PE20080942A1 - Compuestos 1-n-amino-2-imidazolidinonas como inhibidores del canal de potasion kv1.5 - Google Patents
Compuestos 1-n-amino-2-imidazolidinonas como inhibidores del canal de potasion kv1.5Info
- Publication number
- PE20080942A1 PE20080942A1 PE2007000779A PE2007000779A PE20080942A1 PE 20080942 A1 PE20080942 A1 PE 20080942A1 PE 2007000779 A PE2007000779 A PE 2007000779A PE 2007000779 A PE2007000779 A PE 2007000779A PE 20080942 A1 PE20080942 A1 PE 20080942A1
- Authority
- PE
- Peru
- Prior art keywords
- amino
- compounds
- imidazolidinones
- inhibitors
- alkyl
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- STUALXBCJWYUKO-UHFFFAOYSA-N 1-amino-4-(3,4-dimethylphenyl)-3-[2-(4-methoxyphenyl)ethyl]imidazolidin-2-one Chemical compound C1=CC(OC)=CC=C1CCN1C(=O)N(N)CC1C1=CC=C(C)C(C)=C1 STUALXBCJWYUKO-UHFFFAOYSA-N 0.000 abstract 1
- 108010042111 Kv1.5 Potassium Channel Proteins 0.000 abstract 1
- 102000004425 Kv1.5 Potassium Channel Human genes 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81509106P | 2006-06-20 | 2006-06-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080942A1 true PE20080942A1 (es) | 2008-09-03 |
Family
ID=38582320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000779A PE20080942A1 (es) | 2006-06-20 | 2007-06-19 | Compuestos 1-n-amino-2-imidazolidinonas como inhibidores del canal de potasion kv1.5 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7504517B2 (enExample) |
| EP (1) | EP2035392A1 (enExample) |
| JP (1) | JP2009541343A (enExample) |
| KR (1) | KR20090021223A (enExample) |
| CN (1) | CN101573341A (enExample) |
| AR (1) | AR061523A1 (enExample) |
| AU (1) | AU2007260985A1 (enExample) |
| BR (1) | BRPI0713320A2 (enExample) |
| CA (1) | CA2655574A1 (enExample) |
| CL (1) | CL2007001794A1 (enExample) |
| CO (1) | CO6150173A2 (enExample) |
| CR (1) | CR10527A (enExample) |
| EC (1) | ECSP088994A (enExample) |
| MX (1) | MX2008016399A (enExample) |
| NO (1) | NO20085252L (enExample) |
| PE (1) | PE20080942A1 (enExample) |
| RU (1) | RU2008150465A (enExample) |
| TW (1) | TW200815363A (enExample) |
| WO (1) | WO2007149874A1 (enExample) |
| ZA (1) | ZA200810763B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2007001794A1 (es) * | 2006-06-20 | 2008-01-18 | Wyeth Corp | Compuestos derivados de 2-imidazolidinona, inhibidores del canal de potasio kv1.5; composicion farmaceutica que los comprende; y su uso para tratar o prevenir arritmias cardiacas. tromboembolia,apoplejia,insuficiencia cardiaca. |
| RU2373934C1 (ru) * | 2008-03-19 | 2009-11-27 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств |
| CN101544580B (zh) * | 2009-04-28 | 2019-03-15 | 大连凯飞精细化工有限公司 | R-alpha-氨基-4-甲氧基苯乙酰胺的合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4099009A (en) * | 1977-04-11 | 1978-07-04 | Morton-Norwick Products, Inc. | 1-(4-chlorophenyl)-3-(1-ureido)-2-imidazolidinone |
| SK94393A3 (en) | 1992-09-11 | 1994-08-10 | Thomae Gmbh Dr K | Cyclic derivatives of urea, process for their production and their pharmaceutical agents with the content of those |
| DE4332168A1 (de) | 1993-02-22 | 1995-03-23 | Thomae Gmbh Dr K | Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| CA2243121A1 (en) | 1996-01-26 | 1997-07-31 | Francesco Gerald Salituro | Aspartyl protease inhibitors |
| AU716153B2 (en) | 1996-04-03 | 2000-02-17 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| US7129359B2 (en) * | 2002-07-09 | 2006-10-31 | National Health Research Institutes | Imidazolidinone compounds |
| BR0214437A (pt) | 2001-11-30 | 2004-10-13 | Lilly Co Eli | Composto, composição farmacêutica, métodos de modular um receptor ativado por proliferador de peroxissoma, de tratar e de prevenir a diabete melito, e de tratar a sìndrome x, e doenças cardiovasculares em um mamìfero, e, uso de um composto |
| WO2003057214A1 (en) | 2001-12-28 | 2003-07-17 | Somatocor Pharmaceuticals, Inc. | Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands |
| WO2004046137A1 (en) | 2002-11-21 | 2004-06-03 | Vicore Pharma Ab | New tricyclic angiotensin ii agonists |
| JP2004262903A (ja) | 2003-03-04 | 2004-09-24 | Japan Science & Technology Agency | アジリジン類の製造方法 |
| US7259174B2 (en) * | 2004-05-25 | 2007-08-21 | National Health Research Institutes | Imidazolidinone compounds |
| AR050858A1 (es) | 2004-09-07 | 2006-11-29 | Glaxo Group Ltd | Compuesto de heteroaril-nitrilo sustituido, su uso para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para la preparacion del mismo |
| KR100677149B1 (ko) * | 2004-11-12 | 2007-02-02 | 삼성전자주식회사 | 잉크 조성물 |
| CL2007001794A1 (es) * | 2006-06-20 | 2008-01-18 | Wyeth Corp | Compuestos derivados de 2-imidazolidinona, inhibidores del canal de potasio kv1.5; composicion farmaceutica que los comprende; y su uso para tratar o prevenir arritmias cardiacas. tromboembolia,apoplejia,insuficiencia cardiaca. |
-
2007
- 2007-06-19 CL CL2007001794A patent/CL2007001794A1/es unknown
- 2007-06-19 PE PE2007000779A patent/PE20080942A1/es not_active Application Discontinuation
- 2007-06-19 CA CA002655574A patent/CA2655574A1/en not_active Abandoned
- 2007-06-19 MX MX2008016399A patent/MX2008016399A/es unknown
- 2007-06-19 RU RU2008150465/04A patent/RU2008150465A/ru not_active Application Discontinuation
- 2007-06-19 CN CNA2007800285697A patent/CN101573341A/zh active Pending
- 2007-06-19 AR ARP070102688A patent/AR061523A1/es unknown
- 2007-06-19 WO PCT/US2007/071587 patent/WO2007149874A1/en not_active Ceased
- 2007-06-19 BR BRPI0713320-0A patent/BRPI0713320A2/pt not_active IP Right Cessation
- 2007-06-19 KR KR1020097000926A patent/KR20090021223A/ko not_active Withdrawn
- 2007-06-19 EP EP07798773A patent/EP2035392A1/en not_active Withdrawn
- 2007-06-19 JP JP2009516686A patent/JP2009541343A/ja not_active Withdrawn
- 2007-06-19 US US11/765,359 patent/US7504517B2/en not_active Expired - Fee Related
- 2007-06-19 AU AU2007260985A patent/AU2007260985A1/en not_active Abandoned
- 2007-06-20 TW TW096122064A patent/TW200815363A/zh unknown
-
2008
- 2008-11-06 US US12/266,212 patent/US7803827B2/en not_active Expired - Fee Related
- 2008-12-16 NO NO20085252A patent/NO20085252L/no not_active Application Discontinuation
- 2008-12-18 CR CR10527A patent/CR10527A/es not_active Application Discontinuation
- 2008-12-19 ZA ZA200810763A patent/ZA200810763B/xx unknown
- 2008-12-19 CO CO08135447A patent/CO6150173A2/es unknown
- 2008-12-19 EC EC2008008994A patent/ECSP088994A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CR10527A (es) | 2009-02-19 |
| WO2007149874A1 (en) | 2007-12-27 |
| WO2007149874A8 (en) | 2008-03-20 |
| BRPI0713320A2 (pt) | 2012-02-07 |
| ECSP088994A (es) | 2009-01-30 |
| US7803827B2 (en) | 2010-09-28 |
| RU2008150465A (ru) | 2010-07-27 |
| EP2035392A1 (en) | 2009-03-18 |
| NO20085252L (no) | 2009-01-13 |
| MX2008016399A (es) | 2009-02-03 |
| CN101573341A (zh) | 2009-11-04 |
| US20090069342A1 (en) | 2009-03-12 |
| CA2655574A1 (en) | 2007-12-27 |
| CO6150173A2 (es) | 2010-04-20 |
| US7504517B2 (en) | 2009-03-17 |
| AR061523A1 (es) | 2008-09-03 |
| TW200815363A (en) | 2008-04-01 |
| AU2007260985A1 (en) | 2007-12-27 |
| JP2009541343A (ja) | 2009-11-26 |
| US20070299120A1 (en) | 2007-12-27 |
| CL2007001794A1 (es) | 2008-01-18 |
| KR20090021223A (ko) | 2009-02-27 |
| ZA200810763B (en) | 2009-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |