AR054228A1 - Geles acuosos de alta estabilidad a base de metronidazol y procedimiento para su preparacion - Google Patents
Geles acuosos de alta estabilidad a base de metronidazol y procedimiento para su preparacionInfo
- Publication number
- AR054228A1 AR054228A1 AR20060100653A ARP060100653A AR054228A1 AR 054228 A1 AR054228 A1 AR 054228A1 AR 20060100653 A AR20060100653 A AR 20060100653A AR P060100653 A ARP060100653 A AR P060100653A AR 054228 A1 AR054228 A1 AR 054228A1
- Authority
- AR
- Argentina
- Prior art keywords
- procedure
- high stability
- gels
- metronidazol
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Abstract
Procedimiento de preparacion de un gel acuoso a base de metronidazol, que comprende las etapas sucesivas que consisten en: (A) formar un medio solvente M que comprende agua y propilenglicol; (B) disolver el metronidazol en ese medio solvente M y, eventualmente, diluir el medio obtenido por adicion de agua, por lo que se obtiene una solucion S de metronidazol; ( C ) mezclar la solucion S obtenida de esa forma con un polímero gelificante, en una cantidad suficiente para asegurar la gelificacion de la composicion. Geles acuosos de estabilidad elevada que pueden obtenerse de acuerdo con ese procedimiento, así como a la utilizacion de esos geles a título de composiciones dermatologicas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0501949A FR2882552B1 (fr) | 2005-02-25 | 2005-02-25 | Gel aqueux de haute stabilite a base de metronidazole et procedes pour leur preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
AR054228A1 true AR054228A1 (es) | 2007-06-13 |
Family
ID=35044713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR20060100653A AR054228A1 (es) | 2005-02-25 | 2006-02-23 | Geles acuosos de alta estabilidad a base de metronidazol y procedimiento para su preparacion |
Country Status (19)
Country | Link |
---|---|
US (1) | US20090215849A1 (es) |
EP (1) | EP1855650B1 (es) |
JP (1) | JP2008531517A (es) |
KR (1) | KR20070112139A (es) |
CN (1) | CN101128185A (es) |
AR (1) | AR054228A1 (es) |
AU (1) | AU2006218043B2 (es) |
BR (1) | BRPI0608044A2 (es) |
CA (1) | CA2598031A1 (es) |
DK (1) | DK1855650T3 (es) |
ES (1) | ES2400502T3 (es) |
FR (1) | FR2882552B1 (es) |
MX (1) | MX2007010179A (es) |
PL (1) | PL1855650T3 (es) |
PT (1) | PT1855650E (es) |
RU (1) | RU2409346C2 (es) |
SI (1) | SI1855650T1 (es) |
WO (1) | WO2006089804A1 (es) |
ZA (1) | ZA200707558B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112013033759B1 (pt) | 2011-06-28 | 2021-05-25 | Chemo Research Sl | forma de dosagem unitária de um gel de base aquosa de metronidazol mucoadesivo e uso relacionado ao gel de base aquosa de metronidazol |
CN113476397B (zh) * | 2021-07-12 | 2022-11-18 | 海南海神同洲制药有限公司 | 一种甲硝唑凝胶及其制备方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4837378A (en) * | 1986-01-15 | 1989-06-06 | Curatek Pharmaceuticals, Inc. | Topical metronidazole formulations and therapeutic uses thereof |
JPH0825878B2 (ja) * | 1987-03-20 | 1996-03-13 | ガルデルマ エスアー | 局所的メトロニダゾール製剤 |
US5536743A (en) * | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
JP2533723B2 (ja) * | 1992-12-28 | 1996-09-11 | 東興薬品工業株式会社 | 速乾性ゲルタイプ手指消毒剤 |
FR2700952B1 (fr) * | 1993-01-29 | 1995-03-17 | Oreal | Nouvelles compositions cosmétiques ou dermopharmaceutiques sous forme de gels aqueux modifiés par addition de microsphères expansées. |
FR2722098B1 (fr) * | 1994-07-06 | 1996-08-23 | Cird Galderma | Nouveaux medicaments a base de metro-nidazole ou d'un melange synergetique de metronidazole et de clindamycine |
IN188720B (es) * | 1997-11-06 | 2002-11-02 | Panacea Biotec Ltd | |
IL138889A0 (en) * | 1998-04-17 | 2001-11-25 | Bertek Pharm Inc | Topical formulations for the treatment of nail fungal diseases |
US7074832B2 (en) * | 2001-09-24 | 2006-07-11 | Bradley Pharmaceuticals, Inc. | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use |
US7368122B1 (en) * | 2002-03-08 | 2008-05-06 | Dow Pharmaceutical Sciences | Skin cream |
US6846837B2 (en) * | 2002-06-21 | 2005-01-25 | Howard I. Maibach | Topical administration of basic antifungal compositions to treat fungal infections of the nails |
AR041021A1 (es) * | 2002-08-22 | 2005-04-27 | Novartis Consumer Health Sa | Composicion topica |
US20060093675A1 (en) * | 2004-10-29 | 2006-05-04 | Mathew Ebmeier | Intravaginal treatment of vaginal infections with metronidazole compositions |
-
2005
- 2005-02-25 FR FR0501949A patent/FR2882552B1/fr not_active Expired - Fee Related
-
2006
- 2006-02-16 KR KR1020077019197A patent/KR20070112139A/ko not_active Application Discontinuation
- 2006-02-16 RU RU2007135364/15A patent/RU2409346C2/ru not_active IP Right Cessation
- 2006-02-16 EP EP06707447A patent/EP1855650B1/en active Active
- 2006-02-16 SI SI200631537T patent/SI1855650T1/sl unknown
- 2006-02-16 PT PT67074476T patent/PT1855650E/pt unknown
- 2006-02-16 CN CNA2006800059009A patent/CN101128185A/zh active Pending
- 2006-02-16 PL PL06707447T patent/PL1855650T3/pl unknown
- 2006-02-16 MX MX2007010179A patent/MX2007010179A/es active IP Right Grant
- 2006-02-16 AU AU2006218043A patent/AU2006218043B2/en not_active Ceased
- 2006-02-16 JP JP2007556571A patent/JP2008531517A/ja active Pending
- 2006-02-16 BR BRPI0608044-8A patent/BRPI0608044A2/pt not_active IP Right Cessation
- 2006-02-16 ES ES06707447T patent/ES2400502T3/es active Active
- 2006-02-16 DK DK06707447.6T patent/DK1855650T3/da active
- 2006-02-16 WO PCT/EP2006/002074 patent/WO2006089804A1/en active Application Filing
- 2006-02-16 CA CA002598031A patent/CA2598031A1/en not_active Abandoned
- 2006-02-23 AR AR20060100653A patent/AR054228A1/es unknown
-
2007
- 2007-08-21 US US11/892,292 patent/US20090215849A1/en not_active Abandoned
- 2007-09-03 ZA ZA200707558A patent/ZA200707558B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1855650B1 (en) | 2012-12-05 |
PL1855650T3 (pl) | 2013-04-30 |
WO2006089804A1 (en) | 2006-08-31 |
ES2400502T3 (es) | 2013-04-10 |
SI1855650T1 (sl) | 2013-05-31 |
RU2007135364A (ru) | 2009-03-27 |
MX2007010179A (es) | 2007-09-18 |
ZA200707558B (en) | 2008-10-29 |
CN101128185A (zh) | 2008-02-20 |
KR20070112139A (ko) | 2007-11-22 |
FR2882552A1 (fr) | 2006-09-01 |
CA2598031A1 (en) | 2006-08-31 |
US20090215849A1 (en) | 2009-08-27 |
PT1855650E (pt) | 2013-02-28 |
EP1855650A1 (en) | 2007-11-21 |
BRPI0608044A2 (pt) | 2009-11-03 |
JP2008531517A (ja) | 2008-08-14 |
RU2409346C2 (ru) | 2011-01-20 |
AU2006218043B2 (en) | 2012-02-02 |
FR2882552B1 (fr) | 2008-12-26 |
AU2006218043A1 (en) | 2006-08-31 |
DK1855650T3 (da) | 2013-02-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |