis C viral. Estos métodos usan la secuencia y/o estructura de la polimerasa NS5B de ARN dependiente del ARN de la hepatitis C para identificar la aparicion de una infeccion viral de hepatitis C resistente al tratamiento, en particular una infeccion viral de hepatitis C resistente al tratamiento con benzofurano (por ejemplo, VHC-796). Reivindicacion 11: Un método para identificar un individuo con menor probabilidad de responder a un tratamiento contra la hepatitis C viral, que comprende: (a) determinar la secuencia o estructura de aminoácidos del bolsillo de union de VHC-796 de la polimerasa NS5B de ARN dependiente del ARN de la hepatitis C en una muestra del individuo en un primer punto temporal; y (b) determinar la secuencia o estructura de aminoácidos del bolsillo de union de VHC-796 de la polimerasa NS5B de ARN dependiente del ARN de la hepatitis C en una muestra del individuo en un segundo punto temporal, donde un cambio en la secuencia o estructura de aminoácidos del bolsillo de union de VHC-796 de la polimerasa NS5B de ARN dependiente del ARN de la hepatitis C en la muestra del individuo en el segundo punto temporal, en comparacion con la secuencia o estructura de aminoácidos del bolsillo de union de VHC-796 de la polimerasa NS5B de ARN dependiente del ARN de la hepatitis C del individuo en el primer punto temporal, indica una menor probabilidad de que el individuo responda a un tratamiento contra la hepatitis C viral.
ARP070103727A 2006-08-25 2007-08-22 Identificacion y caracterizacion de variantes de replicon de vhc con menor suceptibilidad a vhc 796, y metodos relacionados AR062482A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84035306P 2006-08-25 2006-08-25

Publications (1)

Publication Number Publication Date
AR062482A1 true AR062482A1 (es) 2008-11-12

Family

ID=39022157

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070103727A AR062482A1 (es) 2006-08-25 2007-08-22 Identificacion y caracterizacion de variantes de replicon de vhc con menor suceptibilidad a vhc 796, y metodos relacionados

Country Status (9)

Country Link
US (2) US20080182895A1 (es)
AR (1) AR062482A1 (es)
AU (1) AU2007286754A1 (es)
BR (1) BRPI0715714A2 (es)
CA (1) CA2659461A1 (es)
CL (1) CL2007002447A1 (es)
PE (1) PE20081215A1 (es)
TW (1) TW200816990A (es)
WO (1) WO2008024763A2 (es)

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FR2933094A1 (fr) * 2008-06-26 2010-01-01 Univ Joseph Fourier Mutations dans la proteine ns5b du vhc.
EP2331125A4 (en) * 2008-09-19 2013-03-27 Globeimmune Inc IMMUNOTHERAPY FOR CHRONIC HEPATITIS C-VIRUS INFECTIONS
GB2515942A (en) 2011-10-21 2015-01-07 Abbvie Inc Combination treatment (e.g. with ABT-072 or ABT-333) of DAAs for use in treating HCV
ES2529143B1 (es) 2011-10-21 2015-10-26 Abbvie Inc. Combinación de al menos dos agentes antivirales de acción directa, ribavirina pero no interferón para uso de tratamiento del vhc
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
DE102014219858B4 (de) 2014-09-30 2021-09-23 Aktiebolaget Skf Kreuzgelenk
EP3448392A4 (en) 2016-04-28 2020-01-15 Emory University ALCYNE-CONTAINING NUCLEOTIDES AND NUCLEOSIDES THERAPEUTIC COMPOSITIONS AND USES THEREOF
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Also Published As

Publication number Publication date
AU2007286754A1 (en) 2008-02-28
PE20081215A1 (es) 2008-10-22
TW200816990A (en) 2008-04-16
US20080182895A1 (en) 2008-07-31
CA2659461A1 (en) 2008-02-28
CL2007002447A1 (es) 2008-03-14
WO2008024763A2 (en) 2008-02-28
US20100028922A1 (en) 2010-02-04
WO2008024763A3 (en) 2008-12-24
BRPI0715714A2 (pt) 2014-03-11

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