AR058029A1 - Derivados de pirimidilpirazol, composicion que lo comprende y su uso para preparar un medicamento - Google Patents
Derivados de pirimidilpirazol, composicion que lo comprende y su uso para preparar un medicamentoInfo
- Publication number
- AR058029A1 AR058029A1 ARP060103710A ARP060103710A AR058029A1 AR 058029 A1 AR058029 A1 AR 058029A1 AR P060103710 A ARP060103710 A AR P060103710A AR P060103710 A ARP060103710 A AR P060103710A AR 058029 A1 AR058029 A1 AR 058029A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- substituted
- cycloalkyl
- nr7r8
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composicion que lo comprende y su uso para preparar un medicamento util para tratar enfermedades de proliferacion celular. Entre dichos compuestos se citan en forma preferida: N,N-dietil-N'-(4-{4-[2-({3-[4-(2-hidroxietil)-1-piperazinil]fenilamino)-4- pirimidinil]-1-metil-1H-pirazol-3-il}fenil)urea, N,N-dietil-N'-{4-[1-metil-4-(2-{[3-(4-metil-1-piperazinil)fenil]amino}-4-pirimidinil)-1H-pirazol-3-il]fenil}urea y N'-{4-[1-(2'-hidroxietil)-4-(2-{[3-(1-pirrolidinilmetil)fenil]amino}-4-pirimidinil)- 1H-pirazol-3-il]fenil}-N,N-dimetilurea. Reivindicacion 1: Un compuesto de pirimidil pirazol caracterizado porque es de la formula (1) o su sal farmacéuticamente aceptable, o su solvato, o una combinacion de los mismos, en la que R1 representa fenilo, fenilo sustituido, heteroarilo, alquilo C1-6, cicloalquilo C3-6, o -NR7R8; R2 y R3 representan cada uno independientemente H, halogeno, alquilo C1-3 o -O-alquilo C1-3; R4, un sustituyente de uno de los átomos de N del anillo pirazol, representa H, alquilo C1-6, alquilo C1-6 sustituido, cicloalquilo C3-6, -C(O)alquilo C1-6; -C(O)-alquilo C1-6 sustituido, -C(O)NR7R8, -S(O)2-alquilo C1-6, -S(O)2-cicloalquilo C3-6, o -C(O)NH-alquilo C1-6; R5, R5', y R6 representan cada uno independientemente H, halogeno, alquilo C1-6, alquilo C1-6 sustituido, -NH-C(O)-alquilo C1-6 sustituido, -O-alquilo C1-6, -O-alquilo C1-6 sustituido, -NR7R8, o hidroxilo; y R7 y R8 representan cada uno independientemente H, alquilo C1-6, alquilo C1- 6 sustituido, cicloalquilo C3-6, fenilo, fenilo sustituido o heteroarilo, o forman, junto con el átomo de N al cual están unidos un sustituyente seleccionado del grupo que consiste en pirrolidinilo, piperidinilo, morfolinilo, piperazinilo, 4-alquil C1-6-piperazin-1-ilo, y 4-(hidroxi)-alquil C2-6)-piperazin-1-ilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71197905P | 2005-08-26 | 2005-08-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR058029A1 true AR058029A1 (es) | 2008-01-23 |
Family
ID=37772278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103710A AR058029A1 (es) | 2005-08-26 | 2006-08-25 | Derivados de pirimidilpirazol, composicion que lo comprende y su uso para preparar un medicamento |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20080242667A1 (es) |
| EP (1) | EP1917258A2 (es) |
| JP (1) | JP2009506040A (es) |
| AR (1) | AR058029A1 (es) |
| PE (1) | PE20070359A1 (es) |
| TW (1) | TW200800211A (es) |
| WO (1) | WO2007024843A2 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008277730B2 (en) * | 2007-07-13 | 2013-01-31 | Addex Pharma S.A. | Pyrazole derivatives as modulators of metabotropic glutamate receptors |
| AU2008333136B2 (en) | 2007-12-07 | 2012-05-10 | Astex Therapeutics Ltd | Pyrazole derivatives and use thereof as inhibitors of cyclin dependent kinases |
| NZ587589A (en) | 2008-02-15 | 2012-10-26 | Rigel Pharmaceuticals Inc | Pyrimidine-2-amine compounds and their use as inhibitors of jak kinases |
| BRPI0916356B1 (pt) | 2008-07-24 | 2022-08-23 | Nerviano Medical Sciences S.R.L | 3,4-diaril pirazois como inibidores da proteína quinase |
| CA2763624A1 (en) * | 2009-05-27 | 2010-12-02 | Abbott Laboratories | Pyrimidine inhibitors of kinase activity |
| JO3002B1 (ar) | 2009-08-28 | 2016-09-05 | Irm Llc | مركبات و تركيبات كمثبطات كيناز بروتين |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| CN102762551A (zh) | 2009-12-21 | 2012-10-31 | 拜尔农作物科学股份公司 | 噻吩基吡(嘧)啶基吡唑及其用于防治植物致病菌的用途 |
| AU2011209234B2 (en) * | 2010-01-27 | 2015-05-07 | Nerviano Medical Sciences S.R.L. | Sulfonamido derivatives of 3,4-diarylpyrazoles as protein kinase inhibitors |
| EP2601185B1 (en) | 2010-08-03 | 2015-10-07 | Nerviano Medical Sciences S.r.l. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
| AR086992A1 (es) | 2011-06-20 | 2014-02-05 | Bayer Ip Gmbh | Tienilpiri(mi)dinilpirazoles |
| RU2616293C2 (ru) | 2011-10-06 | 2017-04-14 | Байер Интеллектуэль Проперти Гмбх | Гетероциклилпиридинилпиразолы в качестве фунгицидного средства |
| MX351460B (es) | 2011-10-06 | 2017-10-16 | Bayer Ip Gmbh | Heterociclilpiri(mi)dinilpirazol. |
| JP6150813B2 (ja) | 2011-11-11 | 2017-06-21 | ノバルティス アーゲー | 増殖性疾患の治療方法 |
| WO2013078264A1 (en) | 2011-11-23 | 2013-05-30 | Novartis Ag | Pharmaceutical formulations |
| TWI485146B (zh) | 2012-02-29 | 2015-05-21 | Taiho Pharmaceutical Co Ltd | Novel piperidine compounds or salts thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0129476D0 (en) * | 2001-12-10 | 2002-01-30 | Syngenta Participations Ag | Organic compounds |
-
2006
- 2006-08-23 WO PCT/US2006/032746 patent/WO2007024843A2/en active Application Filing
- 2006-08-23 JP JP2008528062A patent/JP2009506040A/ja not_active Withdrawn
- 2006-08-23 EP EP06802071A patent/EP1917258A2/en not_active Withdrawn
- 2006-08-23 US US12/064,820 patent/US20080242667A1/en not_active Abandoned
- 2006-08-24 PE PE2006001028A patent/PE20070359A1/es not_active Application Discontinuation
- 2006-08-24 TW TW095131061A patent/TW200800211A/zh unknown
- 2006-08-25 AR ARP060103710A patent/AR058029A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20080242667A1 (en) | 2008-10-02 |
| JP2009506040A (ja) | 2009-02-12 |
| TW200800211A (en) | 2008-01-01 |
| WO2007024843A2 (en) | 2007-03-01 |
| EP1917258A2 (en) | 2008-05-07 |
| PE20070359A1 (es) | 2007-04-05 |
| WO2007024843A3 (en) | 2007-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |