AR058230A1 - Derivados de pirilsulfonamida y composicion farmaceutica - Google Patents
Derivados de pirilsulfonamida y composicion farmaceuticaInfo
- Publication number
- AR058230A1 AR058230A1 ARP060105171A ARP060105171A AR058230A1 AR 058230 A1 AR058230 A1 AR 058230A1 AR P060105171 A ARP060105171 A AR P060105171A AR P060105171 A ARP060105171 A AR P060105171A AR 058230 A1 AR058230 A1 AR 058230A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- pharmaceutical composition
- pirilsulfonamide
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Son objetos de la presente los compuestos de la formula (1) y una composicion farmacéutica. Estos compuestos son utiles para el control o la prevencion de enfermedades tales como el cáncer. Reivindicacion 1: Un compuesto de la formula (1) en la que R1 es piridilo que está sustituido de 1 a 3 veces por a) -O-fenilo, en el que el fenilo está sustituido 1 o 2 veces por halogeno, ciano, alquilo, alcoxi, nitro, amino, alquilamino o dialquilamino; b) -NRR', en el que R y R' con independencia entre sí significan H o alquilo; o como alternativa R y R' junto con el átomo de N al que están unidos forman un heterociclo saturado de 5 a 7 eslabones, que está sustituido de 1 a 3 veces por alquilo o alcoxi; c) halogeno; o d) alquilo; R2 es F, Cl, Br, metilo, metoxi o trifluormetilo; R3 es F, Cl, Br, metilo o trifluormetilo; y todas las sales farmacéuticamente aceptables del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05025733 | 2005-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR058230A1 true AR058230A1 (es) | 2008-01-23 |
Family
ID=36143754
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060105171A AR058230A1 (es) | 2005-11-25 | 2006-11-23 | Derivados de pirilsulfonamida y composicion farmaceutica |
Country Status (12)
Country | Link |
---|---|
US (1) | US7625896B2 (es) |
EP (1) | EP1960361A1 (es) |
JP (1) | JP2009515916A (es) |
KR (1) | KR101067313B1 (es) |
CN (1) | CN101300231B (es) |
AR (1) | AR058230A1 (es) |
AU (1) | AU2006317179A1 (es) |
BR (1) | BRPI0618990A2 (es) |
CA (1) | CA2629544A1 (es) |
IL (1) | IL190334A0 (es) |
TW (1) | TW200736220A (es) |
WO (1) | WO2007059872A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7939532B2 (en) * | 2006-10-26 | 2011-05-10 | Hoffmann-La Roche Inc. | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
CN102838515A (zh) * | 2011-06-23 | 2012-12-26 | 南京大学 | 肉桂酰磺酰胺类化合物的制备及其在抗癌治疗药物中的应用 |
CN108558822B (zh) * | 2018-06-01 | 2020-12-18 | 盐城锦明药业有限公司 | N-((5-溴噻吩-2-基)磺酰基)-2,4-二氯苯甲酰胺的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1368948A (en) * | 1970-11-11 | 1974-10-02 | Manuf Prod Pharma | Pyridine derivatives |
GB1477664A (en) * | 1974-04-17 | 1977-06-22 | Christiaens Sa A | Pyridine derivatives |
JP3545461B2 (ja) * | 1993-09-10 | 2004-07-21 | エーザイ株式会社 | 二環式ヘテロ環含有スルホンアミド誘導体 |
JP2000247949A (ja) * | 1999-02-26 | 2000-09-12 | Eisai Co Ltd | スルホンアミド含有インドール化合物 |
JP4007743B2 (ja) * | 1999-02-26 | 2007-11-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害剤 |
CA2446719A1 (en) * | 2001-06-06 | 2002-12-12 | Eli Lilly And Company | Benzoylsulfonamides and sulfonylbenzamidines for use as antitumour agents |
TWI281916B (en) | 2001-10-25 | 2007-06-01 | Lilly Co Eli | Antitumor compounds and methods |
DE60316984T2 (de) | 2002-11-22 | 2008-07-17 | Eli Lilly And Co., Indianapolis | Benzoylsulfonamide als antitumor-mittel |
-
2006
- 2006-11-08 US US11/594,297 patent/US7625896B2/en not_active Expired - Fee Related
- 2006-11-13 BR BRPI0618990-3A patent/BRPI0618990A2/pt not_active IP Right Cessation
- 2006-11-13 KR KR1020087012217A patent/KR101067313B1/ko not_active IP Right Cessation
- 2006-11-13 WO PCT/EP2006/010847 patent/WO2007059872A1/en active Application Filing
- 2006-11-13 JP JP2008540496A patent/JP2009515916A/ja active Pending
- 2006-11-13 CN CN2006800412842A patent/CN101300231B/zh not_active Expired - Fee Related
- 2006-11-13 EP EP06829015A patent/EP1960361A1/en not_active Withdrawn
- 2006-11-13 AU AU2006317179A patent/AU2006317179A1/en not_active Abandoned
- 2006-11-13 CA CA002629544A patent/CA2629544A1/en not_active Abandoned
- 2006-11-14 TW TW095142169A patent/TW200736220A/zh unknown
- 2006-11-23 AR ARP060105171A patent/AR058230A1/es not_active Application Discontinuation
-
2008
- 2008-03-20 IL IL190334A patent/IL190334A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR101067313B1 (ko) | 2011-09-23 |
BRPI0618990A2 (pt) | 2011-09-20 |
WO2007059872A1 (en) | 2007-05-31 |
EP1960361A1 (en) | 2008-08-27 |
CA2629544A1 (en) | 2007-05-31 |
JP2009515916A (ja) | 2009-04-16 |
CN101300231A (zh) | 2008-11-05 |
TW200736220A (en) | 2007-10-01 |
IL190334A0 (en) | 2009-09-22 |
KR20080058501A (ko) | 2008-06-25 |
CN101300231B (zh) | 2011-11-09 |
US7625896B2 (en) | 2009-12-01 |
AU2006317179A1 (en) | 2007-05-31 |
US20070123513A1 (en) | 2007-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |