AR061523A1 - Derivados de n-amino-2-imidazolidinonas como inhibidores del canal de potasio kv1.5, una composicion que los comprende y su empleo en el tratamiento de afecciones cardiacas. - Google Patents
Derivados de n-amino-2-imidazolidinonas como inhibidores del canal de potasio kv1.5, una composicion que los comprende y su empleo en el tratamiento de afecciones cardiacas.Info
- Publication number
- AR061523A1 AR061523A1 ARP070102688A ARP070102688A AR061523A1 AR 061523 A1 AR061523 A1 AR 061523A1 AR P070102688 A ARP070102688 A AR P070102688A AR P070102688 A ARP070102688 A AR P070102688A AR 061523 A1 AR061523 A1 AR 061523A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- branched
- linear
- alkyl
- hydrogen
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 108020001213 potassium channel Proteins 0.000 title abstract 2
- 230000000747 cardiac effect Effects 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 239000001257 hydrogen Substances 0.000 abstract 10
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 5
- 125000006413 ring segment Chemical group 0.000 abstract 5
- 125000004429 atom Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- DHIVBEZCBBHIPZ-UHFFFAOYSA-N 1-aminoimidazolidin-2-one Chemical class NN1CCNC1=O DHIVBEZCBBHIPZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 229940124773 KV1.5 inhibitor Drugs 0.000 abstract 1
- 102000004425 Kv1.5 Potassium Channel Human genes 0.000 abstract 1
- 108010042111 Kv1.5 Potassium Channel Proteins 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 230000001746 atrial effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81509106P | 2006-06-20 | 2006-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR061523A1 true AR061523A1 (es) | 2008-09-03 |
Family
ID=38582320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102688A AR061523A1 (es) | 2006-06-20 | 2007-06-19 | Derivados de n-amino-2-imidazolidinonas como inhibidores del canal de potasio kv1.5, una composicion que los comprende y su empleo en el tratamiento de afecciones cardiacas. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7504517B2 (enExample) |
| EP (1) | EP2035392A1 (enExample) |
| JP (1) | JP2009541343A (enExample) |
| KR (1) | KR20090021223A (enExample) |
| CN (1) | CN101573341A (enExample) |
| AR (1) | AR061523A1 (enExample) |
| AU (1) | AU2007260985A1 (enExample) |
| BR (1) | BRPI0713320A2 (enExample) |
| CA (1) | CA2655574A1 (enExample) |
| CL (1) | CL2007001794A1 (enExample) |
| CO (1) | CO6150173A2 (enExample) |
| CR (1) | CR10527A (enExample) |
| EC (1) | ECSP088994A (enExample) |
| MX (1) | MX2008016399A (enExample) |
| NO (1) | NO20085252L (enExample) |
| PE (1) | PE20080942A1 (enExample) |
| RU (1) | RU2008150465A (enExample) |
| TW (1) | TW200815363A (enExample) |
| WO (1) | WO2007149874A1 (enExample) |
| ZA (1) | ZA200810763B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101573341A (zh) * | 2006-06-20 | 2009-11-04 | 惠氏公司 | 咪唑烷酮Kv1.5钾通道抑制剂 |
| RU2373934C1 (ru) * | 2008-03-19 | 2009-11-27 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств |
| CN101544580B (zh) * | 2009-04-28 | 2019-03-15 | 大连凯飞精细化工有限公司 | R-alpha-氨基-4-甲氧基苯乙酰胺的合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4099009A (en) * | 1977-04-11 | 1978-07-04 | Morton-Norwick Products, Inc. | 1-(4-chlorophenyl)-3-(1-ureido)-2-imidazolidinone |
| SK94393A3 (en) | 1992-09-11 | 1994-08-10 | Thomae Gmbh Dr K | Cyclic derivatives of urea, process for their production and their pharmaceutical agents with the content of those |
| DE4332168A1 (de) | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| JP2000501111A (ja) | 1996-01-26 | 2000-02-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | アスパルチルプロテアーゼインヒビター |
| JP2000507581A (ja) | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質転移酵素の阻害剤 |
| US7129359B2 (en) | 2002-07-09 | 2006-10-31 | National Health Research Institutes | Imidazolidinone compounds |
| CN1582279A (zh) | 2001-11-30 | 2005-02-16 | 伊莱利利公司 | 过氧化物酶体激活的受体激动剂 |
| US7189856B2 (en) | 2001-12-28 | 2007-03-13 | Gideon Shapiro | Non-peptide somatostatin receptor ligands |
| AU2003302027A1 (en) | 2002-11-21 | 2004-06-15 | Vicore Pharma Ab | New tricyclic angiotensin ii agonists |
| JP2004262903A (ja) | 2003-03-04 | 2004-09-24 | Japan Science & Technology Agency | アジリジン類の製造方法 |
| US7259174B2 (en) | 2004-05-25 | 2007-08-21 | National Health Research Institutes | Imidazolidinone compounds |
| WO2006027211A1 (en) * | 2004-09-07 | 2006-03-16 | Glaxo Group Limited | 2,4-substituted pyrimidines as cysteine protease inhibitors |
| KR100677149B1 (ko) | 2004-11-12 | 2007-02-02 | 삼성전자주식회사 | 잉크 조성물 |
| CN101573341A (zh) * | 2006-06-20 | 2009-11-04 | 惠氏公司 | 咪唑烷酮Kv1.5钾通道抑制剂 |
-
2007
- 2007-06-19 CN CNA2007800285697A patent/CN101573341A/zh active Pending
- 2007-06-19 WO PCT/US2007/071587 patent/WO2007149874A1/en not_active Ceased
- 2007-06-19 CA CA002655574A patent/CA2655574A1/en not_active Abandoned
- 2007-06-19 MX MX2008016399A patent/MX2008016399A/es unknown
- 2007-06-19 CL CL2007001794A patent/CL2007001794A1/es unknown
- 2007-06-19 AR ARP070102688A patent/AR061523A1/es unknown
- 2007-06-19 EP EP07798773A patent/EP2035392A1/en not_active Withdrawn
- 2007-06-19 AU AU2007260985A patent/AU2007260985A1/en not_active Abandoned
- 2007-06-19 US US11/765,359 patent/US7504517B2/en not_active Expired - Fee Related
- 2007-06-19 PE PE2007000779A patent/PE20080942A1/es not_active Application Discontinuation
- 2007-06-19 RU RU2008150465/04A patent/RU2008150465A/ru not_active Application Discontinuation
- 2007-06-19 KR KR1020097000926A patent/KR20090021223A/ko not_active Withdrawn
- 2007-06-19 BR BRPI0713320-0A patent/BRPI0713320A2/pt not_active IP Right Cessation
- 2007-06-19 JP JP2009516686A patent/JP2009541343A/ja not_active Withdrawn
- 2007-06-20 TW TW096122064A patent/TW200815363A/zh unknown
-
2008
- 2008-11-06 US US12/266,212 patent/US7803827B2/en not_active Expired - Fee Related
- 2008-12-16 NO NO20085252A patent/NO20085252L/no not_active Application Discontinuation
- 2008-12-18 CR CR10527A patent/CR10527A/es not_active Application Discontinuation
- 2008-12-19 ZA ZA200810763A patent/ZA200810763B/xx unknown
- 2008-12-19 CO CO08135447A patent/CO6150173A2/es unknown
- 2008-12-19 EC EC2008008994A patent/ECSP088994A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US7803827B2 (en) | 2010-09-28 |
| EP2035392A1 (en) | 2009-03-18 |
| US20070299120A1 (en) | 2007-12-27 |
| TW200815363A (en) | 2008-04-01 |
| WO2007149874A1 (en) | 2007-12-27 |
| US20090069342A1 (en) | 2009-03-12 |
| JP2009541343A (ja) | 2009-11-26 |
| CN101573341A (zh) | 2009-11-04 |
| ZA200810763B (en) | 2009-09-30 |
| PE20080942A1 (es) | 2008-09-03 |
| WO2007149874A8 (en) | 2008-03-20 |
| AU2007260985A1 (en) | 2007-12-27 |
| KR20090021223A (ko) | 2009-02-27 |
| CA2655574A1 (en) | 2007-12-27 |
| MX2008016399A (es) | 2009-02-03 |
| RU2008150465A (ru) | 2010-07-27 |
| BRPI0713320A2 (pt) | 2012-02-07 |
| NO20085252L (no) | 2009-01-13 |
| CL2007001794A1 (es) | 2008-01-18 |
| US7504517B2 (en) | 2009-03-17 |
| ECSP088994A (es) | 2009-01-30 |
| CR10527A (es) | 2009-02-19 |
| CO6150173A2 (es) | 2010-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |