AR061269A1 - Composicion y metodo de revascularizacion para el tratamiento de enfermedades isquemicas usando eritropoyetina - Google Patents
Composicion y metodo de revascularizacion para el tratamiento de enfermedades isquemicas usando eritropoyetinaInfo
- Publication number
- AR061269A1 AR061269A1 ARP070102478A ARP070102478A AR061269A1 AR 061269 A1 AR061269 A1 AR 061269A1 AR P070102478 A ARP070102478 A AR P070102478A AR P070102478 A ARP070102478 A AR P070102478A AR 061269 A1 AR061269 A1 AR 061269A1
- Authority
- AR
- Argentina
- Prior art keywords
- subject
- peripheral blood
- mononuclear cells
- treatment
- composition
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000000250 revascularization Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 102000003951 Erythropoietin Human genes 0.000 abstract 3
- 108090000394 Erythropoietin Proteins 0.000 abstract 3
- 229940105423 erythropoietin Drugs 0.000 abstract 3
- 210000005259 peripheral blood Anatomy 0.000 abstract 3
- 239000011886 peripheral blood Substances 0.000 abstract 3
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 3
- 208000023589 ischemic disease Diseases 0.000 abstract 2
- 210000005087 mononuclear cell Anatomy 0.000 abstract 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 abstract 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 abstract 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001483 mobilizing effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/14—Erythropoietin [EPO]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Developmental Biology & Embryology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Método para estimular la revascularizacion en un sujeto, que comprende los siguientes pasos: (a) administrarle eritropoyetina al sujeto; (b) recolectar células mononucleares de la sangre periférica del sujeto; y (c) administrar las células mononucleares de sangre periférica recolectadas en un sitio blanco en el sujeto. Las células mononucleares de sangre periférica, y en particular, las células CD34-positivas, son movilizadas hacia la sangre periférica de un sujeto mediante la administracion de eritropoyetina al sujeto. El método de la presente es util para el tratamiento de enfermedades isquémicas, tales como el trastorno vascular periférico. Reivindicacion 1: Una composicion para movilizar las células mononucleares hacia la sangre periférica que puede usarse para tratar enfermedades isquémicas, caracterizada porque comprende eritropoyetina como ingrediente activo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006158998 | 2006-06-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR061269A1 true AR061269A1 (es) | 2008-08-13 |
Family
ID=38801534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070102478A AR061269A1 (es) | 2006-06-07 | 2007-06-07 | Composicion y metodo de revascularizacion para el tratamiento de enfermedades isquemicas usando eritropoyetina |
Country Status (17)
Country | Link |
---|---|
US (1) | US20090280094A1 (es) |
EP (1) | EP2047859A4 (es) |
JP (2) | JP5326079B2 (es) |
KR (1) | KR20090031547A (es) |
CN (1) | CN101460188B (es) |
AR (1) | AR061269A1 (es) |
AU (1) | AU2007255717B2 (es) |
BR (1) | BRPI0712063A2 (es) |
CA (1) | CA2654154A1 (es) |
HK (1) | HK1128419A1 (es) |
IL (1) | IL195648A0 (es) |
MX (1) | MX2008015392A (es) |
NO (1) | NO20085098L (es) |
NZ (1) | NZ573792A (es) |
RU (1) | RU2008152746A (es) |
TW (1) | TW200815026A (es) |
WO (1) | WO2007142288A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007142288A1 (ja) * | 2006-06-07 | 2007-12-13 | The University Of Tokushima | エリスロポエチンを用いた虚血性疾患の治療 |
EP3150701B1 (en) | 2009-06-05 | 2018-10-03 | FUJIFILM Cellular Dynamics, Inc. | Reprogramming t cells and hematopoietic cells |
FR2957799B1 (fr) * | 2010-03-26 | 2012-08-17 | Inst Des Vaisseaux Et Du Sang | Compositions proangiogeniques, leur procede de preparation et leurs utilisations |
CN101940594B (zh) * | 2010-08-27 | 2013-12-04 | 上海士腾生物技术有限公司 | 用于治疗缺血性心血管疾病的制剂及其制备方法 |
CN101940590B (zh) * | 2010-08-27 | 2013-09-18 | 上海士腾生物技术有限公司 | 促进创伤愈合的制剂及其制备方法 |
JP5582983B2 (ja) * | 2010-11-24 | 2014-09-03 | 楠本化成株式会社 | 水系沈降防止剤 |
KR101544674B1 (ko) | 2013-06-05 | 2015-09-02 | 서울대학교산학협력단 | 에리쓰로포이에틴으로 프라이밍된 혈관 생성능이 향상된 말초혈액 줄기세포 및 그 용도 |
DE102017116204B4 (de) | 2017-07-18 | 2024-06-27 | Universität Rostock | Verfahren zur Vorhersage der Antwort auf die kardiovaskuläre Regeneration |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62501010A (ja) | 1984-12-04 | 1987-04-23 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | エリトロポエチンの生産方法 |
US4677195A (en) | 1985-01-11 | 1987-06-30 | Genetics Institute, Inc. | Method for the purification of erythropoietin and erythropoietin compositions |
KR100263845B1 (ko) | 1989-10-13 | 2000-08-16 | 스튜어트 엘.왓트 | 에리트로포이에틴 동형체와 그의 제조방법 및 그를 포함하는제약학적 조성물 |
TWI240627B (en) | 1996-04-26 | 2005-10-01 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
DE19857609A1 (de) * | 1998-12-14 | 2000-06-15 | Hannelore Ehrenreich | Verwendung von Erythropoietin zur Behandlung von cerebralen Ischämien des Menschen |
CA2465007C (en) | 2001-10-29 | 2012-01-17 | Crucell Holland B.V. | Methods and means for producing proteins with predetermined post-translational modifications |
US6784154B2 (en) * | 2001-11-01 | 2004-08-31 | University Of Utah Research Foundation | Method of use of erythropoietin to treat ischemic acute renal failure |
US20040009908A1 (en) * | 2002-07-10 | 2004-01-15 | Stamler Jonathan S. | Methods for treating or preventing ischemic injury |
DE10234192B4 (de) * | 2002-07-26 | 2009-11-26 | Epoplus Gmbh Co.Kg | Verwendung von Erythropoetin |
US20050058622A1 (en) * | 2002-12-06 | 2005-03-17 | Lyman Stewart D. | Methods of using Flt3-Ligand in hematopoietic cell transplantation procedures incorporating nonmyeloablative conditioning regimens |
CN1764470A (zh) * | 2003-03-27 | 2006-04-26 | 詹森药业有限公司 | 促红细胞生成素在中风康复中的用途 |
BRPI0408829A (pt) * | 2003-03-27 | 2006-04-04 | Janssen Pharmaceutica Nv | uso de eritropoietina em recuperação de acidente vascular cerebral |
US20040198663A1 (en) * | 2003-04-04 | 2004-10-07 | Baker John E. | Method of treating cardiac ischemia by using erythropoietin |
DE102004063927A1 (de) * | 2004-01-23 | 2005-12-15 | Epoplus Gmbh Co.Kg | Einsatz von niedrig dosiertem Erythropoietin zur Stimulation endothelialer Vorläuferzellen sowie zur Organregeneration und Progressionsverlangsamung von Endorganschäden |
JP2007217283A (ja) * | 2004-03-30 | 2007-08-30 | Niigata Tlo:Kk | 血管新生促進剤および血管新生療法 |
JP2006158998A (ja) | 2004-12-02 | 2006-06-22 | Nippon Sheet Glass Co Ltd | ロッドの反り選別装置 |
KR20170027868A (ko) * | 2005-08-05 | 2017-03-10 | 아라임 파마슈티칼즈, 인크. | 조직 보호 펩티드 및 이의 용도 |
WO2007142288A1 (ja) * | 2006-06-07 | 2007-12-13 | The University Of Tokushima | エリスロポエチンを用いた虚血性疾患の治療 |
-
2007
- 2007-06-07 WO PCT/JP2007/061525 patent/WO2007142288A1/ja active Application Filing
- 2007-06-07 NZ NZ573792A patent/NZ573792A/en not_active IP Right Cessation
- 2007-06-07 CA CA002654154A patent/CA2654154A1/en not_active Abandoned
- 2007-06-07 RU RU2008152746/15A patent/RU2008152746A/ru not_active Application Discontinuation
- 2007-06-07 JP JP2008520614A patent/JP5326079B2/ja active Active
- 2007-06-07 MX MX2008015392A patent/MX2008015392A/es active IP Right Grant
- 2007-06-07 AU AU2007255717A patent/AU2007255717B2/en not_active Ceased
- 2007-06-07 TW TW096120549A patent/TW200815026A/zh unknown
- 2007-06-07 CN CN2007800209636A patent/CN101460188B/zh not_active Expired - Fee Related
- 2007-06-07 AR ARP070102478A patent/AR061269A1/es not_active Application Discontinuation
- 2007-06-07 EP EP07744855A patent/EP2047859A4/en not_active Withdrawn
- 2007-06-07 US US12/303,669 patent/US20090280094A1/en not_active Abandoned
- 2007-06-07 BR BRPI0712063-0A patent/BRPI0712063A2/pt not_active IP Right Cessation
- 2007-06-07 KR KR1020097000110A patent/KR20090031547A/ko not_active Application Discontinuation
-
2008
- 2008-12-02 IL IL195648A patent/IL195648A0/en unknown
- 2008-12-08 NO NO20085098A patent/NO20085098L/no not_active Application Discontinuation
-
2009
- 2009-08-20 HK HK09107647.3A patent/HK1128419A1/xx not_active IP Right Cessation
-
2013
- 2013-03-15 JP JP2013054102A patent/JP2013116919A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP2047859A1 (en) | 2009-04-15 |
KR20090031547A (ko) | 2009-03-26 |
CA2654154A1 (en) | 2007-12-13 |
CN101460188B (zh) | 2013-09-04 |
CN101460188A (zh) | 2009-06-17 |
RU2008152746A (ru) | 2010-07-20 |
IL195648A0 (en) | 2011-08-01 |
JP2013116919A (ja) | 2013-06-13 |
NO20085098L (no) | 2009-02-27 |
US20090280094A1 (en) | 2009-11-12 |
AU2007255717A1 (en) | 2007-12-13 |
BRPI0712063A2 (pt) | 2011-12-20 |
TW200815026A (en) | 2008-04-01 |
HK1128419A1 (en) | 2009-10-30 |
JP5326079B2 (ja) | 2013-10-30 |
EP2047859A4 (en) | 2010-05-05 |
JPWO2007142288A1 (ja) | 2009-10-29 |
AU2007255717B2 (en) | 2013-07-11 |
NZ573792A (en) | 2011-09-30 |
WO2007142288A1 (ja) | 2007-12-13 |
MX2008015392A (es) | 2009-05-05 |
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Legal Events
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FA | Abandonment or withdrawal |